CCR5 Signaling Suppresses Inflammation and Reduces Adverse Remodeling of the Infarcted Heart, Mediating Recruitment of Regulatory T Cells

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

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An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

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Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

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Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

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Myocardial Matrix Remodeling and the Matrix Metalloproteinases: Influence on Cardiac Form and Function

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Mechanisms of suppression by suppressor T cells

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Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

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Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

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CCL2/Monocyte Chemoattractant Protein-1 Regulates Inflammatory Responses Critical to Healing Myocardial Infarcts

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Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

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Foxp3 in control of the regulatory T cell lineage

Zheng, Y., & Rudensky, A. Y. (2007) · Nature Immunology · doi:10.1038/ni1455 · Cited by 699 · see citing works

The immune system and cardiac repair

Frangogiannis, N. G. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.007 · Cited by 643 · see citing works

Orchestrating the orchestrators: chemokines in control of T cell traffic

Bromley, S. K., Mempel, T. R., & Luster, A. D. (2008) · Nature Immunology · doi:10.1038/ni.f.213 · Cited by 592 · see citing works

Control of Regulatory T Cell Lineage Commitment and Maintenance

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Interleukin-1β and Tumor Necrosis Factor-α Decrease Collagen Synthesis and Increase Matrix Metalloproteinase Activity in Cardiac Fibroblasts In Vitro

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Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer

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Of Mice and Dogs

Dewald, O., Ren, G., Duerr, G. D., Zoerlein, M., Klemm, C., Gersch, C. M., Tincey, S., Michael, L. H., Entman, M. L., & Frangogiannis, N. G. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63154-9 · Cited by 382 · see citing works

Contrasting Effects of CCR5 and CCR2 Deficiency in the Pulmonary Inflammatory Response to Influenza A Virus

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Interleukin-1 Receptor Type I Signaling Critically Regulates Infarct Healing and Cardiac Remodeling

Bujak, M., Dobaczewski, M. P., Chatila, K. F., Mendoza, L. H., Li, N., Reddy, A. K., & Frangogiannis, N. G. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070974 · Cited by 366 · see citing works

Essential Role of Smad3 in Infarct Healing and in the Pathogenesis of Cardiac Remodeling

Bujak, M., Ren, G., Kweon, H. J., Dobaczewski, M. P., Reddy, A. K., Taffet, G. E., Wang, X.-F., & Frangogiannis, N. G. (2007) · Circulation · doi:10.1161/circulationaha.107.704197 · Cited by 356 · see citing works

Critical Role of Endogenous Thrombospondin-1 in Preventing Expansion of Healing Myocardial Infarcts

Frangogiannis, N. G., Ren, G., Dewald, O., Zymek, P. T., Haudek, S. B., Koerting, A., Winkelmann, K., Michael, L. H., Lawler, J., & Entman, M. L. (2005) · Circulation · doi:10.1161/circulationaha.104.510354 · Cited by 309 · see citing works

The Mechanistic Basis of Infarct Healing

Frangogiannis, N. G. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1907 · Cited by 286 · see citing works

TNF provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways

Haudek, S. B., Taffet, G. E., Schneider, M. D., & Mann, D. L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29134 · Cited by 277 · see citing works

Chemokines in ischemia and reperfusion

Frangogiannis, N. G. (2007) · Thrombosis and Haemostasis · doi:10.1160/th07-01-0022 · Cited by 276 · see citing works

Relevance of matrix metalloproteinases and their inhibitors after myocardial infarction: A temporal and spatial window

Vanhoutte, D., Schellings, M. W. M., Pinto, Y. M., & Heymans, S. R. B. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.10.002 · Cited by 259 · see citing works

Impaired Macrophage Function and Enhanced T Cell-Dependent Immune Response in Mice Lacking CCR5, the Mouse Homologue of the Major HIV-1 Coreceptor

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CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence

Yurchenko, E., Tritt, M., Hay, V., Shevach, E. M., Belkaid, Y., & Piccirillo, C. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060956 · Cited by 226 · see citing works

Targeted Deletion of CC Chemokine Receptor 2 Attenuates Left Ventricular Remodeling after Experimental Myocardial Infarction

Kaikita, K., Hayasaki, T., Okuma, T., Kuziel, W. A., Ogawa, H., & Takeya, M. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63309-3 · Cited by 206 · see citing works

Aging-Related Defects Are Associated With Adverse Cardiac Remodeling in a Mouse Model of Reperfused Myocardial Infarction

Bujak, M., Kweon, H.-J., Chatila, K. F., Li, N., Taffet, G. E., & Frangogiannis, N. G. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.01.011 · Cited by 199 · see citing works

Cutting Edge: Role of C-C Chemokine Receptor 5 in Organ-Specific and Innate Immunity to Cryptococcus neoformans

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CCR5-Dependent Regulatory T Cell Migration Mediates Fungal Survival and Severe Immunosuppression

Serezani, A. P. M., Cavassani, K. A., Tristão, F. S. M., Serezani, A. P. M., Martínez, R., Rossi, M. A., & Silva, J. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3049 · Cited by 115 · see citing works

Reduced Macrophage Infiltration and Demyelination in Mice Lacking the Chemokine Receptor CCR5 Following Infection with a Neurotropic Coronavirus

Glass, W. G., Liu, M. T., Kuziel, W. A., & Lane, T. E. (2001) · Virology · doi:10.1006/viro.2001.1050 · Cited by 114 · see citing works

Serum Profiles of C-C Chemokines in Acute Myocardial Infarction: Possible Implication in Postinfarction Left Ventricular Remodeling

Parissis, J., Adamopoulos, S. N., Venetsanou, K. F., Mentzikof, D., Karas, S. M., & Kremastinos, D. T. (2002) · Journal of Interferon & Cytokine Research · doi:10.1089/107999002753536194 · Cited by 90 · see citing works

Opposing Effects Mediated by the Chemokine Receptor CXCR2 on Myocardial Ischemia-Reperfusion Injury

Tarzami, S. T., Miao, W., Mani, K. M., Lopez, L., Factor, S. M., Berman, J. W., & Kitsis, R. N. (2003) · Circulation · doi:10.1161/01.cir.0000093192.72099.9a · Cited by 90 · see citing works

Ccr1 deficiency reduces inflammatory remodelling and preserves left ventricular function after myocardial infarction

Liehn, E. A., Merx, M. W., Postea, O., Becher, S., Djalali-Talab, Y., Shagdarsuren, E., Kelm, M., Zernecke, A., & Weber, C. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00194.x · Cited by 79 · see citing works

Identification of a Chemokine Network That Recruits FoxP3+ Regulatory T Cells Into Chronically Inflamed Intestine

Kang, S. G., Piniecki, R. J., HogenEsch, H., Lim, H. W., Wiebke, E. A., Braun, S. E., Matsumoto, S., & Kim, C. H. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.008 · Cited by 61 · see citing works

CCR5 Deficiency Aggravates Crescentic Glomerulonephritis in Mice

Turner, J., Paust, H., Steinmetz, O. M., Peters, A., Meyer‐Schwesinger, C., Heymann, F., Helmchen, U. M., Fehr, S., Horuk, R., Wenzel, U. O., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6546 · Cited by 54 · see citing works

CCR5 and CXCR3 Are Dispensable for Liver Infiltration, but CCR5 Protects against Virus-Induced T-Cell-Mediated Hepatic Steatosis

Holst, P. J., Ørskov, C., Qvortrup, K., Christensen, J. P., & Thomsen, A. R. (2007) · Journal of Virology · doi:10.1128/jvi.01242-07 · Cited by 16 · see citing works

The Biological Basis for Cardiac Repair After Myocardial Infarction

Prabhu, S. D., & Frangogiannis, N. G. (2016) · Circulation Research · doi:10.1161/circresaha.116.303577 · Cited by 2,249 · see citing works

The inflammatory response in myocardial injury, repair, and remodelling

Frangogiannis, N. G. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.28 · Cited by 1,758 · see citing works

Regulation of the Inflammatory Response in Cardiac Repair

Frangogiannis, N. G. (2012) · Circulation Research · doi:10.1161/circresaha.111.243162 · Cited by 1,193 · see citing works

Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities

Ong, S., Hernández‐Reséndiz, S., Crespo-Avilan, G. E., Талгатовна, М. Р., Kwek, X.-Y., Cabrera-Fuentes, H. A., & Hausenloy, D. J. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.01.001 · Cited by 925 · see citing works

Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities

Frangogiannis, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.07.001 · Cited by 855 · see citing works

Foxp3 + CD4 + T Cells Improve Healing After Myocardial Infarction by Modulating Monocyte/Macrophage Differentiation

Weirather, J., Hofmann, U., Beyersdorf, N., Ramos, G. C., Vogel, B., Frey, A., Ertl, G., Kerkau, T., & Frantz, S. (2014) · Circulation Research · doi:10.1161/circresaha.115.303895 · Cited by 705 · see citing works

Role of innate and adaptive immune mechanisms in cardiac injury and repair

Epelman, S., Liu, P. P., & Mann, D. L. (2015) · Nature reviews. Immunology · doi:10.1038/nri3800 · Cited by 631 · see citing works

Pathophysiology of Myocardial Infarction

Frangogiannis, N. G. (2015) · Comprehensive physiology · doi:10.1002/cphy.c150006 · Cited by 719 · see citing works

Fibroblasts in myocardial infarction: A role in inflammation and repair

Shinde, A. V., & Frangogiannis, N. G. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.11.015 · Cited by 516 · see citing works

Activation of CD4 + T Lymphocytes Improves Wound Healing and Survival After Experimental Myocardial Infarction in Mice

Hofmann, U., Beyersdorf, N., Weirather, J., Podolskaya, A., Bauersachs, J. K., Ertl, G., Kerkau, T., & Frantz, S. (2012) · Circulation · doi:10.1161/circulationaha.111.044164 · Cited by 478 · see citing works

Matricellular Proteins in Cardiac Adaptation and Disease

Frangogiannis, N. G. (2012) · Physiological Reviews · doi:10.1152/physrev.00008.2011 · Cited by 440 · see citing works

Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure

Hanna, A., & Frangogiannis, N. G. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07071-0 · Cited by 425 · see citing works

Regulatory T cells in cardiovascular diseases

Meng, X., Yang, J., Dong, M., Zhang, K., Tu, E., Gao, Q., Chen, W., Zhang, C., & Zhang, Y. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.169 · Cited by 406 · see citing works

Role of Cardiac Macrophages on Cardiac Inflammation, Fibrosis and Tissue Repair

Lafuse, W. P., Wozniak, D. J., & Rajaram, M. V. S. (2020) · Cells · doi:10.3390/cells10010051 · Cited by 400 · see citing works

Monocyte and macrophage heterogeneity in the heart

Nahrendorf, M., & Swirski, F. (2013) · Circulation Research · doi:10.1161/circresaha.113.300890 · Cited by 350 · see citing works

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.

Kleinschnitz, C., Kraft, P., Dreykluft, A., Hagedorn, I., Göbel, K., Schuhmann, M., Langhauser, F., Helluy, X., Schwarz, T. J., Bittner, S., et al. (2013) · Blood · doi:10.1182/blood-2012-04-426734 · Cited by 360 · see citing works

Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration

Li, J., Tan, J. L., Martino, M. M., & Lui, K. O. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00585 · Cited by 345 · see citing works

Regulatory T cells ameliorate cardiac remodeling after myocardial infarction

Tang, T., Yuan, J., Zhu, Z., Zhang, W.-C., Xiao, H., Xia, N., Yan, X.-X., Nie, S., Liu, J., Zhou, S., et al. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0232-6 · Cited by 319 · see citing works

Cells of the Immune System in Cardiac Remodeling: Main Players in Resolution of Inflammation and Repair After Myocardial Infarction

Кологривова, И. В., Штатолкина, М. А., Суслова, Т. Е., & Ryabov, V. V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.664457 · Cited by 319 · see citing works

Role of Lymphocytes in Myocardial Injury, Healing, and Remodeling After Myocardial Infarction

Hofmann, U., & Frantz, S. (2015) · Circulation Research · doi:10.1161/circresaha.116.304072 · Cited by 298 · see citing works

Anti‐inflammatory therapies in myocardial infarction: failures, hopes and challenges

Huang, S., & Frangogiannis, N. G. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14155 · Cited by 279 · see citing works

In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing

Courties, G., Heidt, T., Sebas, M., Iwamoto, Y., Jeon, D., Truelove, J. J., Tricot, B., Wojtkiewicz, G. R., Dutta, P., Sager, H. B., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.023 · Cited by 278 · see citing works

Fibroblasts in post-infarction inflammation and cardiac repair

Chen, W., & Frangogiannis, N. G. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.08.023 · Cited by 270 · see citing works

Postischemic Revascularization: From Cellular and Molecular Mechanisms to Clinical Applications

Silvestre, J., Smadja, D. M., & Levy, B. I. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2013 · Cited by 257 · see citing works

The Role of the TGF-β Superfamily in Myocardial Infarction

Hanna, A., & Frangogiannis, N. G. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00140 · Cited by 253 · see citing works

Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction

Venugopal, H., Hanna, A., Humeres, C. D., & Frangogiannis, N. G. (2022) · Cells · doi:10.3390/cells11091386 · Cited by 253 · see citing works

IL-1 Induces Proinflammatory Leukocyte Infiltration and Regulates Fibroblast Phenotype in the Infarcted Myocardium

Saxena, A., Chen, W., Su, Y., Rai, V., Uche, O. U., Li, N., & Frangogiannis, N. G. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300725 · Cited by 248 · see citing works

The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction

Stuart, S. D. F., Jesus, N. M. D., Lindsey, M. L., & Ripplinger, C. M. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.12.024 · Cited by 249 · see citing works

Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function

Saxena, A., Dobaczewski, M. P., Rai, V., Haque, Z. K., Chen, W., Li, N., & Frangogiannis, N. G. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00328.2014 · Cited by 210 · see citing works

Targeting inflammatory pathways in myocardial infarction

Christia, P., & Frangogiannis, N. G. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12118 · Cited by 208 · see citing works

Inflammation in cardiac injury, repair and regeneration

Frangogiannis, N. G. (2015) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000158 · Cited by 199 · see citing works

Repair of the Infarcted Heart: Cellular Effectors, Molecular Mechanisms and Therapeutic Opportunities

Hilgendorf, I., Frantz, S., & Frangogiannis, N. G. (2024) · Circulation Research · doi:10.1161/circresaha.124.323658 · Cited by 200 · see citing works

The Immune System and the Remodeling Infarcted Heart

Frangogiannis, N. G. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000003 · Cited by 163 · see citing works

The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability

Li, T., Li, X., Feng, Y., Dong, G., Wang, Y., & Yang, J. (2020) · Mediators of Inflammation · doi:10.1155/2020/3872367 · Cited by 156 · see citing works

CCL20/CCR6-mediated migration of regulatory T cells to the Helicobacter pylori -infected human gastric mucosa

Cook, K., Letley, D. P., Ingram, R. J. M., Staples, E., Skjoldmose, H., Atherton, J. C., & Robinson, K. (2014) · Gut · doi:10.1136/gutjnl-2013-306253 · Cited by 153 · see citing works

Inflammation in Myocardial Ischemia/Reperfusion Injury: Underlying Mechanisms and Therapeutic Potential

Francisco, J. J., & Re, D. P. D. (2023) · Antioxidants · doi:10.3390/antiox12111944 · Cited by 160 · see citing works

Repair After Myocardial Infarction, Between Fantasy and Reality

Liehn, E. A., Postea, O., Curaj, A., & Marx, N. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.034 · Cited by 152 · see citing works

The role of transforming growth factor (TGF)-β in the infarcted myocardium

Frangogiannis, N. G. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2016.11.19 · Cited by 152 · see citing works

Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges

Saxena, A., Russo, I., & Frangogiannis, N. G. (2015) · Translational research · doi:10.1016/j.trsl.2015.07.002 · Cited by 153 · see citing works

Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair

Mathur, A. N., Zirak, B., Boothby, I. C., Tan, M., Cohen, J. N., Mauro, T., Mehta, P., Lowe, M. M., Abbas, A. K., Ali, N., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.013 · Cited by 149 · see citing works

CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in mice

Montecucco, F., Braunersreuther, V., Lenglet, S., Delattre, B. M. A., Pelli, G., Buatois, V., Guilhot, F., Galan, K., Vuilleumier, N., Ferlin, W. G., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr127 · Cited by 147 · see citing works

Endogenous Thrombospondin 1 Protects the Pressure-Overloaded Myocardium by Modulating Fibroblast Phenotype and Matrix Metabolism

Xia, Y., Dobaczewski, M. P., González-Quesada, C. J., Chen, W., Biernacka, A., Li, N., Lee, D.-W., & Frangogiannis, N. G. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.175323 · Cited by 145 · see citing works

The Dynamic Interplay Between Cardiac Inflammation and Fibrosis

Thomas, T. P., & Grisanti, L. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.529075 · Cited by 146 · see citing works

scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T reg function

Gellatly, K. J., Strassner, J. P., Essien, K. I., Refat, M. A., Murphy, R. L., Coffin-Schmitt, A., Pandya, A. G., Tovar‐Garza, A., Frisoli, M. L., Fan, X., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd8995 · Cited by 143 · see citing works

Post-transplant cholangiopathy: Classification, pathogenesis, and preventive strategies

de Vries, Y., von Meijenfeldt, F. A., & Porte, R. J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.06.013 · Cited by 138 · see citing works

Thrombospondin-1 Induction in the Diabetic Myocardium Stabilizes the Cardiac Matrix in Addition to Promoting Vascular Rarefaction Through Angiopoietin-2 Upregulation

González-Quesada, C. J., Cavalera, M., Biernacka, A., Kong, P., Lee, D.-W., Saxena, A., Frunza, O., Dobaczewski, M. P., Shinde, A. V., & Frangogiannis, N. G. (2013) · Circulation Research · doi:10.1161/circresaha.113.302593 · Cited by 131 · see citing works

Fibrous scaffolds for building hearts and heart parts

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C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function

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The Extracellular Matrix Modulates Fibroblast Phenotype and Function in the Infarcted Myocardium

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Chemokines in Myocardial Infarction

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Persistent Microvascular Obstruction After Myocardial Infarction Culminates in the Confluence of Ferric Iron Oxide Crystals, Proinflammatory Burden, and Adverse Remodeling

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Targeting the Chemokines in Cardiac Repair

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Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy

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Abstract 5055: CC Chemokine Receptor 5 Signaling Suppresses Inflammation and Attenuates Adverse Remodeling Following Myocardial Infarction by Recruiting Regulatory T Cells

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CCR5 signaling suppresses inflammation and attenuates adverse remodeling in healing myocardial infarcts.

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CCR5 deletion impairs the post‐myocardial infarction inflammatory response

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CC chemokine receptor 5 deletion impairs macrophage activation and induces adverse remodeling following myocardial infarction

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C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function

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