CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

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    А. А. Квичанский, Л.В. Третьякова, Maria N. Volobueva, А. О. Манолова, M. Yu. Stepanichev, Mikhail V. Onufriev, Ю. В. Моисеева, Н. А. Лазарева, Alexey P. Bolshakov, Н. В. Гуляева · 2021 · Biochemistry (Moscow)
  9. Microglial CX3CR1 deficiency regulates the selective vulnerability of cone photoreceptors via STAT3/CCL–ACKR1 signaling in the mouse retina
    Rong Li, Jing Zhang, Qiong Wang, Jun-Qi Fan, Bin Lin · 2026 · Experimental & Molecular Medicine
  10. Peripheral biomarkers of neuroinflammation in Alzheimer’s disease and vascular dementia
    Xiaoxue Ouyang, Rachel S.L. Chia, Yuek Ling Chai, Chong, Ming Ann Sim, Dong‐Gyu Jo, Thiruma Valavan Arumugam, Gautam Sethi, Gavin Stewart Dawe, Christopher P. Chen et al. · 2026 · Biochemical Pharmacology
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  16. Microglial Biology and Physiology
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  18. Microglia demostrate age-dependent performance and interaction with beta-amyloid peptide
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  24. Microglia: A Double-Sided Sword in Stroke
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  32. Three Potential Risk Genes for Bipolar Disorder: MT1E, MT1X and CX3CR1
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  33. Fractalkine signaling in psychiatric disorder : observations in the postmortem brain
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  34. Expression and Function of Kir2.1 and Kv1.3 Channels in Cytokine-induced Activation of Rat and Mouse Microglia: A Tale of Two Rodents
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  40. CX3CL1
    Paula A. Pino, Astrid E. Cardona · 2012 · Springer eBooks
  41. Angiogenesis
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  42. CX3CL1
    Paula A. Pino, Astrid E. Cardona · 2017 · Springer eBooks
  43. Monocytes and Macrophages in the Aged Lung and Heart
    Marilyn L. Thoman, William Bray, Phyllis‐Jean Linton · 2019 · Springer eBooks
  44. Faculty Opinions recommendation of Microglia Play an Active Role in Obesity-Associated Cognitive Decline.
    Derek Daniels, Jessica Santollo · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  45. Additional file 10 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu‐Abdelahad et al. · 2023 · Figshare
  46. Additional file 9 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
    Zhu, Bing, Yan Liu, Spring Yewon Hwang, Kailey Archuleta, Huijie Huang, Alex Rosa Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y. Huang · 2022 · Figshare
  47. Additional file 8 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
    Zhu, Bing, Liu, Yan, Spring Yewon Hwang, Kailey Archuleta, Huijie Huang, Alex Rosa Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y. Huang · 2022 · Figshare
  48. Neuro-inflammatory Responses in Alzheimer’s v/s Parkinson’s Diseases
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  49. Cytokines and Chemokines in the Nervous System in Health and Disease
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  50. Imaging Alzheimer’s Retinopathy
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  51. Chemokine receptor CX3CR1 modulates microglial activity through Tau and amyloid-β interactions in Alzheimer’s disease
    Vaishnavi Ananathanarayana, Riddhi Upadhyay, Gouri H. Illanad, Deena Krishnan, Neha P. Bochageri, Murugan Sevanan, Zabin Bagewadi, R. Sivasamy, Subashchandrabose Chinnathambi · 2025 · Advances in immunology
  52. C3 lowering in adult APP KI mice rescues synapses and spares cognitive decline
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  53. Additional file 4 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Kozlova, Alena, Sara Bitarafan, Kumar, Prateek, David Beaulieu‐Abdelahad et al. · 2022 · Figshare
  54. Additional file 2 of Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure
    Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Tso, Huen-Yee, Sophia P. Clark, Puttipong Sripinun, Néstor Gómez, Claire H. Mitchell · 2021 · Figshare
  55. Additional file 6 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Kozlova, Alena, Sara Bitarafan, Kumar, Prateek, David Beaulieu‐Abdelahad et al. · 2022 · Figshare
  56. Additional file 3 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
    Zhu, Bing, Liu, Yan, Spring Yewon Hwang, Kailey Archuleta, Huang, Huijie, Campos, Alex, Rabi Murad, Juan Piña-Crespo, Xu, Huaxi, Huang, Timothy Y. · 2022 · Figshare
  57. Additional file 9 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Kozlova, Alena, Sara Bitarafan, Kumar, Prateek, David Beaulieu‐Abdelahad et al. · 2022 · Figshare
  58. Additional file 1 of Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure
    Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Tso, Huen-Yee, Sophia P. Clark, Puttipong Sripinun, Néstor Gómez, Claire H. Mitchell · 2021 · Figshare
  59. Additional file 4 of The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy
    Zheng, Zhicheng, Liang, Peiyu, Hou, Baohua, Lu, Xin, Ma, Qianwen, Yu, Xiaomin, Han, Song, Biwen Peng, 陈桃香, Liu, Wanhong et al. · 2021 · Figshare
  60. Additional file 3 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Kozlova, Alena, Sara Bitarafan, Kumar, Prateek, David Beaulieu‐Abdelahad et al. · 2022 · Figshare
  61. Additional file 6 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
    Zhu, Bing, Liu, Yan, Spring Yewon Hwang, Kailey Archuleta, Huang, Huijie, Campos, Alex, Rabi Murad, Juan Piña-Crespo, Xu, Huaxi, Huang, Timothy Y. · 2022 · Figshare
  62. Additional file of The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy
    Zheng, Zhicheng, Liang, Peiyu, Hou, Baohua, Lu, Xin, Ma, Qianwen, Yu, Xiaomin, Han, Song, Biwen Peng, 陈桃香, Liu, Wanhong et al. · 2021 · Figshare
  63. Additional file 1 of Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
    Guilherme de Araujo Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Reis, Eduardo Moraes, Longo, Beatriz Monteiro, Micheli Mainardi Pillat, Henning Ulrich · 2024 · Figshare
  64. Additional file 5 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
    Zhu, Bing, Liu, Yan, Spring Yewon Hwang, Kailey Archuleta, Huang, Huijie, Campos, Alex, Rabi Murad, Juan Piña-Crespo, Xu, Huaxi, Timothy Y. Huang · 2022 · Figshare
  65. Additional file 4 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
    Zhu, Bing, Liu, Yan, Spring Yewon Hwang, Kailey Archuleta, Huang, Huijie, Campos, Alex, Rabi Murad, Juan Piña-Crespo, Xu, Huaxi, Huang, Timothy Y. · 2022 · Figshare
  66. Additional file 7 of Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
    Guilherme de Araujo Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Reis, Eduardo Moraes, Longo, Beatriz Monteiro, Micheli Mainardi Pillat, Henning Ulrich · 2024 · Figshare
  67. Additional file 7 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
    Zhu, Bing, Liu, Yan, Spring Yewon Hwang, Kailey Archuleta, Huang, Huijie, Campos, Alex, Rabi Murad, Juan Piña-Crespo, Xu, Huaxi, Timothy Y. Huang · 2022 · Figshare
  68. Additional file 8 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Kozlova, Alena, Sara Bitarafan, Kumar, Prateek, David Beaulieu‐Abdelahad et al. · 2022 · Figshare
  69. Additional file 9 of Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
    Guilherme de Araujo Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Reis, Eduardo Moraes, Longo, Beatriz Monteiro, Micheli Mainardi Pillat, Henning Ulrich · 2024 · Figshare
  70. Additional file 6 of Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
    Guilherme de Araujo Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Reis, Eduardo Moraes, Longo, Beatriz Monteiro, Micheli Mainardi Pillat, Henning Ulrich · 2024 · Figshare
  71. Additional file 4 of Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
    Guilherme de Araujo Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Reis, Eduardo Moraes, Longo, Beatriz Monteiro, Micheli Mainardi Pillat, Henning Ulrich · 2024 · Figshare
  72. Additional file 2 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
    Zhu, Bing, Liu, Yan, Spring Yewon Hwang, Kailey Archuleta, Huang, Huijie, Campos, Alex, Rabi Murad, Juan Piña-Crespo, Xu, Huaxi, Huang, Timothy Y. · 2022 · Figshare
  73. Additional file 7 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Kozlova, Alena, Sara Bitarafan, Kumar, Prateek, David Beaulieu‐Abdelahad et al. · 2022 · Figshare
  74. Additional file 2 of Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
    Guilherme de Araujo Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Reis, Eduardo Moraes, Longo, Beatriz Monteiro, Micheli Mainardi Pillat, Henning Ulrich · 2024 · Figshare
  75. Additional file 1 of Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice, an AD model
    Chanho Kong, Yang, Eun-Jeong, Shin, Jaewoo, Junwon Park, Kim, Si-Hyun, Park, Seong-Wook, Chang, Won Seok, Lee, Chang-Han, Kim, Hyunju, Kim, Hye-Sun et al. · 2022 · Figshare
  76. Additional file 3 of Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
    Guilherme de Araujo Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Reis, Eduardo Moraes, Longo, Beatriz Monteiro, Micheli Mainardi Pillat, Henning Ulrich · 2024 · Figshare
  77. Additional file 5 of The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy
    Zheng, Zhicheng, Liang, Peiyu, Hou, Baohua, Lu, Xin, Ma, Qianwen, Yu, Xiaomin, Han, Song, Biwen Peng, 陈桃香, Liu, Wanhong et al. · 2021 · Figshare
  78. Additional file 3 of The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy
    Zheng, Zhicheng, Liang, Peiyu, Hou, Baohua, Lu, Xin, Ma, Qianwen, Yu, Xiaomin, Han, Song, Biwen Peng, 陈桃香, Liu, Wanhong et al. · 2021 · Figshare
  79. Additional file 5 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Kozlova, Alena, Sara Bitarafan, Kumar, Prateek, David Beaulieu‐Abdelahad et al. · 2022 · Figshare
  80. Additional file 2 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Kozlova, Alena, Sara Bitarafan, Kumar, Prateek, David Beaulieu‐Abdelahad et al. · 2022 · Figshare
  81. Additional file 8 of CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease
    Shweta S. Puntambekar, Miguel Moutinho, Peter Bor‐Chian Lin, Vaishnavi Jadhav, Danika M. Tumbleson, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian L. Oblak, Cristian A. Lasagna‐Reeves et al. · 2022 · Figshare
  82. Additional file 5 of Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
    Guilherme de Araujo Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Reis, Eduardo Moraes, Longo, Beatriz Monteiro, Micheli Mainardi Pillat, Henning Ulrich · 2024 · Figshare
  83. Additional file 1 of The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy
    Zheng, Zhicheng, Liang, Peiyu, Hou, Baohua, Lu, Xin, Ma, Qianwen, Yu, Xiaomin, Han, Song, Biwen Peng, 陈桃香, Liu, Wanhong et al. · 2021 · Figshare
  84. Additional file 1 of Inhibition of microfold cells ameliorates early pathological phenotypes by modulating microglial functions in Alzheimer’s disease mouse model
    Namkwon Kim, Ju, In Gyoung, Seung Ho Jeon, Yeongae Lee, Jung, Min-Ji, Min Sung Gee, Cho, Jae Seok, Inn, Kyung-Soo, Garrett-Sinha, Lee Ann, Oh, Myung Sook et al. · 2024 · Figshare
  85. Additional file 10 of CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease
    Shweta S. Puntambekar, Miguel Moutinho, Peter Bor‐Chian Lin, Vaishnavi Jadhav, Danika M. Tumbleson, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian L. Oblak, Cristian A. Lasagna‐Reeves et al. · 2022 · Figshare
  86. Additional file 1 of Trem2 deletion enhances tau dispersion and pathology through microglia exosomes
    Zhu, Bing, Liu, Yan, Spring Yewon Hwang, Kailey Archuleta, Huang, Huijie, Campos, Alex, Rabi Murad, Juan Piña-Crespo, Xu, Huaxi, Huang, Timothy Y. · 2022 · Figshare
  87. Additional file 2 of The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy
    Zheng, Zhicheng, Liang, Peiyu, Hou, Baohua, Lu, Xin, Ma, Qianwen, Yu, Xiaomin, Han, Song, Biwen Peng, 陈桃香, Liu, Wanhong et al. · 2021 · Figshare
  88. Additional file 8 of Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
    Guilherme de Araujo Juvenal, Carine Meinerz, Ana Carolina Ayupe, Henrique Correia Campos, Reis, Eduardo Moraes, Longo, Beatriz Monteiro, Micheli Mainardi Pillat, Henning Ulrich · 2024 · Figshare
  89. Additional file 1 of BIN1 is a key regulator of proinflammatory and neurodegeneration-related activation in microglia
    Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell T. Hansen, Kozlova, Alena, Sara Bitarafan, Prateek Kumar, David Beaulieu‐Abdelahad et al. · 2022 · Figshare
  90. Additional file 9 of CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer’s disease
    Shweta S. Puntambekar, Miguel Moutinho, Peter Bor‐Chian Lin, Vaishnavi Jadhav, Danika M. Tumbleson, Ananya Balaji, Martin Alvarado Benito, Guixiang Xu, Adrian L. Oblak, Cristian A. Lasagna‐Reeves et al. · 2022 · Figshare
  91. Introduction to microglial aging and its involvement in neurodegenerative diseases
    Benneth Ben-Azu, Makenna Gargus, Alexei Verkhratsky, Marie‐Ève Tremblay · 2026 · Elsevier eBooks
  92. Identification of metabolism and inflammation-related biomarkers and potential drugs for schizophrenia based on comprehensive bioinformatics and machine learning
    Yanfang Chen, Min Zhang, Ling Qiao, Feng Lu, Shaoping Ji · 2026 · BMC Psychiatry
  93. Microglial dynamics in physiological conditions : a vigilance state and neuronal activity-driven mechanism
    Inès Hristovska · 2019 · theses.fr (ABES)
  94. MT5-MMP promotes neuroinflammation, pathogenic processing of amyloid precursor protein and synaptic dysfunction at early stages in an Alzheimer's disease model
    Dominika Piłat · 2021 · theses.fr (ABES)
  95. Le métabolisme astrocytaire de la L-sérine et ses implications dans la maladie d'Alzheimer : une potentielle approche thérapeutique
    Pierre-Antoine Vigneron · 2020 · theses.fr (ABES)
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    Anne-Laure Hemonnot-Girard · 2021 · theses.fr (ABES)
  97. Rôle des cellules T CD4+ dans la modulation des réponses microgliales au cours de la maladie d’Alzheimer : potentialités thérapeutiques
    Dylla Ait Ahmed · 2014 · theses.fr (ABES)
  98. Microglia detection and phagocytosis of dying neurons is regulated by CX3CR1
    Maryanne N. Barasa, Alicia N. Pietramale, Robert Hill · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  99. Microglial PD-1/PD-L1 axis in CNS demyelinating diseases: a dual immunoregulatory perspective
    Meiling Zhou, Xiying Yao, Lu Liu, Yuan Gao, Wenli Kelly Chen, Kunwen Zheng, Haixia Li, Qiang Meng · 2026 · Frontiers in Cellular Neuroscience
  100. Impact de la consommation de fructose sur la microglie et la santé cérébrale
    Adeline Coursan · 2024 · theses.fr (ABES)