CoChat
Sign Up
Cited by 78

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Increased Activity and Altered Subcellular Distribution of Lysosomal Enzymes Determine Neuronal Vulnerability in Niemann-Pick Type C1-Deficient Mice

Amritraj, Asha, Peake, Kyle, Kodam, Anitha, Salio, Chiara, Merighi, Adalberto, Vance, Jean E., Kar, Satyabrata·2009·The American Journal of Pathology
DOI 10.2353/ajpath.2009.081096
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2353/ajpath.2009.081096

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 3 references

Research works printed but not linked: 72

  1. Carstea, 1997, Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis, Science, 277, 228, 10.1126/science.277.5323.228 · DOI · Paper page
  2. Naureckiene, 2000, Identification of HE1 as the second gene of Niemann-Pick C disease, Science, 290, 2298, 10.1126/science.290.5500.2298 · DOI
  3. Vanier, 2003, Niemann-Pick disease type C, Clin Genet, 64, 269, 10.1034/j.1399-0004.2003.00147.x · DOI · Paper page
  4. Walkley, 2004, Consequences of NPC1 and NPC2 loss of function in mammalian neurons, Biochim Biophys Acta, 1685, 48, 10.1016/j.bbalip.2004.08.011 · DOI
  5. Vanier, 1998, Recent advances in elucidating Niemann-Pick C disease, Brain Pathol, 8, 163, 10.1111/j.1750-3639.1998.tb00143.x · DOI
  6. Mukherjee, 2004, Lipid and cholesterol trafficking in NPC, Biochim Biophys Acta, 1685, 28, 10.1016/j.bbalip.2004.08.009 · DOI
  7. Vance, 2006, Lipid imbalance in the neurological disorder, Niemann-Pick C disease, FEBS Lett, 580, 5518, 10.1016/j.febslet.2006.06.008 · DOI
  8. Pacheco, 2008, The pathogenesis of Niemann-Pick type C disease: a role for autophagy ?, Expert Rev Mol Med, 10, e26, 10.1017/S146239940800080X · DOI
  9. Loftus, 1997, Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene, Science, 277, 232, 10.1126/science.277.5323.232 · DOI
  10. Karten, 2003, Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1 deficient neurons, J Biol Chem, 278, 4168, 10.1074/jbc.M205406200 · DOI
  11. Paul, 2004, Before the loss: neuronal dysfunction in Niemann-Pick type C disease, Biochim Biophys Acta, 1685, 63, 10.1016/j.bbalip.2004.08.012 · DOI
  12. Li, 2005, Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease, J Neuropathol Exp Neurol, 64, 323, 10.1093/jnen/64.4.323 · DOI
  13. Ong, 2001, Neurodegeneration in Niemann-Pick type C disease mice, Exp Brain Res, 141, 218, 10.1007/s002210100870 · DOI
  14. German, 2001, Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease, J Comp Neurol, 433, 415, 10.1002/cne.1149 · DOI
  15. German, 2002, Neurodegeneration in the Niemann-Pick C mouse: glial involvement, Neuroscience, 109, 437, 10.1016/S0306-4522(01)00517-6 · DOI
  16. Baudry, 2003, Postnatal development of inflammation in a murine model of Niemann-Pick type C disease: immunohistochemical observations of microglia and astroglia, Exp Neurol, 184, 887, 10.1016/S0014-4886(03)00345-5 · DOI
  17. Sarna, 2003, Patterned Purkinje cell degeneration in mouse models of Niemann-Pick type C disease, J Comp Neurol, 456, 279, 10.1002/cne.10522 · DOI
  18. Bahr, 2002, The neuropathogenic contributions of lysosomal dysfunction, J Neurochem, 83, 481, 10.1046/j.1471-4159.2002.01192.x · DOI
  19. Turk, 2002, Apoptotic pathways: involvement of lysosomal proteases, Biol Chem, 383, 1035, 10.1515/BC.2002.112 · DOI
  20. Dahms, 2002, P-type lectins, Biochim Biophys Acta, 1572, 317, 10.1016/S0304-4165(02)00317-3 · DOI
  21. Ghosh, 2003, Mannose 6-phosphate receptors: new twists in the tale, Nat Rev Mol Cell Biol, 4, 202, 10.1038/nrm1050 · DOI
  22. Hawkes, 2004, The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system, Brain Res Rev, 44, 117, 10.1016/j.brainresrev.2003.11.002 · DOI
  23. Nixon, 2001, The neuronal endosomal-lysosomal system in Alzheimer's disease, J Alzheimers Dis, 3, 97, 10.3233/JAD-2001-3114 · DOI
  24. Wraith, 2002, Lysosomal disorders, Semin Neonatol, 7, 75, 10.1053/siny.2001.0088 · DOI
  25. Tardy, 2004, Lysosomal storage diseases: is impaired apoptosis a pathogenic mechanism?, Neurochem Res, 29, 871, 10.1023/B:NERE.0000021232.05175.38 · DOI
  26. Roberg, 1998, Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes, Am J Pathol, 152, 1151
  27. Yamashima, 1998, Inhibition of ischemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on ‘calpain-cathepsin hypothesis.’, Eur J Neurosci, 10, 1723, 10.1046/j.1460-9568.1998.00184.x · DOI
  28. Yong, 1999, Lysosomal dysfunction results in lamina-specific maganeurite formation but not apoptosis in frontal cortex, Exp Neurol, 157, 150, 10.1006/exnr.1999.7038 · DOI
  29. Barlow, 2000, ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal activation, Proc Natl Acad Sci USA, 97, 871, 10.1073/pnas.97.2.871 · DOI
  30. Bendiske, 2003, Lysosomal activation is a compensatory response against protein accumulation and associated synaptogenesis-an approach for slowing Alzheimer disease?, J Neuropathol Exp Neurol, 62, 451, 10.1093/jnen/62.5.451 · DOI
  31. Hawkes, 2006, Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal–lysosomal markers in surviving neurons following 192 IgG-saporin administrations into the adult rat brain, Am J Pathol, 169, 1140, 10.2353/ajpath.2006.051208 · DOI
  32. MacDonald, 1989, Serum form of the rat insulin-like growth factor II/mannose 6-phosphate receptor is truncated in the carboxyl-terminal domain, J Biol Chem, 264, 3256, 10.1016/S0021-9258(18)94060-3 · DOI
  33. O'Gorman, 2002, Insulin-like growth factor-II/mannose 6-phosphate receptor overexpression reduces growth of choriocarcinoma cells in vitro and in vivo, Endocrinology, 143, 4287, 10.1210/en.2002-220548 · DOI
  34. Song, 2008, Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation, Eur J Neurosci, 28, 1989, 10.1111/j.1460-9568.2008.06498.x · DOI
  35. Zheng, 2002, Amyloid β peptide induces tau phosphorylation and neuronal degeneration in rat primary septal cultured neurons, Neuroscience, 115, 201, 10.1016/S0306-4522(02)00404-9 · DOI · Paper page
  36. Wei, 2008, Involvement of calpain and caspase in β-amyloid-induced cell death in rat primary septal cultured neurons, Neuropharmacology, 54, 721, 10.1016/j.neuropharm.2007.12.006 · DOI
  37. Myher, 1989, Molecular species of glycerophospholipids and sphingomyelins of human plasma: comparison to red blood cells, Lipids, 24, 408, 10.1007/BF02535148 · DOI
  38. Jacobs, 2008, Hepatic CTP: phosphocholine cytidylytransferase-α is a critical predictor of plasma high density lipoprotein and very low density lipoprotein, J Biol Chem, 283, 2147, 10.1074/jbc.M706628200 · DOI · Paper page
  39. Bornig, 1974, Staining of cholesterol with the fluorescent antibiotic “filipin.”, Acta Histochem, 50, 110
  40. Schmued, 2005, Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons, Brain Res, 1035, 24, 10.1016/j.brainres.2004.11.054 · DOI
  41. Salio, 2005, Ultrastructural evidence for a pre- and postsynaptic localization of full-length trkB receptors in substantia gelatinosa (lamina II) of rat and mouse spinal cord, Eur J Neurosci, 8, 1951, 10.1111/j.1460-9568.2005.04392.x · DOI
  42. Hawkes, 2006, Single transmembrane IGF-II/M6P receptor regulates central cholinergic function by activating a G protein-sensitive, protein kinase C-dependent pathway, J Neurosci, 26, 585, 10.1523/JNEUROSCI.2730-05.2006 · DOI
  43. Jafferali, 2000, Insulin-like growth factor-I and its receptor in the frontal cortex, hippocampus and cerebellum of normal human and Alzheimer's disease brains, Synapse, 38, 450, 10.1002/1098-2396(20001215)38:4<450::AID-SYN10>3.0.CO;2-J · DOI
  44. Amritraj, 2009, Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains, Neurobiol Aging, 30, 54, 10.1016/j.neurobiolaging.2007.05.004 · DOI
  45. Karten, 2002, Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons, J Neurochem, 83, 1154, 10.1046/j.1471-4159.2002.01220.x · DOI
  46. Mariño, 2004, Autophagy: molecular mechanisms, physiological functions and relevance in human pathology, Cell Mol Life Sci, 61, 1439, 10.1007/s00018-004-4012-4 · DOI
  47. Pacheco, 2007, Autophagy in Niemann-Pick C disease is dependent upon beclin-1 and responsive to lipid trafficking defects, Hum Mol Genet, 16, 1495, 10.1093/hmg/ddm100 · DOI
  48. Bursch, 2001, The autophagosomal-lysosomal compartment in programmed cell death, Cell Death Differ, 8, 569, 10.1038/sj.cdd.4400852 · DOI
  49. Chwieralski, 2006, Cathepsin-regulated apoptosis, Apoptosis, 11, 143, 10.1007/s10495-006-3486-y · DOI
  50. Cheung, 2004, Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons, Biochem Biophys Res Commun, 315, 408, 10.1016/j.bbrc.2004.01.066 · DOI
  51. Oberst, 2008, Living with death: the evolution of the mitochondrial pathway of apoptosis in animals, Cell Death Differ, 7, 1139, 10.1038/cdd.2008.65 · DOI
  52. Zhao, 2003, Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis, Eur J Biochem, 270, 3778, 10.1046/j.1432-1033.2003.03765.x · DOI
  53. Heinrich, 2004, Cathespin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation, Cell Death Differ, 11, 550, 10.1038/sj.cdd.4401382 · DOI
  54. Candé, 2004, Apoptosis-inducing factor (AIF): caspase-independent after all, Cell Death Differ, 11, 591, 10.1038/sj.cdd.4401400 · DOI
  55. Huang, 2006, Neuronal cell death caused by inhibition of intracellular cholesterol trafficking is caspase dependent and associated with activation of the mitochondrial apoptosis pathway, J Neurochem, 97, 280, 10.1111/j.1471-4159.2006.03733.x · DOI
  56. Koh, 2006, Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons, J Neurochem, 98, 1278, 10.1111/j.1471-4159.2006.03958.x · DOI
  57. Figueiredo, 2008, Neuron-microglia crosstalk up-regulates neuronal FGF-2 expression which mediates neuroprotection against excitotoxicity via JNK1/2, J Neurochem, 107, 73, 10.1111/j.1471-4159.2008.05577.x · DOI
  58. Wu, 2005, Apoptosis accompanied by up-regulation of TNF-α death pathway genes in the brain of Niemann-Pick type C disease, Mol Genet Metab, 84, 9, 10.1016/j.ymgme.2004.08.017 · DOI
  59. Alvarez, 2008, Imatinib therapy blocks cerebellar apoptosis an improves neurological symptoms in a mouse model of Niemann-Pick type C disease, FASEB J, 10, 3617, 10.1096/fj.07-102715 · DOI
  60. Erickson, 2002, Studies on neuronal death in the mouse model of Niemann-Pick C disease, J Neurosci Res, 68, 738, 10.1002/jnr.10257 · DOI
  61. Butler, 2005, Cellular responses to protein accumulation involve autophagy and lysosomal enzyme activation, Rejuvenation Res, 8, 227, 10.1089/rej.2005.8.227 · DOI
  62. Jin, 2004, Intracellular accumulation of amyloidogenic fragments of amyloid-β precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities, Am J Pathol, 164, 975, 10.1016/S0002-9440(10)63185-9 · DOI
  63. Dagvajantsan, 2008, Up-regulation of insulin-like growth factor-II receptor in reactive astrocytes in the spinal cord of amyotrophic lateral sclerosis transgenic rats, Tohoku J Exp Med, 214, 303, 10.1620/tjem.214.303 · DOI
  64. Nakanishi, 2003, Neuronal and microglial cathepsins in aging and age-related diseases, Ageing Res Rev, 2, 367, 10.1016/S1568-1637(03)00027-8 · DOI
  65. Sleat, 1997, Ligand binding specificities of the two mannose 6-phosphate receptors, J Biol Chem, 272, 731, 10.1074/jbc.272.2.731 · DOI
  66. Kobayashi, 1999, Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport, Nat Cell Biol, 1, 113, 10.1038/15666 · DOI
  67. Ganley, 2006, Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells, J Biol Chem, 281, 17890, 10.1074/jbc.M601679200 · DOI
  68. Ikeda, 2008, Drug-induced phospholipidosis is caused by blockade of mannose 6-phosphate receptor-mediated targeting of lysosomal enzymes, Biochem Biophys Res Commun, 377, 268, 10.1016/j.bbrc.2008.09.121 · DOI
  69. Zhou, 2002, Cation-independent mannose 6-phosphate receptor blocks apoptosis induced by herpes simplex virus 1 mutants lacking glycoprotein D and is likely the target of antiapoptotic activity of the glycoprotein, J Virol, 76, 6197, 10.1128/JVI.76.12.6197-6204.2002 · DOI
  70. Li, 1999, The up-regulation of endosomal-lysosomal components in amyloid beta-resistant cells, J Neurochem, 73, 1477, 10.1046/j.1471-4159.1999.0731477.x · DOI
  71. Bi, 2005, Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1−/− mouse brain, Am J Pathol, 67, 1081, 10.1016/S0002-9440(10)61197-2 · DOI
  72. Burns, 2003, Presenilin redistribution associated with aberrant cholesterol transport enhances β-amyloid production in vivo, J Neurosci, 23, 5645, 10.1523/JNEUROSCI.23-13-05645.2003 · DOI

Cited by

Sorted by citations

Metadata

Authors
Amritraj, A., Peake, K., Kodam, A., Salio, C., Merighi, A., Vance, J. E., & Kar, S.
Venue
The American Journal of Pathology
Publisher
Elsevier BV
Published
2009-12
Volume
175
Issue
6
Pages
2540-2556
ISSN
0002-9440
DOI
10.2353/ajpath.2009.081096
Cited by
78
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review