Blood vessels and Parkinsonism
Open accessAbstract
Blood vessels are the way for nutrients present outside the brain to gain access into the cerebral parenchyma. When neurons are diseased, for example by toxin exposure, reactive glial cells secrete local factors that induce microangiogenesis, probably as part of a spontaneous neuroprotective mechanism related to the increased metabolic demand. In Parkinson's disease (PD) and non human primate models of PD, nigral degeneration is associated with gliosis and microvascular proliferation. Interestingly, microangiogenesis also facilitates the entrance into the brain parenchyma of neurotoxins and harmful cytokine-releasing blood cells, both of which have been linked to neuronal cell death in PD. In the present review we discuss the potential implications of vascular-related phenomena with mechanisms of neuronal damage in PD.
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Increased angiogenesis is observed throughout the basal ganglia of 6-OHDA-treated rats.
“Similarly, increased angiogenesis is observed throughout the basal ganglia of 6-OHDA-treated rats (44, 501).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [44]
Cites
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
Hirsch, E., Graybiel, A. M., & Agid, Y. A. (1988) · Nature · doi:10.1038/334345a0 · Cited by 1,301 · cited 1× · see citing works
“The highest degree of cell death occurs in the Substantia Nigra pars compacta (SNpc) (80-90%) (1), whereas a lesser degree is encountered in the ventral tegmental area (VTA) and in the peri- and retro-rubral catecholaminergic group (A8) (30-50%), and minimal loss is present in the periaqueductal grey matter (PAG) (3%)…”
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works
Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy
Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B. (2007) · Cell Transplantation · doi:10.3727/000000007783464731 · Cited by 339 · see citing works
6-Hydroxydopamine-induced alterations in blood-brain barrier permeability
Carvey, P. M., Zhao, C. H., Hendey, B., Lum, H., Trachtenberg, J., Desai, B. S., Snyder, J., Zhu, Y. G., & Ling, Z. D. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04281.x · Cited by 218 · see citing works
Desai Bradaric, B., Patel, A., Schneider, J. A., Carvey, P. M., & Hendey, B. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0684-8 · Cited by 139 · see citing works
Dorrell, M. I., Aguilar, E., Jacobson, R., Yanes, O., Gariano, R., Heckenlively, J., Banin, E., Ramirez, G. A., Gasmi, M., Bird, A., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35977 · Cited by 127 · see citing works
Yu, C.-C., Chen, H.-L., Chen, M.-H., Lu, C.-H., Tsai, N.-W., Huang, C.-C., Chang, Y.-Y., Li, S.-H., Chen, Y.-S., Chiang, P.-L., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2591248 · Cited by 37 · see citing works
- Authors
- Barcia, C.
- Affiliations
- Universidad de Murcia (ES)
- Corresponding author
- Barcia, Carlos
- ORCID
- Barcia, Carlos
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2004
- Volume
- 9
- Issue
- 1-3
- Pages
- 277
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/1145
- OpenAlex
- W2035676214
- Cited by
- 41
- References
- 1
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2018: 3 · 2016: 4 · 2014: 3 · 2013: 1
- FWCI
- 0.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS040578, R01-NS40578-01)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- Parkinson's disease, blood vessels, neurovascular unit, nigral degeneration, gliosis, neuroinflammation, neuronal cell death, cerebral microvasculature, nonhuman primate model
- MeSH terms
- Blood Vessels, Humans, Iron, Oxidative Stress, Neurodegenerative Diseases, Parkinsonian Disorders
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