Effect of centrally administered opioid receptor agonists on CSF and plasma oxytocin concentrations in dogs
Open accessAbstract
OBJECTIVE: To measure oxytocin concentrations in blood and CSF following central administration of opioid agonists in dogs. ANIMALS: 5 male dogs. PROCEDURE: In a crossover design, CSF and blood were collected immediately before and 15 and 30 minutes after cisternal administration of D-Ala2, MePhe4, Gly-ol-enkephalin (DAMGO, a mu-receptor agonist); D-Pen, pCl-Phe4, D-Pen5-enkephalin (a delta-receptor agonist); U50488H (a kappa-receptor agonist); morphine; and saline (0.9% NaCl) solution. RESULTS: Plasma oxytocin concentration was significantly increased 15 minutes after administration of DAMGO and 30 minutes after administration of U50488H, compared with concentrations obtained after administration of saline solution. Concentration of oxytocin in CSF was significantly decreased 30 minutes after administration of U50488H, compared with concentration after administration of saline solution. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that in male dogs, activation of centrally located mu and kappa receptors elicits an overall excitatory effect on neurons that regulate peripheral release of oxytocin, whereas activation of centrally located kappa receptors elicits an overall inhibitory effect on neurons that regulate central release. These results are in contrast to those reported for other species, in which opioids have a pronounced inhibitory effect on release of oxytocin from the neurohypophysis.
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Intravenous cholecystokinin releases oxytocin into the blood and hypothalamus, but other agents affect central and peripheral release differently; in dogs, opioids stimulate peripheral secretion while suppressing central secretion.
“In response to i.v.cholecystokinin, oxytocin is released into the blood and in the hypothalamus (79), but several other agents affect release differentially: for instance, in dogs, opioids stimulate peripheral secretion but suppress central secretion (80).”
From Intranasal Oxytocin: Myths and Delusions (2016) · cites this paper as [80]
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Intranasal Oxytocin: Myths and Delusions
Leng, G., & Ludwig, M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.05.003 · Cited by 615 · see citing works
- Authors
- Brown, D. C., Perkowski, S. Z., Shofer, F., & Amico, J. A.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Shofer, Frances
- Venue
- American Journal of Veterinary Research
- Published
- 2001-04-01
- Volume
- 62
- Issue
- 4
- Pages
- 496-499
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W2055723976
- Cited by
- 4
- References
- 40
- Citations by year
- 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Keywords
- oxytocin, opioid agonists, mu-opioid receptor, kappa opioid receptor, delta opioid receptor, DAMGO, U50,488H, morphine, cerebrospinal fluid, plasma oxytocin, neurohypophysis, central nervous system, dogs
- MeSH terms
- Analgesics, Opioid, Animals, Dogs, Enkephalins, Injections, Spinal, Male, Morphine, Oxytocin, Random Allocation, Receptors, Opioid, Cross-Over Studies, Analgesics, Non-Narcotic, 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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