Oxidant/antioxidant imbalance and the risk of Alzheimer's disease
Open accessAbstract
Alzheimer's disease (AD) is the most common form of dementia characterized by progressive loss of memory and other cognitive functions among older people. Senile plaques and neurofibrillary tangles are the most hallmarks lesions in the brain of AD in addition to neurons loss. Accumulating evidence has shown that oxidative stress-induced damage may play an important role in the initiation and progression of AD pathogenesis. Redox impairment occurs when there is an imbalance between the production and quenching of free radicals from oxygen species. These reactive oxygen species augment the formation and aggregation of amyloid-β and tau protein hyperphosphorylation and vice versa. Currently, there is no available treatments can modify the disease. However, wide varieties of antioxidants show promise to delay or prevent the symptoms of AD and may help in treating the disease. In this review, the role of oxidative stress in AD pathogenesis and the common used antioxidant therapies for AD will summarize.
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Studies have reported a rise of oxidative stress markers such as lipid peroxidation, protein oxidation, and reactive oxygen species in brain tissue of AD patients.
“there are studies that heretofore have reported the rise of oxidative stress markers in the brain tissue of AD patients, parameters such as lipid peroxidation, protein oxidation, and formation of reactive oxygen species (ROS) (5,6).”
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Alzheimer’s Disease, Inflammation, and the Role of Antioxidants
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- Authors
- Moneim, A.
- Affiliations
- Universidad de Granada (ES)
- Corresponding author
- Moneim, Ahmed
- ORCID
- Moneim, Ahmed
- Venue
- Current Alzheimer Research
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-04-27
- Volume
- 12
- Issue
- 4
- Pages
- 335-349
- ISSN
- 1567-2050 (ISSN-L)
- PMC
- PMC5384363
- OpenAlex
- W2072195566
- Cited by
- 136
- References
- 171
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 8 · 2022: 16 · 2021: 18 · 2020: 22 · 2019: 13 · 2018: 18 · 2017: 10 · 2016: 13 · 2015: 4
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Alzheimer Research (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- Alzheimer's disease, oxidative stress, antioxidant therapy, redox imbalance, reactive oxygen species, amyloid-beta aggregation, tau hyperphosphorylation, neurofibrillary tangles, amyloid plaques, dementia pathogenesis
- MeSH terms
- Alzheimer Disease, Animals, Antioxidants, Humans, Risk, Oxidative Stress
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