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Cited by 36Muscle metabolism and nutritionBiochemical effects in animalsSports Performance and Training

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Creatine supplementation improves performance, but is it safe? Double-blind placebo-controlled study

Almeida, Douglas, Colombini, Alessandra, Machado, Marco·2020·The Journal of Sports Medicine and Physical Fitness
DOI 10.23736/s0022-4707.20.10437-7
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Abstract

Background Creatine represents a natural supplement and ergogenic aid for sport performance, but there are several concerns regarding its safety for health. The present double-blind placebo-controlled study evaluated the effect of creatine monohydrate supplementation on a panel of blood and urine health indicators in resistance training practitioners. Methods Eighteen males performing resistance training three times per week were supplemented with 0.3 g/kg per day creatine monohydrate for 7 days and compared with matched controls supplemented with dextrosol. Blood and urine samples were collected pre- and 30 days post-supplementation to evaluate 41 biochemical parameters and renal function. Results Creatine monohydrate supplementation did not cause adverse events and, as expected, promoted an increase of the performance and body weight. No modification of red blood cells parameters, white blood cells profile, blood lipid profile, metabolic and urine markers, hepatic and renal function were observed in the supplemented group. Conclusions Despite the expected weight increase, the creatine monohydrate supplementation is safe for health and no detrimental effects on different organs and physiological systems were observed in our cohort of volunteers.

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Crossref · 10.23736/s0022-4707.20.10437-7

Cites

14 of 14 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 14 references

Research works printed but not linked: 16

  1. 10.1152/jappl.1996.81.1.232 · DOI · Paper page
  2. 10.1023/A:1022465203458 · DOI · Paper page
  3. Bizzarini E, 2004, Is the use of oral creatine supplementation safe?, J Sports Med Phys Fitness, 44, 411
  4. 10.1097/00042752-200007000-00007 · DOI · Paper page
  5. Greenwood M, 2003, Cramping and Injury Incidence in Collegiate Football Players Are Reduced by Creatine Supplementation, J Athl Train, 38, 216
  6. Watson G, 2006, Creatine use and exercise heat tolerance in dehydrated men, J Athl Train, 41, 18
  7. Rosene JM, 2015, The effects of creatine supplementation on thermoregulation and isokinetic muscular performance following acute (3-day) supplementation, J Sports Med Phys Fitness, 55, 1488
  8. 10.1136/bjsm.2007.042473 · DOI · Paper page
  9. Hile AM, 2006, Creatine supplementation and anterior compartment pressure during exercise in the heat in dehydrated men, J Athl Train, 41, 30
  10. 10.1007/s00421-012-2514-6 · DOI · Paper page
  11. 10.1007/s00394-004-0519-6 · DOI · Paper page
  12. 10.1016/j.nutres.2008.01.001 · DOI · Paper page
  13. 10.1097/00005768-200003000-00024 · DOI
  14. 10.1159/000180580 · DOI
  15. 10.1111/j.1468-2958.2002.tb00828.x · DOI · Paper page
  16. 10.1056/NEJM199810083391508 · DOI

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Metadata

Authors
Almeida, D., Colombini, A., & Machado, M.
Affiliations
  • Universidade Iguaçu (BR)
  • IRCCS Ospedale Galeazzi - Sant'Ambrogio (IT)
Corresponding author
Colombini, Alessandra
ORCID
Venue
The Journal of Sports Medicine and Physical Fitness
Publisher
Edizioni Minerva Medica
Published
2020-06
Volume
60
Issue
7
Pages
1034-1039
ISSN
  • 0022-4707 (ISSN-L)
  • 1827-1928
DOI
10.23736/s0022-4707.20.10437-7
OpenAlex
W3037667437
Cited by
36
References
14
Citations by year
2026: 5 · 2025: 11 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 3
FWCI
2.00
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Sports Medicine and Physical Fitness (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
creatine monohydrate, dietary supplementation, ergogenic aids, resistance training, athletic performance, safety, serum biochemistry, urinary biomarkers, renal function, liver function, weight gain
MeSH terms
Adult, Creatine, Double-Blind Method, Hematologic Tests, Humans, Kidney, Leukocyte Count, Lipids, Liver, Male, Biomarkers, Weight Gain, Muscle, Skeletal, Dietary Supplements, Athletic Performance, Resistance Training, Young Adult, Performance-Enhancing Substances

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