Inflammatory Murine Skin Responses to UV-B Light are Partially Dependent on Endothelin-1 and Mast Cells
Open accessAbstract
Endothelin (ET-1) has been shown to crucially contribute to UV-induced skin responses such as tanning. To test whether ET-1 is also involved in early cutaneous reactions to UV, we assessed ET-1 skin levels in UV-irradiated mice. In correlation with the levels of UV-induced skin inflammation, ET-1 concentrations increased substantially and continually. Moreover, blocking of ET-1 receptors (ETA) resulted in significantly decreased cutaneous inflammation following UV irradiation. When we assessed skin responses to ET-1 injections, we observed prominent mast cell degranulation and mast cell-dependent inflammation. Since mast cells also critically contributed to UV-induced inflammation, we determined the ET-1-dependent inflammatory response to UV in the absence and presence of these cells. Interestingly, ETA blockade did not decrease UV-induced inflammation in mast cell-deficient mice, unless these mice had been adoptively transferred with mast cells before irradiation. This indicates that skin inflammation due to UV irradiation is caused in part by ET-1 acting on skin mast cells.
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The MPO system has been involved in various skin pathologies, either serving as a causative factor or biomarker in inflammation, contact hypersensitivity and irritation, psoriasis, UV-damage, photoaging, and carcinogenesis.
“beyond a role in cutaneous innate immunity, the MPO system has also been involved in various skin pathologies, either serving as a causative factor or biomarker in inflammation, contact hypersensitivity and irritation, psoriasis, UV-damage, photoaging, and carcinogenesis (51–59).”
From Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022) · cites this paper as [52]
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“The binding of these endothelins to their respective receptors induces burning pain and pruritus [54], triggers mast cell degranulation and mast cell-dependent inflammation, and promotes melanocyte proliferation [55].”
- Authors
- Metz, M., Lammel, V., Gibbs, B. F., & Maurer, M.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- University of Lübeck (DE)
- Corresponding author
- Maurer, Marcus
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 169
- Issue
- 3
- Pages
- 815-822
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC1698813
- OpenAlex
- W1979965143
- Cited by
- 58
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Kent Academic Repository (University of Kent) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB548, SPP1110)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- endothelin-1, UVB irradiation, skin inflammation, mast cells, mast cell degranulation, mast cell-deficient mice, adoptive transfer, tanning
- MeSH terms
- Animals, Dermatitis, Dose-Response Relationship, Radiation, Inflammation, Mast Cells, Mice, Transgenic, Ultraviolet Rays, Cell Degranulation, Endothelin-1, Receptor, Endothelin A, Mice, Endothelin A Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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