Long-term recurrence of nonmelanoma skin cancer after topical methylaminolevulinate photodynamic therapy in a dermato-oncology department
Open accessAbstract
BACKGROUND: Most available studies on the efficacy of topical photodynamic therapy focus on short-to medium-term results. Long-term data are scarce. OBJECTIVE: To evaluate the long-term efficacy of photodynamic therapy with topical methylaminolevulinate to treat Bowen's disease and basal cell carcinoma in the clinical practice setting of a dermato-oncology department. METHODS: The study included patients diagnosed with Bowen's disease or basal cell carcinoma, and who received photodynamic therapy from 2004 to 2008. Treatment protocol and clinical follow-up were standardized. The primary endpoint was clinically observed recurrence in a previous photodynamic therapy-treated area. Descriptive and survival analyses were performed. RESULTS: A total of 31 Bowen's disease lesions and 44 superficial basal cell carcinoma were treated, with a median follow-up of 43.5 months. Recurrence was observed in 14 Bowen's disease lesions (53.8%) and in 11 superficial basal cell carcinoma (33.3%). Significantly higher estimates for recurrence rates were found in patients with Bowen's disease (p=0.0036) or those aged under 58 years (p=0.039). The risk of recurrence was higher in patients with Bowen's disease than in those with superficial basal cell carcinoma and younger patients. CONCLUSIONS: Recurrence should be considered when choosing to treat non-melanoma skin cancer with photodynamic therapy. Younger age and Bowen's disease were independent predictors for long-term recurrence, suggesting the need to establish an extended period of follow-up for this subset of patients.
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A retrospective study of 31 Bowen's lesions treated with MAL/PDT in Brazil found 14 of 31 lesions recurrent, for a rate of 53.8%, with a mean follow-up of 43.5 months.
“A retrospective study of 31 Bowen’s lesions treated with MAL/PDT in Brazil found 14 of 31 lesions recurrent, for a rate of 53.8%, with a mean follow-up of 43.5 months [57].”
From Photodynamic Therapy for Non-Melanoma Skin Cancers (2016) · cites this paper as [57]
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- Authors
- Cabete, J., Rafael, M., Cravo, M., Moura, C., Sachse, F., & Pecegueiro, M.
- Affiliations
- Unidade Local de Saúde de São José (PT)
- Instituto Português de Oncologia Francisco Gentil (PT)
- Corresponding author
- Cabete, Joana
- Venue
- Anais Brasileiros de Dermatologia
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2015-12
- Volume
- 90
- Issue
- 6
- Pages
- 846-850
- ISSN
- 0365-0596 (ISSN-L)
- PMC
- PMC4689073
- OpenAlex
- W2401024839
- Cited by
- 29
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 3 · 2017: 4 · 2016: 3
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Anais Brasileiros de Dermatologia (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Cancer and Skin Lesions
- Keywords
- non-melanoma skin cancer, photodynamic therapy, methyl aminolevulinate, Bowen's disease, superficial basal cell carcinoma, tumor recurrence, long-term efficacy, predictors of recurrence, age as risk factor, follow-up duration
- MeSH terms
- Administration, Cutaneous, Adult, Age Factors, Aged, Aged, 80 and over, Aminolevulinic Acid, Bowen's Disease, Basal Cell Carcinoma, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Photochemotherapy, Retrospective Studies, Skin Neoplasms, Time Factors, Treatment Outcome, Photosensitizing Agents, Risk Assessment, Statistics, Nonparametric
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