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Cited by 170Antibiotic Resistance in BacteriaAntibiotic Use and ResistanceSalmonella and Campylobacter epidemiology

Sharing more than friendship – transmission of NDM-5 ST167 and CTX-M-9 ST69 Escherichia coli between dogs and humans in a family, Finland, 2015

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Grönthal, Thomas, Österblad, Monica, Eklund, Marjut, Jalava, Jari, Nykäsenoja, Suvi, Pekkanen, Katariina, Rantala, Merja·2018·Eurosurveillance
DOI 10.2807/1560-7917.es.2018.23.27.1700497PMC PMC6152158
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Abstract

Introduction: Carbapenemase-producing Enterobacteriaceae (CPE) have rarely been reported in dogs, and never in animals in Finland. However, in April 2015, two meropenem-resistant Escherichia coli were identified from two dogs in one family. Both dogs suffered from chronic otitis externa . Methods: Epidemiological and molecular investigations (pulsed-field gel electrophoresis (PFGE), multilocus sequence typing) were conducted to investigate the source of infection and transmission routes. Results: In both dogs and one family member New Delhi metallo-beta-lactamase (NDM-5)-producing multidrug-resistant ST167 E. coli was found. Whole genome sequencing confirmed that the isolates were identical or only had one or two allelic differences. Additionally, the dogs and humans of the family carried an identical extended-spectrum beta-lactamase (ESBL) CTX-M-group 9 E. coli ST69 strain, indicating interspecies transmission. While the original source remains unclear, human-to-canine transmission is possible. No carbapenems had been administered to the dogs, but exposure to numerous other antimicrobials likely sustained the bacteria and supported its propagation in the canine host. Conclusion: To our knowledge, canine clinical NDM-5 E. coli in Europe, and confirmed CPE transmission between dogs and humans have not been previously reported. The screening of veterinary Enterobacteriaceae isolates for carbapenem resistance is highly recommended.

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  • Dog owners who did not consider obesity to be a disease were more likely to have obese dogs.

    “Dog owners who did not consider obesity to be a disease, maybe because the facial features of their pets fit the concept of baby schema [87], were more likely to have obese dogs [97].”

    From A One Health Perspective on the Human-Companion Animal Relationship with Emphasis on Zoonotic Aspects. (2020) · cites this paper as [97]

    The Results (Epidemiological investigation and Case presentations; page unavailable) describe two dogs, their owners, and the dogs’ ear infections. The Discussion addresses antibiotic-resistant E. coli transmission. Searches for obesity as a disease and for owners’ perceptions of canine weight found no passage addressing the claimed association. (LLM, conf=0.78)

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Authors
Grönthal, T., Österblad, M., Eklund, M., Jalava, J., Nykäsenoja, S., Pekkanen, K., & Rantala, M.
Affiliations
  • University of Helsinki (FI)
  • Finnish Institute for Health and Welfare (FI)
  • Herttoniemi Hospital (FI)
ORCID
Venue
Eurosurveillance
Publisher
European Centre for Disease Control and Prevention (ECDC)
Published
2018-07-05
Volume
23
Issue
27
ISSN
  • 1025-496X (ISSN-L)
  • 1560-7917
DOI
10.2807/1560-7917.es.2018.23.27.1700497
PMC
PMC6152158
OpenAlex
W2824121307
Cited by
170
References
3
Citations by year
2026: 5 · 2025: 21 · 2024: 33 · 2023: 19 · 2022: 36 · 2021: 19 · 2020: 22 · 2019: 12 · 2018: 3
FWCI
5.29
Type
journal article
Language
en
Open access
Licence
Locations
  • Eurosurveillance (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Työväentutkimus Vuosikirja (submittedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
  • WOS
Funders
  • Helsingin Yliopisto
  • Alfred Kordelinin Säätiö
  • Suomen Kulttuurirahasto
  • Eläinlääketieteen Tutkimuksen Tukisäätiö
  • Suomen Eläinlääketieteen Säätiö
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
Keywords
carbapenemase-producing Enterobacteriaceae, New Delhi metallo-beta-lactamase, CTX-M-9, interspecies transmission, dogs, chronic otitis externa, antimicrobial resistance, extended-spectrum beta-lactamase, family outbreak, Finland
MeSH terms
Whole Genome Sequencing, Animals, beta-Lactamases, Dogs, Escherichia coli, Escherichia coli Infections, Finland, Humans, Carbapenems, Polymerase Chain Reaction, Electrophoresis, Gel, Pulsed-Field, Friends, Pets, Multilocus Sequence Typing

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