Salicylate (Salsalate) in Patients With Type 2 Diabetes: A Randomized Trial
Open accessAbstract
BACKGROUND: Short-duration studies show that salsalate improves glycemia in type 2 diabetes mellitus (T2DM). OBJECTIVE: To assess 1-year efficacy and safety of salsalate in T2DM. DESIGN: Placebo-controlled, parallel trial; computerized randomization and centralized allocation, with patients, providers, and researchers blinded to assignment. (ClinicalTrials.gov: NCT00799643). SETTING: 3 private practices and 18 academic centers in the United States. PATIENTS: Persons aged 18 to 75 years with fasting glucose levels of 12.5 mmol/L or less (≤225 mg/dL) and hemoglobin A1c (HbA1c) levels of 7.0% to 9.5% who were treated for diabetes. INTERVENTION: 286 participants were randomly assigned (between January 2009 and July 2011) to 48 weeks of placebo (n = 140) or salsalate, 3.5 g/d (n = 146), in addition to current therapies, and 283 participants were analyzed (placebo, n = 137; salsalate, n = 146). MEASUREMENTS: Change in hemoglobin A1c level (primary outcome) and safety and efficacy measures. RESULTS: The mean HbA1c level over 48 weeks was 0.37% lower in the salsalate group than in the placebo group (95% CI, -0.53% to -0.21%; P < 0.001). Glycemia improved despite more reductions in concomitant diabetes medications in salsalate recipients than in placebo recipients. Lower circulating leukocyte, neutrophil, and lymphocyte counts show the anti-inflammatory effects of salsalate. Adiponectin and hematocrit levels increased more and fasting glucose, uric acid, and triglyceride levels decreased with salsalate, but weight and low-density lipoprotein cholesterol levels also increased. Urinary albumin levels increased but reversed on discontinuation; estimated glomerular filtration rates were unchanged. LIMITATION: Trial duration and number of patients studied were insufficient to determine long-term risk-benefit of salsalate in T2DM. CONCLUSION: Salsalate improves glycemia in patients with T2DM and decreases inflammatory mediators. Continued evaluation of mixed cardiorenal signals is warranted.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Look AHEAD, with weight loss a greater proportion of subjects achieved partial or complete diabetes remission.
“with weight loss a greater proportion of subjects achieved either partial or complete diabetes remission134”
From Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future (2014) · cites this paper as [134]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works
Self-citationMutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works
Self-citationUric Acid and Cardiovascular Risk
Feig, D. I., Kang, D., & Johnson, R. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800885 · Cited by 2,443 · see citing works
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884 · see citing works
Self-citationInterleukin-1-receptor antagonist in type 2 diabetes mellitus
Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works
Inhibition of NF-κB by Sodium Salicylate and Aspirin
Kopp, E. B., & Ghosh, S. (1994) · Science · doi:10.1126/science.8052854 · Cited by 1,765 · see citing works
The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
Yin, M.-J., Yamamoto, Y., & Gaynor, R. B. (1998) · Nature · doi:10.1038/23948 · Cited by 1,596 · see citing works
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367 · see citing works
Self-citationSchmidt, M. I., Duncan, B. B., Sharrett, A. R., Lindberg, G., Savage, P. J., Offenbacher, S., Azambuja, M. I. R., Tracy, R. P., & HEISS, G. M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01046-6 · Cited by 1,069 · see citing works
Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation
Grilli, M., Pizzi, M., Memo, M., & Spano, P. (1996) · Science · doi:10.1126/science.274.5291.1383 · Cited by 751 · see citing works
The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase
Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., et al. (2012) · Science · doi:10.1126/science.1215327 · Cited by 745 · see citing works
Vozarova, B., Weyer, C., Lindsay, R. S., Pratley, R. E., Bogardus, C., & Tataranni, P. A. (2002) · Diabetes · doi:10.2337/diabetes.51.2.455 · Cited by 564 · see citing works
Ridker, P. M., Howard, C. P., Walter, V., Everett, B., Libby, P., Hensen, J., & Thuren, T. (2012) · Circulation · doi:10.1161/circulationaha.112.122556 · Cited by 530 · see citing works
Apoptosis: Activate NF-κB or die?
Baichwal, V. R., & Baeuerle, P. A. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00046-7 · Cited by 528 · see citing works
Loll, P. J., Picot, D., & Garavito, R. M. (1995) · Nature Structural Biology · doi:10.1038/nsb0895-637 · Cited by 490 · see citing works
The Leukocyte Count as a Predictor of Myocardial Infarction
FRIEDMAN, G. D., Klatsky, A. L., & SIEGELAUB, A. B. (1974) · New England Journal of Medicine · doi:10.1056/nejm197406062902302 · Cited by 486 · see citing works
Heat Shock Response Modulators as Therapeutic Tools for Diseases of Protein Conformation
Westerheide, S. D., & Morimoto, R. I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.r500010200 · Cited by 481 · see citing works
Effect of Sodium Salicylate on the Human Heat Shock Response
Jurivich, D. A., Sistonen, L., Kroes, R. A., & Morimoto, R. I. (1992) · Science · doi:10.1126/science.1546322 · Cited by 395 · see citing works
Prognostic Importance of the White Blood Cell Count for Coronary, Cancer, and All-Cause Mortality
Grimm, R. H. (1985) · JAMA · doi:10.1001/jama.1985.03360140090031 · Cited by 367 · see citing works
Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
Fleischman, A., Shoelson, S. E., Bernier, R., & Goldfine, A. B. (2008) · Diabetes Care · doi:10.2337/dc07-1338 · Cited by 352 · see citing works
Self-citationGallwitz, B., Rosenstock, J., Rauch, T., Bhattacharya, S., Patel, S. D., von Eynatten, M., Dugi, K. A., & Woerle, H. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60691-6 · Cited by 339 · see citing works
Pierce, J. W., Read, M. A., Ding, H. T., Luscinskas, F. W., & Collins, T. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3961 · Cited by 301 · see citing works
Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes
Goldfine, A. B., Silver, R., Aldhahi, W., Cai, D., Tatro, E., Lee, J., & Shoelson, S. E. (2008) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2008.00026.x · Cited by 289 · see citing works
Self-citationSchwenger, P., Bellosta, P., Vietor, I., Basilico, C., Skolnik, E. Y., & Vilček, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2869 · Cited by 273 · see citing works
Gao, Z., Zuberi, A. R., Quon, M. J., Dong, Z., & Ye, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300423200 · Cited by 258 · see citing works
Jack, D. B. (1997) · The Lancet · doi:10.1016/s0140-6736(97)07087-6 · Cited by 257 · see citing works
Schwenger, P., Alpert, D. R., Skolnik, E. Y., & Vilček, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.78 · Cited by 196 · see citing works
The Effect of Sodium Salicylate and Aspirin on NF-κB
Frantz, B., & O’Neill, E. A. (1995) · Science · doi:10.1126/science.270.5244.2017 · Cited by 158 · see citing works
Gillum, R. F., Mussolino, M. E., & Madans, J. H. (2004) · Annals of Epidemiology · doi:10.1016/j.annepidem.2004.08.009 · Cited by 132 · see citing works
Short term effects of infliximab on the lipid profile in patients with rheumatoid arthritis.
Vis, M., Nurmohamed, M. T., Wolbink, G., Voskuyl, A. E., Koning, M. H. M. T. D., van de Stadt, R. J., Twisk, J. W. R., Dijkmans, B. A. C., & Lems, W. F. (2005) · PubMed · Cited by 126 · see citing works
Koška, J., Ortega, E., Bunt, J. C., Gasser, A., Impson, J., Hanson, R. L., Forbes, J. M., de Courten, B. V., & Krakoff, J. A. (2008) · Diabetologia · doi:10.1007/s00125-008-1239-x · Cited by 119 · see citing works
Lafrance, J., & Miller, D. R. (2009) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1798 · Cited by 119 · see citing works
The Aspirin Wars: Money, Medicine and 100 Years of Rampant Competition
Mann, C., & Plummer, M. L. (1993) · Cited by 98 · see citing works
Kullo, I. J., Hensrud, D. D., & Allison, T. G. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02366-4 · Cited by 86 · see citing works
THE TREATMENT OF ACUTE RHEUMATISM BY SALICIN.
MACLAGAN, T. (1876) · The Lancet · doi:10.1016/s0140-6736(02)46434-3 · Cited by 76 · see citing works
THE TREATMENT OF ACUTE RHEUMATISM BY SALICIN.
Maclagan, T. J. (1876) · The Lancet · doi:10.1016/s0140-6736(02)49509-8 · Cited by 68 · see citing works
Salsalate improves glycemic control in patients with newly diagnosed type 2 diabetes
Faghihimani, E., Aminorroaya, A., Rezvanian, H., Adibi, P., Ismail‐Beigi, F., & Amini, M. (2011) · Acta Diabetologica · doi:10.1007/s00592-011-0329-2 · Cited by 66 · see citing works
Nixon, M., Wake, D. J., Livingstone, D. E. W., Stimson, R. H., Esteves, C. L., Seckl, J. R., Chapman, K. E., Andrew, R., & Walker, B. R. (2012) · Diabetes · doi:10.2337/db11-0931 · Cited by 64 · see citing works
Stevenson, M. A., Zhao, M. J., Asea, A. A. A., Coleman, C. N., & Calderwood, S. K. (1999) · PubMed · Cited by 62 · see citing works
Lack of platelet effect with the aspirin analog, salsalate
Estes, D., & Kaplan, K. L. (1980) · Arthritis & Rheumatism · doi:10.1002/art.1780231113 · Cited by 59 · see citing works
Stevenson, M. A., Zhao, M., Asea, A. A. A., Coleman, C. N., & Calderwood, S. K. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5608 · Cited by 51 · see citing works
Alpert, D. R., & Vilček, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.15.10925 · Cited by 49 · see citing works
A New Pharmacological Effect of Salicylates: Inhibition of NFAT-Dependent Transcription
Aceves, M., Dueñas, A., Gómez, C., Vicente, E. S., Crespo, M. S., & García‐Rodríguez, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5721 · Cited by 43 · see citing works
Inhibition of Dehydrogenases by Salicylate
Hines, W. J. W., & Smith, M. J. H. (1964) · Nature · doi:10.1038/201192a0 · Cited by 39 · see citing works
Effects of Salsalate (Nonacetylated Salicylate) and Aspirin on Serum Prostaglandins in Humans
Morris, H. G., Sherman, N. A., McQuain, C., Goldlust, M. B., Chang, S.-W., & Harrison, L. I. (1985) · Therapeutic Drug Monitoring · doi:10.1097/00007691-198512000-00012 · Cited by 37 · see citing works
Roth, S. H., Bennett, R., Caldron, P. H., Hartman, R., Mitchell, C. S., Doucette, M., Ekholm, B. P., Goldlust, B., Lee, E., & Wilson, R. (1990) · PubMed · Cited by 36 · see citing works
Scheiman, J. M., & Elta, G. H. (1990) · Seminars in Arthritis and Rheumatism · doi:10.1016/0049-0172(90)90025-b · Cited by 32 · see citing works
Edmar, D. (1971) · Acta Radiologica Diagnosis · doi:10.1177/028418517101100107 · Cited by 29 · see citing works
An endoscopic comparison of the gastroduodenal injury seen with salsalate and naproxen.
Lanza, F., Rack, M. F., Doucette, M., Ekholm, B. P., Goldlust, B., & Wilson, R. (1989) · PubMed · Cited by 29 · see citing works
The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes
Goldfine, A. B., Fonseca, V. A., Jablonski, K. A., Pyle, L. L., Staten, M. A., Shoelson, S. E., & for the TINSAL-T2D (Targeting Inflammation Using Salsalate in Type 2 Diabetes) Study Team* (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-6-201003160-00004 · Cited by 18 · see citing works
Self-citationHemostatic effects of salsalate in normal subjects and patients with hemophilia A
Sweeney, J. D., & Hoernig, L. A. (1991) · Thrombosis Research · doi:10.1016/0049-3848(91)90165-s · Cited by 15 · see citing works
The treatment of acute rheumatism by salicin, by T.J. Maclagan--The Lancet, 1876.
Buchanan, W. W., & Kean, W. F. (2002) · PubMed · Cited by 13 · see citing works
Smith, M. J. H., Bryant, C. R., & Hines, W. J. W. (1964) · Nature · doi:10.1038/202096a0 · Cited by 8 · see citing works
ST. MARY'S HOSPITAL. TREATMENT OF RHEUMATIC FEVER BY SALICYLIC ACID
BROADBENT, D. (1876) · The Lancet · doi:10.1016/s0140-6736(02)49921-7 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works
Inflammation, metaflammation and immunometabolic disorders
Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570 · see citing works
Inflammation in obesity, diabetes, and related disorders
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066 · see citing works
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743 · see citing works
The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
Tsalamandris, S., Antonopoulos, A. S., Oikonomou, E., Papamikroulis, G.-A., Vogiatzi, G., Papaioannou, S., Deftereos, S., & Tousoulis, D. (2019) · European Cardiology Review · doi:10.15420/ecr.2018.33.1 · Cited by 1,381 · see citing works
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180 · see citing works
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works
Targeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works
Targeting inflammation in the treatment of type 2 diabetes: time to start
Donath, M. Y. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4275 · Cited by 690 · see citing works
Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus
Yaribeygi, H., Sathyapalan, T., Atkin, S. L., & Sahebkar, A. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8609213 · Cited by 689 · see citing works
The link between depression and diabetes: the search for shared mechanisms
Moulton, C. D., Pickup, J. C., & Ismail, K. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00134-5 · Cited by 670 · see citing works
Exercises for mechanical neck disorders
Gross, A., Kay, T. M., Paquin, J.-P., Blanchette, S., Lalonde, P., Christie, T., Dupont, G., Graham, N., Burnie, S. J., Gelley, G., et al. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004250.pub5 · Cited by 613 · see citing works
Anti-inflammatory therapies for cardiovascular disease
Ridker, P. M., & Lüscher, T. F. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu203 · Cited by 558 · see citing works
Treatment of nonalcoholic fatty liver disease: role of AMPK
Smith, B. K., Marcinko, K., Desjardins, E. M., Lally, J., Ford, R. J., & Steinberg, G. R. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00225.2016 · Cited by 502 · see citing works
The role of infiltrating immune cells in dysfunctional adipose tissue
Guzik, T. J., Skiba, D. S., Touyz, R. M., & Harrison, D. G. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx108 · Cited by 453 · see citing works
Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications
Sarma, S., Sockalingam, S., & Dash, S. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14290 · Cited by 461 · see citing works
Ridker, P. M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.11.037 · Cited by 414 · see citing works
The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
Ying, W., Fu, W., Lee, Y. S., & Olefsky, J. M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0286-3 · Cited by 395 · see citing works
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 427 · see citing works
Obesity and Cancer: The Oil that Feeds the Flame
Font-Burgada, J., Sun, B., & Karin, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.015 · Cited by 354 · see citing works
Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes
Everett, B. M., Donath, M. Y., Pradhan, A. D., Thuren, T. Y., Pais, P. S., Nicolau, J. C., Glynn, R. J., Libby, P., & Ridker, P. M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.03.002 · Cited by 328 · see citing works
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 318 · see citing works
TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation
Velloso, L. A., Folli, F. B., & Saad, M. J. A. (2015) · Endocrine Reviews · doi:10.1210/er.2014-1100 · Cited by 314 · see citing works
Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?
Blüher, M. (2016) · Clinical Science · doi:10.1042/cs20160005 · Cited by 262 · see citing works
Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis
Ridker, P. M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313129 · Cited by 260 · see citing works
Inflammation as a Therapeutic Target for Diabetic Neuropathies
Pop‐Busui, R., Ang, L. P., Holmes, C., Gallagher, K. A., & Feldman, E. L. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0727-5 · Cited by 272 · see citing works
Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications
Pollack, R. M., Donath, M. Y., LeRoith, D., & Leibowitz, G. (2016) · Diabetes Care · doi:10.2337/dcs15-3015 · Cited by 261 · see citing works
Macrophage function in adipose tissue homeostasis and metabolic inflammation
Chavakis, T., Alexaki, V. I., & Ferrante, A. W. (2023) · Nature Immunology · doi:10.1038/s41590-023-01479-0 · Cited by 264 · see citing works
Esser, N., Paquot, N., & Scheen, A. J. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.974804 · Cited by 252 · see citing works
Inflammation and resolution in obesity
Soták, M., Clark, M., Suur, B. E., & Börgeson, E. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01047-y · Cited by 234 · see citing works
Menne, J., Eulberg, D., Beyer, D., Baumann, M., Saudek, F., Valkusz, Z., Więcek, A., Haller, H. G., & for the Emapticap Study Group (2016) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv459 · Cited by 203 · see citing works
Varra, F., Varras, M. N., Varra, V., & Theodosis‐Nobelos, P. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13219 · Cited by 194 · see citing works
Regulation of energy balance by inflammation: Common theme in physiology and pathology
Wang, H., & Ye, J. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9306-8 · Cited by 173 · see citing works
Targeting Residual Inflammatory Risk: A Shifting Paradigm for Atherosclerotic Disease
Aday, A. W., & Ridker, P. M. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00016 · Cited by 176 · see citing works
Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk
Goldfine, A. B., & Shoelson, S. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88884 · Cited by 172 · see citing works
Self-citationSex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Lagou, V., Mägi, R., Hottenga, J., Grallert, H., Perry, J. R. B., Bouatia‐Naji, N., Marullo, L., Rybin, D. V., Jansen, R., Min, J. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-19366-9 · Cited by 154 · see citing works
Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes
Kohlgruber, A. C., & Lynch, L. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0670-x · Cited by 157 · see citing works
Type‐2 diabetes: Current understanding and future perspectives
Pandey, A., Chawla, S., & Guchhait, P. (2015) · IUBMB Life · doi:10.1002/iub.1396 · Cited by 150 · see citing works
Lactoferrin in aseptic and septic inflammation
Lepanto, M. S., Rosa, L., Paesano, R., Valenti, P., & Cutone, A. (2019) · Molecules · doi:10.3390/molecules24071323 · Cited by 147 · see citing works
Dragano, N. R. V., Solon, C., Ramalho, A. F. S., de Moura, R. F., Razolli, D. S., Christiansen, E., Azevedo, C., Ulven, T., & Velloso, L. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0869-7 · Cited by 140 · see citing works
Strategies and Challenges in Clinical Trials Targeting Human Aging
Newman, J. C., Milman, S., Hashmi, S. K., Austad, S. N., Kirkland, J. L., Halter, J. B., & Barzilai, N. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw149 · Cited by 137 · see citing works
Calvo, S. S.-C., Bharath, L. P., Pugh, G. H., SantaCruz-Calvo, L., Lenin, R. R., Lutshumba, J., Liu, R., Bachstetter, A. D., Zhu, B., & Nikolajczyk, B. S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00575-1 · Cited by 141 · see citing works
Diabetes and Sepsis: Risk, Recurrence, and Ruination
Frydrych, L. M., Fattahi, F., He, K., Ward, P. A., & Delano, M. J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00271 · Cited by 133 · see citing works
Jin, T., Song, Z., Weng, J., & Fantus, I. G. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00285.2017 · Cited by 128 · see citing works
Inflammation in diabetes complications: molecular mechanisms and therapeutic interventions
Zhao, L., Hu, H., Zhang, L., Liu, Z., Huang, Y., Liu, Q., Jin, L., Zhu, M., & Zhang, L. (2024) · MedComm · doi:10.1002/mco2.516 · Cited by 136 · see citing works
Novel Protein Glycan Side-Chain Biomarker and Risk of Incident Type 2 Diabetes Mellitus
Akinkuolie, A. O., Pradhan, A. D., Buring, J. E., Ridker, P. M., & Mora, S. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305635 · Cited by 125 · see citing works
Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease
Donath, M. Y., Meier, D. T., & Böni‐Schnetzler, M. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00002 · Cited by 126 · see citing works
Martínez-Colón, G. J., Ratnasiri, K., Chen, R., Jiang, S., ZANLEY, E. J., Rustagi, A., Verma, R., Chen, H. M., Andrews, J. R., Mertz, K. D., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm9151 · Cited by 136 · see citing works
The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing
Cavadas, C., Aveleira, C. A., Souza, G. F. P., & Velloso, L. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.107 · Cited by 105 · see citing works
Macrophages, fat, and the emergence of immunometabolism
Ferrante, A. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci73658 · Cited by 104 · see citing works
Multiple benefits of targeting inflammation in the treatment of type 2 diabetes
Donath, M. Y. (2016) · Diabetologia · doi:10.1007/s00125-016-3873-z · Cited by 102 · see citing works
Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes
Kuryłowicz, A., & Koźniewski, K. (2020) · Molecules · doi:10.3390/molecules25092224 · Cited by 101 · see citing works
Hage, M. P., Al-Badri, M. R., & Azar, S. T. (2014) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018814547204 · Cited by 98 · see citing works
Ghanbari, M., Maragheh, S. M., Aghazadeh, A., Mehrjuyan, S. R., Hussen, B. M., Shadbad, M. A., Dastmalchi, N., & Safaralizadeh, R. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107765 · Cited by 99 · see citing works
The Role of Mitochondria in Diabetic Kidney Disease
Hallan, S. I., & Sharma, K. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0748-0 · Cited by 94 · see citing works
Inflammatory Trajectory of Type 2 Diabetes: Novel Opportunities for Early and Late Treatment
Pellegrini, V., Grotta, R. L., Carreras, F., Giuliani, A., Sabbatinelli, J., Olivieri, F., Berra, C., Ceriello, A., & Prattichizzo, F. (2024) · Cells · doi:10.3390/cells13191662 · Cited by 96 · see citing works
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 87 · see citing works
Handelsman, Y., Anderson, J. E., Bakris, G. L., Ballantyne, C. M., Bhatt, D. L., Bloomgarden, Z. T., Bozkurt, B., Budoff, M. J., Butler, J., Cherney, D. Z. I., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155931 · Cited by 93 · see citing works
Self-citationTranslating the Science of Aging into Therapeutic Interventions
Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78 · see citing works
Williams, K. J., & Wu, X. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.004 · Cited by 81 · see citing works
Salsalate and adiponectin ameliorate hepatic steatosis by inhibition of the hepatokine fetuin-A
Jung, T. W., Youn, B., Choi, H. Y., Lee, S. Y., Hong, H. C., Yang, S. J., Yoo, H. J., Kim, B., Baik, S. H., & Choi, K. M. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.034 · Cited by 82 · see citing works
Mechanisms underlying the metabolic actions of testosterone in humans: A narrative review
Dandona, P., Dhindsa, S., Ghanim, H., & Saad, F. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14206 · Cited by 86 · see citing works
Walker, A. E., Kaplon, R. E., Pierce, G. L., Nowlan, M. J., & Seals, D. R. (2014) · Clinical Science · doi:10.1042/cs20140030 · Cited by 81 · see citing works
Moulton, C. D., Hopkins, C. W. P., Ismail, K., & Stahl, D. R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.010 · Cited by 79 · see citing works
Targeting inflammatory pathways for the treatment of cardiovascular disease
Ridker, P. M. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht398 · Cited by 76 · see citing works
Lorenzo, C., Hanley, A. J., & Haffner, S. M. (2013) · Diabetologia · doi:10.1007/s00125-013-3080-0 · Cited by 71 · see citing works
Novel agents for the treatment of type 2 diabetes
DeFronzo, R. A., Triplitt, C. L., Abdul-Ghani, M., & Cersosimo, E. (2014) · Diabetes Spectrum · doi:10.2337/diaspect.27.2.100 · Cited by 83 · see citing works
Controlling diabetes by chromium complexes: The role of the ligands
Peng, M., & Yang, X. (2015) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2015.01.002 · Cited by 70 · see citing works
Lu, M., Yan, S.-T., Yin, W., Koo, M., & Lai, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101528 · Cited by 70 · see citing works
Gong, J., Li, J., Dong, H., Chen, G., Qin, X., Hu, M., Yuan, F., Fang, K., Wang, D., Jiang, S., et al. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2710-6 · Cited by 69 · see citing works
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2019) · Comprehensive physiology · doi:10.1002/j.2040-4603.2019.tb00055.x · Cited by 65 · see citing works
Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity
Malle, E. K., Zammit, N. W., Walters, S. N., Koay, Y. C., Wu, J., Tan, B. M., Villanueva, J. E., Brink, R. A., Loudovaris, T., Cantley, J., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150218 · Cited by 63 · see citing works
Cafeteria diet-induced obesity causes oxidative damage in white adipose
Johnson, A. R., Wilkerson, M. D., Sampey, B. P., Troester, M. A., Hayes, D. N., & Makowski, L. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.113 · Cited by 63 · see citing works
Effect of Targeting Inflammation With Salsalate
Hauser, T. H., Salastekar, N. V., Schaefer, E. J., Desai, T., Goldfine, H. L., Fowler, K. M., Weber, G. M., Welty, F. K., Clouse, M. E., Shoelson, S. E., et al. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.0605 · Cited by 63 · see citing works
Self-citationCombating Inflammation in Cardiovascular Disease
Sethwala, A., Goh, I. Y., & Amerena, J. V. (2020) · Heart Lung and Circulation · doi:10.1016/j.hlc.2020.09.003 · Cited by 62 · see citing works
Brénachot, X., Ramadori, G., Ioris, R. M., Veyrat‐Durebex, C., Altirriba, J., Aras, E., Ljubicic, S., Kohno, D., Fabbiano, S., Clément, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02074-2 · Cited by 60 · see citing works
Targeting Inflammation to Reduce Residual Cardiovascular Risk
Ajala, O. N., & Everett, B. M. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00883-3 · Cited by 65 · see citing works
LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding
Lee, H. H., Sanada, S., An, S. M., Ye, B. J., Lee, J. H., Seo, Y., Lee, C., Lee‐Kwon, W., Küper, C., Neuhofer, W., et al. (2016) · Scientific Reports · doi:10.1038/srep24921 · Cited by 56 · see citing works
Novelli, M., Masiello, P., Beffy, P., & Menegazzi, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218108 · Cited by 57 · see citing works
Latent Inflammation and Insulin Resistance in Adipose Tissue
Stafeev, I., Vorotnikov, A. V., Ratner, E. I., Menshikov, M. Y., & Parfyonova, Y. V. (2017) · International Journal of Endocrinology · doi:10.1155/2017/5076732 · Cited by 57 · see citing works
Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes
Kimple, M. E., Neuman, J. C., Linnemann, A. K., & Casey, P. J. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.40 · Cited by 54 · see citing works
Repurposing Drugs to Target the Diabetes Epidemic
Turner, N. A., Zeng, X., Osborne, B., Rogers, S., & Ye, J.-M. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.01.007 · Cited by 59 · see citing works
Plant Hormones: Key Players in Gut Microbiota and Human Diseases?
Chanclud, E., & Lacombe, B. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2017.07.003 · Cited by 51 · see citing works
Goldfine, A. B., Buck, J. S., Desouza, C. V., Fonseca, V. A., Chen, Y.-D. I., Shoelson, S. E., Jablonski, K. A., Creager, M. A., & for the TINSAL-FMD (Targeting Inflammation Using Salsalate in Type 2 Diabetes–Flow-Mediated Dilation) Ancillary Study Team (2013) · Diabetes Care · doi:10.2337/dc13-0859 · Cited by 51 · see citing works
Self-citationInfluence of Elicitors and Eustressors on the Production of Plant Secondary Metabolites
Alvarado, A. M., Aguirre-Becerra, H., Vázquez-Hernández, C., Magaña-López, E., Parola-Contreras, I., Caicedo-López, L. H., Contreras-Medina, L. M., García‐Trejo, J. F., Guevara-González, R. G., & Feregrino‐Pérez, A. A. (2019) · Springer eBooks · doi:10.1007/978-981-13-7154-7_11 · Cited by 51 · see citing works
Riera, C. E., & Dillin, A. G. (2015) · Nature Medicine · doi:10.1038/nm.4005 · Cited by 46 · see citing works
Involvements of long noncoding RNAs in obesity‐associated inflammatory diseases
Wijesinghe, S. N., Nicholson, T. A., Tsintzas, K., & Jones, S. W. (2020) · Obesity Reviews · doi:10.1111/obr.13156 · Cited by 47 · see citing works
Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients
Kataria, Y., Ellervik, C., & Mandrup-Poulsen, T. R. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00743-6 · Cited by 46 · see citing works
Effect of Periodontal Treatment on HbA1c among Patients with Prediabetes
Kocher, T., Holtfreter, B., Petersmann, A., Eickholz, P., Hoffmann, T. K., Kaner, D., Kim, T., Meyle, J., Schlagenhauf, U., Doering, S., et al. (2018) · Journal of Dental Research · doi:10.1177/0022034518804185 · Cited by 45 · see citing works
Patel, M. S., Miranda-Nieves, D., Chen, J., Haller, C. A., & Chaikof, E. L. (2016) · Translational research · doi:10.1016/j.trsl.2016.11.007 · Cited by 44 · see citing works
Effects of anti-inflammatory therapies on glycemic control in type 2 diabetes mellitus
Li, D., Zhong, J., Zhang, Q., & Zhang, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125116 · Cited by 47 · see citing works
Salsalate Activates Brown Adipose Tissue in Mice
van Dam, A. D., Nahon, K. J., Kooijman, S., van den Berg, S. M., Kanhai, A. A., Kikuchi, T., Heemskerk, M. M., van Harmelen, V., Lombès, M., van den Hoek, A. M., et al. (2014) · Diabetes · doi:10.2337/db14-1125 · Cited by 42 · see citing works
Wang, N., Tian, X., Chen, Y., Tan, H.-Q., Xie, P.-J., Shao-jun, C., Fu, Y., Chen, Y., Xu, W., & Wei, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-14408-7 · Cited by 42 · see citing works
Self-citationKnudsen, S. H., & Pedersen, B. K. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0642-1 · Cited by 41 · see citing works
Salicylic acid-mediated plant defense: Recent developments, missing links, and future outlook
Palmer, I. A., Shang, Z., & Fu, Z. Q. (2017) · Frontiers in Biology · doi:10.1007/s11515-017-1460-4 · Cited by 41 · see citing works
Kim, J., & Lee, J. (2021) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2040188.094 · Cited by 41 · see citing works
Mohandoss, S., Edison, T. N. J. I., Atchudan, R., Palanisamy, S., Prabhu, N. M., Napoleon, A. A., You, S., & Lee, Y. R. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.114358 · Cited by 39 · see citing works
Skeletal muscle non-shivering thermogenesis as an attractive strategy to combat obesity
Li, H., Wang, C., Li, L., & Li, L. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119024 · Cited by 38 · see citing works
Cardoso, C. R. L., Leite, N. C., Carlos, F., Loureiro, A. A., Viegas, B. B., & Salles, G. F. (2017) · Diabetes Care · doi:10.2337/dc17-0374 · Cited by 38 · see citing works
Contributions of innate type 2 inflammation to adipose function
Bolus, W. R., & Hasty, A. H. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r085993 · Cited by 38 · see citing works
- Authors
- Goldfine, A. B., Fonseca, V., Jablonski, K. A., Chen, Y.-D. I., Tipton, L., Staten, M. A., & Shoelson, S. E.
- Affiliations
- Tulane University (US)
- Corresponding author
- Shoelson, Steven E.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2013-07-02
- Volume
- 159
- Issue
- 1
- Pages
- 1-12
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- PMC
- PMC4128629
- OpenAlex
- W2031980199
- Cited by
- 251
- References
- 55
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 12 · 2023: 14 · 2022: 10 · 2021: 16 · 2020: 19 · 2019: 19 · 2018: 12 · 2017: 20 · 2016: 38 · 2015: 31 · 2014: 28 · 2013: 15
- FWCI
- 29.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000124, UL1TR000454, 5p50hl083813-05)
- National Heart, Lung, and Blood Institute (P50 HL83813, P50-HL083813)
- National Institute of General Medical Sciences (U54GM104940)
- National Institute of Diabetes and Digestive and Kidney Diseases (RC4DK090792, U01DK074556, P30 DK03836, P30DK036836, P30DK063491)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- salsalate, type 2 diabetes, glycemic control, HbA1c, nonsteroidal anti-inflammatory drugs, anti-inflammatory activity, white blood cell count, adiponectin, uric acid, triglycerides, urinary albumin, estimated glomerular filtration rate, drug safety, long-term efficacy, weight gain
- MeSH terms
- Adolescent, Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Kidney, Male, Middle Aged, Salicylates, Single-Blind Method, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
