Gut microbiota and aging-A focus on centenarians
Open accessAbstract
Gut microbiota (GM) is a dynamic organ throughout the lifespan. Aging is a complex process that comprises a plethora of mechanisms such as senescence, immunosenescence and inflammaging, representing important pathways of age-related diseases. GM structure could both influence and be influenced by aging occurring changes within the host. A unique category of long living individuals exists, namely centenarians that have the outstanding capacity to adapt to various challenges. Longevity seems to be associated with certain GM which, among other factors, might render individuals more resistant to age-related diseases and subsequently to long living. Diet, prebiotics, probiotics and synbiotics may contribute to longevity through GM modulating. Currently, the exact mechanisms of the association between GM and the host in relation with extended lifespan remain unknown and should be further investigated.
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This translocation is associated with increased levels of circulating inflammatory markers and immune-regulating cytokines.
“This in turn is associated with increased levels of circulating inflammatory markers such as interleukin (IL)-1, IL-1 receptor antagonist protein (IL-1RN), IL-6, IL-8, IL-13, IL-18, C-reactive protein (CRP) and tumor necrosis factor (TNF)-α, and immune regulating cytokines such as transforming growth factor (TGF)-β (Ctoi et al., 2020).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Ctoi et al., 2020
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Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures
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Self-citationNutrition and longevity – diet in centenarians
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Improvements in Gut Microbiota Dysbiosis in Aged Mice Transplanted with Adipose-Derived Stem Cells
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Editorial: Diet-microbe-host interactions in metabolic syndrome
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- Authors
- Cӑtoi, A. F., Corina, A., Katsiki, N., Vodnar, D. C., Andreicuț, A. D., Stoian, A. P., Rizzo, M., & Pérez-Martínez, P.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Aristotle University of Thessaloniki (GR)
- University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca (RO)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Carol Davila University of Medicine and Pharmacy (RO)
- University of Palermo (IT)
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 1866
- Issue
- 7
- Pages
- 165765
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W3011669642
- Cited by
- 70
- References
- 130
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 14 · 2023: 9 · 2022: 19 · 2021: 13 · 2020: 4
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- gut microbiota, aging, centenarians, longevity, age-related diseases, immunosenescence, inflammaging, senescence, prebiotics, probiotics, synbiotics, diet
- MeSH terms
- Gastrointestinal Microbiome, Aged, 80 and over, Aging, Humans, Longevity, Probiotics, Prebiotics, Synbiotics
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