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Levothyroxine Dose Changes and Hypothyroid Patient Satisfaction-Results of the CONTROL TS Study
Open accessAbstract
Introduction:The effects of levothyroxine dose adjustments on patient satisfaction with drug therapy and physician care have not been described previously.Primary Objective: To measure those effects among: patients who had no changes in levothyroxine dosage within the past year (n = 150), and patients who had ≥ 2 changes in levothyroxine dosage within the past year (n = 150).Methods: Eligible participants completed a 21-question online survey that employed ThyTSQ, a scientifically-validated instrument designed to assess patient satisfaction with: therapy performance and convenience, and the perceived quality of care provided by physicians.Between-group statistical testing was determined using a Chi-square test to compare proportions.Results: Compared with those reporting no levothyroxine dose changes in the past year, patients reporting ≥ 2 dose changes were significantly less satisfied with their treatment and treating physician: these patients had lower mean ThyTSQ-Present scores (30.1 vs. 33.2;P=.002); were less likely to be "very satisfied" with their treatment and dose (22% vs. 39%; P=.001); and were less likely to feel their hypothyroid symptoms were well controlled (15% vs. 34%; P<.001).Patients experiencing ≥ 2 dose changes were also less likely to be "very satisfied" with how their physician dealt with their condition since its diagnosis (21% vs. 34%; P=.015), and were more likely to have changed physicians in the past year (23% vs. 14%; P=.054).Conclusion: Results showed a strong correlation between the frequency of levothyroxine dose changes and reduced patient satisfaction with treatment, treatment convenience, symptom control and physician performance.
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In CONTROL TS, a survey involving 300 hypothyroid patients taking levothyroxine for more than 1 year, overall patient satisfaction with treatment was 44% lower among patients experiencing levothyroxine dose changes versus those without such changes (P < 0.001).
“Overall patient satisfaction with treatment was 44% lower among patients experiencing levothyroxine dose changes versus those without such changes (P < 0.001).”
From Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report (2017) · cites this paper as [105]
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When thyroid hormone replacement is ineffective?
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Dissatisfaction with thyroxine therapy — could the patients be right?
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Diagnosis and management of treatment-refractory hypothyroidism: an expert consensus report
Centanni, M., Benvenga, S., & Sachmechi, I. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0706-y · Cited by 113
Metadata
- Authors
- M, M.
- Corresponding author
- M, McMillan
- Venue
- Annals of Thyroid Research
- Publisher
- Austin Journals
- Published
- 2017-08-08
- Volume
- 3
- Issue
- 2
- ISSN
- 2690-0165 (ISSN-L)
- OpenAlex
- W2939952333
- Cited by
- 2
- References
- 15
- Citations by year
- 2017: 2
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Thyroid Research (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Health Professions › General Health Professions › Patient Satisfaction in Healthcare
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- levothyroxine, dose adjustment, hypothyroidism, patient satisfaction, quality of care, physician-patient relationship, symptom management, treatment convenience
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