The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Occurrence and distribution of neuropeptides in the human skin. An immunocytochemical and immunochemical study on normal skin and blister fluid from inflamed skin
Open accessAbstract
The content and distribution of substance P (SP), somatostatin, vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY) in human skin were investigated. Radioimmunoassay was performed on pooled tissue samples from several regions (fingers, toes, axillas and thighs) and on tissue fluid from spontaneous blisters on inflamed skin. Immunocytochemical localization showed all peptides examined except somatostatin to be present in nerve fibers. Nerve fibers storing SP and CGRP, which were found to coexist, were mostly present as free nerve endings in the superficial part of dermis and in epidermis. SP/CGRP fibers were most abundant in fingers and toes. VIP fibers and NPY fibers were localized in the deeper parts of dermis around blood vessels and acini of sweat glands. Also fibers containing these neuropeptides were most common in fingertips and toes. VIP occurred in relatively high amounts also in skin from axilla whereas NPY in this region was below detection limit. Immunoreactive somatostatin was found in low concentrations in tissue extracts and was not present in amounts sufficient for reliable immunostaining. Fluid from spontaneous blisters on inflamed skin contained detectable amounts of all neuropeptides.
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Citations
Cites
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Rosenfeld, M. G., Mermod, J.-J., Amara, S. G., Swanson, L. W., Sawchenko, P. E., Rivier, J., Vale, W. W., & Evans, R. M. (1983) · Nature · doi:10.1038/304129a0 · Cited by 2,302
Cited by
Neuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 665
Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide
Hosoi, J., Murphy, G. F., Egan, C. L., Lerner, E. A., Grabbe, S., Asahina, A., & Granstein, R. D. (1993) · Nature · doi:10.1038/363159a0 · Cited by 631
Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems
Scholzen, T., Armstrong, C. A., Bunnett, N. W., Luger, T. A., Olerud, J. E., & Ansel, J. C. (1998) · Experimental Dermatology · doi:10.1111/j.1600-0625.1998.tb00307.x · Cited by 391
Local thermal control of the human cutaneous circulation
Johnson, J. M., & Kellogg, D. L. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00407.2010 · Cited by 324
Metadata
- Authors
- Wallengren, J., Ekman, R., & Sundler, F.
- Venue
- Acta Dermato-Venereologica
- Publisher
- Medical Journals Sweden AB
- Published
- 1987-05-01
- Volume
- 67
- Issue
- 3
- Pages
- 185-192
- ISSN
- 0001-5555 (ISSN-L)
- 1651-2057
- OpenAlex
- W2474358686
- Cited by
- 192
- References
- 1
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wallengren, J., Ekman, R., & Sundler, F. (1987). Occurrence and distribution of neuropeptides in the human skin. An immunocytochemical and immunochemical study on normal skin and blister fluid from inflamed skin. Acta Dermato-Venereologica. https://doi.org/10.2340/0001555567185192
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