Influence of age and sex on plasma lipid and lipoprotein concentrations and associated enzyme activities in cats
Open accessAbstract
Objective—To determine effects of age and sex on plasma lipid and lipoprotein metabolism in cats. Animals—33 kittens and 16 adolescent, 23 adult, and 10 senior cats. Procedure—Plasma concentrations of cholesterol, triglyceride, and lipoprotein-cholesterol and activities of lipoprotein lipase, hepatic lipase, and lecithin:cholesterol acyl transferase (LCAT) were measured and compared within and among groups. Results—Plasma cholesterol and triglyceride concentrations were significantly higher in 5- and 7-week-old kittens, compared with the same kittens after weaning and cats in the other age groups. Cholesterol concentration was significantly less in 20-week-old kittens, compared with adolescent and adult cats. Lipid and lipoprotein-cholesterol concentrations were not significantly different among the adolescent, adult, and senior groups, nor did sex influence lipid and lipoprotein-cholesterol concentrations in these groups. Activities of lipoprotein and hepatic lipases were significantly less in senior cats, compared with the other groups. Activity of LCAT was highest in 20-week-old kittens and was greater in sexually intact adult and adolescent females, compared with their male counterparts. After castration, activities of hepatic lipase and LCAT significantly decreased in adolescent male cats. Conclusions and Clinical Relevance—The upper limits of reference ranges for plasma cholesterol and triglyceride concentrations should be increased for kittens < 8 weeks of age. Low cholesterol concentrations in adolescent cats likely reflect high tissue demands for growth and steroidogenesis. Decrease in lipoprotein and hepatic lipase activity in senior cats could predispose this age group to hypertriglyceridemia, particularly in insulin-resistant cats or those fed a high fat diet. (Am J Vet Res 2001;62:331–336)
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The developmental mechanisms that account for major remodeling of connectivity occur before the onset of adolescence, i.e., before postnatal day 28 (PD28) in rodents, 9 months in cats, and 3 years in non-human primates.
“The developmental mechanisms that account for major remodeling of connectivity occur before the onset of adolescence, i.e., before postnatal day 28 (PD28) in rodents, 9 months in cats, and 3 years in non-human primates15, 16, 17”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [17]
The Materials and Methods section (page not available) classifies cats aged 9–12 months as adolescent, supporting the cat age used in the claim. The paper examines lipid metabolism, not connectivity remodeling or when its developmental mechanisms occur; it also provides no evidence for the rodent or primate ages. (LLM, conf=0.88)
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Short communication SERUM LIPID AND LIPOPROTEIN PARAMETERS OF IRANIAN PERSIAN CAT (FELIS CATUS )
Asadi, F., Jamshidi, S., & Asadian, P. (2007)
- Authors
- Butterwick, R. F., McConnell, M., Markwell, P. J., & Watson, T. D. G.
- Affiliations
- Waltham Centre for Pet Nutrition (GB)
- Venue
- American Journal of Veterinary Research
- Published
- 2001-03-01
- Volume
- 62
- Issue
- 3
- Pages
- 331-336
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W2088586814
- Cited by
- 19
- References
- 25
- Citations by year
- 2021: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- cats, plasma lipids, lipoproteins, cholesterol, triglycerides, lipoprotein lipase, hepatic lipase, lecithin:cholesterol acyltransferase, age effects, sex differences, kittens, senior cats, castration, hypertriglyceridemia, reference values, lipid metabolism
- MeSH terms
- Age Factors, Animals, Animal Feed, Castration, Cats, Cholesterol, Female, Phosphatidylcholine-Sterol O-Acyltransferase, Lipoprotein Lipase, Lipoproteins, Cholesterol, HDL, Cholesterol, LDL, Male, Reference Values, Sex Factors, Triglycerides, Cohort Studies
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