Protein kinase C isoforms: Multi-functional regulators of cell life and death

Direct activation of calcium‐activated, phospholipid‐dependent protein kinase by tumor‐promoting phorbol esters

Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., & Nishizuka, Y. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34459-4 · Cited by 4,725

The extended protein kinase C superfamily

MELLOR, H., & PARKER, P. J. (1998) · Biochemical Journal · doi:10.1042/bj3320281 · Cited by 1,538

Protein kinase Cα activates RAF-1 by direct phosphorylation

Kolch, W., Heidecker, G., Kochs, G., Hummel, R., Vahidi, H., Mischak, H., Finkenzeller, G., Marmé, D., & Rapp, U. R. (1993) · Nature · doi:10.1038/364249a0 · Cited by 1,277

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

Le Good, J. A., Ziegler, W. H., Parekh, D. B., Alessi, D. R., Cohen, P., & Parker, P. J. (1998) · Science · doi:10.1126/science.281.5385.2042 · Cited by 1,110

Protein kinase C and other diacylglycerol effectors in cancer

Griner, E. M., & Kazanietz, M. G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2110 · Cited by 978

Protein Kinase C: Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions

Newton, A. C. (2001) · Chemical Reviews · doi:10.1021/cr0002801 · Cited by 962

The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

Gartel, A. L., & Tyner, A. L. (2002) · PubMed · Cited by 918

Protein kinase C as a possible receptor protein of tumor‐promoting phorbol esters

Kikkawa, U., Takai, Y., Tanaka, Y., Miyake, R., & Nishizuka, Y. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44245-1 · Cited by 881

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.

Inoue, M., Kishimoto, A., Takai, Y., & Nishizuka, Y. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41010-6 · Cited by 862

Lost in Transcription: p21 Repression, Mechanisms, and Consequences

Gartel, A. L., & Radhakrishnan, S. K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3995 · Cited by 818

Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm

NEWTON, A. C. (2003) · Biochemical Journal · doi:10.1042/bj20021626 · Cited by 798

Protein kinase C isozymes and the regulation of diverse cell responses

Dempsey, E. C., Newton, A. C., Mochly-Rosen, D., Fields, A. P., Reyland, M. E., Insel, P. A., & Messing, R. O. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.3.l429 · Cited by 737

The structure, expression, and properties of additional members of the protein kinase C family.

Ono, Y., Fujii, T., Ogita, K., Kikkawa, U., Igarashi, K., & Nishizuka, Y. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68732-0 · Cited by 692

Activation of protein kinase C by tyrosine phosphorylation in response to H 2 O 2

Konishi, H., Tanaka, M., Takemura, Y., Matsuzaki, H., Ono, Y., Kikkawa, U., & Nishizuka, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11233 · Cited by 605

Multiple pathways control protein kinase C phosphorylation

Parekh, D. B., Ziegler, W., & Parker, P. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.496 · Cited by 601

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

Takai, Y., Kishimoto, A., Inoue, M., & Nishizuka, Y. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41009-x · Cited by 595

Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity.

Mischak, H., Goodnight, J. A., Kolch, W., Martiny-Baron, G., Schaechtle, C., Kazanietz, M. G., Blumberg, P. M., Pierce, J. H., & Mushinski, J. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53223-3 · Cited by 541

Proteolytic Activation of Protein Kinase C δ by an ICE/CED 3-like Protease Induces Characteristics of Apoptosis

Ghayur, T., Hugunin, M., Talanian, R. V., Ratnofsky, S., Quinlan, C., Emoto, Y., Pandey, P., Datta, R., Huang, Y., Kharbanda, S., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.6.2399 · Cited by 472

A Functional Role for Mitochondrial Protein Kinase Cα in Bcl2 Phosphorylation and Suppression of Apoptosis

Ruvolo, P. P., Deng, X., Carr, B. K., & May, W. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.39.25436 · Cited by 452

Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

Dutil, E. M., Toker, A., & Newton, A. C. (1998) · Current Biology · doi:10.1016/s0960-9822(98)00017-7 · Cited by 381

Distinctive activation mechanisms and functions for protein kinase Cδ

STEINBERG, S. F. (2004) · Biochemical Journal · doi:10.1042/bj20040704 · Cited by 376

Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

Leitges, M., Sanz, L., Martin, P., Duran, A., Braun, U., Garcı́a, J. F., Camacho, F., Diaz-Meco, M. T., Rennert, P. D., & Moscat, J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00361-6 · Cited by 371

Ceramide Disables 3-Phosphoinositide Binding to the Pleckstrin Homology Domain of Protein Kinase B (PKB)/Akt by a PKCζ-Dependent Mechanism

Powell, D. J., Hajduch, E., Kular, G., & Hundal, H. S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.21.7794-7808.2003 · Cited by 370

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

Díaz-Meco, M. T., Municio, M. M., Frutos, S., Sanchez, P., Lozano, J., Sanz, L., & Moscat, J. (1996) · Cell · doi:10.1016/s0092-8674(00)80152-x · Cited by 361

Caspase-3-mediated Cleavage of Protein Kinase C θ in Induction of Apoptosis

Datta, R., Kojima, H., Yoshida, K., & Kufe, D. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20317 · Cited by 313

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

Akimoto, K., Takahashi, R., Moriya, S., Nishioka, N., Takayanagi, J., Kimura, K., Fukui, Y., Osada, S.-I., Mizuno, K., Hirai, S.-I., et al. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00414.x · Cited by 273

Protein Kinase C δ Is Essential for Etoposide-induced Apoptosis in Salivary Gland Acinar Cells

Reyland, M. E., Anderson, S. M., Matassa, A. A., Barzen, K. A., & Quissell, D. O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19115 · Cited by 269

MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.

Ways, D. K., Kukoly, C. A., deVente, J., Hooker, J. L., Bryant, W. O., Posekany, K. J., Fletcher, D. J., Cook, P. P., & Parker, P. J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117872 · Cited by 266

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

Berra, E., Díaz-Meco, M. T., Lozano, J., Frutos, S., Municio, M. M., Sánchez, P., Sanz, L., & Moscat, J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00306.x · Cited by 263

Protein kinase C binding partners

Jaken, S., & Parker, P. J. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200003)22:3<245::aid-bies6>3.0.co;2-x · Cited by 260

Functional interaction between DNA-PK and c-Abl in response to DNA damage

Kharbanda, S., Pandey, P., Jin, S., Inoue, S., Bharti, A., Yuan, Z.-M., Weichselbaum, R., Weaver, D., & Kufe, D. (1997) · Nature · doi:10.1038/386732a0 · Cited by 251

Protein Kinase Cϵ Is Required for Macrophage Activation and Defense Against Bacterial Infection

Castrillo, A., Pennington, D. J., Otto, F., Parker, P. J., Owen, M. J., & Boscá, L. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1231 · Cited by 246

Nuclear import of PKCδ is required for apoptosis: identification of a novel nuclear import sequence

DeVries, T. A., Neville, M. C., & Reyland, M. E. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf606 · Cited by 231

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

Diaz-Meco, M. T., Berra, E., Municio, M., Sanz, L., Lozano, J., Dominguez, I., Diaz-Golpe, V., Lain de Lera, M. T., Alcamí, J., Payá, C. V., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4770-4775.1993 · Cited by 222

Interaction between Protein Kinase C δ and the c-Abl Tyrosine Kinase in the Cellular Response to Oxidative Stress

Sun, X., Wu, F., Datta, R., Kharbanda, S., & Kufe, D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7470 · Cited by 208

Inactivation of DNA-Dependent Protein Kinase by Protein Kinase Cδ: Implications for Apoptosis

Bharti, A., Kraeft, S.-K., Gounder, M., Pandey, P., Jin, S., Yuan, Z.-M., Lees-Miller, S. P., Weichselbaum, R., Weaver, D., Chen, L. B., et al. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6719 · Cited by 208

Tumor Promotion by Depleting Cells of Protein Kinase Cδ

Lu, Z., Hornia, A., Jiang, Y.-W., Zang, Q., Ohno, S., & Foster, D. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.3418 · Cited by 207

Protein Kinase Cδ Activation Induces Apoptosis in Response to Cardiac Ischemia and Reperfusion Damage

Murriel, C. L., Churchill, E., Inagaki, K., Szweda, L. I., & Mochly-Rosen, D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405071200 · Cited by 198

Tyrosine Phosphorylation of Protein Kinase Cδ Is Essential for Its Apoptotic Effect in Response to Etoposide

Blass, M., Kronfeld, I., Kazimirsky, G., Blumberg, P. M., & Brodie, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.1.182-195.2002 · Cited by 197

The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival

Jackson, D. N., & Foster, D. A. (2004) · The FASEB Journal · doi:10.1096/fj.03-0979rev · Cited by 195

Roles of Specific Isoforms of Protein Kinase C in the Transcriptional Control of Cyclin D1 and Related Genes

Soh, J.-W., & Weinstein, I. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302016200 · Cited by 194

Phosphorylation of Protein Kinase C-α on Serine 657 Controls the Accumulation of Active Enzyme and Contributes to Its Phosphatase-resistant State

Bornancin, F., & Parker, P. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3544 · Cited by 191

Protein kinase Calpha and protein kinase Cdelta play opposite roles in the proliferation and apoptosis of glioma cells.

Mandil, R., Ashkenazi, E., Blass, M., Kronfeld, I., Kazimirsky, G., Rosenthal, G., Umansky, F., Lorenzo, P. S., Blumberg, P. M., & Brodie, C. (2001) · PubMed · Cited by 184

FGF‐2 protects small cell lung cancer cells from apoptosis through a complex involving PKCε, B‐Raf and S6K2

Pardo, O. E., Wellbrock, C., Khanzada, U. K., Aubert, M., Arozarena, I., Davidson, S., Bowen, F., Parker, P. J., Filonenko, V. V., Gout, I. T., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601198 · Cited by 183

Atypical Protein Kinase C ι Protects Human Leukemia Cells against Drug-induced Apoptosis

Murray, N. R., & Fields, A. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.44.27521 · Cited by 177

Mammalian TOR Controls One of Two Kinase Pathways Acting upon nPKCδ and nPKCε

Parekh, D., Ziegler, W., Yonezawa, K., Hara, K., & Parker, P. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34758 · Cited by 174

Targeting of protein kinase C delta to mitochondria in the oxidative stress response.

Majumder, P. K., Mishra, N. C., Sun, X., Bharti, A. K., Kharbanda, S. M., Saxena, S. P., & Kufe, D. W. (2001) · PubMed · Cited by 171

Positioning Atypical Protein Kinase C Isoforms in the UV-Induced Apoptotic Signaling Cascade

Berra, E., Municio, M. M., Sanz, L., Frutos, S., Diaz-Meco, M. T., & Moscat, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.8.4346 · Cited by 166

PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase.

Cacace, A. M., Ueffing, M., Philipp, A., Han, E. K.-H., Kölch, W., & Weinstein, I. B. (1996) · PubMed · Cited by 157

Direct Binding to Ceramide Activates Protein Kinase Cζ before the Formation of a Pro-apoptotic Complex with PAR-4 in Differentiating Stem Cells

Wang, G., Silva, J., Krishnamurthy, K., Tran, E., Condie, B. G., & Bieberich, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501492200 · Cited by 155

Protein kinase Cδ is responsible for constitutive and DNA damage‐induced phosphorylation of Rad9

Yoshida, K., Wang, H., Miki, Y., & Kufe, D. W. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg134 · Cited by 153

Reversible Phosphorylation of Bcl2 following Interleukin 3 or Bryostatin 1 Is Mediated by Direct Interaction with Protein Phosphatase 2A

Deng, X., Ito, T., Carr, B. K., Mumby, M. C., & May, W. S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34157 · Cited by 147

Protein Kinase Cε Is a Predictive Biomarker of Aggressive Breast Cancer and a Validated Target for RNA Interference Anticancer Therapy

Pan, Q., Bao, L., Kleer, C. G., Sabel, M. S., Griffith, K. A., Teknos, T. N., & Merajver, S. D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0553 · Cited by 147

Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation

Yuan, Z.-M., Utsugisawa, T., Ishiko, T., Nakada, S., Huang, Y., Kharbanda, S. M., Weichselbaum, R. R., & Kufe, D. W. (1998) · Oncogene · doi:10.1038/sj.onc.1201698 · Cited by 146

Protein Kinase C Isoenzyme Patterns Characteristically Modulated in Early Prostate Cancer

Cornford, P. A., Evans, J., Dodson, A. R., PARSONS, K. F., Woolfenden, A., Neoptolemos, J. P., & Foster, C. S. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65260-1 · Cited by 144

Suppression of Apoptosis in the Protein Kinase Cδ Null Mouse in Vivo

Humphries, M. J., Limesand, K. H., Schneider, J. C., Nakayama, K. I., Anderson, S. M., & Reyland, M. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m507851200 · Cited by 138

PKCδ Is Required for Mitochondrial-dependent Apoptosis in Salivary Epithelial Cells

Matassa, A. A., Carpenter, L., Biden, T. J., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100273200 · Cited by 131

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.

Díaz-Meco, M. T., Berra, E., Municio, M. M., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4770 · Cited by 130

A Common Binding Site Mediates Heterodimerization and Homodimerization of Bcl-2 Family Members

Díaz, J.-L., Oltersdorf, T., Horne, W. A., McConnell, M. R., Wilson, G., Weeks, S., Garcia, T., & Fritz, L. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11350 · Cited by 128

Protein Kinase Cζ Is a Negative Regulator of Protein Kinase B Activity

Doornbos, R. P., Theelen, M., van der Hoeven, P. C. J., BLITTERSWIJK, W. J. V., Verkleij, A. J., & Henegouwen, P. M. P. V. B. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8589 · Cited by 128

PKCζ at the crossroad of NF-κB and Jak1/Stat6 signaling pathways

Moscat, J., Rennert, P. D., & Díaz-Meco, M. T. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401823 · Cited by 127

Protein Kinase Cε Interacts with Signal Transducers and Activators of Transcription 3 (Stat3), Phosphorylates Stat3Ser727, and Regulates Its Constitutive Activation in Prostate Cancer

Aziz, M. H., Manoharan, H. T., Church, D. R., Dreckschmidt, N. E., Zhong, W., Oberley, T. D., Wilding, G., & Verma, A. K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1604 · Cited by 124

Caspase-Mediated Proteolysis and Activation of Protein Kinase Cδ Plays a Central Role in Neutrophil Apoptosis

Khwaja, A., & Tatton, L. (1999) · Blood · doi:10.1182/blood.v94.1.291.413k10_291_301 · Cited by 123

Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase C$alpha; in endothelial cells

Partovian, C., & Simons, M. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.01.008 · Cited by 123

Protein kinase cepsilon has the potential to advance the recurrence of human prostate cancer.

Wu, D., Foreman, T. L., Gregory, C. W., et al. (2002) · PubMed · Cited by 121

Protein kinase Cι: Human oncogene, prognostic marker and therapeutic target

Fields, A. P., & Regala, R. P. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.04.015 · Cited by 120

Inactivation of the Inhibitory κB Protein Kinase/Nuclear Factor κB Pathway by Par-4 Expression Potentiates Tumor Necrosis Factor α-induced Apoptosis

Díaz-Meco, M. T., Lallena, M.-J., Monjas, A., Frutos, S., & Moscat, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19606 · Cited by 119

Involvement of p21 Waf1/Cip1 in Protein Kinase C Alpha-Induced Cell Cycle Progression

Besson, A., & Yong, V. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4580-4590.2000 · Cited by 118

Protein Kinase C α but not PKCζ Suppresses Intestinal Tumor Formation in ApcMin/+ Mice

Oster, H., & Leitges, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0268 · Cited by 116

p73β Is Regulated by Protein Kinase Cδ Catalytic Fragment Generated in the Apoptotic Response to DNA Damage

Ren, J., Datta, R., Shioya, H., Li, Y., Oki, E., Biedermann, V., Bharti, A. K., & Kufe, D. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110667200 · Cited by 114

Upregulation and activation of PKCα by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKCα and Src inhibitors

Tan, M., Li, P., Sun, M.-E., Yin, G., & Yu, D.-H. (2006) · Oncogene · doi:10.1038/sj.onc.1209361 · Cited by 114

Protein Kinase C-ε Promotes Survival of Lung Cancer Cells by Suppressing Apoptosis through Dysregulation of the Mitochondrial Caspase Pathway

Ding, L., Wang, H., Lang, W., & Xiao, L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201460200 · Cited by 110

Protein kinase Cɛ interacts with Bax and promotes survival of human prostate cancer cells

McJilton, M. A., Sikes, C. V., Wescott, G. G., Wu, D., Foreman, T. L., Gregory, C. W., Weidner, D. A., Ford, O. H., Lasater, A. M., Mohler, J. L., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206795 · Cited by 110

Protein Kinase C Signaling Mediates a Program of Cell Cycle Withdrawal in the Intestinal Epithelium

Frey, M. R., Clark, J. A., Leontieva, O. V., Uronis, J. M., Black, A. R., & Black, J. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.763 · Cited by 110

Protein Kinase C-ε Regulates the Apoptosis and Survival of Glioma Cells

Okhrimenko, H., Lü, W., Xiang, C., Hamburger, N., Kazimirsky, G., & Brodie, C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1064 · Cited by 108

Protein Kinase Cι Activity Is Necessary for Bcr-Abl-mediated Resistance to Drug-induced Apoptosis

Jamieson, L., Carpenter, L., Biden, T. J., & Fields, A. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.7.3927 · Cited by 107

Phosphorylation of Protein Kinase Cδ (PKCδ) at Threonine 505 Is Not a Prerequisite for Enzymatic Activity

Stempka, L., Girod, A., Müller, H., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6805 · Cited by 107

Protein kinase C-α overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal

Li, W., Zhang, J., Flechner, L., Hyun, T. S., Yam, A., Franke, T. F., & Pierce, J. H. (1999) · Oncogene · doi:10.1038/sj.onc.1203065 · Cited by 105

Protein Kinase C Negatively Regulates Akt Activity and Modifies UVC-induced Apoptosis in Mouse Keratinocytes

Li, L., Sampat, K., Hu, N. N., Zakari, J., & Yuspa, S. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m512167200 · Cited by 103

Induction of Apoptosis Is Driven by Nuclear Retention of Protein Kinase Cδ

Seimon, T. A., Ohm, A. M., Humphries, M. J., & Reyland, M. E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703661200 · Cited by 102

Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.

Sharif, T. R., & Sharif, M. (1999) · International Journal of Oncology · doi:10.3892/ijo.15.2.237 · Cited by 97

Protein Kinase C Alpha Expression in Breast and Ovarian Cancer

Lahn, M., Köhler, G., Sundell, K. L., Chen, S., Li, S., Paterson, B. M., & Bumol, T. F. (2004) · Oncology · doi:10.1159/000080279 · Cited by 97

Diacylglycerol (DAG)-lactones, a New Class of Protein Kinase C (PKC) Agonists, Induce Apoptosis in LNCaP Prostate Cancer Cells by Selective Activation of PKCα

García‐Bermejo, L., Leskow, F. C., Fujii, T., Wang, Q. J., Blumberg, P. M., Ohba, M., Kuroki, T., Han, K., Lee, J., Márquez, V. E., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107639200 · Cited by 97

Overexpression of protein kinase C epsilon is oncogenic in rat colonic epithelial cells.

Perletti, G. P., Folini, M., Lin, H. C., et al. (1996) · PubMed · Cited by 97

Protein Kinase Cϵ Activates Protein Kinase B/Akt via DNA-PK to Protect against Tumor Necrosis Factor-α-induced Cell Death

Lu, D., Huang, J., & Basu, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603390200 · Cited by 96

Association between v-Src and Protein Kinase C δ in v-Src-transformed Fibroblasts

Zang, Q. S., Lu, Z., Curto, M., Barile, N., Shalloway, D. I., & Foster, D. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.13275 · Cited by 90

Reduction of PKCα decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma

Wu, T., Hsieh, Y., Hsieh, Y., & Liu, J.-Y. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21378 · Cited by 89

Regulation of Monocyte Apoptosis by the Protein Kinase Cδ-dependent Phosphorylation of Caspase-3

Voss, O. H., Kim, S., Wewers, M. D., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412449200 · Cited by 89

Activation of protein kinase Cα inhibits growth of pancreatic cancer cells via p21cip-mediated G1 arrest

Detjen, K. M., Brembeck, F. H., Welzel, M., Kaiser, A., Haller, H. G., Wiedenmann, B. J., & Rosewicz, S. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.17.3025 · Cited by 87

Lining the pockets of kinases and phosphatases

Gold, M. G., Barford, D., & Komander, D. (2006) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2006.10.006 · Cited by 85

Inhibition of Insulin-like Growth Factor-I-mediated Cell Signaling by the von Hippel-Lindau Gene Product in Renal Cancer

Datta, K., Nambudripad, R., Pal, S., Zhou, M., Cohen, H. T., & Mukhopadhyay, D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909970199 · Cited by 84

Activation of Atypical Protein Kinase C ζ by Caspase Processing and Degradation by the Ubiquitin-Proteasome System

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Involvement of the ERK Signaling Cascade in Protein Kinase C-mediated Cell Cycle Arrest in Intestinal Epithelial Cells

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Requirements of Protein Kinase Cδ for Catalytic Function

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Protein Kinase C-mediated Down-regulation of Cyclin D1 Involves Activation of the Translational Repressor 4E-BP1 via a Phosphoinositide 3-Kinase/Akt-independent, Protein Phosphatase 2A-dependent Mechanism in Intestinal Epithelial Cells

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Activation of SAPK/JNK Signaling by Protein Kinase Cδ in Response to DNA Damage

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Protein kinase Cε is oncogenic in colon epithelial cells by interaction with the ras signal transduction pathway

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Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells

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Protein Kinase C-δ Is an Important Signaling Molecule in Insulin-Like Growth Factor I Receptor-Mediated Cell Transformation

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Identification of Serine 643 of Protein Kinase C-δ as an Important Autophosphorylation Site for Its Enzymatic Activity

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Protein Kinase Cζ Abrogates the Proapoptotic Function of Bax through Phosphorylation

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siRNA agents inhibit oncogene expression and attenuate human tumor cell growth

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Involvement of Protein Kinase Cε (PKCε) in Thyroid Cell Death

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S-Phase-specific Activation of PKCα Induces Senescence in Non-small Cell Lung Cancer Cells

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PKC α mediates chemoresistance in acute lymphoblastic leukemia through effects on Bcl2 phosphorylation

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Evidence That Protein Kinase Cε Mediates Phorbol Ester Inhibition of Calphostin C- and Tumor Necrosis Factor-α-induced Apoptosis in U937 Histiocytic Lymphoma Cells

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The link between PKCα regulation and cellular transformation

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Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-α delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas

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Induction of p53-Dependent, Insulin-Like Growth Factor-Binding Protein-3-Mediated Apoptosis in Glioblastoma Multiforme Cells by a Protein Kinase Cα Antisense Oligonucleotide

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Bax Activation and Induction of Apoptosis in Human Keratinocytes by the Protein Kinase C δ Catalytic Domain

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Protein Kinase Cζ Is Up-regulated in Osteoarthritic Cartilage and Is Required for Activation of NF-κB by Tumor Necrosis Factor and Interleukin-1 in Articular Chondrocytes

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The proapoptotic tumor suppressor protein kinase C-δ is lost in human squamous cell carcinomas

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Flow Antagonizes TNF-&agr; Signaling in Endothelial Cells by Inhibiting Caspase-Dependent PKC&zgr; Processing

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Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest

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Antisense Targeting Protein Kinase C α and β1 Inhibits Gastric Carcinogenesis

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Protein Kinase Cδ Regulates Apoptosis via Activation of STAT1

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HSP25 Inhibits Protein Kinase Cδ-mediated Cell Death through Direct Interaction

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Protein kinase Cε interacts with Stat3 and regulates its activation that is essential for the development of skin cancer

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A Protein Kinase Cε-Anti-apoptotic Kinase Signaling Complex Protects Human Vascular Endothelial Cells against Apoptosis through Induction of Bcl-2

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Isozyme-Specific Inhibitors and Activators of Protein Kinase C

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The Protein Kinase Cδ Catalytic Fragment Targets Mcl-1 for Degradation to Trigger Apoptosis

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Protein Kinase C and Prostate Carcinogenesis: Targeting the Cell Cycle and Apoptotic Mechanisms

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Suppression of cell migration by protein kinase Cδ

Jackson, D. N., Yang, Z., Lyo, D., Shen, Y., Nakayama, K., Nakayama, K., Humphries, M. J., Reyland, M. E., & Foster, D. A. (2005) · Oncogene · doi:10.1038/sj.onc.1208465 · Cited by 54

Roles of Protein Kinase C δ in the Accumulation of P53 and the Induction of Apoptosis in H 2 O 2 -treated Bovine Endothelial Cells

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Inhibition of PKCα induces a PKCδ-dependent apoptotic program in salivary epithelial cells

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Protein Kinase C α Signaling Inhibits Cyclin D1 Translation in Intestinal Epithelial Cells

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Analysis of protein kinase C delta (PKCδ) expression in endometrial tumors

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Subversion of Protein Kinase Cα Signaling in Hematopoietic Progenitor Cells Results in the Generation of a B-Cell Chronic Lymphocytic Leukemia–Like Population In vivo

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Regulation of tumor invasion and metastasis in protein kinase C epsilon‐transformed NIH3T3 fibroblasts

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Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C α activity

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A Protective Role of PKCϵ against TNF-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis in Glioma Cells

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Atypical protein kinase C zeta as a target for chemosensitization of tumor cells.

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Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2

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Overexpression of the Atypical Protein Kinase C ζ Reduces Topoisomerase II Catalytic Activity, Cleavable Complexes Formation, and Drug-induced Cytotoxicity in Monocytic U937 Leukemia Cells

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p38 kinase mediates nitric oxide-induced apoptosis of chondrocytes through the inhibition of protein kinase C ζ by blocking autophosphorylation

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Randomized phase II evaluation of aprinocarsen in combination with gemcitabine and cisplatin for patients with advanced/metastatic non-small cell lung cancer

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Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

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