Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works

Atopic Dermatitis

Williams, H. C., Leung, D. Y. M., Thestrup‐Pedersen, K., & David, T. J. (2000) · Cited by 4,597 · see citing works

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978 · see citing works

Severity Scoring of Atopic Dermatitis: The SCORAD Index

(2009) · Dermatology · doi:10.1159/000247298 · Cited by 2,282 · see citing works

Filaggrin Mutations Associated with Skin and Allergic Diseases

Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217 · see citing works

Atopic dermatitis

Leung, D. Y. M., & Bieber, T. R. M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12193-9 · Cited by 1,149 · see citing works

Cytokine modulation of atopic dermatitis filaggrin skin expression

Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084 · see citing works

Decreased Level of Ceramides in Stratum Corneum of Atopic Dermatitis: An Etiologic Factor in Atopic Dry Skin?

Imokawa, G., Abe, A., Jin, K., Higaki, Y., Kawashima, M., & Hidano, A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470233 · Cited by 1,040 · see citing works

In Vivo Confocal Raman Microspectroscopy of the Skin: Noninvasive Determination of Molecular Concentration Profiles

Caspers, P. J., Bruining, H. A., Puppels, G. J., Lucassen, G. W., & Carter, E. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01258.x · Cited by 880 · see citing works

The pH of the Skin Surface and Its Impact on the Barrier Function

Schmid-Wendtner, M.-H., & Korting, H. C. (2006) · Skin Pharmacology and Physiology · doi:10.1159/000094670 · Cited by 860 · see citing works

Stratum Corneum Defensive Functions: An Integrated View

Elias, P. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23668.x · Cited by 781 · see citing works

Structural and Lipid Biochemical Correlates of the Epidermal Permeability Barrier

Elias, P. M., & Menon, G. K. (1991) · Advances in lipid research · doi:10.1016/b978-0-12-024924-4.50005-5 · Cited by 677 · see citing works

The skin barrier in healthy and diseased state

Bouwstra, J. A., & Ponec, M. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.06.021 · Cited by 665 · see citing works

Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema

Sandilands, A., Terron-Kwiatkowski, A., Hull, P. R., O’Regan, G. M., Clayton, T. H., Watson, R. M., Carrick, T., Evans, A. T., Liao, H., Zhao, Y., et al. (2007) · Nature Genetics · doi:10.1038/ng2020 · Cited by 662 · see citing works

Structural Investigations of Human Stratum Corneum by Small-Angle X-Ray Scattering

Bouwstra, J. A., Gooris, G. S., van der Spek, J. A., & Bras, W. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12492217 · Cited by 566 · see citing works

New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene–environment interactions

Cork, M. J., Robinson, D. A., Vasilopoulos, Y., Ferguson, A., Moustafa, M., MacGowan, A., Duff, G. W., Ward, S. J., & Tazi‐Ahnini, R. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.04.042 · Cited by 526 · see citing works

Ceramide and cholesterol composition of the skin of patients with atopic dermatitis

Nardo, A. D. (1998) · Acta Dermato Venereologica · doi:10.1080/00015559850135788 · Cited by 483 · see citing works

Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: Changes in barrier function provide a sensitive indicator of disease activity

Chamlin, S. L., Kao, J. S., Frieden, I. J., Sheu, M. Y., Fowler, A. J., Fluhr, J. W., Williams, M. L. K., & Elias, P. M. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.124617 · Cited by 450 · see citing works

Combined In Vivo Confocal Raman Spectroscopy and Confocal Microscopy of Human Skin

Caspers, P. J., Lucassen, G. W., & Puppels, G. J. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74501-9 · Cited by 446 · see citing works

Ceramide composition of the psoriatic scale

Motta, S., Monti, M., Sesana, S., Caputo, R., Carelli, S., & Ghidoni, R. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(93)90135-n · Cited by 435 · see citing works

Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis

Werner, Y., & Lindberg, M. (1985) · Acta Dermato Venereologica · doi:10.2340/0001555565102105 · Cited by 410 · see citing works

ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis

Ohno, Y., Suto, S., Yamanaka, M., Mizutani, Y., Mitsutake, S., Igarashi, Y., Sassa, T., & Kihara, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005572107 · Cited by 382 · see citing works

Skin barrier function, epidermal proliferation and differentiation in eczema

Proksch, E., Fölster‐Holst, R., & Jensen, J. (2006) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2006.06.003 · Cited by 374 · see citing works

Changes in the Ceramide Profile of Atopic Dermatitis Patients

Ishikawa, J., Narita, H., Kondo, N., Hotta, M., Takagi, Y., Masukawa, Y., Kitahara, T., Takema, Y., Koyano, S., Yamazaki, S., et al. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.161 · Cited by 372 · see citing works

Presence of Intact Intercellular Lipid Lamellae in the Upper Layers of the Stratum Corneum

Madison, K. C., Swartzendruber, D. C., Wertz, P. W., & Downing, D. T. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470386 · Cited by 366 · see citing works

“Outside-to-Inside” (and Now Back to “Outside”) Pathogenic Mechanisms in Atopic Dermatitis

Elias, P. M., & Steinhoff, M. S. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.88 · Cited by 344 · see citing works

Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin.

Seidenari, S., & Giusti, G. (1995) · Acta Dermato-Venereologica · doi:10.2340/0001555575429433 · Cited by 344 · see citing works

Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema

Jungersted, J. M., Scheer, H., Mempel, M., Baurecht, H., Cifuentes, L., Høgh, J. K., Hellgren, L. I., Jemec, G. B. E., Agner, T., & Weidinger, S. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02326.x · Cited by 344 · see citing works

Loss-of-Function Mutations in the Filaggrin Gene Lead to Reduced Level of Natural Moisturizing Factor in the Stratum Corneum

Kežić, S., Kemperman, P. M. J. H., Koster, E. S., de Jongh, C. M., Thio, H. B., Campbell, L., Irvine, A. D., McLean, W. H. I., Puppels, G. J., & Caspers, P. J. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.29 · Cited by 325 · see citing works

How epidemiology has challenged 3 prevailing concepts about atopic dermatitis

Williams, H. C., & Flohr, C. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.04.043 · Cited by 323 · see citing works

Sustained Serine Proteases Activity by Prolonged Increase in pH Leads to Degradation of Lipid Processing Enzymes and Profound Alterations of Barrier Function and Stratum Corneum Integrity

Hachem, J. P., Man, M.-Q., Crumrine, D. A., Uchida, Y., Brown, B. E., Rogiers, V., Roseeuw, D. I., Feingold, K. R., & Elias, P. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23838.x · Cited by 314 · see citing works

Recent experiments on a small-angle/wide-angle X-ray scattering beam line at the ESRF

Bras, W., Dolbnya, I. P., Detollenaere, D., van Tol, R., Malfois, M., Greaves, G. N., Ryan, A. J., & Heeley, E. L. (2003) · Journal of Applied Crystallography · doi:10.1107/s002188980300400x · Cited by 293 · see citing works

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

Scharschmidt, T. C., Man, M., Hatano, Y., Crumrine, D. A., Gunathilake, R., Sundberg, J. P., Silva, K. A., Mauro, T. M., Hupe, M., Cho, S., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.06.046 · Cited by 286 · see citing works

Stratum corneum lipid abnormalities in atopic dermatitis

Yamamoto, A., Serizawa, S., Ito, M., & Sato, Y. (1991) · Archives of Dermatological Research · doi:10.1007/bf01106105 · Cited by 272 · see citing works

Molecular organization of the lipid matrix in intact Stratum corneum using ATR-FTIR spectroscopy

Boncheva, M., Damien, F., & Normand, V. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.01.022 · Cited by 264 · see citing works

Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age: Filaggrin mutations, TEWL and eczema at 3 months

Flohr, C., England, K., Radulovic, S., McLean, W. H. I., Campbell, L. E., Barker, J., Perkin, M., & Lack, G. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10068.x · Cited by 251 · see citing works

Abnormal skin barrier in the etiopathogenesis of atopic dermatitis

Elias, P. M., & Schmuth, M. (2009) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32832e7d36 · Cited by 247 · see citing works

Examination of Stratum Corneum Barrier Function In Vivo by Infrared Spectroscopy

Bommannan, D. B., Potts, R. O., & Guy, R. H. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12555503 · Cited by 238 · see citing works

Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

Gruber, R. W., Elias, P. M., Crumrine, D. A., Lin, T.-K., Brandner, J. M., Hachem, J. P., Presland, R. B., Fleckman, P. H., Janecke, A., Sandilands, A., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.01.053 · Cited by 237 · see citing works

LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery

van Smeden, J., Hoppel, L., van der Heijden, R., Hankemeier, T., Vreeken, R. J., & Bouwstra, J. A. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014456 · Cited by 229 · see citing works

Comprehensive quantification of ceramide species in human stratum corneum

Masukawa, Y., Narita, H., Sato, H., Naoe, A., Kondo, N., Sugai, Y., Oba, T., Homma, R., Ishikawa, J., Takagi, Y., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.d800055-jlr200 · Cited by 228 · see citing works

Aberrant Lipid Organization in Stratum Corneum of Patients with Atopic Dermatitis and Lamellar Ichthyosis

Pilgram, G. S. K., Vissers, D. C. J., van der Meulen, H., Koerten, H. K., Pavel, S., Lavrijsen, S., & Bouwstra, J. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01455.x · Cited by 224 · see citing works

Skin barrier function and allergic risk

Hudson, T. J. (2006) · Nature Genetics · doi:10.1038/ng0406-399 · Cited by 210 · see citing works

Clinical Severity Correlates with Impaired Barrier in Filaggrin-Related Eczema

Nemoto‐Hasebe, I., Akiyama, M., Nomura, T., Sandilands, A., McLean, W. H. I., & Shimizu, H. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.280 · Cited by 180 · see citing works

The Extent of Orthorhombic Lipid Phases in the Stratum Corneum Determines the Barrier Efficiency of Human Skin In Vivo

Damien, F., & Boncheva, M. (2009) · Journal of Investigative Dermatology · doi:10.1038/jid.2009.272 · Cited by 179 · see citing works

Decreased expression of filaggrin in atopic skin

Seguchi, T., Chang-Yi, C., Kusuda, S., Takahashi, M., Aisu, K., & Tezuka, T. (1996) · Archives of Dermatological Research · doi:10.1007/bf02505232 · Cited by 175 · see citing works

Relationship Between NMF (Lactate and Potassium) Content and the Physical Properties of the Stratum Corneum in Healthy Subjects

Nakagawa, N., Sakai, S., Matsumoto, M., Yamada, K., Nagano, M., Yuki, T., Sumida, Y., & Uchiwa, H. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22317.x · Cited by 175 · see citing works

FTIR Spectroscopy Studies of the Conformational Order and Phase Behavior of Ceramides

Moore, D. J., Rerek, M. E., & Mendelsohn, R. (1997) · The Journal of Physical Chemistry B · doi:10.1021/jp9718109 · Cited by 171 · see citing works

Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations

Chen, H.-W., Common, J., Haines, R. L., Balakrishnan, A., Brown, S., Goh, C. S. M., Cordell, H. J., Sandilands, A., Campbell, L., Kroboth, K., et al. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10331.x · Cited by 152 · see citing works

Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes

O’Regan, G. M., Kemperman, P. M. J. H., Sandilands, A., Chen, H., Campbell, L. E., Kroboth, K., Watson, R., Rowland, M., Puppels, G. J., McLean, W. H. I., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.04.038 · Cited by 148 · see citing works

Depression, anxiety, and dermatologic quality of life in adolescents with atopic dermatitis

Slattery, M. J., Essex, M. J., Paletz, E. M., Vanness, E. R., Infante, M., Rogers, G. M., & Gern, J. E. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.05.003 · Cited by 140 · see citing works

Barrier Characteristics of Different Human Skin Types Investigated with X-Ray Diffraction, Lipid Analysis, and Electron Microscopy Imaging

Schreiner, V., Pfeiffer, S., Lanzendörfer, G., Wenck, H., Diembeck, W., Gooris, G. S., Proksch, E., & Bouwstra, J. A. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00941.x · Cited by 137 · see citing works

Two Ceramide Subfractions Detectable in Cer(AS) Position by HPTLC in Skin Surface Lipids of Non-Lesional Skin of Atopic Eczema

Bleck, O., Abeck, D., Ring, J., Hoppe, U., Vietzke, J., Wolber, R., Brandt, O., & Schreiner, V. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00809.x · Cited by 135 · see citing works

Polymorphism in stratum corneum lipids

Ongpipattanakul, B., Francoeur, M. L., & Potts, R. O. (1994) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(94)90040-x · Cited by 130 · see citing works

Efficient and simple quantification of stratum corneum proteins on tape strippings by infrared densitometry

Voegeli, R., Heiland, J. J., Doppler, S., Rawlings, A. V., & Schreier, T. (2007) · Skin Research and Technology · doi:10.1111/j.1600-0846.2007.00214.x · Cited by 127 · see citing works

A Novel in Vitro Percutaneous Penetration Model: Evaluation of Barrier Properties with P-Aminobenzoic Acid and Two of Its Derivatives

de Jager, M., Groenink, W., Guivernau, R. B. I., Andersson, E., Angelova, N., Ponec, M., & Bouwstra, J. A. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9909-1 · Cited by 120 · see citing works

Ceramide profiles of the uninvolved skin in atopic dermatitis and psoriasis are comparable to those of healthy skin

Farwanah, H., Raith, K., Neubert, R. H. H., & Wohlrab, J. (2005) · Archives of Dermatological Research · doi:10.1007/s00403-005-0551-2 · Cited by 119 · see citing works

Disturbed extruding mechanism of lamellar bodies in dry non-eczematous skin of atopics

FARTASCH, M., Bassukas, I. D., & Diepgen, T. L. (1992) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1992.tb00118.x · Cited by 118 · see citing works

Lamellar Lipid Organization and Ceramide Composition in the Stratum Corneum of Patients with Atopic Eczema

Janssens, M., van Smeden, J., Gooris, G. S., Bras, W., Portale, G., Caspers, P. J., Vreeken, R. J., Kežić, S., Lavrijsen, A. P. M., & Bouwstra, J. A. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.175 · Cited by 118 · see citing works

Distinct barrier integrity phenotypes in filaggrin-related atopic eczema following sequential tape stripping and lipid profiling

Angelova‐Fischer, I., Mannheimer, A.-C., Hinder, A., Ruether, A., Franke, A., Neubert, R. H. H., Fischer, T. W., & Zillikens, D. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01259.x · Cited by 117 · see citing works

Is an orthorhombic lateral packing and a proper lamellar organization important for the skin barrier function?

Groen, D., Poole, D. S., Gooris, G. S., & Bouwstra, J. A. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.10.015 · Cited by 101 · see citing works

Skin Barrier Function in Healthy Subjects and Patients with Atopic Dermatitis in Relation to Filaggrin Loss-of-Function Mutations

Jakaša, I., Koster, E. S., Calkoen, F., McLean, W. H. I., Campbell, L. E., Bos, J. D., Verberk, M. M., & Kežić, S. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.307 · Cited by 98 · see citing works

Deficiency of PPARβ/δ in the Epidermis Results in Defective Cutaneous Permeability Barrier Homeostasis and Increased Inflammation

Man, M., Barish, G. D., Schmuth, M., Crumrine, D. A., Barak, Y., Chang, S., Jiang, Y. J., Evans, R. M., Elias, P. M., & Feingold, K. R. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701026 · Cited by 86 · see citing works

Skin barrier defect in atopic dermatitis: increased permeability of the stratum corneum using dimethyl sulfoxide and theophylline

Yoshiike, T., Aikawa, Y., Sindhvananda, J., Suto, H., Nishimura, K., Kawamoto, T., & Ogawa, H. (1993) · Journal of Dermatological Science · doi:10.1016/0923-1811(93)90076-2 · Cited by 82 · see citing works

In vitro human skin barrier perturbation by oleic acid: Thermal analysis and freeze fracture electron microscopy studies

Tanojo, H., Geest, A. B.-V., Bouwstra, J. A., Junginger, H. E., & Boddé, H. E. (1997) · Thermochimica Acta · doi:10.1016/s0040-6031(97)00063-4 · Cited by 73 · see citing works

Filaggrin Genotype Determines Functional and Molecular Alterations in Skin of Patients with Atopic Dermatitis and Ichthyosis Vulgaris

Winge, M. C. G., Hoppe, T., Berne, B., Vahlquist, A., Nordenskjöld, M., Bradley, M., & Törmä, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028254 · Cited by 68 · see citing works

Difference in Ceramide Composition between "Dry" and "Normal" Skin in Patients with Atopic Dermatitis

Motonobu Matsumoto, N. U. (1999) · Acta Dermato Venereologica · doi:10.1080/000155599750011183 · Cited by 65 · see citing works

Assessment of Topical Bioavailability in vivo: The Importance of Stratum corneum Thickness

Kalia, Y. N., Alberti, I., Naik, A., & Guy, R. H. (2001) · Skin Pharmacology and Physiology · doi:10.1159/000056394 · Cited by 63 · see citing works

Decrease of Ceramides with Very Long–Chain Fatty Acids and Downregulation of Elongases in a Murine Atopic Dermatitis Model

Park, Y.-H., Jang, W.-H., Seo, J. A., Park, M., Lee, T. R., Park, Y.-H., Kim, D. K., & Lim, K. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.333 · Cited by 61 · see citing works

Transmission electron microscopy studies in an experimental model of canine atopic dermatitis

Marsella, R., Samuelson, D. A., & Doerr, K. (2009) · Veterinary Dermatology · doi:10.1111/j.1365-3164.2009.00802.x · Cited by 61 · see citing works

Effect of the ω-acylceramides on the lipid organization of stratum corneum model membranes evaluated by X-ray diffraction and FTIR studies (Part I)

Neto, D. D. S., Gooris, G. S., & Bouwstra, J. A. (2011) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2010.12.007 · Cited by 56 · see citing works

Quality of life in atopic dermatitis patients

Mozaffari, H., Pourpak, Z., Pourseyed, S., Farhoodi, A., Aghamohammadi, A., Movahadi, M., Gharaghozloo, M., & Moin, M. (2008) · CRC Press eBooks · doi:10.3109/9780203091449-16 · Cited by 45 · see citing works

Quality of life in infants with atopic dermatitis and healthy infants: a follow‐up from birth to 24 months

Alanne, S., Nermes, M., Söderlund, R., & Laitinen, K. (2011) · Acta Paediatrica · doi:10.1111/j.1651-2227.2011.02229.x · Cited by 34 · see citing works

Quality of Life Measurement and its Relationship to Disease Severity in Children with Atopic Dermatitis in General Practice

van Valburg, R. W. C., Willemsen, M., Dirven-Meijer, P. C., Oranje, A. P., van der Wouden, J. C., & Moed, H. D. (2011) · Acta Dermato Venereologica · doi:10.2340/00015555-1026 · Cited by 32 · see citing works

Generation of Human Skin Equivalents Under Submerged Conditions—Mimicking the In Utero Environment

Thakoersing, V. S., Ponec, M., & Bouwstra, J. A. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0358 · Cited by 29 · see citing works

Atopic dermatitis

Weidinger, S., & Novak, N. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00149-x · Cited by 1,908 · see citing works

Atopic dermatitis

Weidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0001-z · Cited by 1,549 · see citing works

Pathophysiology of atopic dermatitis: Clinical implications

Kim, J., Kim, B. E., & Leung, D. Y. M. (2019) · Allergy and Asthma Proceedings · doi:10.2500/aap.2019.40.4202 · Cited by 652 · see citing works

The important role of stratum corneum lipids for the cutaneous barrier function

van Smeden, J., Janssens, M., Gooris, G. S., & Bouwstra, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.11.006 · Cited by 549 · see citing works

Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis

Yang, G., Seok, J. K., Kang, H. C., Cho, Y., Lee, H. S., & Lee, J. Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082867 · Cited by 446 · see citing works

Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis

Thyssen, J. P., & Kežić, S. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.06.014 · Cited by 398 · see citing works

Stratum Corneum Lipids: Their Role for the Skin Barrier Function in Healthy Subjects and Atopic Dermatitis Patients

van Smeden, J., & Bouwstra, J. A. (2016) · Current Problems in Dermatology · doi:10.1159/000441540 · Cited by 366 · see citing works

TNF-α and Th2 Cytokines Induce Atopic Dermatitis–Like Features on Epidermal Differentiation Proteins and Stratum Corneum Lipids in Human Skin Equivalents

Danso, M. O., van Drongelen, V., Mulder, A. A., van Esch, J., Scott, H. C., van Smeden, J., Ghalbzouri, A. E., & Bouwstra, J. A. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.83 · Cited by 333 · see citing works

Lipid abnormalities in atopic skin are driven by type 2 cytokines

Berdyshev, E., Goleva, E., Bronova, I., Dyjack, N., Rios, C., Jung, J., Taylor, P., Jeong, M., Hall, C. F., Richers, B. N., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.98006 · Cited by 283 · see citing works

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

van Smeden, J., Janssens, M., Kaye, E., Caspers, P. J., Lavrijsen, A. P. M., Vreeken, R. J., & Bouwstra, J. A. (2013) · Experimental Dermatology · doi:10.1111/exd.12293 · Cited by 271 · see citing works

Emollients and moisturisers for eczema

van Zuuren, E. J., Fedorowicz, Z., Christensen, R., Lavrijsen, A. P. M., & Arents, B. W. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012119.pub2 · Cited by 266 · see citing works

Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations

Brunner, P. M., Israel, A., Zhang, N., Leonard, A., Wen, H., Huynh, T. N., Tran, G., Lyon, S., Rodriguez, G., Immaneni, S., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.02.040 · Cited by 257 · see citing works

Epithelial barrier repair and prevention of allergy

Goleva, E., Berdyshev, E., & Leung, D. Y. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124608 · Cited by 251 · see citing works

Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis

Beck, L. A., Cork, M. J., Amagai, M., Benedetto, A. D., Kabashima, K., Hamilton, J. D., & Rossi, A. B. (2022) · JID Innovations · doi:10.1016/j.xjidi.2022.100131 · Cited by 258 · see citing works

The role of tight junctions in skin barrier function and dermal absorption

Bäsler, K., Bergmann, S., Heisig, M., Nägel, A., Zorn‐Kruppa, M., & Brandner, J. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.08.007 · Cited by 245 · see citing works

Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis

Elias, P. M., & Wakefield, J. S. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.05.048 · Cited by 238 · see citing works

Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides

Kihara, A. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.04.001 · Cited by 238 · see citing works

Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

Trompette, A., Pernot, J., Perdijk, O., Alqahtani, R. A. A., Domingo, J. S., Camacho‐Muñoz, D., Wong, N. C., Kendall, A. C., Wiederkehr, A., Nicod, L. P., et al. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00524-9 · Cited by 247 · see citing works

Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?

Gorzelanny, C., Meß, C., Schneider, S. W., Huck, V., & Brandner, J. M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070684 · Cited by 236 · see citing works

Tape strips detect distinct immune and barrier profiles in atopic dermatitis and psoriasis

He, H., Bissonnette, R., Wu, J., Diaz, A., Proulx, É. S., Maari, C., Jack, C. S., Louis, M., Estrada, Y. D., Krueger, J. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.05.048 · Cited by 232 · see citing works

3D skin models for 3R research: The potential of 3D reconstructed skin models to study skin barrier function

Niehues, H., Bouwstra, J. A., El Ghalbzouri, A., Brandner, J. M., Zeeuwen, P. L. J. M., & van den Bogaard, E. H. (2018) · Experimental Dermatology · doi:10.1111/exd.13531 · Cited by 210 · see citing works

Skin barrier defects in atopic dermatitis

Agrawal, R., & Woodfolk, J. A. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0433-9 · Cited by 201 · see citing works

Skin lipids in health and disease: A review

Knox, S. E., & O’Boyle, N. M. (2021) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2021.105055 · Cited by 201 · see citing works

Etiology of epithelial barrier dysfunction in patients with type 2 inflammatory diseases

Schleimer, R. P., & Berdnikovs, S. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.04.010 · Cited by 188 · see citing works

The skin barrier: An extraordinary interface with an exceptional lipid organization

Bouwstra, J. A., Nădăban, A., Bras, W., McCabe, C., Bunge, A. L., & Gooris, G. S. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101252 · Cited by 184 · see citing works

The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products

Meckfessel, M., & Brandt, S. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2014.01.891 · Cited by 178 · see citing works

Depth profiles of hydrogen bound water molecule types and their relation to lipid and protein interaction in the human stratum corneum in vivo

Choe, C., Lademann, J. M., & Darvin, M. E. (2016) · The Analyst · doi:10.1039/c6an01717g · Cited by 177 · see citing works

Essential role of the cytochrome P450 CYP4F22 in the production of acylceramide, the key lipid for skin permeability barrier formation

Ohno, Y., Nakamichi, S., Ohkuni, A., Kamiyama, N., Naoe, A., Tsujimura, H., Yokose, U., Sugiura, K., Ishikawa, J., Akiyama, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1503491112 · Cited by 168 · see citing works

Impaired Epidermal Permeability Barrier in Mice Lacking Elovl1 , the Gene Responsible for Very-Long-Chain Fatty Acid Production

Sassa, T., Ohno, Y., Suzuki, S., Nomura, T., Nishioka, C., Kashiwagi, T., Hirayama, T., Akiyama, M., Taguchi, R., Shimizu, H., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-13 · Cited by 167 · see citing works

Meta-analysis derived atopic dermatitis (MADAD) transcriptome defines a robust AD signature highlighting the involvement of atherosclerosis and lipid metabolism pathways

Ewald, D. A., Malajian, D., Krueger, J. G., Workman, C. T., Wang, T., Tian, S., Litman, T., Guttman‐Yassky, E., & Suárez‐Fariñas, M. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0133-x · Cited by 166 · see citing works

Petrolatum: Barrier repair and antimicrobial responses underlying this “inert” moisturizer

Czarnowicki, T., Malajian, D., Khattri, S., Correa da Rosa, J., Dutt, R., Finney, R., Dhingra, N., Xiangyu, P., Xu, H., Estrada, Y. D., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.013 · Cited by 161 · see citing works

Influence of Th2 Cytokines on the Cornified Envelope, Tight Junction Proteins, and β-Defensins in Filaggrin-Deficient Skin Equivalents

Hönzke, S., Wallmeyer, L., Ostrowski, A., Radbruch, M., Mundhenk, L., Schäfer‐Korting, M., & Hedtrich, S. (2015) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.11.007 · Cited by 154 · see citing works

Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis

Kim, J. E., Kim, J., Cho, D., & Park, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081234 · Cited by 147 · see citing works

Unraveling the skin; a comprehensive review of atopic dermatitis, current understanding, and approaches

Afshari, M., Koláčková, M., Rosecká, M., Čelakovská, J., & Krejsek, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1361005 · Cited by 144 · see citing works

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

Cole, C., Kroboth, K., Schurch, N., Sandilands, A., Sherstnev, A., O’Regan, G. M., Watson, R. M., McLean, W. H. I., Barton, G. J., Irvine, A. D., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.04.021 · Cited by 140 · see citing works

Membrane Position of Ibuprofen Agrees with Suggested Access Path Entrance to Cytochrome P450 2C9 Active Site

Berka, K., Hendrychova, T., Anzenbacher, P., & Otyepka, M. (2011) · The Journal of Physical Chemistry A · doi:10.1021/jp204488j · Cited by 142 · see citing works

Altered expression of epidermal lipid bio-synthesis enzymes in atopic dermatitis skin is accompanied by changes in stratum corneum lipid composition

Danso, M. O., Boiten, W. A., van Drongelen, V., Meijling, K. A. G., Gooris, G. S., Ghalbzouri, A. E., Absalah, S., Vreeken, R. J., Kežić, S., van Smeden, J., et al. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.05.005 · Cited by 140 · see citing works

Ceramides in Skin Health and Disease: An Update

Uchida, Y., & Park, K. (2021) · American Journal of Clinical Dermatology · doi:10.1007/s40257-021-00619-2 · Cited by 138 · see citing works

Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers

He, H., Olesen, C. M., Pavel, A. B., Clausen, M., Wu, J., Estrada, Y. D., Zhang, N., Agner, T., & Guttman‐Yassky, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01768 · Cited by 136 · see citing works

Epidermal lipids: key mediators of atopic dermatitis pathogenesis

Bhattacharya, N., Sato, W. J., Kelly, A., Ganguli-Indra, G., & Indra, A. K. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.001 · Cited by 128 · see citing works

Basics and recent advances in the pathophysiology of atopic dermatitis

Nakahara, T., Kido‐Nakahara, M., Tsuji, G., & Furue, M. (2020) · The Journal of Dermatology · doi:10.1111/1346-8138.15664 · Cited by 135 · see citing works

Comparative profiling and comprehensive quantification of stratum corneum ceramides in humans and mice by LC/MS/MS

Kawana, M., Miyamoto, M., Ohno, Y., & Kihara, A. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120000671 · Cited by 129 · see citing works

The mechanism of skin lipids influencing skin status

Jia, Y., Gan, Y., He, C., Chen, Z., & Zhou, C. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.11.006 · Cited by 130 · see citing works

Epithelial barrier dysfunctions in atopic dermatitis: a skin-gut-lung model linking microbiome alteration and immune dysregulation

Zhu, T. H., Zhu, T. R., Tran, K. A., Sivamani, R. K., & Shi, V. Y. (2018) · British Journal of Dermatology · doi:10.1111/bjd.16734 · Cited by 130 · see citing works

Filaggrin and Skin Barrier Function

Kežić, S., & Jakaša, I. (2016) · Current problems in dermatology · doi:10.1159/000441539 · Cited by 128 · see citing works

Ceramides in the Skin Lipid Membranes: Length Matters

Školová, B., Janůšová, B., Zbytovská, J., Gooris, G. S., Bouwstra, J. A., Slepička, P., Berka, P., Roh, J., Palat, K. J., Hrabálek, A., et al. (2013) · Langmuir · doi:10.1021/la4037474 · Cited by 121 · see citing works

Leveraging Multilayered “Omics” Data for Atopic Dermatitis: A Road Map to Precision Medicine

Ghosh, D., Bernstein, J. A., Hershey, G. K. K., Rothenberg, M. E., & Baye, T. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02727 · Cited by 121 · see citing works

Dupilumab significantly improves skin barrier function in patients with moderate‐to‐severe atopic dermatitis

Berdyshev, E. V., Goleva, E., Bissonnette, R., Bronova, I. A., Bronoff, A. S., Richers, B. N., Garcia, S. L., Ramirez-Gama, M. A., Taylor, P. A., Praestgaard, A. H., et al. (2022) · Allergy · doi:10.1111/all.15432 · Cited by 120 · see citing works

Skin barrier in atopic dermatitis

Kezic, S. (2014) · Frontiers in Bioscience · doi:10.2741/4225 · Cited by 115 · see citing works

Distribution of Bioactive Lipid Mediators in Human Skin

Kendall, A. C., Pilkington, S. M., Massey, K. A., Sassano, G., Rhodes, L. E., & Nicolaou, A. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.41 · Cited by 115 · see citing works

Tape strips from early‐onset pediatric atopic dermatitis highlight disease abnormalities in nonlesional skin

Pavel, A. B., Renert‐Yuval, Y., Wu, J., DUCA, E. D., Diaz, A., Lefferdink, R., Fang, M. M., Canter, T., Rangel, S. M., Zhang, N., et al. (2020) · Allergy · doi:10.1111/all.14490 · Cited by 114 · see citing works

The role of epidermal sphingolipids in dermatologic diseases

Borodzicz-Jażdżyk, S., Rudnicka, L., Mirowska-Guzel, D. M., & Cudnoch‐Jędrzejewska, A. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0178-7 · Cited by 112 · see citing works

Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development

Nakamura, Y., Takahashi, H., Takaya, A., Inoue, Y., Katayama, Y., Kusuya, Y., Shoji, T., Takada, S., Nakagawa, S., Oguma, R., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay4068 · Cited by 113 · see citing works

Barrier Repair Therapy in Atopic Dermatitis: An Overview

Hon, K. E., Leung, A. K. C., & Barankin, B. (2013) · American Journal of Clinical Dermatology · doi:10.1007/s40257-013-0033-9 · Cited by 107 · see citing works

Tight junctions in skin inflammation

Bäsler, K., & Brandner, J. M. (2016) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-016-1903-9 · Cited by 105 · see citing works

Glucocerebrosidase: Functions in and Beyond the Lysosome

Boer, D. E. C., van Smeden, J., Bouwstra, J. A., & Aerts, J. M. F. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030736 · Cited by 101 · see citing works

Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models

van Drongelen, V., Haisma, E. M., Out‐Luiting, J. J., Nibbering, P. H., & Ghalbzouri, A. E. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12443 · Cited by 101 · see citing works

Whole picture of human stratum corneum ceramides, including the chain-length diversity of long-chain bases

Suzuki, M., Ohno, Y., & Kihara, A. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100235 · Cited by 101 · see citing works

A Mouse Model for Atopic Dermatitis Using Topical Application of Vitamin D3 or of Its Analog MC903

Moosbrugger‐Martinz, V., Schmuth, M., & Dubrac, S. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6786-5_8 · Cited by 99 · see citing works

Skin Barrier in Atopic Dermatitis

Schmuth, M., Eckmann, S., Moosbrugger‐Martinz, V., Ortner, D., Blunder, S., Trafoier, T., Gruber, R. W., & Elias, P. M. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.03.006 · Cited by 111 · see citing works

The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes

Mojumdar, E. H., Kariman, Z., van Kerckhove, L., Gooris, G. S., & Bouwstra, J. A. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.05.023 · Cited by 97 · see citing works

Topical administration of EGF suppresses immune response and protects skin barrier in DNCB-induced atopic dermatitis in NC/Nga mice

Kim, Y.-J., Choi, M. J., Bak, D., Lee, B. C., Ko, E. J., Ahn, G. R., Ahn, S. W., Kim, M. J., Na, J., & Kim, B. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-30404-x · Cited by 96 · see citing works

Human skin equivalents: Impaired barrier function in relation to the lipid and protein properties of the stratum corneum

Bouwstra, J. A., Helder, R. W. J., & Ghalbzouri, A. E. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.012 · Cited by 94 · see citing works

The heterogeneity and complexity of skin surface lipids in human skin health and disease

Mijaljica, D., Townley, J. P., Spada, F., & Harrison, I. P. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101264 · Cited by 95 · see citing works

Molecular Biology of Atopic Dermatitis

Mu, Z., Zhao, Y. P., Liu, X., Chang, C. C.-C., & Zhang, J. (2014) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-014-8415-1 · Cited by 95 · see citing works

Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin

Kahraman, E., Kaykın, M., Bektay, H. Ş., & Güngör, S. (2019) · Cosmetics · doi:10.3390/cosmetics6030052 · Cited by 91 · see citing works

Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients

van Smeden, J., Janssens, M., Boiten, W. A., van Drongelen, V., Furio, L., Vreeken, R. J., Hovnanian, A., & Bouwstra, J. A. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.517 · Cited by 90 · see citing works

pH-sensitive Eudragit® L 100 nanoparticles promote cutaneous penetration and drug release on the skin

Dong, P., Sahle, F. F., Lohan, S. B., Saeidpour, S., Albrecht, S., Teutloff, C., Bodmeier, R. A., Unbehauen, M. L., Wolff, C., Haag, R., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.045 · Cited by 88 · see citing works

Stratum corneum lipid matrix: Location of acyl ceramide and cholesterol in the unit cell of the long periodicity phase

Mojumdar, E. H., Gooris, G. S., Groen, D., Barlow, D. J., Lawrence, M. J., Demé, B., & Bouwstra, J. A. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2016.05.006 · Cited by 87 · see citing works

The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update

Çetinarslan, T., Kümper, L., & Fölster‐Holst, R. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1159404 · Cited by 92 · see citing works

Molecular Functionality of Cytochrome P450 4 (CYP4) Genetic Polymorphisms and Their Clinical Implications

Jarrar, Y. B., & Lee, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174274 · Cited by 86 · see citing works

Molecular interactions of plant oil components with stratum corneum lipids correlate with clinical measures of skin barrier function

Mack Correa, M. C., Mao, G., Saad, P., Flach, C. R., Mendelsohn, R., & Walters, R. M. (2014) · Experimental Dermatology · doi:10.1111/exd.12296 · Cited by 87 · see citing works

Targeting Skin Barrier Function in Atopic Dermatitis

van den Bogaard, E. H. J., Elias, P. M., Goleva, E., Berdyshev, E. V., Smits, J. P. H., Danby, S. G., Cork, M. J., & Leung, D. Y. M. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.02.005 · Cited by 86 · see citing works

The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis

Fujii, M. (2021) · Cells · doi:10.3390/cells10092386 · Cited by 84 · see citing works

Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema‐prone skin*

Danby, S. G., Andrew, P. V., Kay, L. J., Pinnock, A., Chittock, J., Brown, K., Williams, S. F., & Cork, M. J. (2021) · British Journal of Dermatology · doi:10.1111/bjd.20955 · Cited by 91 · see citing works

Skin biomarkers predict development of atopic dermatitis in infancy

Rinnov, M. R., Halling, A., Gerner, T., Ravn, N. H., Knudgaard, M. H., Trautner, S., Goorden, S. M. I., der Vlugt, K. G., Stet, F. S., Skov, L., et al. (2022) · Allergy · doi:10.1111/all.15518 · Cited by 85 · see citing works

Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis

Koppes, S. A., Engebretsen, K. A., Agner, T., Angelova‐Fischer, I., Berents, T. L., Brandner, J. M., Brans, R., Clausen, M., Hümmler, E., Jakaša, I., et al. (2017) · Contact Dermatitis · doi:10.1111/cod.12789 · Cited by 82 · see citing works

The role of skin barrier in occupational contact dermatitis

Jakaša, I., Thyssen, J. P., & Kežić, S. (2018) · Experimental Dermatology · doi:10.1111/exd.13704 · Cited by 82 · see citing works

Advancements in the maintenance of skin barrier/skin lipid composition and the involvement of metabolic enzymes

Cui, L., Jia, Y., Cheng, Z., Gao, Y. H., Zhang, G., Li, J., & He, C. (2016) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12245 · Cited by 82 · see citing works

Skin barrier and dry skin in the mature patient

Tončić, R. J., Kežić, S., Hadžavdić, S. L., & Marinović, B. (2017) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2017.10.002 · Cited by 83 · see citing works

Insights into atopic dermatitis gained from genetically defined mouse models

Nakajima, S., Nomura, T., Common, J., & Kabashima, K. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.11.014 · Cited by 80 · see citing works

Moisturizers versus Current and Next-Generation Barrier Repair Therapy for the Management of Atopic Dermatitis

Elias, P. M., Wakefield, J. S., & Man, M. (2018) · Skin Pharmacology and Physiology · doi:10.1159/000493641 · Cited by 79 · see citing works

Lipid abnormalities and lipid-based repair strategies in atopic dermatitis

Elias, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.001 · Cited by 78 · see citing works

Staphylococcus aureus causes aberrant epidermal lipid composition and skin barrier dysfunction

Kim, J., Kim, B. E., Berdyshev, E. V., Bronova, I. A., Bin, L., Bae, J., Kim, S., Kim, H., Lee, U. H., Kim, M. S., et al. (2023) · Allergy · doi:10.1111/all.15640 · Cited by 79 · see citing works

Filaggrin loss‐of‐function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part II of a prospective cohort study

Visser, M., Verberk, M. M., Campbell, L. E., McLean, W. H. I., Calkoen, F., Bakker, J. G., van Dijk, F. J. H., Bos, J. D., & Kežić, S. (2013) · Contact Dermatitis · doi:10.1111/cod.12139 · Cited by 77 · see citing works

Large-scale human skin lipidomics by quantitative, high-throughput shotgun mass spectrometry

Sadowski, T., Klose, C. D., Gerl, M. J., Wójcik-Maciejewicz, A., Herzog, R., Simons, K., Reich, A., & Surma, M. A. (2017) · Scientific Reports · doi:10.1038/srep43761 · Cited by 77 · see citing works

Skin barrier integrity and natural moisturising factor levels after cumulative dermal exposure to alkaline agents in atopic dermatitis

Angelova-Fischer, I., Dapic, I., Hoek, A., Jakasa, I., Fischer, T., Zillikens, D., & Kezic, S. (2014) · Acta Dermato Venereologica · doi:10.2340/00015555-1815 · Cited by 76 · see citing works

Different Phase Behavior and Packing of Ceramides with Long (C16) and Very Long (C24) Acyls in Model Membranes: Infrared Spectroscopy Using Deuterated Lipids

Školová, B., Hudská, K., Pullmannová, P., Kováčik, A., Palat, K. J., Roh, J., Fleddermann, J., Estrela‐Lopis, I., & Vávrová, K. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp506407r · Cited by 76 · see citing works

The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin

Danby, S. G., Brown, K., Higgs-Bayliss, T., Chittock, J., Albenali, L., & Cork, M. J. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000445955 · Cited by 79 · see citing works

Dry skin management: practical approach in light of latest research on skin structure and function

Proksch, E., Berardesca, E., Misery, L., Engblom, J., & Bouwstra, J. A. (2019) · Journal of Dermatological Treatment · doi:10.1080/09546634.2019.1607024 · Cited by 73 · see citing works

Olive Oil, Sunflower Oil or no Oil for Baby Dry Skin or Massage: A Pilot, Assessor-blinded, Randomized Controlled Trial (the Oil in Baby SkincaRE [OBSeRvE] Study)

Cooke, A., Cork, M., Victor, S., Campbell, M., Danby, S., Chittock, J., & Lavender, T. (2016) · Acta Dermato Venereologica · doi:10.2340/00015555-2279 · Cited by 73 · see citing works

Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis

Patrick, G. J., Archer, N. K., & Miller, L. S. (2020) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2020.07.006 · Cited by 71 · see citing works

Monounsaturated Fatty Acids Reduce the Barrier of Stratum Corneum Lipid Membranes by Enhancing the Formation of a Hexagonal Lateral Packing

Mojumdar, E. H., Helder, R. W. J., Gooris, G. S., & Bouwstra, J. A. (2014) · Langmuir · doi:10.1021/la500972w · Cited by 72 · see citing works

Skin Lipids: Localization of Ceramide and Fatty Acid in the Unit Cell of the Long Periodicity Phase

Mojumdar, E. H., Gooris, G. S., Barlow, D. J., Lawrence, M. J., Demé, B., & Bouwstra, J. A. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.04.030 · Cited by 70 · see citing works

Ceramide Acyl Chain Length and Its Relevance to Intracellular Lipid Regulation

Ho, Q. W. C., Zheng, X., & Ali, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179697 · Cited by 68 · see citing works

Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains

Pullmannová, P., Pavlíková, L., Kováčik, A., Sochorová, M., Školová, B., Slepička, P., Maixner, J., Zbytovská, J., & Vávrová, K. (2017) · Biophysical Chemistry · doi:10.1016/j.bpc.2017.03.004 · Cited by 68 · see citing works

Altered Levels of Sphingosine, Sphinganine and Their Ceramides in Atopic Dermatitis Are Related to Skin Barrier Function, Disease Severity and Local Cytokine Milieu

Tončić, R. J., Jakaša, I., Hadžavdić, S. L., Goorden, S. M. I., der Vlugt, K. G., Stet, F. S., Balić, A., Petković, M., Pavičić, B., Žužul, K., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061958 · Cited by 67 · see citing works

Update on the pathogenesis of atopic dermatitis.

Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66 · see citing works

An ex vivo human skin model for studying skin barrier repair

Danso, M. O., Berkers, T., Mieremet, A., Hausil, F., & Bouwstra, J. A. (2014) · Experimental Dermatology · doi:10.1111/exd.12579 · Cited by 66 · see citing works

Phase behavior of skin lipid mixtures: the effect of cholesterol on lipid organization

Mojumdar, E. H., Gooris, G. S., & Bouwstra, J. A. (2015) · Soft Matter · doi:10.1039/c4sm02786h · Cited by 65 · see citing works

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

van Smeden, J., Janssens, M., Kaye, E., Caspers, P. J., Lavrijsen, A. P. M., Vreeken, R. J., & Bouwstra, J. A. (2013) · Experimental Dermatology · doi:10.1111/exd.12293 · Cited by 271 · see citing works

Lamellar Lipid Organization and Ceramide Composition in the Stratum Corneum of Patients with Atopic Eczema

Janssens, M., van Smeden, J., Gooris, G. S., Bras, W., Portale, G., Caspers, P. J., Vreeken, R. J., Kežić, S., Lavrijsen, A. P. M., & Bouwstra, J. A. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.175 · Cited by 118 · see citing works

Atopic eczema : the role of stratum corneum lipids in the skin barrier

Janssens, M. (2013) · Data Archiving and Networked Services (DANS)

Electron diffraction study of lipids in non-lesional stratum corneum of atopic eczema patients

Janssens, M., Mulder, A. A., van Smeden, J., Pilgram, G. S. K., Wolterbeek, R., Lavrijsen, A. P. M., Koning, R. I., Koster, A. J., & Bouwstra, J. A. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.04.001 · Cited by 18 · see citing works

Invited Lecture 2 : The Stratum Corneum Lipid Composition is Key Factor for the Skin Barrier: An Integrated Approach

Bouwstra, J. A., Janssens, M., Lavrijsen, A. P. M., & van Smeden, J. (2015) · 한국피부장벽학회지