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Cited by 11Hydrogels: synthesis, properties, applicationsCellular Mechanics and Interactions3D Printing in Biomedical Research

Programmable Control in Extracellular Matrix-mimicking Polymer Hydrogels

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Hof, Kevin S., Bastings, Maartje M. C.·2017·CHIMIA
DOI 10.2533/chimia.2017.342
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Abstract

The extracellular matrix (ECM) and cells have a reciprocal relationship, one shapes the other and vice versa. One of the main challenges of synthetic material systems for developmental cell culturing, organoid and stem cell work includes the implementation of this reciprocal nature. The largest hurdle to achieve true cell-instructive materials in biomaterials engineering is a lack of spatial and temporal control over material properties and the display of bioactive signals compared to the natural cell environment. ECM-mimicking hydrogels have been developed using a wide range of polymers, assembly and cross-linking strategies. While our synthetic toolbox is larger than nature, often our systems underperform when compared to ECM systems with natural components like Matrigel. Material properties and three-dimensional structure ill-represent the three-dimensional ECM reciprocal nature and ligand presentation is an oversimplified version of the complexity found in nature. We hypothesize that the lack of programmable control in properties and ligand presentation forms the basis of this mismatch in performance and analyze the presence of control in current state of the art ECM-mimicking systems based on covalent, supramolecular and recombinant polymers. We conclude that through combining the dynamics of supramolecular materials, robustness from covalent systems and the programmable spatial control of bio-activation in recombinant ECM materials, the optimal synthetic artificial ECM could be assembled.

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    “Improper spacing of biochemical cues can also lead to cell death182.”

    From Towards organoid culture without Matrigel (2021) · cites this paper as [182]

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Authors
Hof, K. S., & Bastings, M. M. C.
Affiliations
École Polytechnique Fédérale de Lausanne (CH)
Corresponding author
Bastings, Maartje M. C.
ORCID
Bastings, Maartje M. C.
Venue
CHIMIA
Publisher
Swiss Chemical Society
Published
2017-06-28
Volume
71
Issue
6
Pages
342
ISSN
  • 0009-4293 (ISSN-L)
  • 2673-2424
DOI
10.2533/chimia.2017.342
OpenAlex
W2732411645
Cited by
11
References
1
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 2 · 2018: 1
FWCI
0.05
Type
journal article
Language
en
Open access
Licence
Locations
  • CHIMIA International Journal for Chemistry (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
extracellular matrix mimics, polymer hydrogels, programmable materials, supramolecular polymers, covalent polymers, ligand presentation, spatiotemporal control, organoids, stem cell culture
MeSH terms
Extracellular Matrix, Polymers, Hydrogels, Biomimetics, Biomimetic Materials

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