Role of viral regulatory and accessory proteins in HIV-1 replication

A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus

Vivès, É., Brodin, P. M., & Lebleu, B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.16010 · Cited by 2,377 · see citing works

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

Sheehy, A. M., Gaddis, N., Choi, J. D., & Malim, M. H. (2002) · Nature · doi:10.1038/nature00939 · Cited by 2,323 · see citing works

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

Mangeat, B., Turelli, P., Caron, G., Friedli, M., Perrin, L., & Trono, D. (2003) · Nature · doi:10.1038/nature01709 · Cited by 1,486 · see citing works

A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA

Wei, P., Garber, M. E., Fang, S.-M., Fischer, W. H., & Jones, K. A. (1998) · Cell · doi:10.1016/s0092-8674(00)80939-3 · Cited by 1,251 · see citing works

Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients

Deacon, N. J., Tsykin, A., Solomon, A., Smith, K. A., Ludford-Menting, M. J., Hooker, D. J., McPhee, D. A., Greenway, A. L., Ellett, A. M., Chatfield, C., et al. (1995) · Science · doi:10.1126/science.270.5238.988 · Cited by 1,152 · see citing works

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

Fischer, U., Huber, J., Boelens, W. C., Mattaj, I. W., & Lührmann, R. (1995) · Cell · doi:10.1016/0092-8674(95)90436-0 · Cited by 1,140 · see citing works

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcriptionPreprint

Komarnitsky, P. B., Cho, E., & Buratowski, S. (2000) · Genes & Development · doi:10.1101/gad.824700 · Cited by 1,098 · see citing works

The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

Zhang, H., Yang, B., Pomerantz, R. J., Zhang, C., Arunachalam, S., & Gao, L. (2003) · Nature · doi:10.1038/nature01707 · Cited by 1,061 · see citing works

The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

Sheehy, A. M., Gaddis, N., & Malim, M. H. (2003) · Nature Medicine · doi:10.1038/nm945 · Cited by 961 · see citing works

HIV-1: Fifteen Proteins and an RNA

Frankel, A. D., & Young, J. A. T. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.1 · Cited by 913 · see citing works

Species-Specific Exclusion of APOBEC3G from HIV-1 Virions by Vif

Mariani, R., Chen, D., Schröfelbauer, B., Navarro, F., König, R., Bollman, B., Münk, C., Nymark-McMahon, H., & Landau, N. R. (2003) · Cell · doi:10.1016/s0092-8674(03)00515-4 · Cited by 903 · see citing works

What's Up and Down with Histone Deacetylation and Transcription?

Pazin, M. J., & Kadonaga, J. T. (1997) · Cell · doi:10.1016/s0092-8674(00)80211-1 · Cited by 820 · see citing works

HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation

Marin, M., Rose, K. M., Kozak, S. L., & Kabat, D. (2003) · Nature Medicine · doi:10.1038/nm946 · Cited by 794 · see citing works

HIV-1 Vif Blocks the Antiviral Activity of APOBEC3G by Impairing Both Its Translation and Intracellular Stability

Stopak, K., de Noronha, C. M. C., Yonemoto, W. M., & Greene, W. C. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00353-8 · Cited by 723 · see citing works

Internalization of HIV-1 Tat Requires Cell Surface Heparan Sulfate Proteoglycans

Tyagi, M., Rusnati, M., Presta, M., & Giacca, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006701200 · Cited by 718 · see citing works

Transcription elongation factor P-TEFb is required for HIV-1 Tat transactivation in vitroPreprint

Zhu, Y., Peery, T., Peng, J., Ramanathan, Y., Marshall, N. F., Marshall, T. K., Amendt, B. A., Mathews, M. B., & Price, D. H. (1997) · Genes & Development · doi:10.1101/gad.11.20.2622 · Cited by 700 · see citing works

A Novel Human WD Protein, h-βTrCP, that Interacts with HIV-1 Vpu Connects CD4 to the ER Degradation Pathway through an F-Box Motif

Margottin-Goguet, F., Bour, S. P., Durand, H., Selig, L., Bénichou, S., Richard, V., Thomas, D., Strebel, K., & Bénarous, R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80056-8 · Cited by 670 · see citing works

Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase

Chen, H.-W., Lin, R. J., Xie, W., Wilpitz, D. C., & Evans, R. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80054-9 · Cited by 635 · see citing works

Flavopiridol Inactivates P-TEFb and Blocks Most RNA Polymerase II Transcription in Vivo

Chao, S., & Price, D. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102306200 · Cited by 623 · see citing works

Transcriptional activation and chromatin remodeling of the HIV‐1 promoter in response to histone acetylation.

Lint, C. M. V., Emiliani, S., Ott, M., & Verdin, E. M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00449.x · Cited by 579 · see citing works

HIV-1 Tat protein increases transcriptional initiation and stabilizes elongation

Laspia, M. F., Rice, A. P., & Mathews, M. B. (1989) · Cell · doi:10.1016/0092-8674(89)90290-0 · Cited by 571 · see citing works

5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase IIPreprint

McCracken, S. A., Fong, N., Rosonina, E., Yankulov, K., Brothers, G. M., Siderovski, D. P., Hessel, A., Foster, S., Program, A. E., Shuman, S., et al. (1997) · Genes & Development · doi:10.1101/gad.11.24.3306 · Cited by 548 · see citing works

Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation.

Verdin, E. M., Paras, P., & Lint, C. M. V. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05994.x · Cited by 515 · see citing works

Endocytosis and targeting of exogenous HIV‐1 Tat protein.

Mann, D. A., & Frankel, A. D. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07697.x · Cited by 485 · see citing works

mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domainPreprint

Cho, E., Takagi, T., Moore, C. R., & Buratowski, S. (1997) · Genes & Development · doi:10.1101/gad.11.24.3319 · Cited by 478 · see citing works

Cell Membrane Lipid Rafts Mediate Caveolar Endocytosis of HIV-1 Tat Fusion Proteins

Fittipaldi, A., Ferrari, A., Zoppè, M., Arcangeli, C., Pellegrini, V., Beltram, F., & Giacca, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303045200 · Cited by 475 · see citing works

Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway

Mehle, A., Strack, B., Ancuța, P., Zhang, C., McPike, M. P., & Gabuzda, D. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313093200 · Cited by 470 · see citing works

The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

Jacotot, E. D., Ravagnan, L., Loeffler, M. W., Ferri, K. F., Vieira, H. L. A., Zamzami, N., Costantini, P., Druillennec, S., Hoebeke, J., Briand, J. P., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.33 · Cited by 450 · see citing works

Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes

Gabuzda, D. H., Lawrence, K., Langhoff, E., Terwilliger, E., Dorfman, T., Haseltine, W. A., & Sodroski, J. (1992) · Journal of Virology · doi:10.1128/jvi.66.11.6489-6495.1992 · Cited by 444 · see citing works

Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells

von Schwedler, U. K., Song, J., Aiken, C., & Trono, D. (1993) · Journal of Virology · doi:10.1128/jvi.67.8.4945-4955.1993 · Cited by 441 · see citing works

HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region

Chang, H. C., Samaniego, F., Nair, B. C., Buonaguro, L., & Ensoli, B. (1997) · AIDS · doi:10.1097/00002030-199712000-00006 · Cited by 441 · see citing works

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export

Neville, M., Stutz, F., Lee, L., Davis, L. I., & Rosbash, M. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00335-6 · Cited by 439 · see citing works

Cdk-activating kinase complex is a component of human transcription factor TFIIH

Shiekhattar, R., Mermelstein, F. H., Fisher, R. P., Drapkin, R., Dynlacht, B. D., Wessling, H. C., Morgan, D. O., & Reinberg, D. (1995) · Nature · doi:10.1038/374283a0 · Cited by 431 · see citing works

HIV‐1 Tat transcriptional activity is regulated by acetylation

Kiernan, R. E., Vanhulle, C., Schiltz, L., Adam, E., Xiao, H., Maudoux, F., Calomme, C., Burny, A., Nakatani, Y., Jeang, K., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.21.6106 · Cited by 416 · see citing works

The Arginine-Rich Domains Present in Human Immunodeficiency Virus Type 1 Tat and Rev Function as Direct Importin β-Dependent Nuclear Localization Signals

Truant, R., & Cullen, B. R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1210 · Cited by 392 · see citing works

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

Aiken, C., & Trono, D. (1995) · Journal of Virology · doi:10.1128/jvi.69.8.5048-5056.1995 · Cited by 387 · see citing works

HIV-1 Regulatory/Accessory Genes: Keys to Unraveling Viral and Host Cell Biology

Emerman, M., & Malim, M. H. (1998) · Science · doi:10.1126/science.280.5371.1880 · Cited by 385 · see citing works

Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS

Alimonti, J. B., Ball, T. B., & Fowke, K. R. (2003) · Journal of General Virology · doi:10.1099/vir.0.19110-0 · Cited by 378 · see citing works

Nef Interacts with the μ Subunit of Clathrin Adaptor Complexes and Reveals a Cryptic Sorting Signal in MHC I Molecules

Gall, S. L., Erdtmann, L., Bénichou, S., Berlioz‐Torrent, C., Liu, L., Bénarous, R., Heard, J., & Schwartz, O. (1998) · Immunity · doi:10.1016/s1074-7613(00)80553-1 · Cited by 376 · see citing works

Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner.

Lama, J., Mangasarian, A., & Trono, D. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80284-x · Cited by 374 · see citing works

Selective CXCR4 antagonism by Tat: Implications for in vivo expansion of coreceptor use by HIV-1

Xiao, H., Neuveut, C., Tiffany, H. L., Benkirane, M., Rich, E. A., Murphy, P. M., & Jeang, K.-T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11466 · Cited by 369 · see citing works

Nef Protein of HIV-1 Is a Transcriptional Repressor of HIV-1 LTR

Ahmad, N., & Venkatesan, S. (1988) · Science · doi:10.1126/science.3262235 · Cited by 365 · see citing works

Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat.Preprint

Selby, M., Bain, E. S., Luciw, P. A., & Peterlin, B. M. (1989) · Genes & Development · doi:10.1101/gad.3.4.547 · Cited by 342 · see citing works

Stimulatory effect of splicing factors on transcriptional elongation

Fong, Y. W., & Zhou, Q. (2001) · Nature · doi:10.1038/414929a · Cited by 341 · see citing works

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

Geleziunas, R., Xu, W., Takeda, K., Ichijo, H., & Greene, W. C. (2001) · Nature · doi:10.1038/35071111 · Cited by 320 · see citing works

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

Piguet, V., Wan, L., Borel, C., Mangasarian, A., Demaurex, N., Thomas, G., & Trono, D. (2000) · Nature Cell Biology · doi:10.1038/35004038 · Cited by 309 · see citing works

HIV-1 replication.

Freed, E. O. (2001) · Somatic Cell and Molecular Genetics · doi:10.1023/a:1021070512287 · Cited by 307 · see citing works

HIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway

Blagoveshchenskaya, A. D., Thomas, L., Feliciangeli, S. F., Hung, C., & Thomas, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01162-5 · Cited by 305 · see citing works

Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins

Bogerd, H. P., Fridell, R. A., Madore, S. J., & Cullen, B. R. (1995) · Cell · doi:10.1016/0092-8674(95)90437-9 · Cited by 305 · see citing works

Activation of Integrated Provirus Requires Histone Acetyltransferase

Benkirane, M., Chun, R. F., Xiao, H., Ogryzko, V. V., Howard, B. H., Nakatani, Y., & Jeang, K.-T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24898 · Cited by 299 · see citing works

HIV-1 Nef associated PAK and PI3-Kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

Wolf, D., Witte, A. V., Laffert, B., Blume, K., Stromer, E., Trapp, S., D’Aloja, P., Schürmann, A., & Baur, A. S. (2001) · Nature Medicine · doi:10.1038/nm1101-1217 · Cited by 297 · see citing works

Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation.

Ruhl, M., Himmelspach, M., Bahr, G. M., Hammerschmid, F., Jaksche, H., Wolff, B., Aschauer, H. N., Farrington, G. K., Probst, H., & Bevec, D. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.6.1309 · Cited by 282 · see citing works

Nef-Induced CD4 Degradation

Piguet, V., Gu, F., Foti, M., Demaurex, N., Gruenberg, J. E., Carpentier, J., & Trono, D. (1999) · Cell · doi:10.1016/s0092-8674(00)80715-1 · Cited by 281 · see citing works

Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity

Ott, M., Schnölzer, M., Garnica, J., Fischle, W., Emiliani, S., Rackwitz, H., & Verdin, E. M. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80120-7 · Cited by 276 · see citing works

The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains

Schubert, U., Bour, S. P., Ferrer-Montiel, A. V., Montal, M., Maldarell, F., & Strebel, K. (1996) · Journal of Virology · doi:10.1128/jvi.70.2.809-819.1996 · Cited by 275 · see citing works

Dynamic Disruptions in Nuclear Envelope Architecture and Integrity Induced by HIV-1 Vpr

de Noronha, C. M. C., Sherman, M. P., Lin, H. W., Cavrois, M., Moir, R. D., Goldman, R. D., & Greene, W. C. (2001) · Science · doi:10.1126/science.1063957 · Cited by 275 · see citing works

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

Wang, J.-K., Kiyokawa, E., Verdin, E. M., & Trono, D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.394 · Cited by 274 · see citing works

Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2

Jacotot, E. D., Ferri, K. F., Hamel, C. E., Brenner, C., Druillennec, S., Hoebeke, J., Rustin, P., Métivier, D., Lenoir, C., Geuskens, M., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.509 · Cited by 273 · see citing works

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr

Marzio, P. D., Choe, S., Ebright, M. I., Knoblauch, R. E., & Landau, N. R. (1995) · Journal of Virology · doi:10.1128/jvi.69.12.7909-7916.1995 · Cited by 263 · see citing works

Tat Modifies the Activity of CDK9 To Phosphorylate Serine 5 of the RNA Polymerase II Carboxyl-Terminal Domain during Human Immunodeficiency Virus Type 1 Transcription

Zhou, M., Halanski, M. A., Radonovich, M. F., Kashanchi, F., Peng, J., Price, D. H., & Brady, J. N. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5077-5086.2000 · Cited by 261 · see citing works

Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat

Berkhout, B., & Jeang, K.-T. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.139-149.1992 · Cited by 258 · see citing works

CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating Pathway

Schubert, U., Antón, L. C., Bačík, I., Cox, J. H., Bour, S. P., Bennink, J. R., Orłowski, M., Strebel, K., & Yewdell, J. W. (1998) · Journal of Virology · doi:10.1128/jvi.72.3.2280-2288.1998 · Cited by 258 · see citing works

Human immunodeficiency virus type 1 Vpu protein regulates the formation of intracellular gp160-CD4 complexes

Willey, R. L., Maldarelli, F. M., Martin, M. A., & Strebel, K. (1992) · Journal of Virology · doi:10.1128/jvi.66.1.226-234.1992 · Cited by 249 · see citing works

Direct interaction of human TFIID with the HIV-1 transactivator Tat

Kashanchi, F., Piras, G., Radonovich, M. F., Duvall, J. F., Fattaey, A., Chiang, C., Roeder, R. G., & Brady, J. N. (1994) · Nature · doi:10.1038/367295a0 · Cited by 245 · see citing works

Identification of a host protein essential for assembly of immature HIV-1 capsids

Zimmerman, C., Klein, K. C., Kiser, P. K., Singh, A. R., Firestein, B. L., Riba, S. C., & Lingappa, J. R. (2002) · Nature · doi:10.1038/415088a · Cited by 245 · see citing works

Interactions between HIV1 Nef and Vacuolar ATPase Facilitate the Internalization of CD4

Lü, X., Yu, H., Liu, S., Brodsky, F. M., & Peterlin, B. M. (1998) · Immunity · doi:10.1016/s1074-7613(00)80569-5 · Cited by 242 · see citing works

Induction of Fas Ligand Expression by HIV Involves the Interaction of Nef with the T Cell Receptor ζ Chain

Xu, X., Laffert, B., Screaton, G. R., Kraft, M. S., Wolf, D., Kolanus, W., Mongkolsapay, J., McMichael, A. J., & Baur, A. S. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.9.1489 · Cited by 242 · see citing works

Counterregulation of Chromatin Deacetylation and Histone Deacetylase Occupancy at the Integrated Promoter of Human Immunodeficiency Virus Type 1 (HIV-1) by the HIV-1 Repressor YY1 and HIV-1 Activator Tat

He, G., & Margolis, D. M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.9.2965-2973.2002 · Cited by 241 · see citing works

Structural Basis of Lysine-Acetylated HIV-1 Tat Recognition by PCAF Bromodomain

Mujtaba, S., He, Y., Zeng, L., Farooq, A., Carlson, J. E., Ott, M., Verdin, E. M., & Zhou, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00483-5 · Cited by 241 · see citing works

Highly Purified Human Immunodeficiency Virus Type 1 Reveals a Virtual Absence of Vif in Virions

Dettenhofer, M., & Yu, X.-F. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1460-1467.1999 · Cited by 239 · see citing works

Extranuclear Apoptosis

Mills, J. C., Stone, N. L., & Pittman, R. N. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.4.703 · Cited by 232 · see citing works

Human immunodeficiency virus type 1 negative factor is a transcriptional silencer.

Niederman, T. M. J., Thielan, B. J., & Ratner, L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.4.1128 · Cited by 231 · see citing works

CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor

Crise, B. J., Buonocore, L., & Rose, J. K. (1990) · Journal of Virology · doi:10.1128/jvi.64.11.5585-5593.1990 · Cited by 229 · see citing works

A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor

Bresnahan, P. A., Yonemoto, W. M., Ferrell, S., Williams‐Herman, D., Geleziunas, R., & Greene, W. C. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00517-9 · Cited by 226 · see citing works

Cytoskeletal proteins inside human immunodeficiency virus type 1 virions

Ott, D. E., Coren, L., Kane, B. P., Busch, L. K., Johnson, D. G., Sowder, R. C., Chertova, E. N., Arthur, L. O., & Henderson, L. E. (1996) · Journal of Virology · doi:10.1128/jvi.70.11.7734-7743.1996 · Cited by 217 · see citing works

In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor

Jeang, K.-T., Chun, R. F., Lin, N., Gatignol, A., Glabe, C. G., & Fan, H. (1993) · Journal of Virology · doi:10.1128/jvi.67.10.6224-6233.1993 · Cited by 217 · see citing works

Cofactor Requirements for Nuclear Export of Rev Response Element (Rre)–And Constitutive Transport Element (Cte)–Containing Retroviral Rnas

Hofmann, W. A., Reichart, B., Ewald, A., Müller, E., Schmitt, I. M., Stauber, R. H., Lottspeich, F., Jockusch, B. M., Scheer, U., Hauber, J., et al. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.5.895 · Cited by 216 · see citing works

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling

Arold, S. T., Franken, P. A., Strub, M., Hoh, F., Bénichou, S., Bénarous, R., & Dumas, C. (1997) · Structure · doi:10.1016/s0969-2126(97)00286-4 · Cited by 210 · see citing works

Transcription elongation factor hSPT5 stimulates mRNA cappingPreprint

Wen, Y., & Shatkin, A. J. (1999) · Genes & Development · doi:10.1101/gad.13.14.1774 · Cited by 210 · see citing works

Mechanism of Nef‐induced CD4 endocytosis: Nef connects CD4 with the μ chain of adaptor complexes

Piguet, V., Chen, Y., Mangasarian, A., Foti, M., Carpentier, J., & Trono, D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2472 · Cited by 209 · see citing works

Calcium Dysregulation and Neuronal Apoptosis by the HIV-1 Proteins Tat and gp120

Haughey, N. J., & Mattson, M. P. (2002) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/00126334-200210012-00005 · Cited by 208 · see citing works

Mechanism for down‐regulation of CD28 by Nef

Swigut, T., Shohdy, N., & Skowronski, J. (2001) · The EMBO Journal · doi:10.1093/emboj/20.7.1593 · Cited by 206 · see citing works

The downregulation of CD4 and MHC‐I by primate lentiviruses: a paradigm for the modulation of cell surface receptors

Piguet, V., Schwartz, O., Gall, S. L., & Trono, D. (1999) · Immunological Reviews · doi:10.1111/j.1600-065x.1999.tb01282.x · Cited by 204 · see citing works

Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acids.Preprint

Olsen, H. S., Cochrane, A., Dillon, P., Nalin, C. M., & Rosen, C. A. (1990) · Genes & Development · doi:10.1101/gad.4.8.1357 · Cited by 204 · see citing works

Interaction of Human Immunodeficiency Virus Type 1 Tat with the Transcriptional Coactivators p300 and CREB Binding Protein

Hottiger, M. O., & Nabel, G. J. (1998) · Journal of Virology · doi:10.1128/jvi.72.10.8252-8256.1998 · Cited by 201 · see citing works

Differential activities of the human immunodeficiency virus type 1-encoded Vpu protein are regulated by phosphorylation and occur in different cellular compartments

Schubert, U. S., & Strebel, K. (1994) · Journal of Virology · doi:10.1128/jvi.68.4.2260-2271.1994 · Cited by 201 · see citing works

The Human Immunodeficiency Virus Type 1 (HIV-1) Vpu Protein Interferes with an Early Step in the Biosynthesis of Major Histocompatibility Complex (MHC) Class I Molecules

Kerkau, T., Bačík, I., Bennink, J. R., Yewdell, J. W., Hünig, T., Schimpl, A., & Schubert, U. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.7.1295 · Cited by 197 · see citing works

Human Immunodeficiency Virus Type 1 Tat Induces Apoptosis and Increases Sensitivity to Apoptotic Signals by Up-Regulating FLICE/Caspase-8

Bartz, S. R., & Emerman, M. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.1956-1963.1999 · Cited by 196 · see citing works

Transforming growth factor beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection.

Kekow, J., Wachsman, W., McCutchan, J. A., Cronin, M., Carson, D. A., & Lotz, M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8321 · Cited by 195 · see citing works

SH3-mediated Hck Tyrosine Kinase Activation and Fibroblast Transformation by the Nef Protein of HIV-1

Briggs, S. D., Sharkey, M. E., Stevenson, M., & Smithgall, T. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17899 · Cited by 195 · see citing works

HIV‐1 Tat targets microtubules to induce apoptosis, a process promoted by the pro‐apoptotic Bcl‐2 relative Bim

Chen, D., Wang, M., Zhou, S., & Zhou, Q. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf683 · Cited by 195 · see citing works

HIV-1 Nef-Induced Upregulation of DC-SIGN in Dendritic Cells Promotes Lymphocyte Clustering and Viral Spread

Sol‐Foulon, N., Moris, A., Nobile, C., Boccaccio, C., Engering, A. J., Abastado, J., Heard, J., van Kooyk, Y., & Schwartz, O. (2002) · Immunity · doi:10.1016/s1074-7613(02)00260-1 · Cited by 193 · see citing works

Neuronal apoptosis induced by HIV-1 Tat protein and TNF-α: potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia

Shi, B., Raina, J., Lorenzo, A., Busciglio, J. A., & Gabuzda, D. H. (1998) · Journal of NeuroVirology · doi:10.3109/13550289809114529 · Cited by 192 · see citing works

A Molecular Rheostat

Mann, D. A., Mikaélian, I., Zemmel, R. W., Green, S. M., Lowe, A. D., Kimura, T., Singh, M., Jonathan, P., Butler, G., Gait, M. J., et al. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1488 · Cited by 188 · see citing works

A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter

Brès, V., Kiernan, R., Linares, L. K., Chable-Bessia, C., Plechakova, O., Tréand, C., Emiliani, S., Peloponese, J., Jeang, K., Coux, O., et al. (2003) · Nature Cell Biology · doi:10.1038/ncb1023 · Cited by 187 · see citing works

The human immunodeficiency virus type 1 Vpu protein specifically binds to the cytoplasmic domain of CD4: implications for the mechanism of degradation

Bour, S. P., Schubert, U. S., & Strebel, K. (1995) · Journal of Virology · doi:10.1128/jvi.69.3.1510-1520.1995 · Cited by 187 · see citing works

Efficiency of viral DNA synthesis during infection of permissive and nonpermissive cells with vif-negative human immunodeficiency virus type 1

Sova, P., & Volsky, D. J. (1993) · Journal of Virology · doi:10.1128/jvi.67.10.6322-6326.1993 · Cited by 180 · see citing works

Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr

Mahalingam, S., Ayyavoo, V., Patel, M., Kieber‐Emmons, T., & Weiner, D. B. (1997) · Journal of Virology · doi:10.1128/jvi.71.9.6339-6347.1997 · Cited by 179 · see citing works

Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions

Zheng, Y., Plemenitaš, A., Fielding, C. J., & Peterlin, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1437453100 · Cited by 179 · see citing works

Histone acetyltransferases regulate HIV-1 enhancer activity in vitroPreprint

Sheridan, P. L., Mayall, T. P., Verdin, E. M., & Jones, K. A. (1997) · Genes & Development · doi:10.1101/gad.11.24.3327 · Cited by 179 · see citing works

Constitutive cell surface association between CD4 and CCR5

Xiao, X., Wu, L., Stantchev, T. S., Feng, Y., Ugolini, S., Chen, H., Shen, Z., Riley, J. L., Broder, C. C., Sattentau, Q. J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7496 · Cited by 175 · see citing works

The Human Immunodeficiency Virus Type 1 Vpu Protein Inhibits NF-κB Activation by Interfering with βTrCP-mediated Degradation of IκB

Bour, S. P., Perrin, C., Akari, H., & Strebel, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010533200 · Cited by 175 · see citing works

Tat Protein Induces Human Immunodeficiency Virus Type 1 (HIV-1) Coreceptors and Promotes Infection with both Macrophage-Tropic and T-Lymphotropic HIV-1 Strains

Huang, L., Bosch, I., Hofmann, W., Sodroski, J., & Pardee, A. B. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8952-8960.1998 · Cited by 171 · see citing works

Enhancement of Nuclear Factor-κB Acetylation by Coactivator p300 and HIV-1 Tat Proteins

Furia, B., Deng, L., Wu, K., Baylor, S., Kehn‐Hall, K., Hong Li, A., DONNELLY, R. J., Coleman, T., & Kashanchi, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107848200 · Cited by 166 · see citing works

The Ability of Positive Transcription Elongation Factor b To Transactivate Human Immunodeficiency Virus Transcription Depends on a Functional Kinase Domain, Cyclin T1, and Tat

Fujinaga, K., Cujec, T. P., Peng, J., Garriga, J., Price, D. H., Graña, X., & Peterlin, B. M. (1998) · Journal of Virology · doi:10.1128/jvi.72.9.7154-7159.1998 · Cited by 165 · see citing works

Non-homologous DNA end joining.

Pastwa, E., & Błasiak, J. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3622 · Cited by 163 · see citing works

Acetylation of HIV-1 Tat by CBP/P300 Increases Transcription of Integrated HIV-1 Genome and Enhances Binding to Core Histones

Deng, L., de la Fuente, C., Fu, P. C., Wang, L., DONNELLY, R. J., Wade, J. D., Lambert, P. F., Hong Li, A., Lee, C.-G., & Kashanchi, F. (2000) · Virology · doi:10.1006/viro.2000.0593 · Cited by 160 · see citing works

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

Baur, A. S., Sass, G., Laffert, B., Willbold, D., Cheng‐Mayer, C., & Peterlin, B. M. (1997) · Immunity · doi:10.1016/s1074-7613(00)80331-3 · Cited by 156 · see citing works

Cytoskeleton association and virion incorporation of the human immunodeficiency virus type 1 Vif protein

Karczewski, M. K., & Strebel, K. (1996) · Journal of Virology · doi:10.1128/jvi.70.1.494-507.1996 · Cited by 156 · see citing works

The Histone Acetyltransferase, hGCN5, Interacts with and Acetylates the HIV Transactivator, Tat

Col, E., Caron, C., Seigneurin‐Berny, D., Gracia, J., Favier, A. E., & Khochbin, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101385200 · Cited by 155 · see citing works

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration

Stephenson, D. T., Rash, K. S., Smalstig, B., Roberts, E. F., Johnstone, E., Sharp, J., Panetta, J., Little, S. P., Kramer, R. M., & Clemens, J. A. (1999) · Glia · doi:10.1002/(sici)1098-1136(199908)27:2 · Cited by 152 · see citing works

Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat

Chun, R. F., Semmes, O. J., Neuveut, C., & Jeang, K. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.2615-2629.1998 · Cited by 151 · see citing works

Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1

Demarchi, F., di Fagagna, F. D., Falaschi, A., & Giacca, M. (1996) · Journal of Virology · doi:10.1128/jvi.70.7.4427-4437.1996 · Cited by 151 · see citing works

HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator

Felzien, L. K., Woffendin, C., Hottiger, M. O., Subbramanian, R. A., Cohen, É. A., & Nabel, G. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5281 · Cited by 148 · see citing works

The Human Immunodeficiency Virus Type 1 Accessory Protein Vpu Induces Apoptosis by Suppressing the Nuclear Factor κB–dependent Expression of Antiapoptotic Factors

Akari, H., Bour, S. P., Kao, S., Adachi, A., & Strebel, K. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1299 · Cited by 146 · see citing works

Human Immunodeficiency Virus Type 1 Nef Functions at the Level of Virus Entry by Enhancing Cytoplasmic Delivery of Virions

Schaeffer, E., Geleziunas, R., & Greene, W. C. (2001) · Journal of Virology · doi:10.1128/jvi.75.6.2993-3000.2001 · Cited by 145 · see citing works

Human Immunodeficiency Virus Type 1 Nef Binds to Tumor Suppressor p53 and Protects Cells against p53-Mediated Apoptosis

Greenway, A. L., McPhee, D. A., Allen, K., Johnstone, R. W., Holloway, G., MILLS, J. S., Azad, A. A., Sankovich, S., & Lambert, P. F. (2002) · Journal of Virology · doi:10.1128/jvi.76.6.2692-2702.2002 · Cited by 140 · see citing works

Human Immunodeficiency Virus Type 1 Vpr Is a Positive Regulator of Viral Transcription and Infectivity in Primary Human Macrophages

Subbramanian, R. A., Kessous, A., Lodge, R., Forget, J., Yao, X., Bergeron, D., & Cohen, É. A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.7.1103 · Cited by 139 · see citing works

The HIV-1 vpr Protein Acts as a Negative Regulator of Apoptosis in a Human Lymphoblastoid T Cell Line: Possible Implications for the Pathogenesis of AIDS

Conti, L., Rainaldi, G., Matarrese, P., Varano, B., Rivabene, R., Columba, S., Sato, A., Belardelli, F., Malorni, W., & Gessani, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.3.403 · Cited by 138 · see citing works

Quantitation of the Tumor-Targeting Properties of Antibody Fragments Conjugated to Cell-Permeating HIV-1 TAT Peptides

Niesner, U., Halin, C., Lozzi, L., Günthert, M., Neri, P., Wunderli‐Allenspach, H., Zardi, L., & Neri, D. (2002) · Bioconjugate Chemistry · doi:10.1021/bc025517+ · Cited by 137 · see citing works

HIV-1 Tat binds TAF II 250 and represses TAF II 250-dependent transcription of major histocompatibility class I genes

Weissman, J. D., Brown, J. A., Howcroft, T. K., Hwang, J. R., Chawla, A., Roche, P. A., Schiltz, L., Nakatani, Y., & Singer, D. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11601 · Cited by 137 · see citing works

Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity

Greenway, A. L., Azad, A. A., MILLS, J. S., & McPhee, D. A. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6701-6708.1996 · Cited by 134 · see citing works

Functional similarity of HIV-I rev and HTLV-I rex proteins: Identification of a new nucleolar-targeting signal in rev protein

Kubota, S., Siomi, H., Satoh, T., Endo, S.-I., Maki, M., & Hatanaka, M. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)90767-5 · Cited by 131 · see citing works

Subcellular localization of the Vif protein of human immunodeficiency virus type 1

Gonçalves, J., Jallepalli, P. V., & Gabuzda, D. H. (1994) · Journal of Virology · doi:10.1128/jvi.68.2.704-712.1994 · Cited by 130 · see citing works

Inhibition of Human Immunodeficiency Virus Type 1 Transcription by Chemical Cyclin-Dependent Kinase Inhibitors

Wang, D., de la Fuente, C., Deng, L., Wang, L., Zilberman, I., Eadie, C., Healey, M., Stein, D., Denny, T. N., Harrison, L. E., et al. (2001) · Journal of Virology · doi:10.1128/jvi.75.16.7266-7279.2001 · Cited by 130 · see citing works

The Guanylyltransferase Domain of Mammalian mRNA Capping Enzyme Binds to the Phosphorylated Carboxyl-terminal Domain of RNA Polymerase II

Ho, C. K., Sriskanda, V., McCracken, S. A., Bentley, D. L., Schwer, B., & Shuman, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.16.9577 · Cited by 129 · see citing works

Human Immunodeficiency Virus Type 1 Vif Protein Is an Integral Component of an mRNP Complex of Viral RNA and Could Be Involved in the Viral RNA Folding and Packaging Process

Zhang, H., Pomerantz, R., Dornadula, G., & Sun, Y. (2000) · Journal of Virology · doi:10.1128/jvi.74.18.8252-8261.2000 · Cited by 127 · see citing works

A conserved LXXLF sequence is the major determinant in p6gag required for the incorporation of human immunodeficiency virus type 1 Vpr

Kondo, E., & Göttlinger, H. G. (1996) · Journal of Virology · doi:10.1128/jvi.70.1.159-164.1996 · Cited by 126 · see citing works

Activation of Human Immunodeficiency Virus Transcription in T Cells Revisited: NF-κB p65 Stimulates Transcriptional Elongation

West, M. J., Lowe, A. D., & Karn, J. (2001) · Journal of Virology · doi:10.1128/jvi.75.18.8524-8537.2001 · Cited by 125 · see citing works

Acetylation of Tat Defines a CyclinT1-Independent Step in HIV Transactivation

Kaehlcke, K., Dorr, A., Hetzer‐Egger, C., Kiermer, V., Henklein, P., Schnoelzer, M., Loret, E. P., Cole, P. A., Verdin, E. M., & Ott, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00245-4 · Cited by 121 · see citing works

Human Immunodeficiency Virus Type 1 (HIV-1) Accessory Protein Vpr Induces Transcription of the HIV-1 and Glucocorticoid-Responsive Promoters by Binding Directly to p300/CBP Coactivators

Kino, T., Gragerov, A., Slobodskaya, O. R., Tsopanomichalou, M., Chrousos, G. P., & Pavlakis, G. N. (2002) · Journal of Virology · doi:10.1128/jvi.76.19.9724-9734.2002 · Cited by 121 · see citing works

Cooperative Interaction between HIV-1 Regulatory Proteins Tat and Vpr Modulates Transcription of the Viral Genome

Sawaya, B. E., Khalili, K., Gordon, J., Taube, R., & Amini, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005197200 · Cited by 120 · see citing works

Expression, purification, and activities of full‐length and truncated versions of the integral membrane protein Vpu from HIV‐1

Ma, C., Marassi, F. M., Jones, D. H., Straus, S. K., Bour, S. P., Strebel, K., Schubert, U., Oblatt-Montal, M., Montal, M., & Opella, S. J. (2002) · Protein Science · doi:10.1110/ps.37302 · Cited by 120 · see citing works

Virion Incorporation of Human Immunodeficiency Virus Type 1 Nef Is Mediated by a Bipartite Membrane-Targeting Signal: Analysis of Its Role in Enhancement of Viral Infectivity

Welker, R., Harris, M., Cardel, B., & Kräusslich, H. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8833-8840.1998 · Cited by 120 · see citing works

HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes

Lafrenie, R. M., WAHL, L. M., Epstein, J. S., HEWLETT, I. K., Yamada, K. M., & Dhawan, S. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.3.974 · Cited by 119 · see citing works

Docking of HIV-1 Vpr to the Nuclear Envelope Is Mediated by the Interaction with the Nucleoporin hCG1

Rouzic, E. L., Mousnier, A., Rustum, C., Stutz, F., Hallberg, E., Dargemont, C., & Bénichou, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207439200 · Cited by 119 · see citing works

Role of Vif in human immunodeficiency virus type 1 reverse transcription

Gonçalves, J., Korin, Y. D., Zack, J. A., & Gabuzda, D. H. (1996) · Journal of Virology · doi:10.1128/jvi.70.12.8701-8709.1996 · Cited by 119 · see citing works

Control of the Histone-Acetyltransferase Activity of Tip60 by the HIV-1 Transactivator Protein, Tat

Creaven, M., Hans, F., Mutskov, V. J., Col, E., Caron, C., Dimitrov, S. I., & Khochbin, S. (1999) · Biochemistry · doi:10.1021/bi9907274 · Cited by 118 · see citing works

Specific binding of a HeLa cell nuclear protein to RNA sequences in the human immunodeficiency virus transactivating region.

Gaynor, R. B., Soultanakis, E., Kuwabara, M., Garcia, J. A., & Sigman, D. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.13.4858 · Cited by 118 · see citing works

Peripheral blood mononuclear cells produce normal amounts of defective Vif- human immunodeficiency virus type 1 particles which are restricted for the preretrotranscription steps

Courcoul, M., Patience, C., Gondois‐Rey, F., Blanc, D. F., Harmache, A., Sire, J., Vigne, R., & Spire, B. (1995) · Journal of Virology · doi:10.1128/jvi.69.4.2068-2074.1995 · Cited by 118 · see citing works

The HIV-1 Vpu protein: a multifunctional enhancer of viral particle release

Bour, S. P., & Strebel, K. (2003) · Microbes and Infection · doi:10.1016/s1286-4579(03)00191-6 · Cited by 117 · see citing works

Direct Binding of Human Immunodeficiency Virus Type 1 Nef to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail Disrupts MHC-I Trafficking

Williams, M., Roeth, J. F., Kasper, M. R., Fleis, R. I., Przybycin, C. G., & Collins, K. L. (2002) · Journal of Virology · doi:10.1128/jvi.76.23.12173-12184.2002 · Cited by 117 · see citing works

Human Immunodeficiency Virus Type 1 Nef Protein Sensitizes CD4+ T Lymphoid Cells to Apoptosis via Functional Upregulation of the CD95/CD95 Ligand Pathway

Zauli, G., Gibellini, D., Secchiero, P., Dutartre, H., Olive, D., Capitani, S., & Collette, Y. (1999) · Blood · doi:10.1182/blood.v93.3.1000.403a12_1000_1010 · Cited by 117 · see citing works

Role of CXCR4 in Cell-Cell Fusion and Infection of Monocyte-Derived Macrophages by Primary Human Immunodeficiency Virus Type 1 (HIV-1) Strains: Two Distinct Mechanisms of HIV-1 Dual Tropism

Yi, Y., Isaacs, S. N., Williams, D. A., Frank, I., Schols, D., Clercq, E. D., Kolson, D. L., & Collman, R. G. (1999) · Journal of Virology · doi:10.1128/jvi.73.9.7117-7125.1999 · Cited by 113 · see citing works

Role of vif during Packing of the Core of HIV-1

Höglund, S., Öhagen, Å., Lawrence, K., & Gabuzda, D. H. (1994) · Virology · doi:10.1006/viro.1994.1300 · Cited by 111 · see citing works

A Putative G Protein-Coupled Receptor, RDC1, Is a Novel Coreceptor for Human and Simian Immunodeficiency Viruses

Shimizu, N., Soda, Y., Kanbe, K., Liu, H.-Y., Mukai, R., Kitamura, T., & Hoshino, H. (2000) · Journal of Virology · doi:10.1128/jvi.74.2.619-626.2000 · Cited by 111 · see citing works

CDK9: From Basal Transcription to Cancer and AIDS

Falco, G. D., & Giordano, A. (2002) · Cancer Biology & Therapy · doi:10.4161/cbt.1.4.6113 · Cited by 110 · see citing works

Association of Human Immunodeficiency Virus Type 1 Vif with RNA and Its Role in Reverse Transcription

Dettenhofer, M., Cen, S., Carlson, B. A., Kleiman, L., & Yu, X. (2000) · Journal of Virology · doi:10.1128/jvi.74.19.8938-8945.2000 · Cited by 110 · see citing works

Phosphorylation of Vif and Its Role in HIV-1 Replication

Yang, X., Gonçalves, J., & Gabuzda, D. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.10121 · Cited by 109 · see citing works

Synergistic Activation of NFAT by HIV-1 Nef and the Ras/MAPK Pathway

Manninen, A., Renkema, G. H., & Saksela, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910032199 · Cited by 109 · see citing works

Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.

Wittmann, S., Bali, P., Donapaty, S., Nimmanapalli, R., Guo, F., Yamaguchi, H., Huang, M., Jove, R., Wang, H., & Bhalla, K. N. (2003) · PubMed · Cited by 107 · see citing works

HIV-1 Nef Blocks Transport of MHC Class I Molecules to the Cell Surface Via a PI 3-Kinase-Dependent Pathway

Swann, S. A., Williams, M., Story, C. M., Bobbitt, K. R., Fleis, R. I., & Collins, K. L. (2001) · Virology · doi:10.1006/viro.2000.0816 · Cited by 107 · see citing works

Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP

Zhang, S., Feng, Y., Narayan, O., & Zhao, L.-J. (2001) · Gene · doi:10.1016/s0378-1119(00)00583-7 · Cited by 106 · see citing works

Nucleolar Protein B23 Stimulates Nuclear Import of the HIV-1 Rev Protein and NLS-Conjugated Albumin

Szebeni, A., Mehrotra, B. D., Baumann, A. P., Adam, S. A., Wingfield, P. T., & Olson, M. O. J. (1997) · Biochemistry · doi:10.1021/bi9627931 · Cited by 105 · see citing works

HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs

Fritz, C., & Green, M. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00608-5 · Cited by 105 · see citing works

Cyclin-dependent kinases as cellular targets for antiviral drugs

Schang, L. M. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf227 · Cited by 104 · see citing works

p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by Nef

Fackler, O., Lü, X., Frost, J. A., Geyer, M., Jiang, B., Luo, W., Abo, A., Alberts, A. S., & Peterlin, B. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2619-2627.2000 · Cited by 104 · see citing works

HIV Tat, its TARgets and the control of viral gene expression

Brigati, C., Giacca, M., Noonan, D. M., & Albini, A. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00067-3 · Cited by 104 · see citing works

Activation of Transcription Factors NF-κB and NF-IL-6 by Human Immunodeficiency Virus Type 1 Protein R (Vpr) Induces Interleukin-8 Expression

Roux, P., Alfieri, C., Hrimech, M., Cohen, É. A., & Tanner, J. E. (2000) · Journal of Virology · doi:10.1128/jvi.74.10.4658-4665.2000 · Cited by 104 · see citing works

The Multimerization of Human Immunodeficiency Virus Type I Vif Protein

Yang, S., Sun, Y., & Zhang, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004895200 · Cited by 103 · see citing works

Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells.

Sastry, K. J., Marín, M. C., Nehete, P. N., McConnell, K., El‐Naggar, A. K., & McDonnell, T. J. (1996) · PubMed · Cited by 102 · see citing works

Subunit H of the V-ATPase Binds to the Medium Chain of Adaptor Protein Complex 2 and Connects Nef to the Endocytic Machinery

Geyer, M., Yu, H., Mandić, R., Linnemann, T., Zheng, Y., Fackler, O., & Peterlin, B. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200522200 · Cited by 101 · see citing works

Mitogen-activated Protein Kinase Phosphorylates and Regulates the HIV-1 Vif Protein

Yang, X., & Gabuzda, D. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29879 · Cited by 97 · see citing works

HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors

Federico, M., Percario, Z. A., Olivetta, E., Fiorucci, G., Muratori, C., Micheli, A., Romeo, G., & Affabris, E. (2001) · Blood · doi:10.1182/blood.v98.9.2752 · Cited by 97 · see citing works

Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis

Stoddart, C. A., Geleziunas, R., Ferrell, S., Linquist-Stepps, V. D., Moreno, M. E., Bare, C., Xu, W., Yonemoto, W. M., Bresnahan, P. A., McCune, J. M., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.3.2124-2133.2003 · Cited by 96 · see citing works

Regulation of HIV-1 transcription.

Roebuck, K. A., & Saifuddin, M. (1999) · PubMed · Cited by 96 · see citing works

Cooperative Actions of HIV-1 Vpr and p53 Modulate Viral Gene Transcription

Sawaya, B. E., Khalili, K., Mercer, W. E., Denisova, L., & Amini, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20052 · Cited by 95 · see citing works

CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4 + T-Cell Depletion in Human Lymphoid Tissue Ex Vivo

Glushakova, S. E., Münch, J., Carl, S., Greenough, T. C., Sullivan, J. L., Margolis, L. B., & Kirchhoff, F. (2001) · Journal of Virology · doi:10.1128/jvi.75.21.10113-10117.2001 · Cited by 94 · see citing works

Identification of a Potential HIV-Induced Source of Bystander-Mediated Apoptosis in T Cells: Upregulation of TRAIL in Primary Human Macrophages by HIV-1 Tat

Zhang, M., Li, X., Pang, X., Ding, L., Wood, O., Clouse, K., HEWLETT, I. K., & Dayton, A. I. (2001) · Journal of Biomedical Science · doi:10.1007/bf02256603 · Cited by 92 · see citing works

Expression of human immunodeficiency virus type 1 vif and vpr mRNAs is rev-dependent and regulated by splicing

Schwartz, S., Felber, B. K., & Pavlakis, G. N. (1991) · Virology · doi:10.1016/0042-6822(91)90996-o · Cited by 92 · see citing works

In Vitro Interaction between Human Immunodeficiency Virus Type 1 Rev Protein and Splicing Factor ASF/SF2-associated Protein, p32

Tange, T. Ø., Jensen, T. H., & Kjems, J. K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.10066 · Cited by 91 · see citing works

HIV-1 Protein Vpr Suppresses IL-12 Production from Human Monocytes by Enhancing Glucocorticoid Action: Potential Implications of Vpr Coactivator Activity for the Innate and Cellular Immunity Deficits Observed in HIV-1 Infection

Mirani, M., Elenkov, I. J., Volpi, S., Hiroi, N., Chrousos, G. P., & Kino, T. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.11.6361 · Cited by 91 · see citing works

Monocytes Treated with Human Immunodeficiency Virus Tat Kill Uninfected CD4+Cells by a Tumor Necrosis Factor-Related Apoptosis-Induced Ligand-Mediated Mechanism

Yang, Y., Tikhonov, I., Ruckwardt, T. J., Djavani, M. M., Zapata, J. C., Pauza, C. D., & Salvato, M. S. (2003) · Journal of Virology · doi:10.1128/jvi.77.12.6700-6708.2003 · Cited by 90 · see citing works

Multiple Modes of Transcriptional Regulation by the HIV‐1 Tat Transactivator

Marcello, A., Zoppè, M., & Giacca, M. (2001) · IUBMB Life · doi:10.1080/152165401753544241 · Cited by 89 · see citing works

HIV-1 Vpr Displays Natural Protein-Transducing Properties: Implications for Viral Pathogenesis

Sherman, M. P., Schubert, U., Williams, S. A., de Noronha, C. M. C., Kreisberg, J. F., Henklein, P., & Greene, W. C. (2002) · Virology · doi:10.1006/viro.2002.1576 · Cited by 89 · see citing works

Functional Interaction of Human Immunodeficiency Virus Type 1 Vpu and Gag with a Novel Member of the Tetratricopeptide Repeat Protein Family

Callahan, M. A., Handley, M. A., Lee, Y.-H., Talbot, K. J., Harper, J. W., & Panganiban, A. T. (1998) · Journal of Virology · doi:10.1128/jvi.72.6.5189-5197.1998 · Cited by 89 · see citing works

Evidence for stimulation of the transforming growth factor beta 1 promoter by HIV-1 Tat in cells derived from CNS.

Cupp, C., Taylor, J. P., Khalili, K., & Amini, S. (1993) · PubMed · Cited by 89 · see citing works

The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway

Roumier, T., Vieira, H. L. A., Castedo, M., Ferri, K. F., Boya, P., Andréau, K., Druillennec, S., Joza, N. A., Penninger, J. M., Roques, B. P., et al. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401089 · Cited by 87 · see citing works

HIV-1 Tat Interaction with RNA Polymerase II C-terminal Domain (CTD) and a Dynamic Association with CDK2 Induce CTD Phosphorylation and Transcription from HIV-1 Promoter

Deng, L., Ammosova, T., Pumfery, A. M., Kashanchi, F., & Nekhai, S. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111349200 · Cited by 86 · see citing works

Vpu Exerts a Positive Effect on HIV-1 Infectivity by Down-modulating CD4 Receptor Molecules at the Surface of HIV-1-producing Cells

Lévesque, K., Zhao, Y., & Cohen, É. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300327200 · Cited by 85 · see citing works

Lentiviral-mediated gene transfer into human lymphocytes: role of HIV-1 accessory proteins

Chinnasamy, D., Chinnasamy, N., Enriquez, M. J., Otsu, M., Morgan, R. A., & Candotti, F. (2000) · Blood · doi:10.1182/blood.v96.4.1309 · Cited by 84 · see citing works

Chromatin Remodeling and Modification during HIV-1 Tat-activated Transcription

Pumfery, A. M., Deng, L., Maddukuri, A., de la Fuente, C. L., Hong Li, A., Wade, J. D., Lambert, P. F., Kumar, A., & Kashanchi, F. (2003) · Current HIV Research · doi:10.2174/1570162033485186 · Cited by 84 · see citing works

Contribution of the TATA motif to Tat-mediated transcriptional activation of human immunodeficiency virus gene expression

Olsen, H. S., & Rosen, C. A. (1992) · Journal of Virology · doi:10.1128/jvi.66.9.5594-5597.1992 · Cited by 83 · see citing works

The Nef protein of primate lentiviruses

Piguet, V., & Trono, D. (1999) · Reviews in Medical Virology · doi:10.1002/(sici)1099-1654(199904/06)9:2 · Cited by 83 · see citing works

The Amino-Terminal Region of Vpr from Human Immunodeficiency Virus Type 1 Forms Ion Channels and Kills Neurons

Piller, S. C., Ewart, G. D., Jans, D. A., Gage, P. W., & Cox, G. B. (1999) · Journal of Virology · doi:10.1128/jvi.73.5.4230-4238.1999 · Cited by 79 · see citing works

Role of Vif in Stability of the Human Immunodeficiency Virus Type 1 Core

Öhagen, Å., & Gabuzda, D. H. (2000) · Journal of Virology · doi:10.1128/jvi.74.23.11055-11066.2000 · Cited by 79 · see citing works

Transient Induction of Cyclin T1 during Human Macrophage Differentiation Regulates Human Immunodeficiency Virus Type 1 Tat Transactivation Function

Liou, L., Herrmann, C. H., & Rice, A. P. (2002) · Journal of Virology · doi:10.1128/jvi.76.21.10579-10587.2002 · Cited by 79 · see citing works

Gene expression profile of HIV-1 Tat expressing cells: a close interplay between proliferative and differentiation signals

de la Fuente, C., Santiago, F., Deng, L., Eadie, C., Zilberman, I., Kehn‐Hall, K., Maddukuri, A., Baylor, S., Wu, K., Lee, C. G., et al. (2002) · BMC Biochemistry · doi:10.1186/1471-2091-3-14 · Cited by 79 · see citing works

Lentivirus Nef Specifically Activates Pak2

Arora, V. K., Molina, R. P., Foster, J. L., Blakemore, J. L., Chernoff, J., Fredericksen, B. L., & García, J. V. (2000) · Journal of Virology · doi:10.1128/jvi.74.23.11081-11087.2000 · Cited by 79 · see citing works

Chemokine receptors and mechanisms of cell death in HIV neuropathogenesis.

Gabuzda, D. H., & Wang, J. (2000) · PubMed · Cited by 78 · see citing works

HIV-1 nuclear import in search of a leader

Bukrinsky, M. (1997) · Frontiers in bioscience · doi:10.2741/a213 · Cited by 78 · see citing works

Death by Deamination

Goff, S. P. (2003) · Cell · doi:10.1016/s0092-8674(03)00602-0 · Cited by 77 · see citing works

Inhibition of CXCR4-Dependent HIV-1 Infection by Extracellular HIV-1 Tat

Ghezzi, S., Noonan, D. M., Aluigi, M. G., Vallanti, G., Cota, M., Benelli, R., Morini, M., Reeves, J. D., Vicenzi, E., Poli, G., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2523 · Cited by 77 · see citing works

Functional mapping of the human immunodeficiency virus type 1 Rev RNA binding domain: new insights into the domain structure of Rev and Rex

Böhnlein, E., Berger, J., & Hauber, J. (1991) · Journal of Virology · doi:10.1128/jvi.65.12.7051-7055.1991 · Cited by 76 · see citing works

Phosphorylation of Both Phosphoacceptor Sites in the HIV-1 Vpu Cytoplasmic Domain Is Essential for Vpu-Mediated ER Degradation of CD4

Paul, M., & Jabbar, M. A. (1997) · Virology · doi:10.1006/viro.1997.8541 · Cited by 76 · see citing works

The Growth Factor Granulin Interacts with Cyclin T1 and Modulates P-TEFb-Dependent Transcription

Hoque, M., Young, T. M., Lee, C.-G., Serrero, G., Mathews, M. B., & Pe’ery, T. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.5.1688-1702.2003 · Cited by 76 · see citing works

Disassembly of Human Immunodeficiency Virus Type 1 Cores In Vitro Reveals Association of Nef with the Subviral Ribonucleoprotein Complex

Forshey, B. M., & Aiken, C. R. (2003) · Journal of Virology · doi:10.1128/jvi.77.7.4409-4414.2003 · Cited by 76 · see citing works

Vpu Increases Susceptibility of Human Immunodeficiency Virus Type 1-Infected Cells to Fas Killing

Casella, C. R., Rapaport, E. L., & Finkel, T. H. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.92-100.1999 · Cited by 76 · see citing works

HIV-1 Nef Interacts with Inositol Trisphosphate Receptor to Activate Calcium Signaling in T Cells

Manninen, A., & Saksela, K. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012039 · Cited by 76 · see citing works

A unified classification system for eukaryotic transposable elements

Wicker, T., Sabot, F., Hua‐Van, A., Bennetzen, J. L., Capy, P., Chalhoub, B., Flavell, A. J., Leroy, P., Morgante, M., Panaud, O., et al. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2165 · Cited by 3,021 · see citing works

Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus

Kramer-Hämmerle, S., Rothenaigner, I., Wolff, H., Bell, J. E., & Brack‐Werner, R. (2005) · Virus Research · doi:10.1016/j.virusres.2005.04.009 · Cited by 335 · see citing works

HIV-1 associated dementia: symptoms and causes

Ghafouri, M., Amini, S., Khalili, K., & Sawaya, B. E. (2006) · Retrovirology · doi:10.1186/1742-4690-3-28 · Cited by 215 · see citing works

CD4+ T Cell Depletion in Human Immunodeficiency Virus (HIV) Infection: Role of Apoptosis

Février, M., Dorgham, K., & Rebollo, A. (2011) · Viruses · doi:10.3390/v3050586 · Cited by 201 · see citing works

Structural Disorder in Viral Proteins

Xue, B., Blocquel, D., Habchi, J., Uversky, A. V., Kurgan, L., Uversky, V. N., & Longhi, S. (2014) · Chemical Reviews · doi:10.1021/cr4005692 · Cited by 201 · see citing works

Activation of the ATR Pathway by Human Immunodeficiency Virus Type 1 Vpr Involves Its Direct Binding to Chromatin In Vivo

Lai, M., Zimmerman, E. S., Planelles, V., & Chen, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.24.15443-15451.2005 · Cited by 89 · see citing works

Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis

Mishra, P. M., Verma, N. C., Rao, C., Uversky, V. N., & Nandi, C. K. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.03.001 · Cited by 86 · see citing works

Intracellular Transport of Human Immunodeficiency Virus Type 1 Genomic RNA and Viral Production Are Dependent on Dynein Motor Function and Late Endosome Positioning

Lehmann, M., Milev, M. P., Abrahamyan, L. G., Yao, X., Panté, N., & Mouland, A. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808531200 · Cited by 78 · see citing works

Generation of HIV-1 Resistant and Functional Macrophages From Hematopoietic Stem Cell–derived Induced Pluripotent Stem Cells

Kambal, A., Mitchell, G., Cary, W., Gruenloh, W., Jung, Y., Kalomoiris, S., Nacey, C., McGee, J., Lindsey, M., Fury, B., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.269 · Cited by 76 · see citing works

HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread

Kalinichenko, S., Komkov, D., & Mazurov, D. (2022) · Viruses · doi:10.3390/v14010152 · Cited by 68 · see citing works

Use of HIV as a gene transfer vector.

Pluta, K. D., & Kacprzak, M. M. (2009) · Acta Biochimica Polonica · doi:10.18388/abp.2009_2490 · Cited by 68 · see citing works

Measurement of Long-Range 1H−19F Scalar Coupling Constants and Their Glycosidic Torsion Dependence in 5-Fluoropyrimidine-Substituted RNA

Hennig, M., Munzarová, M., Bermel, W., Scott, L. G., Sklenář, V., & Williamson, J. R. (2006) · Journal of the American Chemical Society · doi:10.1021/ja060165t · Cited by 65 · see citing works

Influence of the 2′-Hydroxyl Group Conformation on the Stability of A-form Helices in RNA

Fohrer, J., Hennig, M., & Carlomagno, T. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.11.043 · Cited by 56 · see citing works

Plasma membrane signaling in HIV-1 infection

Abbas, W., & Herbein, G. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.06.020 · Cited by 40 · see citing works

Antiviral roles of APOBEC proteins against HIV-1 and suppression by Vif

Romani, B., Engelbrecht, S., & Glashoff, R. H. (2009) · Archives of Virology · doi:10.1007/s00705-009-0481-y · Cited by 36 · see citing works

Highly active antiretroviral therapy and human immunodeficiency virus encephalitis

Cook, J. E., Dasgupta, S., Middaugh, L. D., Terry, E. C., Gorry, P. R., Wesselingh, S. L., & Tyor, W. R. (2005) · Annals of Neurology · doi:10.1002/ana.20479 · Cited by 36 · see citing works

30 years of HIV therapy: Current and future antiviral drug targets

Nuwagaba, J., Li, J. A., Ngo, B., & Sutton, R. E. (2024) · Virology · doi:10.1016/j.virol.2024.110362 · Cited by 33 · see citing works

On the Solution Conformation and Dynamics of the HIV-1 Viral Infectivity Factor

Marcsisin, S. R., Narute, P. S., Emert‐Sedlak, L. A., Kloczewiak, M. A., Smithgall, T. E., & Engen, J. R. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.04.053 · Cited by 33 · see citing works

19F-Site-Specific-Labeled Nucleotides for Nucleic Acid Structural Analysis by NMR

Scott, L. G., & Hennig, M. (2015) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2015.05.015 · Cited by 33 · see citing works

Nature and Pathogenicity of Micro-organisms

Fierer, J., Looney, D. J., & Péchère, J.-C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-7020-6285-8.00002-2 · Cited by 33 · see citing works

Inhibition of HIV-1 virus replication using small soluble Tat peptides

Agbottah, E. T., Zhang, N., Dadgar, S., Pumfery, A. M., Wade, J. D., Zeng, C., & Kashanchi, F. (2005) · Virology · doi:10.1016/j.virol.2005.09.062 · Cited by 31 · see citing works

A Review: The Antiviral Activity of Cyclic Peptides

Chia, L. Y., Kumar, P. V., Maki, M. A. A., Ravichandran, G., & Thilagar, S. (2022) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-022-10478-y · Cited by 29 · see citing works

Reciprocal transactivation between HIV-1 and other human viruses

White, M. K., Gorrill, T. S., & Khalili, K. (2006) · Virology · doi:10.1016/j.virol.2006.04.006 · Cited by 29 · see citing works

Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging

Wolff, H., Hadian, K., Ziegler, M., Weierich, C., Kramer-Hämmerle, S., Kleinschmidt, A., Erfle, V., & Brack‐Werner, R. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.11.020 · Cited by 25 · see citing works

Human immunodeficiency virus (HIV-1) infection selectively downregulates PD-1 expression in infected cells and protects the cells from early apoptosis in vitro and in vivo

Venkatachari, N. J., Buchanan, W. G., & Ayyavoo, V. (2008) · Virology · doi:10.1016/j.virol.2008.03.015 · Cited by 24 · see citing works

The Evolution of Dendritic Cell Immunotherapy against HIV‐1 Infection: Improvements and Outlook

Mohamed, H., Miller, V., Jennings, S. R., Wigdahl, B. L., & Krebs, F. C. (2020) · Journal of Immunology Research · doi:10.1155/2020/9470102 · Cited by 20 · see citing works

Jumping Ahead with Sleeping Beauty: Mechanistic Insights into Cut-and-Paste Transposition

Ochmann, M. T., & Ivics, Z. (2021) · Viruses · doi:10.3390/v13010076 · Cited by 20 · see citing works

Viral Pathogenesis, Modulation of Immune Receptor Signaling and Treatment

Kim, W. M., & Sigalov, A. B. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09789-3_22 · Cited by 20 · see citing works

Prime-boost immunization strategies against HIV-1

Bråve, A. (2007) · Figshare · Cited by 19 · see citing works

Innovative Approaches to Develop Prophylactic and Therapeutic Vaccines against HIV/AIDS

Cafaro, A., Macchia, I., Maggiorella, M. T., Titti, F., & Ensoli, B. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1132-2_14 · Cited by 13 · see citing works

Understanding the Process of Envelope Glycoprotein Incorporation into Virions in Simian and Feline Immunodeficiency Viruses

Affranchino, J. L., & González, S. A. (2014) · Viruses · doi:10.3390/v6010264 · Cited by 12 · see citing works

Tuning Rex rules HTLV-1 pathogenesis

Nakano, K., & Watanabe, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.959962 · Cited by 11 · see citing works

Illustrating the machinery of life: Viruses

Goodsell, D. S. (2012) · Biochemistry and Molecular Biology Education · doi:10.1002/bmb.20636 · Cited by 11 · see citing works

Evidence of a Direct Evolutionary Selection for Strong Folding and Mutational Robustness Within HIV Coding Regions

Goz, E., & Tuller, T. (2016) · Journal of Computational Biology · doi:10.1089/cmb.2016.0052 · Cited by 10 · see citing works

Nature and pathogenicity of micro-organisms

Fierer, J., Looney, D. J., Kok, M., & Péchère, J.-C. (2010) · Elsevier eBooks · doi:10.1016/b978-0-323-04579-7.00001-0 · Cited by 10 · see citing works

Positive Selection on HIV Accessory Proteins and the Analysis of Molecular Adaptation After Interspecies Transmission

Soares, A. E. R., Soares, M. A., & Schrago, C. G. (2008) · Journal of Molecular Evolution · doi:10.1007/s00239-008-9112-6 · Cited by 10 · see citing works

Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development

Dahiya, S., Nonnemacher, M. R., & Wigdahl, B. L. (2012) · Journal of General Virology · doi:10.1099/vir.0.041186-0 · Cited by 9 · see citing works

The SCHOOL of nature. IV. Learning from viruses

Sigalov, A. B. (2010) · Self/Nonself · doi:10.4161/self.1.4.13279 · Cited by 9 · see citing works

HIV-1 Tat protein attenuates the clinical course of experimental autoimmune encephalomyelitis (EAE)

Karampoor, S., Zahednasab, H., Bokharaei‐Salim, F., Mirzaei, R., Mojallal-Tabatabaei, Z., Esghaei, M., & Keyvani, H. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105943 · Cited by 9 · see citing works

In silico prediction of HIV-1-host molecular interactions and their directionality

Chai, H., Gu, Q., Hughes, J., & Robertson, D. L. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009720 · Cited by 8 · see citing works

Therapeutic innovations against HIV

Uckun, F. M., & D’Cruz, O. J. (2006) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.16.3.265 · Cited by 8 · see citing works

Engineering Baculo- and Lentiviral Vectors for Enhanced and Targeted Gene Delivery

Kaikkonen, M. U. (2008) · Cited by 8 · see citing works

Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4

Shimane, K., Kodama, E. N., Nakase, I., Futaki, S., Sakurai, Y., Sakagami, Y., Li, X., Hattori, T., Sarafianos, S. G., & Matsuoka, M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.05.005 · Cited by 7 · see citing works

Highly versatile small virus-encoded proteins in cellular membranes: A structural perspective on how proteins’ inherent conformational plasticity couples with host membranes’ properties to control cellular processes

Delkhosh, A. S., Hadadianpour, E., Islam, M. M., & Georgieva, E. R. (2024) · Journal of Structural Biology X · doi:10.1016/j.yjsbx.2024.100117 · Cited by 7 · see citing works

Reacciones y alteraciones del sistema inmune durante la infección por el VIH-1

Guarín, C. J. M., Fernández, M. E. M., & López, M. T. R. (2006) · Institutional Repository University of Antioquia (University of Antioquia) · Cited by 7 · see citing works

CD4-gp120 interaction interface - a gateway for HIV-1 infection in human: molecular network, modeling and docking studies

Pandey, D., Podder, A., Pandit, M., & Latha, N. (2016) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2016.1227722 · Cited by 7 · see citing works

Do Viral Proteins Possess Unique Features?

Xue, B., Williams, R. W., Oldfield, C. J., Goh, G. K., Dunker, A. K., & Uversky, V. N. (2011) · Wiley eBooks · doi:10.1002/9781118135570.ch1 · Cited by 7 · see citing works

NMR assignments of HIV-2 TAR RNA

Carlomagno, T., Amata, I., Williamson, J. R., & Hennig, M. (2008) · Biomolecular NMR Assignments · doi:10.1007/s12104-008-9112-x · Cited by 6 · see citing works

Peroxisomes and Viruses: Overview on Current Knowledge and Experimental Approaches

Ferreira, V., Ferreira, A., & Ribeiro, D. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3048-8_19 · Cited by 5 · see citing works

Comparison of Adjuvant Effects of Montanide ISA-720 and Heat Shock Protein 27 in Increasing Immunostimulatory Properties of HIV-1 Nef-Vif Fusion Protein Construct

Khairkhah, N., Shahhosseini, F., Agi, E., Milani, A., & Bolhassani, A. (2023) · Protein and Peptide Letters · doi:10.2174/0929866530666230403093538 · Cited by 3 · see citing works

Casp8p41: The Protean Mediator of Death in CD4 T-cells that Replicate HIV

Sampath, R., Cummins, N. W., & Badley, A. D. (2016) · Journal of Cell Death · doi:10.4137/jcd.s39872 · Cited by 3 · see citing works

Y44A Mutation in the Acidic Domain of HIV-2 Tat Impairs Viral Reverse Transcription and LTR-Transactivation

Szojka, Z. I., Mótyán, J. A., Miczi, M., Mahdi, M., & Tőzsér, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165907 · Cited by 2 · see citing works

Overexpression of recombinant HIV-1 Subtype C Tat and Nef in a Salmonella vaccine vector

Chin’ombe, N., Lebeko, M., & Kgatle, M. M. (2013) · Pan African Medical Journal · doi:10.11604/pamj.2013.16.19.2759 · Cited by 2 · see citing works

Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production

Na, H., Huisman, W., Ellestad, K. K., Phillips, T. R., & Power, C. (2010) · Virology · doi:10.1016/j.virol.2010.04.009 · Cited by 2 · see citing works

Dendritic cells during the HIV-1 infection.

Montoya, C. J., & Piedrahita, L. D. (2007) · Colombia medica · doi:10.25100/cm.v38i4.529 · Cited by 2 · see citing works

Construction of Rough Set-Based Classifiers for Predicting HIV Resistance to Nucleoside Reverse Transcriptase Inhibitors

Kierczak, M., Rudnicki, W. R., & Komorowski, J. (2007) · Springer eBooks · doi:10.1007/978-3-540-76973-6_16 · Cited by 2 · see citing works

Strain-specific epistasis shapes fitness landscapes of APOBEC3G antagonism by HIV-1 Vif proteins

Langley, C. A., Lilly, M., Malik, H. S., & Emerman, M. (2026) · Science Advances · doi:10.1126/sciadv.aed4872 · Cited by 1 · see citing works

HIV-1 Biology at the Protein Level

Ott, D. E. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6542-7_2 · Cited by 1 · see citing works

Caracterización de la neoplasia intraepitelial cervical inducida por el virus del papiloma humano en pacientes seropositivas a virus de la inmunodeficiencia humana

Bravo, T. C. R. (2013) · doi:10.14201/gredos.123042 · Cited by 1 · see citing works

The Role of HIV-1 Proteins in Alzheimer's Disease Pathology

Giunta, B. N. (2011) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1 · see citing works

Análise e caracterização molecular, estrutural e populacional de proteases de HIV-1 do Estado de São Paulo.

Iamarino, A. (2012) · doi:10.11606/t.42.2012.tde-13112012-083943 · Cited by 1 · see citing works

Caracterização biológica e molecular de recombinantes naturais de HIV-1.

de Melo, F. L. (2011) · doi:10.11606/t.42.2011.tde-20102011-133503 · Cited by 1 · see citing works

HIV-1 Tat and Apoptotic Death

Muller, S., & Des̀granges, C. (2005) · CRC Press eBooks · doi:10.1201/9781420038156.ch9 · Cited by 1 · see citing works

The role of the HIV-1 reverse transcriptase mutation H208Y to drug resistance and viral fitness

Malik, S. A. (2011) · UCL Discovery (University College London)

Improving the immunogenicity of HIV-1 DNA vaccines.

Hallengärd, D. (2010) · Figshare

Studies on HIV-1 core assembly

Abdurahman, S. (2007) · Figshare

Determinants of HIV-1 Gag Localization to Uropods in Polarized T Cells and the Role Uropods Play in Virus Spread.

Llewellyn, G. N. (2012) · Deep Blue (University of Michigan)

Etude de l’établissement des réservoirs VIH lors de la primo-infection et de l’impact des traitements antirétroviraux très précoces sur ces réservoirs

Chéret, A. (2014) · doi:10.70675/476201c0z519az47dfz9e6az9e7e63dc4e55

Characterization of hiv-1 populations in infected cells

Josefsson, L. (2013) · Figshare

Vpu Mediated Enhancement of Human Immunodeficiency Virus Pathogenesis: The Role of Conserved and Unique Domains in Protein Function

Ruiz, A. J. (2010) · KU ScholarWorks (University of Kansas)

DETECTION OF HIV-1 VIRAL PROTEIN R IN HIV ENCEPHALITIC BRAIN TISSUE

Dale, E., & Wheeler, A. C. (2005) · D-Scholarship@Pitt (University of Pittsburgh)

UNIFYING VIRAL EVOLUTION AND IMMUNOLOGICAL PATTERNS TO INVESTIGATE RISK OF HIV-1 DISEASE PROGRESSION

Norström, M. M. (2012) · Figshare

Strategies to enhance the potency of HIV-1 DNA vaccines

Hallengärd, D. (2011) · Figshare

Open Access SHORT COMMUNICATION

Iio, A., Nakagawa, Y., Hirata, I., Naoe, T., & Akao, Y. (2010)

AVALIAÇÃO DE POLIMORFISMOS EM GENES ENVOLVIDOS NA RESPOSTA IMUNE INATA DE PACIENTES INFECTADOS COM HIV-1 E SUA INFLUÊNCIA NA PROGRESSÃO À AIDS

de Medeiros, R. M. (2012) · Americanae (AECID Library)

Immune reconstitution in HIV-1 infection : the effects of antiretroviral and immune therapy

Sullivan, A. (2011) · UTAS Research Repository · doi:10.25959/23250950

Evaluation of the NIH clinical collection to identify potential HIV-1 integrase inhibitors

Abrahams, S. (2014) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)

Assessing the potential of non-integrating lentiviral vectors for cardiovascular gene therapy

Chick, H. E. (2011) · Enlighten: Theses (The University of Glasgow) · doi:10.5525/gla.thesis.3045

Towards a more complete conformational understanding of the HIV-1 viral infectivity factor

Marcsisin, S. R. (2011) · doi:10.17760/d20002111

HIV-specific CD8+ T cell responses in infected infacts enrolled on a study of early highly active antiretroviral treatment (HAART) and supervised treatment interruption (STI).

Thobakgale, C. (2011) · ResearchSpace (University of KwaZulu-Natal)

CARACTERIZAÇÃO BIOLÓGICA E MOLECULAR DE RECOMBINANTES NATURAIS DE HIV-1

Paulo, S. (2011)

Análise e Caracterização Molecular, Estrutural e Populacional de Proteases de HIV-1 do Estado de São Paulo

Microbiologia, G. E. (2012)

The use of genetic sequencing technologies to determine HIV-1 viral tropism and to evaluate the effects of maraviroc on patient viral populations

McGovern, R. A. (2015) · cIRcle (University of British Columbia) · doi:10.14288/1.0166738

Development and clinical evaluation of an in-house human immunodeficiency virus-1 real-time RT-PCR quantitation assay

Wee, S. Y. (2012) · doi:10.32657/10356/48079

Cohorte observationnelle analysant l’évolution des patients débutant un traitement antirétroviral comprenant du dolutégravir au CHU de Bordeaux et dans les autres CHR d’Aquitaine : projet « Cotivy »

Machelart, I. (2015) · HAL

Caracterização de variantes virais de HIV-1 em indivíduos soropositivos com perfil de controle da progressão para a AIDS e da replicação viralavaliação da ocorrência de variantes de escape da resposta imune

Caetano, D. G. (2016) · Americanae (AECID Library)

Caractérisation du rôle de LFA-1 dans l'infection des lymphocytes T CD4+ par le virus de l'immunodéficience humaine de type 1

Tardif, M. R. (2005) · Corpus Université Laval (Université Laval)

Assessing Immunological and Microbiome Determinants of HIV Susceptibility in the Male Genital Tract

Galiwango, R. M. (2020) · TSpace (University of Toronto)

Expression and Characterization of Two DNA Constructs Derived from HIV-1-vif in Escherichia coli and Mammalian Cells

Zamani, F., Bolhassani, A., Shahbazi, S., Faghih, A., & Sadat, S. M. (2021) · Avicenna Journal of Medical Biotechnology · doi:10.18502/ajmb.v13i3.6369

Foreseeability Decoded

Villiers, M. D. (2015) · Minnesota journal of law science & technology · doi:10.24926/15529541.3714

El TARGA como factor determinante en el tamaño del reservorio y la diversidad de los genes accesorios y reguladores del provirus del VIH-1

Romero, L. L. F. (2022) · doi:10.24275/uami.bc386j502

Identification and evaluation of inhibitors targeting the HIV-1 integrase-LEDGF/p75 interaction

Harrison, A. T. (2014) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)

The Role of Second Generation Antiretroviral Drugs in HIV-1 Subtype B and non-B Variants Harboring Natural Polymorphisms and Drug Resistance Mutations

Asahchop, E. L. (2012) · doi:10.71781/27479

DELINEATING THE ROLE OF SIV-VPR AND VPX ON DENDRITIC CELLS, NK CELLS, AND IMMUNE FUNCTION

Baglyas, K. (2008) · D-Scholarship@Pitt (University of Pittsburgh)

Dynamique des interactions de la protéine de la nucléocapside avec la transcriptase inverse du VIH-1 : étude en molécule unique

Jouonang, A. (2013) · doi:10.70675/6ff45657z3136z4fa6z9760ze2b251d40452

Étude comparative des processus intégratifs des rétrovirus aviaires et porcins

Andary, E. A. (2011) · doi:10.70675/ae4a827fzcf7az49d6zb25ez334c2c0d5829

Modélisation pharmacocinétique et pharmacodynamique de la rilpivirine chez les patients infectés par le VIH-1 traités par l'association fixe rilpivirine/ténofovir disoproxil fumarate/emtricitabine

Néant, N. (2019) · doi:10.70675/cec059a2z873az4143za4cdz1fbf30654d6d

Manipulation of the cell cycle by HIV-1

Bandini, M., & Sherer, N. M. (2026) · Biochemical Society Transactions · doi:10.1042/bst20250120

Mechanisms of Inflammation in HIV-Associated Dementia

Giunta, B. N., Fernandez, F., & Tan, J. (2007) · Springer eBooks · doi:10.1007/978-0-387-30398-7_19

HIV accessory proteins and surviving the host cell

Anderson, J. L., & Hope, T. J. (2004) · Current HIV/AIDS Reports · doi:10.1007/s11904-004-0007-x · Cited by 31 · see citing works

HIV Accessory Proteins: Emerging Therapeutic Targets

Miller, R. H., & Sarver, N. (1995) · Molecular Medicine · doi:10.1007/bf03401585 · Cited by 5 · see citing works

Accessory proteins of HIV and innate anti-retroviral factors

Nomaguchi, M., & Adachi, A. (2009) · Uirusu · doi:10.2222/jsv.59.67 · Cited by 1 · see citing works

Recent insights into HIV accessory proteins

Anderson, J. L., & Hope, T. J. (2003) · Current Infectious Disease Reports · doi:10.1007/s11908-003-0024-8 · Cited by 15 · see citing works

Making Sense of Multifunctional Proteins: Human Immunodeficiency Virus Type 1 Accessory and Regulatory Proteins and Connections to Transcription

Faust, T. B., Binning, J. M., Gross, J. D., & Frankel, A. D. (2017) · Annual Review of Virology · doi:10.1146/annurev-virology-101416-041654 · Cited by 58 · see citing works