Cited by 206Alzheimer's disease research and treatmentsHeavy Metal Exposure and ToxicityCholinesterase and Neurodegenerative Diseases

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Metal ions, Alzheimer's disease and chelation therapy

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Budimir, Ana·2011·Acta Pharmaceutica

DOI 10.2478/v10007-011-0006-6

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Abstract

Metal ions, Alzheimer's disease and chelation therapy: In the last few years, various studies have been providing evidence that metal ions are critically involved in the pathogenesis of major neurological diseases (Alzheimer, Parkinson). Metal ion chelators have been suggested as potential therapies for diseases involving metal ion imbalance. Neurodegeneration is an excellent target for exploiting the metal chelator approach to therapeutics. In contrast to the direct chelation approach in metal ion overload disorders, in neurodegeneration the goal seems to be a better and subtle modulation of metal ion homeostasis, aimed at restoring ionic balance. Thus, moderate chelators able to coordinate deleterious metals without disturbing metal homeostasis are needed. To date, several chelating agents have been investigated for their potential to treat neurodegeneration, and a series of 8-hydroxyquinoline analogues showed the greatest potential for the treatment of neurodegenerative diseases.

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Authors: Budimir, A.
Affiliations: University of Zagreb (HR)
Corresponding author: Budimir, Ana
ORCID: Budimir, Ana
Venue: Acta Pharmaceutica
Publisher: Walter de Gruyter GmbH
Published: 2011-03-01
Volume: 61
Issue: 1
Pages: 1-14
ISSN: 1330-0075 (ISSN-L)
1846-9558
DOI: 10.2478/v10007-011-0006-6
OpenAlex: W2033807567
Cited by: 202
References: 75
Citations by year: 2026: 2 · 2025: 9 · 2024: 13 · 2023: 12 · 2022: 14 · 2021: 18 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 13 · 2016: 18 · 2015: 12 · 2014: 14 · 2013: 12 · 2012: 12
FWCI: 1.36
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
Locations: Acta Pharmaceutica (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
University of Zagreb University Computing Centre (SRCE) (submittedVersion, other-oa)
Repozitorij Farmaceutsko-biokemijskog fakulteta (Sveučilišta u Zagrebu) (submittedVersion, cc-by)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Keywords: metal ions, Alzheimer's disease, chelation therapy, metal chelators, neurodegeneration, metal homeostasis, Parkinson's disease, metal imbalance
MeSH terms: Alzheimer Disease, Animals, Chelating Agents, Homeostasis, Humans, Hydroxyquinolines, Ions, Metals, Neurodegenerative Diseases

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Metal ions, Alzheimer's disease and chelation therapy

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