Role of cytokines in the endometrial-peritoneal cross-talk and development of endometriosis

Kyama, Cleophas M

doi:10.2741/e40

Cited by 65Endometriosis Research and TreatmentIntestinal and Peritoneal AdhesionsEctopic Pregnancy Diagnosis and Management

Role of cytokines in the endometrial-peritoneal cross-talk and development of endometriosis

Kyama, Cleophas M·2009·Frontiers in Bioscience

DOI 10.2741/e40

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Abstract

A clear picture of the dynamic relationship between the endometrium and peritoneum is emerging as both tissues may participate in the spontaneous development of endometriosis. Various adhesion molecules, pro-inflammatory cytokines and chemoattractants cytokines have emerged as central coordinators of endometrial-peritoneal interactions. The peritoneal microenvironment which consists of the peritoneal fluid, normal peritoneum and peritoneal endometriotic lesions may play an active role in the pathogenesis of endometriosis, by harbouring most inflammatory responses that are triggered by the presence of endometrial cells, leading to recruitment of activated macrophages and leukocytes locally. Menstrual endometrium has the ability to bond and invade the peritoneal tissue. In baboons intrapelvic injection of menstrual endometrium permits the study of early endometrial-peritoneal interaction in an in vivo culture microenvironment and can lead to important insight in the early development of endometriotic lesions. In this review, we discuss the roles of the endometrial-peritoneal interactions, not only in disease development but also in the broader process of aetiopathogenesis.

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Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of many different cytokines and angiogenic factors.
“Pelvic endometriosis is associated with a low-grade inflammation of the peritoneal cavity with higher concentrations of activated macrophages and thus with higher concentrations of the many different cytokines (68-72) and angiogenic factors (73)(74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [72]

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Authors: Kyama, C. M.
Affiliations: Universitair Ziekenhuis Leuven (BE)
Corresponding author: Kyama, Cleophas M
ORCID: Kyama, Cleophas M
Venue: Frontiers in Bioscience
Publisher: IMR Press
Published: 2009
Volume: E1
Issue: 2
Pages: 444-454
ISSN: 1944-7892 (ISSN-L)
1945-0494
1945-0508
DOI: 10.2741/e40
OpenAlex: W33495223
Cited by: 64
References: 0
Citations by year: 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 4 · 2012: 5
FWCI: 5.50
Type: journal article
Language: en
Open access: closed
Locations: Frontiers in Bioscience-Elite (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
Keywords: endometriosis, inflammatory cytokines, chemokines, adhesion molecules, peritoneal microenvironment, endometrial invasion, macrophage recruitment, leukocyte recruitment, endometrium, baboon model
MeSH terms: Endometriosis, Endometrium, Female, Humans, Peritoneum, Signal Transduction, Integrins, Cytokines, Hyaluronan Receptors, Receptor Cross-Talk, Matrix Metalloproteinases

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Role of cytokines in the endometrial-peritoneal cross-talk and development of endometriosis

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