Gut microbiota and aging
Abstract
The hypothesis of an important role of gut microbiota in maintaining physiological state into the gastrointestinal (GI) system is supported by qualitative and quantitative alteration of the intestinal flora in a number of physiological and pathological condition as shown in several studies. The evidence of the inflammatory state alteration, highlighted in neurodegenerative diseases such as Parkinson's and Alzheimer's strongly recalls the microbiota disturbance, highly suggesting a link between the gastrointestinal system and cognitive functions. Given this perspective, looking at the mutual influence between microbiota products, inflammation mediators and immune system, the modulation of gut microbiota may help to facilitate a physiological and non-pathological aging process and, perhaps, to contrast the progression of degenerating mechanisms. Some studies have already characterized gut microbiota in elderly, with promising results. Future studies should be designed to better understand the correlation between the gut microbiota, the ageing process and degenerative diseases typical of the elderly.
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Aging is associated with changes in the composition and activity of the intestinal microbiota and associated immune responses.
“there are also changes in the composition and activity of the intestinal microbiota and associated immune responses.”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Mangiola et al., 2018
Reduced intestinal barrier function is associated with translocation of pro-inflammatory bacterially derived products such as lipopolysaccharides into the body.
“A reduced intestinal barrier function is associated with the translocation of pro-inflammatory, bacterially derived products, such as lipopolysaccharides (LPS), into the body (Mangiola et al., 2018).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Mangiola et al., 2018
Aging is associated with a reduction in butyrate-producing organisms from Clostridium cluster XIVa and in anti-inflammatory organisms such as Faecalibacterium prausnitzii and Akkermansia muciniphila.
“A reduction in butyrate producing organisms from the Clostridium cluster XIVa has been reported as well as a reduction in anti-inflammatory organisms such as Faecalibacterium prausnitzii and Akkermansia muciniphila (Mangiola et al., 2018).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Mangiola et al., 2018
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Negative Lifestyle Factors Specific to Aging Persons Living with HIV and Multimorbidity
Smith, W. P. (2024) · Journal of the International Association of Providers of AIDS Care (JIAPAC) · doi:10.1177/23259582241245228 · Cited by 5 · see citing works
“77 Speci fi cally, SCFAs are important metabolites, including acetate, butyrate, and propionate, produced by the fermentation of fi ber-rich food or non-digestible carbohydrates that escape digestion and absorption in the small intestine.”
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Shestakova, E. A., Pokrovskaya, E. V., & Samsonova, M. D. (2021) · Consilium Medicum · doi:10.26442/20751753.2021.12.201289 · Cited by 3 · see citing works
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“…Microbiota Composition Results of several studies suggest that even healthy aging is associated with alterations of intestinal microbiota composition both in the small and large intestines ([12,59]; and for an overview, see [60]) and impairments of the intestinal barrier function [14,61].”
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“PEER REVIEW 6 This is characterized by a decline in Bacteroidetes and Bifidobacterium populations, alongside an increase in Firmicutes [38,50] (Figure 1).”
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Gkotzamanis, V., Panagiotakos, D. B., Yannakoulia, M., Maraki, M. I., Kosmidis, M. H., Dardiotis, E., Hadjigeorgiou, G. M., Sakka, P., Ntanasi, E., Mamalaki, E., et al. (2023) · Applied Neuropsychology Adult · doi:10.1080/23279095.2023.2289548 · Cited by 1 · see citing works
“As gut microbiota alterations have been associated with aging (Mangiola et al., 2018) and various neurodegenerative conditions (Quigley, 2017) they might constitute another potential link of healthy aging with neurodegeneration and pPD. Therapeutic targeting of inflammation has not presented…”
Abbaspour, E., Karimzadhagh, S., Bayat, Z., Damirchi, A., Bibalan, M. H., & Babaei, P. (2024) · Research Square · doi:10.21203/rs.3.rs-4110400/v1 · Cited by 1 · see citing works
Gut microbiota – invaluable guardian of immunity and vitality of the human body
Ziółkowska, S., Kijek, N., Malinowski, K., & Kostrzewska, P. (2022) · Medycyna Ogólna i Nauki o Zdrowiu · doi:10.26444/monz/146484
“Najważniejszą cechą mikrobioty osób w podeszłym wieku jest jej zubożała różnorodność, obniżona ilość bakterii produkujących maślany oraz obecność potencjalnych patogenów [58, 59].”
Immunomodulatory Role of Milk on Gut Microbiota: Implications for Enhancing Oral Vaccine Efficacy
Asri, N. A. M., Bushra, S. M. R., Asri, A. A. M., Suppıan, R., & Norazmi, M. N. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10785-y · Cited by 1 · see citing works
“This is often associated with an imbalanced gut microbiome, featuring increased pro-inflammatory bacteria such as Bacteroides and Enterobacteriaceae and decreased SCFAs [148].”
Li, Y., Bai, X., Kraus, V. B., Zhou, H., Gao, X., Qiu, X., & Yin, Z. D. (2026) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s592952
“20 Notably, most existing research has focused on younger or general adult populations, and among the few studies involving older adults, at least one has used a cross-sectional design.”
- Authors
- Mangiola
- Venue
- PubMed
- Publisher
- National Institutes of Health
- Published
- 2018-11-01
- Volume
- 22
- Issue
- 21
- Pages
- 7404-7413
- OpenAlex
- W2988584676
- Cited by
- 102
- References
- 0
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 24 · 2023: 18 · 2022: 27 · 2021: 10 · 2020: 10 · 2019: 3
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PubMed (publishedVersion)
- Frontiers of Medicine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- gut microbiota, aging, microbiome, longevity
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Aged, 80 and over, Aging, Humans, Inflammation, Middle Aged, Young Adult
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