The DOI matches its Crossref record.
The effect of various levels of ractopamine hydrochloride on the performance and carcass characteristics of finishing swine.
Abstract
Six trials involving 888 pigs (Study 1) and three trials involving 360 pigs (Study 2) were conducted at various geographical locations in the U.S. and Canada to evaluate the effect of ractopamine hydrochloride on the performance and carcass characteristics of finishing swine. All trials were conducted using a randomized complete block design. Trial data were pooled within study for statistical analysis. Pigs averaged approximately 64.5 kg (Study 1) and 65.9 kg (Study 2) initially and had ad libitum access to a 16% crude protein corn-soybean meal or barley-soybean meal diet. Ractopamine was included in the diet at 0, 2.5, 5, 10, 20 or 30 ppm (Study 1), or at 0, 5, 10, 15 or 20 ppm (Study 2); diets were fed for an average of 45 d (Study 1) and 50 d (Study 2) to a final weight of about 104.3 kg (Study 1) and 106.6 kg (Study 2). Carcass dissection data were collected in three of the six trials in Study 1 (0, 5 and 20 ppm ractopamine) and in all three trials in Study 2 (0, 5, 10, 15 and 20 ppm ractopamine). All ractopamine levels improved (P less than .05) ADG and feed: gain (Studies 1 and 2) above those of control pigs. Ractopamine levels of 10 to 30 ppm (Studies 1 and 2) improved (P less than .05) dressing percentage over controls. Pigs fed ractopamine at 5 and 20 ppm (Study 1) and 10, 15 and 20 ppm (Study 2) had increased (P less than .05) dissected leanness compared with controls.(ABSTRACT TRUNCATED AT 250 WORDS)
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“β2-adrenergic agonist such as salbutamol [40], clenbuterol [41], and ractopamine [42] promote muscle hypertrophy in animal models.”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [42]
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Items 101–198 of 198
Fatty Acid and Cholesterol Changes in Pork Longissimus Muscle and Fat due to Ractopamine
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Self-citationCarcass Composition of Animals Given Partitioning Agents
Beermann, D. H. (1994) · Elsevier eBooks · doi:10.1016/b978-0-08-091853-2.50017-2 · Cited by 15
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Metanálise dos níveis de ractopamina em dietas para suínos em terminação
Kiefer, C., & Sanches, J. F. (2009) · Revista Brasileira de Zootecnia · doi:10.1590/s1516-35982009000600010 · Cited by 13
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Stress susceptibility in pigs supplemented with ractopamine1
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“Ractopamine hydrochloride is a synthetic b-agonist that repartitions nutrients to increase lean muscle deposition, decreases the rate of adipose tissue deposition [12, 13], and improves performance, carcass leanness, and dressing percentage in finishing pigs [14, 15].”
BackgroundPleadin, J., Vulić, A., Peri, N., et al. (2012) · InTech eBooks · doi:10.5772/31732 · Cited by 11
“Ractopamine hydrochloride increases the amount of lean meat and decreases the amount of carcass fat when fed to swine during the last 50 kg of gain, also increasing the rate of weight gain and feed conversion (Anderson et al., 1989; Merkel et al., 1987; Watkins et al., 1990; Williams et al., 1994).”
BackgroundJames, B. W., Tokach, M. D., Goodband, R. D., et al. (2013) · Journal of Animal Science · doi:10.2527/jas.2011-4287 · Cited by 11
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“Over the past 20 years several studies have confirmed that treatment of finisher pigs with dietary RAC improves daily gain and feed efficiency commensurate with increased protein deposition in finishing pigs (Watkins et al. 1990; Dunshea et al. 1993a; Apple et al. 2007; Fernandez-Duenas et al. 2008).”
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“The feed additive ractopamine, a β-adrenergic agonist, acts as a repartitioning agent, promoting lean tissue deposition in pigs (Watkins et al., 1990).”
Smith, D. J., Shelver, W. L., & Marx, A. (2016) · Journal of Animal Science · doi:10.2527/jas.2016-0899 · Cited by 11
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“Therefore, this compound has been widely used as growth promoter in livestock production (Watkins et al. 1990; Engeseth et al. 1992; Xiong et al. 2006).”
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“…ne soit pas amenée à se développer. c) β-agonistes Chez le porc, administré dans l’aliment à la dose de 5-20 ppm, la ractopamine améliore l’efficacité alimentaire et le gain de poids tout en abaissant la proportion de tissu adipeux dans la carcasse (Watkins et al 1990, Crome et al 1996, FOIS 1999).”
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Biology and regulation of carcass composition
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Ractopamine and Clenbuterol Urinary Residues in Pigs as Food-Producing Animals
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“when fed to swine.([20,21]) Ractopamine has two chiral centers and is currently commercialized as a mixture of four stereoisomers in approximately equal proportions, although studies have shown that the RR isomer is responsible for a majority of the leanness-enhancing effects of ractopamine in rats.”
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“1), a β-agonist that is also known as albuterol, is a sympathomimetic drug with potent β2adrenoceptor-stimulating properties (Moser et al. 1986; Watkins et al. 1990).”
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“The literature reports that only incremental gains aremade indaily gain at levels higher than 5 mg/kg, while carcass improvements tend to occur at higher inclusion levels of RAC (Watkins et al. 1990; Armstrong et al. 2004; Rikard-Bell et al. 2007).”
BackgroundResultInfluentialComparison of ractopamine residue depletion from internal tissues
Pleadin, J., Vulić, A., Perši, N., et al. (2012) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2012.702115 · Cited by 7
“Watkins et al.((24)) summarized the results of nine experiments conducted at different levels of ractopamine administration (2.”
BackgroundInfluentialSwine Nutrition and Pork Quality
APPLE, J. K. (2012) · doi:10.1002/9781118491454.ch17 · Cited by 7
The effects of R-salbutamol on behavior and physiology of finishing pigs1,2
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“The carcase length was measured from the aitch bone ’ s anterior tip to the first rib ’ s anterior edge near the vertebrae (Watkins et al. 1990).”
MethodMarchand, J., Guitton, Y., Martineau, E., Royer, A., Balgoma, D., Bizec, B. L., Giraudeau, P., & Dervilly, G. (2021) · Foods · doi:10.3390/foods10061218 · Cited by 8
“RAC is a synthetic drug belonging to the β-agonist family, widely used as a growth promoter in several countries, as it has been shown to improve growth performance such as average daily gain [50] in pigs.”
BackgroundSensory Characteristics of Meat from Animals Given Partitioning Agents
MCKEITH, F. K., LAN, Y. H., & Beermann, D. H. (1994) · Elsevier eBooks · doi:10.1016/b978-0-08-091853-2.50018-4 · Cited by 6
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Optimal Control of Desensitizing Inputs: The Case of Paylean
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Simulação técnico-econômica da inclusão de ractopamina em dietas de suínos em terminação
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“Ractopamine has been shown to improve the efficiency of feed utilization in pigs (WATKINS et al., 1990; HE et al., 1993; DUNSHEA et al., 1998).”
BackgroundEmerging technologies with the potential to improve feed efficiency in swine
Dunshea, F. R. (2012) · Wageningen Academic Publishers eBooks · doi:10.3920/978-90-8686-756-1_13 · Cited by 3
“, 1991) whereas backfat depths measured off the midline have been either decreased (Aalhus et al., 1990; Adeola et al., 1990; Dunshea et al., 1993b; Gu et al., 1991a; Watkins et al., 1990; Yen et al., 1991) or unchanged (Dunshea et al.”
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Abney, C. S. (2006) · ThinkTech (Texas Tech University) · Cited by 3
Swine Nutrition and Pork Quality
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Qualidade da carne de suínos submetidos a dietas com diferentes nivéis de ractopamina
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Effects of ractopamine HCl on growth performance and within-pen weight variation in finishing pigs
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Electroanalysis, Electrodeposition and Electrochemical Characterization of Ractopamine
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Nutritional and other factors affecting efficacy of B-agonists in pigs.
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“16 RAC is a synthetic drug belonging to the -agonist family, widely used as a growth promoter in several 372 countries, as it has been shown to improve growing performance such as average daily gain [39] in 373 pigs.”
BackgroundDESEMPENHO, QUALIDADE DE CARNE E ESTRESSE DE SUÍNOS SUPLEMENTADOS COM RACTOPAMINA
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“El laboratorio que produce la RAC en forma comercial, así como diversos estudios(16,17), recomiendan su uso con dietas que contengan un mínimo de 16 % de proteína cruda (PC) para alcanzar la concentración adecuada de aminoácidos que sustenten el desarrollo muscular.”
BackgroundResultInfluentialReducing the fat content by production practices
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“Ractopamine hydrochloride is a synthetic b-agonist that repartitions nutrients to increase lean vs adipose disposition (Ricks et al, 1984; Moody et al, 2000) and improves performance, carcass leanness and dressing percent in finishing pigs (Anderson et al, 1987; Watkins et al, 1990).”
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“It belongs to the phenethylamine category of ß-adrenergic agonists (Watkins et al. , 1990).”
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Yen, C., Bodmer, J. S., Gerrard, S. D., Wicks, J. C., Zumbaugh, M. D., Scheffler, T. L., El‐Kadi, S. W., Shi, T. H., & Gerrard, D. E. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf401
Metadata
- Authors
- Watkins, L. E., Jones, D. J., Mowrey, D. H., Anderson, D. B., & Veenhuizen, E. L.
- Affiliations
- Eli Lilly (United States) (US)
- ORCID
- Anderson, D B
- Venue
- Journal of Animal Science
- Publisher
- Oxford University Press (OUP)
- Published
- 1990
- Volume
- 68
- Issue
- 11
- Pages
- 3588
- ISSN
- 0021-8812 (ISSN-L)
- OpenAlex
- W191217324
- Cited by
- 198
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 10 · 2012: 18
- FWCI
- 12.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Animal Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Pharmacological Effects and Assays
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Meat and Animal Product Quality
- Keywords
- ractopamine hydrochloride, fattening pigs, growth performance, carcass characteristics, average daily gain, feed efficiency, carcass yield, carcass leanness, feed additive dosage, corn-soybean meal diet
- MeSH terms
- Adipose Tissue, Adrenergic beta-Antagonists, Animals, Eating, Female, Growth Substances, Male, Muscles, Phenethylamines, Swine, Weight Gain, Muscle Development
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