The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Local thermal control of the human cutaneous circulation
Open accessAbstract
The level of skin blood flow is subject to both reflex thermoregulatory control and influences from the direct effects of warming and cooling the skin. The effects of local changes in temperature are capable of maximally vasoconstricting or vasodilating the skin. They are brought about by a combination of mechanisms involving endothelial, adrenergic, and sensory systems. Local warming initiates a transient vasodilation through an axon reflex, succeeded by a plateau phase due largely to nitric oxide. Both phases are supported by sympathetic transmitters. The plateau phase is followed by the die-away phenomenon, a slow reversal of the vasodilation that is dependent on intact sympathetic vasoconstrictor nerves. The vasoconstriction with local skin cooling is brought about, in part, by a postsynaptic upregulation of α 2c-adrenoceptors and, in part, by inhibition of the nitric oxide system at at least two points. There is also an early vasodilator response to local cooling, dependent on the rate of cooling. The mechanism for that transient vasodilation is not known, but it is inhibited by intact sympathetic vasoconstrictor nerve function and by intact sensory nerve function.
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Cites
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Cited by
Sawka, M. N., Leon, L. R., Montain, S. J., & Sonna, L. A. (2011) · Comprehensive Physiology · doi:10.1002/cphy.c100082 · Cited by 470
Assessment of endothelial and neurovascular function in human skin microcirculation
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Raynaud’s Phenomenon: A Brief Review of the Underlying Mechanisms
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Metadata
- Authors
- Johnson, J. M., & Kellogg, D. L.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2010-10
- Volume
- 109
- Issue
- 4
- Pages
- 1229-1238
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1969320004
- Cited by
- 324
- References
- 136
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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