Radiotherapy in combination with vascular-targeted therapies
Open accessAbstract
BACKGROUND: Given the critical role of tumor vasculature in tumor development, considerable efforts have been spent on developing therapeutic strategies targeting the tumor vascular network. A variety of agents have been developed, with two general approaches being pursued. Antiangiogenic agents (AAs) aim to interfere with the process of angiogenesis, preventing new tumor blood vessel formation. Vascular-disrupting agents (VDAs) target existing tumor vessels causing tumor ischemia and necrosis. Despite their great therapeutic potential, it has become clear that their greatest clinical utility may lie in combination with conventional anticancer therapies. Radiotherapy is a widely used treatment modality for cancer with its distinct therapeutic challenges. Thus, combining the two approaches seems reasonable. CONCLUSIONS: Strong biological rationale exist for combining vascular-targeted therapies with radiation. AAs and VDAs were shown to alter the tumor microenvironment in such a way as to enhance responses to radiation. The results of preclinical and early clinical studies have confirmed the therapeutic potential of this new treatment strategy in the clinical setting. However, concerns about increased normal tissue toxicity, have been raised.
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Antiangiogenic drugs have a synergistic antitumor effect in combination with radiotherapy and chemotherapy in clinical practice.
“Therefore, antiangiogenic drugs have a synergistic antitumor effect in combination with radiotherapy and chemotherapy in clinical practice.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [261]
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Tumor necrosis factor as an adjunct to fractionated radiotherapy in the treatment of murine tumors
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The dosimetry of 60Co total body irradiation
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Targeted gene therapy in radiotherapy
Kamenšek, U., & Serša, G. (2008) · Radiology and Oncology · doi:10.2478/v10019-008-0009-1 · Cited by 14 · see citing works
In vivo antitumour effect of combretastatin A-4 phosphate added to fractionated irradiation.
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Adenocarcinoma skin metastases treated by electrochemotherapy with cisplatin combined with radiation
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Advancement of Antiangiogenic and Vascular Disrupting Agents Combined with Radiation
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Tolerance: A useful concept in radiation therapy
Schultheiss, T. E. (1987) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(87)90026-5 · Cited by 2 · see citing works
Flagged first, then by citations
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Research works printed but not linked: 2
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Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers
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Tumor radiosensitization by gene therapy against endoglin
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Targeting of Tumor Neovasculature with GrB/VEGF121, a Novel Cytotoxic Fusion Protein
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- Authors
- Ciric, E., & Sersa, G.
- Venue
- Radiology and Oncology
- Publisher
- Walter de Gruyter GmbH
- Published
- 2010-01-01
- Volume
- 44
- Issue
- 2
- Pages
- 67-78
- ISSN
- 1318-2099 (ISSN-L)
- 1581-3207
- PMC
- PMC3423684
- OpenAlex
- W2141173616
- Cited by
- 30
- References
- 120
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2014: 3 · 2012: 2
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Radiology and Oncology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DiRROS repository (University of Maribor) (publishedVersion)
- Funders
- Javna Agencija za Raziskovalno Dejavnost RS
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- radiotherapy, vascular-targeted therapy, angiogenesis inhibitors, vascular disrupting agents, tumor vasculature, tumor microenvironment, radiosensitization, combination therapy, normal tissue toxicity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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