The Proton Sponge: a Trick to Enter Cells the Viruses Did Not Exploit
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- Chitosan for Gene Delivery and Orthopedic Tissue Engineering ApplicationsRosanne M. Raftery, Fergal J. O’Brien, Sally‐Ann Cryan · 2013 · Molecules
- Dextran–spermine polycation: an efficient nonviral vector for in vitro and in vivo gene transfectionHossein Hosseinkhani, Tony Azzam, Yasuhiko Tabata, Abraham Jacob Domb · 2004 · Gene Therapy
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- 1,8-Bis(hexamethyltriaminophosphazenyl)naphthalene, HMPN: A Superbasic Bisphosphazene “Proton Sponge”Volker Raab, Ekaterina V. Gauchenova, Alexei Merkoulov · 2005 · Journal of the American Chemical Society
- Dendritic vectors for gene transfectionMarine Guillot-Nieckowski, Sara Eisler, François Diederich · 2006 · New Journal of Chemistry
- Revisit complexation between DNA and polyethylenimine — Effect of uncomplexed chains free in the solution mixture on gene transfectionYanan Yue, Fan Jin, Rui Deng, Jinge Cai, Yangchao Chen, Marie C.M. Lin, Hsiang‐Fu Kung, Chi Wu · 2010 · Journal of Controlled Release
- Recent Developments in Nucleic Acid Delivery with PolyethyleniminesPatrick Neuberg, Antoine Kichler · 2014 · Advances in genetics
- Improving chitosan-mediated gene transfer by the introduction of intracellular buffering moieties into the chitosan backboneCátia Moreira, Hugo Oliveira, Liliana R. Pires, Sérgio Simões, Mário Adolfo Barbosa, Ana Paula Pêgo · 2009 · Acta Biomaterialia
- Bioreducible alginate-poly(ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responsesPing Li, Zichao Luo, Peng Liu · 2013 · Journal of Controlled Release
- The Structure of PEG-Modified Poly(Ethylene Imines) Influences Biodistribution and Pharmacokinetics of Their Complexes with NF-κB Decoy in MiceKlaus Kunath, Anke von Harpe, Holger Petersen, Dagmar Fischer, Karlheinz Voigt, Thomas Kissel, Ulrich Bickel · 2002 · Pharmaceutical Research
- Polymeric Engineering of Nanoparticles for Highly Efficient Multifunctional Drug Delivery SystemsBeatrice Fortuni, Tomoko Inose, Monica Ricci, Yasuhiko Fujita, Indra Van Zundert, Akito Masuhara, Eduard Fron, Hideaki Mizuno, Loredana Latterini, Susana Rocha et al. · 2019 · Scientific Reports
- Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticlesJung Soo Suk, Junghae Suh, Kokleong Choy, Samuel K. Lai, Jie Fu, Justin S. Hanes · 2006 · Biomaterials
- Polymers in Drug Delivery—State of the Art and Future TrendsStefan Grund, Marius Bauer, Dagmar Fischer · 2011 · Advanced Engineering Materials
- Progress and perspectives in developing polymeric vectors for in vitro gene deliveryYanan Yue, Chi Chung Wu · 2012 · Biomaterials Science
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- Modeling the proton sponge hypothesis: examining proton sponge effectiveness for enhancing intracellular gene delivery through multiscale modelingEric C. Freeman, Lisa Mauck Weiland, Wilson S. Meng · 2012 · Journal of Biomaterials Science Polymer Edition
- Progress of RAFT based polymers in gene deliveryMarya Ahmed, Ravin Narain · 2012 · Progress in Polymer Science
- PEG grafting of polyethylenimine (PEI) exerts different effects on DNA transfection and siRNA-induced gene targeting efficacyAnastasia V. Malek, Frank Czubayko, Achim Michael Aigner · 2008 · Journal of drug targeting
- Injectable nanomaterials for drug delivery: Carriers, targeting moieties, and therapeuticsDavid M. Webster, Padma Sundaram, Mark Edward Byrne · 2013 · European Journal of Pharmaceutics and Biopharmaceutics
- Self-assembly of biodegradable polyurethanes for controlled delivery applicationsMingming Ding, Jiehua Li, Hong Sheng Tan, Qiang Fu · 2012 · Soft Matter
- Measuring the pH environment of DNA delivered using nonviral vectors: Implications for lysosomal traffickingAkin Akinc, Róbert Langer · 2002 · Biotechnology and Bioengineering
- Functional lipids and lipoplexes for improved gene deliveryXiaoxiang Zhang, Thomas J. McIntosh, Mark W. Grinstaff · 2011 · Biochimie
- Solid lipid nanoparticles as nucleic acid delivery system: Properties and molecular mechanismsMarcelo Bispo de Jesus, Inge S. Zuhorn · 2015 · Journal of Controlled Release
- Acetylation of PAMAM dendrimers for cellular delivery of siRNACarolyn L. Waite, Sarah M. Sparks, Kathryn E. Uhrich · 2009 · BMC Biotechnology
- Revisit complexation between DNA and polyethylenimine — Effect of length of free polycationic chains on gene transfectionYanan Yue, Fan Jin, Rui Deng, Jinge Cai, Zhuojun Dai, Marie C.M. Lin, Hsiang‐Fu Kung, Maria Ahlm Mattebjerg, Thomas L. Andresen, Chi Chung Wu · 2011 · Journal of Controlled Release
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- Stimuli-responsive drug delivery systems triggered by intracellular or subcellular microenvironmentsTao Sun, Chen Jiang · 2023 · Advanced Drug Delivery Reviews
- Ratiometric Fluorescent Probe for Alkaline Phosphatase Based on Betaine-Modified Polyethylenimine via Excimer/Monomer ConversionFangyuan Zheng, Sihua Guo, Fang Zeng · 2014 · Analytical Chemistry
- Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivoOlga Vyacheslavovna Chumakova, Anton V. Liopo, В. Г. Андреев, Inga Cicenaite, Bernard Mark Evers, Shilla Chakrabarty, Todd C. Pappas, Rinat O. Esenaliev · 2008 · Cancer Letters
- On the Kinetics of Polyplex Endocytic Trafficking: Implications for Gene Delivery Vector DesignMarcus Laird Forrest, Daniel W. Pack · 2002 · Molecular Therapy
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- Poly-l-glutamic acid derivatives as vectors for gene therapyLuc Dekie, Veska Toncheva, Peter Dubruel, Etienne H. Schacht, Lee B Barrett, Leonard William Seymour · 2000 · Journal of Controlled Release
- Delivery Systems for the Direct Application of siRNAs to Induce RNA Interference (RNAi) In VivoAchim Michael Aigner · 2006 · BioMed Research International
- Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexesTae Hee Kim, Su Il Kim, Toshihiro Akaike · 2005 · Journal of Controlled Release
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- Interactions at the cell membrane and pathways of internalization of nano-sized materials for nanomedicineValentina Francia, Daphne Montizaan, Anna Laura Salvati · 2020 · Beilstein Journal of Nanotechnology
- Effective co-delivery of doxorubicin and dasatinib using a PEG-Fmoc nanocarrier for combination cancer chemotherapyPeng Zhang, Jiang Li, Mohammed Ghazwani, Wenchen Zhao, Yixian Huang, Xiaolan Zhang, Raman Venkataramanan, Li Song · 2015 · Biomaterials
- Micelle-like Nanoparticles as Carriers for DNA and siRNAGemma Navarro, Jiayi Pan, Vladimir P. Torchilin · 2015 · Molecular Pharmaceutics
- Escaping the endosome: assessing cellular trafficking mechanisms of non-viral vehiclesEmily Xu, W. Mark Saltzman, Alexandra S. Piotrowski-Daspit · 2021 · Journal of Controlled Release
- Fine-tuning of proton sponges by precise diaminoethanes and histidines in pDNA polyplexesUlrich Lächelt, Petra Kós, Frauke Martina Mickler · 2013 · Nanomedicine Nanotechnology Biology and Medicine
- Cationic Nanohydrogel Particles as Potential siRNA Carriers for Cellular DeliveryLutz Nuhn, Markus Hirsch, Bettina Krieg, Kaloian Koynov, Karl Fischer, Manfred Schmidt, Mark Helm, Rudolf Zentel · 2012 · ACS Nano
- Applications of RNA interference: current state and prospects for siRNA-based strategies in vivoAchim Michael Aigner · 2007 · Applied Microbiology and Biotechnology
- Hydrophobic modification of low molecular weight polyethylenimine for improved gene transfectionPei Y. Teo, Chuan He Yang, James L. Hedrick, Amanda C. Engler, Daniel J. Coady, Sadaf Ghaem‐Maghami, Andrew J.T. George, Yi Yan Yang · 2013 · Biomaterials
- Gal8 Visualization of Endosome Disruption Predicts Carrier-Mediated Biologic Drug Intracellular BioavailabilityKameron V. Kilchrist, Somtochukwu C. Dimobi, Meredith A. Jackson, Brian C. Evans, Thomas A. Werfel, Eric A. Dailing, Sean K. Bedingfield, Isom B. Kelly, Craig L. Duvall · 2019 · ACS Nano
- Gene Expression, Biodistribution, and Pharmacoscintigraphic Evaluation of Chondroitin Sulfate−PEI Nanoconstructs Mediated Tumor Gene TherapyAtul Pathak, Pradeep Kumar, Krishna Chuttani, Sanyog Jain, Anil Kumar Mishra, Suresh Prasad Vyas, K.C. Gupta · 2009 · ACS Nano
- Application of Living Free Radical Polymerization for Nucleic Acid DeliveryDavid S.H. Chu, Joan G. Schellinger, Julie Shi, Anthony J. Convertine, Patrick S. Stayton, Suzie Hwang Pun · 2012 · Accounts of Chemical Research
- Polyhistidine–PEG:DNA nanocomposites for gene deliveryDavid A. Putnam, Alexander N. Zelikin, Vladimir A. Izumrudov, Róbert Langer · 2003 · Biomaterials
- Materials for Non-Viral Gene DeliveryTatiana Segura, Lonnie D. Shea · 2001 · Annual Review of Materials Research
- Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery SystemsWanling Liang, Jenny K.W. Lam · 2012 · InTech eBooks
- Effects of Chemistries of Trifunctional Amines on Mechanisms of Michael Addition Polymerizations with DiacrylatesWu, Ye Liu, Chaobin He · 2004 · Macromolecules
- Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene SilencingChristian Dohmen, Thomas Fröhlich, Ulrich Lächelt, Ingo Röhl, Hans‐Peter Vornlocher, Philipp Hadwiger, Ernst Wagner · 2012 · Molecular Therapy — Nucleic Acids
- Dual Responsive, Stabilized Nanoparticles for Efficient In Vivo Plasmid DeliveryHua Wei, Lisa R. Volpatti, Drew L. Sellers, Don O. Maris, Ian W. Andrews, Ashton S. Hemphill, Leslie W. Chan, David S.H. Chu, Philip J. Horner, Suzie Hwang Pun · 2013 · Angewandte Chemie International Edition
- Imidazole groups on a linear, cyclodextrin-containing polycation produce enhanced gene delivery via multiple processesSwaroop Mishra, Jeremy D. Heidel, Paul Christopher Webster, Mark E. Davis · 2006 · Journal of Controlled Release
- Targeting antibodies to the cytoplasmAndrea L. J. Marschall, André Frenzel, Thomas Schirrmann, Manuela Schüngel, Stefan Dübel · 2011 · mAbs
- Elucidating the interplay between DNA-condensing and free polycations in gene transfection through a mechanistic study of linear and branched PEIZhuojun Dai, Torben Gjetting, Maria Ahlm Mattebjerg, Chi Chung Wu, Thomas L. Andresen · 2011 · Biomaterials
- Chitosan polyplex mediated delivery of miRNA-124 reduces activation of microglial cells in vitro and in rat models of spinal cord injuryLouw, Andrew M., Kolar, Mallappa K., Novikova, Liudmila N., Kingham, Paul J., Wiberg, Mikael, Kjems, Jørgen, Novikov, Lev N. · 2016 · Nanomedicine: Nanotechnology, Biology and Medicine
- Development of a gene-activated scaffold platform for tissue engineering applications using chitosan-pDNA nanoparticles on collagen-based scaffoldsRosanne M. Raftery, Erica G. Tierney, Caroline M. Curtin, Sally‐Ann Cryan, Fergal J. O’Brien · 2015 · Journal of Controlled Release
- Smart polymeric micelles for gene and drug deliveryNobuhiro Nishiyama, Younsoo Bae, Kanjiro Miyata, Shigeto Fukushima, Kazunori Kataoka · 2005 · Drug Discovery Today Technologies
- Chitosan based oligoamine polymers: Synthesis, characterization, and gene deliveryBo Lu, Chang‐Fang Wang, Dequn Wu · 2009 · Journal of Controlled Release
- Cell-Penetrating Peptides Escape the Endosome by Inducing Vesicle Budding and CollapseAshweta Sahni, Ziqing Qian, Dehua Pei · 2020 · ACS Chemical Biology
- Polymer‐coated polyethylenimine/DNA complexes designed for triggered activation by intracellular reductionRobert C. Carlisle, Tomáš Etrych, Simon S. Briggs, Jon A. Preece, Karel Ulbrich, Leonard William Seymour · 2004 · The Journal of Gene Medicine
- The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffoldsErica G. Tierney, Garry P. Duffy, Alan Hibbitts, Sally‐Ann Cryan, Fergal J. O’Brien · 2011 · Journal of Controlled Release
- Polyethylenimine/small interfering RNA‐mediated knockdown of vascular endothelial growth factor in vivo exerts anti‐tumor effects synergistically with BevacizumabSabrina Höbel, Ivette Koburger, Matthias John, Frank Czubayko, Philipp Hadwiger, Hans‐Peter Vornlocher, Achim Michael Aigner · 2010 · The Journal of Gene Medicine
- Stem cell-based gene therapy activated using magnetic hyperthermia to enhance the treatment of cancerPerry To‐Tien Yin, Shreyas Shah, Nicholas J. Pasquale, Olga B. Garbuzenko, Tamara Minko, Ki‐Bum Lee · 2015 · Biomaterials
- Dendritic Polyamines: Simple Access to New Materials with Defined Treelike Structures for Application in Nonviral Gene DeliveryMichael Krämer, Jean‐François Stumbé, Günther N. Grimm, Brigitte Kaufmann, Ute Krüger, Martin Weber, Rainer Haag · 2004 · ChemBioChem
- Structure–activity relationships of siRNA carriers based on sequence-defined oligo (ethane amino) amidesThomas Fröhlich, Daniel Edinger, Raphaela Kläger, Christina Troiber, Eveline Edith Salcher, Naresh S. Badgujar, Irene Martín, David Schaffert, Arzu Cengizeroglu, Philipp Hadwiger et al. · 2012 · Journal of Controlled Release
- Recent advances in biocompatible nanocarriers for delivery of chemotherapeutic cargoes towards cancer therapyChung Yen Ang, Si Yu Tan, Yanli Zhao · 2014 · Organic & Biomolecular Chemistry
- Nanoparticles for radiooncology: Mission, vision, challengesLeoni A. Kunz‐Schughart, Anna Dubrovska, Claudia Peitzsch, Alexander Ewe, Achim Michael Aigner, Samuel Schellenburg, Michael H. Muders, Silke Hampel, Giuseppe Cirillo, Francesca Iemma et al. · 2016 · Biomaterials
- Release of cationic polymer-DNA complexes from the endosome: A theoretical investigation of the proton sponge hypothesisShuang Yang, Sylvio May · 2008 · The Journal of Chemical Physics
- Hierarchical Self‐assembly of Discrete Metal–Organic Cages into Supramolecular Nanoparticles for Intracellular Protein DeliveryJi Liu, Tianli Luo, Yifei Xue, Lanqun Mao, Peter J. Stang, Ming Wang · 2020 · Angewandte Chemie International Edition
- How Do Biomolecules Cross the Cell Membrane?Dehua Pei · 2022 · Accounts of Chemical Research
- Comprehensive NMR Studies of the Structures and Properties of PEI PolymersDaniel R. Holycross, Minghui Chai · 2013 · Macromolecules
- Stimuli responsive drug delivery application of polymer and silica in biomedicineArif Gulzar, Shili Gai, Piaoping Yang, Chunxia Li, Mohd Bismillah Ansari, Jun Lin · 2015 · Journal of Materials Chemistry B
- Synthesis of PAMAM Dendrimer Derivatives with Enhanced Buffering Capacity and Remarkable Gene Transfection EfficiencyGwang Sig Yu, Yun Mi Bae, Hye Jin Choi · 2011 · Bioconjugate Chemistry
- Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuationMyosotys Rodriguez, Jessica Lapierre, Chet Raj Ojha, Ajeet Kumar Kaushik, Elena V. Batrakova, Fatah Kashanchi, Seth M. Dever, Madhavan Nair, Nazira El‐Hage · 2017 · Scientific Reports
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- Maltose- and maltotriose-modified, hyperbranched poly(ethylene imine)s (OM-PEIs): Physicochemical and biological properties of DNA and siRNA complexesSabrina Höbel, Andrea Loos, Dietmar Appelhans, Simona Schwarz, Jürgen Seidel, Brigitte I. Voit, Achim Michael Aigner · 2010 · Journal of Controlled Release
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