The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Signaling through protein kinase C
Open accessAbstract
Protein kinase C (PKC) comprises a large family of serine/threonine kinases which are activated by many extracellular signals. Inside the cell, PKCs are regulated by a variety of lipid second messengers, including the ubiquitous diacylglycerol and phosphatidylserine. Phosphorylation has also emerged as an important mechanism of regulation of all PKCs. Work in the last 20 years has provided evidence that these enzymes are involved in a multitude of physiological processes. Similarly, a number of proteins which are phosphorylated by PKCs have also been discovered and their role in cell biology has been investigated. More recently, there has been considerable interest in a number of specific PKC isoforms and their role in signaling pathways in the cell. This review will focus on recent findings on the mechanism of regulation of PKCepsilon, PKCmu and PKCzeta, and how these enzymes regulate cell growth, the actin cytoskeleton, apoptosis and other biological functions.
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Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., & Nishizuka, Y. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34459-4 · Cited by 4,725
Protein kinase C and lipid signaling for sustained cellular responses
Nishizuka, Y. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737456 · Cited by 2,499
Taxonomy and function of C1 protein kinase C homology domains
Hurley, J. H., Newton, A. C., Parker, P. J., Blumberg, P. M., & Nishizuka, Y. (1997) · Protein Science · doi:10.1002/pro.5560060228 · Cited by 362
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Newton, A. C. (2001) · Chemical Reviews · doi:10.1021/cr0002801 · Cited by 962
Protein Kinases and Phosphatases in the Control of Cell Fate
Bononi, A., Agnoletto, C., De Marchi, E., Marchi, S., Patergnani, S., Bonora, M., Giorgi, C., Missiroli, S., Poletti, F., Rimessi, A., et al. (2011) · Enzyme Research · doi:10.4061/2011/329098 · Cited by 285
GnRH signaling, the gonadotrope and endocrine control of fertility
Bliss, S. P., Navratil, A. M., Xie, J., & Roberson, M. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.04.002 · Cited by 259
Perspectives for mass spectrometry and functional proteomics
Godovac-Zimmermann, J., & Brown, L. R. (2001) · Mass Spectrometry Reviews · doi:10.1002/1098-2787(2001)20:1<1::aid-mas1001>3.0.co;2-j · Cited by 264
Metadata
- Authors
- Toker, A.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 1998
- Volume
- 3
- Issue
- 4
- Pages
- d1134-1147
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/a350
- OpenAlex
- W93019692
- Cited by
- 322
- References
- 3
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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