Cited by 214Medical Imaging Techniques and ApplicationsRadiomics and Machine Learning in Medical ImagingLung Cancer Diagnosis and Treatment

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Repeatability of SUV in Oncologic 18F-FDG PET

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Lodge, Martin A.·2017·Journal of Nuclear Medicine

DOI 10.2967/jnumed.116.186353PMC PMC5373499

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Abstract

F-FDG PET. Growing literature suggests that the difference between SUVs measured before and after treatment can be used to predict tumor response at an early stage. SUV is, however, associated with multiple sources of variability, and to best use SUV for response assessment, an understanding of the repeatability of the technique is required. Test-retest studies involve repeated scanning of the same patient on the same scanner using the same protocol no more than a few days apart and provide basic information on the repeatability of the technique. Multiple test-retest studies have been performed to assess SUV repeatability, although a comparison of reports is complicated by the use of different methodologies and statistical metrics. This article reviews the available data, addressing issues such as different repeatability metrics, relative units, log transformation, and asymmetric limits of repeatability. When acquired with careful attention to protocol, tumor SUV has a within-subject coefficient of variation of approximately 10%. In a response assessment setting, SUV reductions of more than 25% and increases of more than 33% are unlikely to be due to measurement variability. Broader margins may be required for sites with less rigorous protocol compliance, but in general, SUV is a highly repeatable imaging biomarker that is ideally suited to monitoring tumor response to treatment in individual patients.

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Authors: Lodge, M. A.
Affiliations: Johns Hopkins University (US)
Corresponding author: Lodge, Martin A.
ORCID: Lodge, Martin A.
Venue: Journal of Nuclear Medicine
Publisher: Society of Nuclear Medicine
Published: 2017-02-23
Volume: 58
Issue: 4
Pages: 523-532
ISSN: 0161-5505 (ISSN-L)
2159-662X
DOI: 10.2967/jnumed.116.186353
PMC: PMC5373499
OpenAlex: W2590848133
Cited by: 214
References: 47
Citations by year: 2026: 26 · 2025: 21 · 2024: 31 · 2023: 14 · 2022: 18 · 2021: 23 · 2020: 23 · 2019: 23 · 2018: 21 · 2017: 14
FWCI: 3.35
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Nuclear Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Radiological Society of North America (HHSN268201300071C)
Society of Nuclear Medicine and Molecular Imaging
National Institutes of Health (HHSN268201300071C)
National Cancer Institute (U01CA140204)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
Keywords: standardized uptake value, 18F-FDG PET, test-retest repeatability, tumor response assessment, within-subject coefficient of variation, imaging biomarkers, treatment response monitoring, logarithmic transformation, tumor imaging
MeSH terms: Biological Transport, Humans, Neoplasms, Reproducibility of Results, Fluorodeoxyglucose F18, Positron-Emission Tomography

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Repeatability of SUV in Oncologic 18F-FDG PET

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