Effect of metoclopramide on nosocomial pneumonia in patients with nasogastric feeding in the intensive care unit
Open accessAbstract
This study in the Islamic Republic of Iran aimed to determine whether metoclopramide can prevent nosocomial pneumonia in the intensive care unit (ICU). Of 220 patients admitted to the surgical ICU who had a nasogastric tube for more than 24 hours, 68 case patients received oral metoclopramide (10 mg every 8 hours) and 152 control patients did not. Similar proportions of cases and controls developed nosocomial pneumonia (33.8% versus 33.6%). Endotracheal intubation was a risk factor for nosocomial pneumonia (odds ratio 7.70). There were no significant differences between groups in mortality rate or time of onset of nosocomial pneumonia. Metoclopramide appears to have no effect on the development of nosocomial pneumonia with nasogastric feeding.
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A meta-analysis based on six studies finds a significant advantage to erythromycin for 24 to 48 hours, since it promotes gastric motility.
“Our meta-analysis based on six studies finds a significant advantage to erythromycin and its use should be encouraged for 24 to 48 hours, since it promotes gastric motility, and if a large (> 500 mL) GRV still persists, the use of post-pyloric feeding should be considered over withholding EN, unless a new abdominal complication (obstruction, perforation, severe distension…) is suspected (see Meta-”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [108]
The Introduction describes metoclopramide as a prokinetic agent, and the Discussion reports this study's findings on metoclopramide and nosocomial pneumonia. Searches for erythromycin, a six-study meta-analysis, and a 24–48-hour recommendation found no passage addressing those claims in our copy. (LLM, conf=0.77)
Experimental — accuracy not yet measuredAccording to a meta-analysis, prokinetic use is associated with a trend towards better enteral feeding tolerance (RR 0.65, CI 0.37, 1.14, p=0.14).
“According to our meta-analysis (see Meta-analysis V in Supplemental Materials), prokinetic use is associated with a trend towards better enteral feeding tolerance (RR 0.65, CI 0.37, 1.14, p=0.14).”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [108]
The Introduction describes metoclopramide as a prokinetic, but the Results report pneumonia and mortality outcomes, not enteral feeding tolerance. A search for feeding tolerance and the stated RR, CI, and p-value found no matching result in our copy. The citing sentence identifies the meta-analysis as the citing authors’ own, rather than this source paper’s. (LLM, conf=0.77)
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- Authors
- Nassaji, M., Ghorbani, R., Frozeshfard, M., & Mesbahian, F.
- Affiliations
- Semnan University of Medical Sciences (IR)
- Venue
- Eastern Mediterranean Health Journal
- Published
- 2010-04-01
- Volume
- 16
- Issue
- 4
- Pages
- 371-374
- ISSN
- 1020-3397 (ISSN-L)
- 1687-1634
- OpenAlex
- W1699419409
- Cited by
- 17
- References
- 15
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 1
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Eastern Mediterranean Health Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
- Keywords
- metoclopramide, nosocomial pneumonia, nasogastric tube feeding, intensive care unit, endotracheal intubation, risk factors, mortality, pharmacological prophylaxis
- MeSH terms
- Administration, Oral, Adult, Antiemetics, Critical Care, Cross Infection, Double-Blind Method, Enteral Nutrition, Female, Humans, Intubation, Gastrointestinal, Intubation, Intratracheal, Iran, Male, Metoclopramide, Middle Aged, Pneumonia, Aspiration, Risk Factors, Time Factors, Incidence, Chi-Square Distribution, Logistic Models, Treatment Outcome
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