Hematologic alterations in adult cats fed 6 or 12% propylene glycol
Open accessAbstract
Summary: Cat foods containing propylene glycol (pg) induce Heinz body formation in feline erythrocytes. To further study the hematologic importance of dietary pg, 21 adult cats were allotted to 3 groups of 7 each and fed diets containing 0,6, or 12% pg on a dry-weight basis. Cats fed pg had a dose-related increase in Heinz bodies within 2 weeks, and the increase persisted throughout the study. Although only slight changes occurred in pcv, hemoglobin concentration, and rbc count, punctate reticulocytes were significantly increased in the group fed 12% pg. Mean rbc survival was decreased in the groups fed 6 or 12% pg by 30 and 55%, respectively, compared with the control group. These data indicate that pg-containing diets cause a dose-dependent erythrocyte destruction, even when fed at concentrations as low as 6%.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other compounds that cause oxidative damage to mammalian RBCs, such as propylene glycol and phenylhydrazine, appear to act in a concentration- or dose-dependent manner.
“Other compounds that have been shown to cause oxidative damage to mammalian RBCs, such as propylene glycol and phenylhydrazine, appear to do so in a concentration-or dose-dependent manner.[14][15][16]”
From Heinz body anemia in a dog that had been sprayed with skunk musk (2005) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cited by
Sorted by citations
Heinz body anemia in a dog that had been sprayed with skunk musk
Zaks, K. L., Tan, E. O., & Thrall, M. A. (2005) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.2005.226.1516 · Cited by 22 · see citing works
- Authors
- Bauer, M. C., Weiss, D. J., & Perman, V.
- Affiliations
- University of Minnesota (US)
- Venue
- American Journal of Veterinary Research
- Published
- 1992-01-01
- Volume
- 53
- Issue
- 1
- Pages
- 69-72
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W159526750
- Cited by
- 27
- References
- 0
- Citations by year
- 2025: 2 · 2018: 2 · 2017: 1 · 2016: 1 · 2012: 2
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Keywords
- propylene glycol, feline diet, Heinz bodies, erythrocyte destruction, erythrocyte survival, hematological changes, cats, dose-dependent effects, erythrocyte membrane
- MeSH terms
- Animals, Animal Feed, Body Weight, Bone Marrow, Cats, Dose-Response Relationship, Drug, Eating, Erythrocyte Count, Erythrocyte Indices, Erythrocytes, Female, Heinz Bodies, Hematocrit, Hemoglobins, Leukocyte Count, Male, Propylene Glycols, Random Allocation, Reticulocytes, Specific Pathogen-Free Organisms, Propylene Glycol
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
