The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Mechanism of cytokine modulation of epithelial tight junction barrier
Open accessAbstract
Cytokines play a crucial role in the modulation of inflammatory response in the gastrointestinal tract. Pro-inflammatory cytokines including tumor necrosis factor-alpha, interferon-gamma, interleukin-1beta?IL-1beta?, and interleukin-12 are essential in mediating the inflammatory response, while anti-inflammatory cytokines including interleukin-10 and transforming growth factor-beta are important in the attenuation or containment of inflammatory process. It is increasingly recognized that cytokines have an important physiological and pathological effect on intestinal tight junction (TJ) barrier. Consistent with their known pro-inflammatory activities, pro-inflammatory cytokines cause a disturbance in intestinal TJ barrier, allowing increased tissue penetration of luminal antigens. Recent studies indicate that the inhibition of cytokine induced increase in intestinal TJ permeability has an important protective effect against intestinal mucosal damage and development of intestinal inflammation. In this review, the effects of various pro-inflammatory and anti-inflammatory cytokines on intestinal TJ barrier and the progress into the mechanisms that mediate the cytokine modulation of intestinal TJ barrier are reviewed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
IL-1β Causes an Increase in Intestinal Epithelial Tight Junction Permeability
Al-Sadi, R. M., & Ma, T. Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4641 · Cited by 601
Self-citationMa, T. Y., Boivin, M. A., Ye, D., Pedram, A., & Said, H. M. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2004 · Cited by 452
Gwee, K.-A. (2003) · Gut · doi:10.1136/gut.52.4.523 · Cited by 415
Leaks in the epithelial barrier caused by spontaneous and TNF‐α‐induced single‐cell apoptosis
Gitter, A. H., Bendfeldt, K., Schulzke, J.-D., & Fromm, M. (2000) · The FASEB Journal · doi:10.1096/fj.99-0898com · Cited by 250
Ivanov, A. I., Nusrat, A., & Parkos, C. A. (2004) · Novartis Foundation Symposia · doi:10.1002/0470090480.ch9 · Cited by 103
YAMAGATA, K., TAGAMI, M., TAKENAGA, F., YAMORI, Y., & ITOH, S. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.08.001 · Cited by 73
Cited by
Nazli, A., Chan, O., Dobson-Belaire, W. N., Ouellet, M., Tremblay, M. J., Gray-Owen, S. D., Arsenault, A. L., & Kaushic, C. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000852 · Cited by 593
IL-1β and the Intestinal Epithelial Tight Junction Barrier
Kaminsky, L. W., Al-Sadi, R., & Ma, T. Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767456 · Cited by 432
Self-citationOccludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
Al-Sadi, R., Khatib, K., Guo, S., Ye, D., Youssef, M., & Ma, T. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00055.2011 · Cited by 417
Self-citationAge-Associated Remodeling of the Intestinal Epithelial Barrier
Tran, L., & Greenwood-Van Meerveld, B. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt106 · Cited by 320
Martín, R., Miquel, S., Chain, F., Natividad, J. M., Jury, J., Lu, J., Sokol, H., Theodorou, V., Bercik, P., Verdu, E. F., et al. (2015) · BMC Microbiology · doi:10.1186/s12866-015-0400-1 · Cited by 309
Metadata
- Authors
- Al-Sadi, R.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2009
- Volume
- Volume
- Issue
- 14
- Pages
- 2765
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/3413
- OpenAlex
- W2004633453
- Cited by
- 647
- References
- 8
- FWCI
- 10.64
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mechanism of cytokine modulation of epithelial tight junction barrier. https://app.cochat.ai/papers/10.2741/3413
- The paper
- Al-Sadi, R. (2009). Mechanism of cytokine modulation of epithelial tight junction barrier. Frontiers in Bioscience. https://doi.org/10.2741/3413
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
