Evaluation of recurrence after photodynamic therapy with topical methylaminolaevulinate for 157 basal cell carcinomas in 90 patients
Open accessAbstract
The aim of this study was to evaluate the effect of photodynamic therapy with topical methylaminolevulinate for the treatment of basal cell carcinomas in a single dermatological department. Ninety patients (34.4% men and 65.6% women) with a total of 157 basal cell carcinomas (111 superficial, 40 nodular, 6 unknown) were treated. Primary endpoint was clinically observed recurrence verified by biopsy 3, 6 and 12 months after treatment, then once a year. Estimated patient recurrence rates were 7% at 3 months, 19% at 6 months, 27% at 12 months and 31% at 24 months. Patients aged over 60 years had significantly higher estimated recurrence rates compared with patients aged 60 years or under (at 12 months, 35% vs. 19%, p?=?0.01). Estimated recurrence rates for tumours was 4% at 3 months, 11% at 6 months, 16% at 12 months and 19% at 24 months. There were significantly higher estimated recurrence rates for nodular basal cell carcinomas compared with superficial basal cell carcinomas (at 12 months, 28% vs. 13%, p?=?0.008). In conclusion, photodynamic therapy is only appropriate for treatment of superficial basal cell carcinoma, and, age above 60 years and histology showing nodular basal cell carcinoma are independent risk factors for developing a recurrent basal cell carcinoma.
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PDT is effective for superficial basal cell carcinoma (BCC).
“Photodynamic therapy (PDT) offers an effective treatment for AKs, and is also effective for superficial basal cell carcinoma (BCC).”
From Photodynamic Therapy for Non-Melanoma Skin Cancers (2016) · cites this paper as [50]
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New options for non-invasive imaging and non-invasive treatment of skin cancers
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Christensen, E. (2013) · NORA - Norwegian Open Research Archives
- Authors
- Lindberg-Larsen, R., Sølvsten, H., & Kragballe, K.
- Affiliations
- Aarhus University Hospital (DK)
- Venue
- Acta Dermato Venereologica
- Published
- 2012
- Volume
- 92
- Issue
- 2
- Pages
- 144-147
- ISSN
- 0001-5555 (ISSN-L)
- OpenAlex
- W2323866009
- Cited by
- 45
- References
- 11
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 1
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Acta Dermato Venereologica (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- photodynamic therapy, methyl aminolevulinate, basal cell carcinoma, tumor recurrence, nodular basal cell carcinoma, superficial basal cell carcinoma, risk factors, age over 60, recurrence rate
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Aminolevulinic Acid, Basal Cell Carcinoma, Carcinoma, Basal Cell, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Photochemotherapy, Retrospective Studies, Skin Neoplasms, Multivariate Analysis, Proportional Hazards Models, Photosensitizing Agents, Young Adult
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