Effects of increases in dietary fat intake on plasma lipid and lipoprotein cholesterol concentrations and associated enzyme activities in cats
Abstract
OBJECTIVE: To determine the effects of increases in dietary intake of polyunsaturated and saturated fatty acids on plasma lipid and lipoprotein concentrations and activity of associated enzymes in healthy domestic cats. ANIMALS: 16 healthy adult sexually intact female cats. PROCEDURES: A baseline diet (40% energy from fat) and 4 test diets, with increased amounts of fat (51% and 66% energy from fat) from the addition of polyunsaturated and saturated fatty acids, were fed for 6 weeks each. Plasma cholesterol, triglyceride, and lipoprotein cholesterol concentrations, along with activities of lipoprotein lipase, hepatic lipase, and lecithin-cholesterol acyl transferase, were measured at the end of each feeding period. RESULTS: Diet, amount of fat, or ratio of polyunsaturated to saturated fatty acids had no effect on plasma concentrations of cholesterol, triglycerides, and very-low-density or high-density lipoproteins or the activity of lecithin-cholesterol acyl transferase. Low-density lipoprotein concentrations were significantly lower in cats fed a high-fat diet containing polyunsaturated fatty acids. Lipoprotein concentration and hepatic lipase activity were significantly higher in cats fed the fat-supplemented diets, and this was unrelated to whether diets were enriched with polyunsaturated or saturated fatty acids. CONCLUSIONS AND CLINICAL RELEVANCE: Diets containing up to 66% of energy from fat were tolerated well by healthy cats and did not affect plasma lipid concentrations. Therefore, high-fat diets probably will not contribute to hypercholesterolemia or hypertriglyceridemia in cats.
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Cats fed a diet rich in saturated and polyunsaturated fatty acids showed no effects on plasma lipid concentrations that in humans are risk factors for coronary heart disease and atherosclerosis.
“Furthermore, cats fed a diet rich in saturated and polyunsaturated fatty acids showed no effects on plasma lipid concentrations that in humans are risk factors for coronary heart disease and atherosclerosis (28).”
From Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication (2014) · cites this paper as [28]
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- Authors
- Butterwick, R. F., Salt, C., & Watson, T. D. G.
- Affiliations
- Waltham Centre for Pet Nutrition (GB)
- ORCID
- Salt, Carina
- Venue
- American Journal of Veterinary Research
- Published
- 2012-01
- Volume
- 73
- Issue
- 1
- Pages
- 62-67
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W2097386056
- Cited by
- 6
- References
- 30
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 1 · 2016: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- high-fat diet, dietary fat intake, polyunsaturated fatty acids, saturated fatty acids, plasma lipids, lipoprotein cholesterol, triglycerides, lipoprotein lipase, hepatic lipase, lecithin:cholesterol acyltransferase, low-density lipoprotein, hypercholesterolemia, hypertriglyceridemia, cats
- MeSH terms
- Animals, Cats, Cholesterol, Dietary Fats, Dietary Fats, Unsaturated, Female, Phosphatidylcholine-Sterol O-Acyltransferase, Lipase, Lipoprotein Lipase, Lipoproteins, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Triglycerides
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