Cited by 136Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAntioxidant Activity and Oxidative Stress

Oxidant/antioxidant imbalance and the risk of Alzheimer's disease

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Moneim, Ahmed·2015·Current Alzheimer Research

Abstract

Alzheimer's disease (AD) is the most common form of dementia characterized by progressive loss of memory and other cognitive functions among older people. Senile plaques and neurofibrillary tangles are the most hallmarks lesions in the brain of AD in addition to neurons loss. Accumulating evidence has shown that oxidative stress-induced damage may play an important role in the initiation and progression of AD pathogenesis. Redox impairment occurs when there is an imbalance between the production and quenching of free radicals from oxygen species. These reactive oxygen species augment the formation and aggregation of amyloid-β and tau protein hyperphosphorylation and vice versa. Currently, there is no available treatments can modify the disease. However, wide varieties of antioxidants show promise to delay or prevent the symptoms of AD and may help in treating the disease. In this review, the role of oxidative stress in AD pathogenesis and the common used antioxidant therapies for AD will summarize.

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Authors
Moneim, A.
Affiliations
Universidad de Granada (ES)
Corresponding author
Moneim, Ahmed
Venue
Current Alzheimer Research
Published
2015-04-27
Volume
12
Issue
4
Pages
335-349
ISSN
1567-2050 (ISSN-L)
OpenAlex
W2072195566
Cited by
136
References
171
Citations by year
2026: 4 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 16 · 2021: 18 · 2020: 22 · 2019: 13 · 2018: 18 · 2017: 10 · 2016: 13 · 2015: 4
FWCI
1.83
Type
journal article
Language
en
Open access
Locations
  • Current Alzheimer Research (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
Alzheimer's disease, oxidative stress, antioxidant therapy, redox imbalance, reactive oxygen species, amyloid-beta aggregation, tau hyperphosphorylation, neurofibrillary tangles, amyloid plaques, dementia pathogenesis
MeSH terms
Alzheimer Disease, Animals, Antioxidants, Humans, Risk, Oxidative Stress

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