The DOI matches its Crossref record; 183 of the 183 references it cites were found in a registry or an index.
Targeting the AMPK pathway for the treatment of Type 2 diabetes
Open accessAbstract
Type 2 diabetes is one of the fastest growing public health problems worldwide, resulting from both genetic factors and inadequate adaptation to environmental changes. It is characterized by abnormal glucose and lipid metabolism due in part to resistance to the actions of insulin in skeletal muscle, liver and fat. AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine protein kinase, acts as an integrator of regulatory signals monitoring systemic and cellular energy status. The growing realization that AMPK regulates the coordination of anabolic and catabolic metabolic processes represents an attractive concept for type 2 diabetes therapy. Recent findings showing that pharmacological activation of AMPK improves blood glucose homeostasis, lipid profile and blood pressure in insulin-resistant rodents suggest that this kinase could be a novel therapeutic target in the treatment of type 2 diabetes. Consistent with these results, physical exercise and major classes of antidiabetic drugs have recently been reported to activate AMPK. In the present review, we update these topics and discuss the concept of targeting the AMPK pathway for the treatment of type 2 diabetes.
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1 retracted
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Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy
Knapp, M., Tu, X., & Wu, R. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0042-6 · Cited by 328
Diabetes and Alpha Lipoic Acid
Golbidi, S., Badran, M., & Laher, I. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00069 · Cited by 270
Exercise sustains the hallmarks of health
Qiu, Y., Fernández-García, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otín, C., & Xiao, J. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.10.003 · Cited by 270
Mahapatra, D. K., Asati, V., & Bharti, S. K. (2015) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2015.01.051 · Cited by 253
Eid, H. M., Martineau, L. C., Saleem, A., Muhammad, A., Vallerand, D., Benhaddou-Andaloussi, A., Nistor, L., Afshar, A., Arnason, J. T., & Haddad, P. S. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900218 · Cited by 218
Metadata
- Authors
- Viollet, B.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2009
- Volume
- Volume
- Issue
- 14
- Pages
- 3380
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/3460
- OpenAlex
- W2007415406
- Cited by
- 278
- References
- 183
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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