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Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis
Open accessAbstract
To obtain data on the function of the epidermal barrier in patients with atopic dermatitis (AD) the transepidermal water loss (TEWL) was studied. Measurements were made on three body locations in two clinically well defined groups of patients with AD and in a control group. The TEWL was found to be increased both in dry non-eczematous skin and in clinically normal skin in patients with AD. The TEWL was highest in patients with dry skin. The result of the study may indicate a primary defect in the epidermal barrier: the stratum corneum.
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Citations
Cited by
Filaggrin Mutations Associated with Skin and Allergic Diseases
Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217
The important role of stratum corneum lipids for the cutaneous barrier function
van Smeden, J., Janssens, M., Gooris, G. S., & Bouwstra, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.006 · Cited by 549
Role of Topical Emollients and Moisturizers in the Treatment of Dry Skin Barrier Disorders
Lod??n, M. (2003) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200304110-00005 · Cited by 539
Briot, A., Deraison, C., Lacroix, M., Bonnart, C., Robin, A., Besson, C., Dubus, P., & Hovnanian, A. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082242 · Cited by 504
“Clinically unaffected skin in AD manifests impaired skin barrier function that could favor the penetration of microbes and allergens (15), leading to the development of cutaneous and systemic allergies through activation of antigen-presenting cells such as Langerhans cells (LCs) (16).”
BackgroundJanssens, M., van Smeden, J., Gooris, G. S., Bras, W., Portale, G., Caspers, P. J., Vreeken, R. J., Hankemeier, T., Kezic, S., Wolterbeek, R., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.p030338 · Cited by 488
Metadata
- Authors
- Werner, Y., & Lindberg, M.
- Venue
- Acta Dermato-Venereologica
- Publisher
- Medical Journals Sweden AB
- Published
- 1985-03-01
- Volume
- 65
- Issue
- 2
- Pages
- 102-105
- ISSN
- 0001-5555 (ISSN-L)
- 1651-2057
- OpenAlex
- W146662650
- Cited by
- 404
- References
- 0
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. https://app.cochat.ai/papers/10.2340/0001555565102105
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- Werner, Y., & Lindberg, M. (1985). Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Dermato-Venereologica. https://doi.org/10.2340/0001555565102105
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
