The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
First Human Imaging Studies with the EXPLORER Total-Body PET Scanner*
Open accessAbstract
Within the EXPLORER Consortium, the construction of the world’s first total-body PET/CT scanner has recently been completed. The 194-cm axial field of view of the EXPLORER PET/CT scanner is sufficient to cover, for the first time, the entire human adult body in a single acquisition in more than 99% of the population and allows total-body pharmacokinetic studies with frame durations as short as 1 s. The large increase in sensitivity arising from total-body coverage as well as increased solid angle for detection at any point within the body allows whole-body 18F-FDG PET studies to be acquired with unprecedented count density, improving the signal-to-noise ratio of the resulting images. Alternatively, the sensitivity gain can be used to acquire diagnostic PET images with very small amounts of activity in the field of view (25 MBq, 0.7 mCi or less), with very short acquisition times (∼1 min or less) or at later time points after the tracer’s administration. We report here on the first human imaging studies on the EXPLORER scanner using a range of different protocols that provide initial evidence in support of these claims. These case studies provide the foundation for future carefully controlled trials to quantitatively evaluate the improvements possible through total-body PET imaging.
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Cherry, S. R., Jones, T., Karp, J. S., Qi, J., Moses, W. W., & Badawi, R. D. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.184028 · Cited by 763
Self-citationRadiation exposure of patients undergoing whole-body dual-modality 18F-FDG PET/CT examinations.
Brix, G., Lechel, U., Glatting, G., Ziegler, S. I., Münzing, W., Müller, S. P., & Beyer, T. (2005) · PubMed · Cited by 458
Total-body imaging: Transforming the role of positron emission tomography
Cherry, S. R., Badawi, R. D., Karp, J. S., Moses, W. W., Price, P., & Jones, T. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6169 · Cited by 251
Self-citationPoon, J. K., Dahlbom, M. L., Moses, W. W., Balakrishnan, K., Wang, W., Cherry, S. R., & Badawi, R. D. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/13/4077 · Cited by 129
Self-citationAyati, N., Lee, S. T., Zakavi, S. R., Pathmaraj, K., Al-Qatawna, L., Poon, A. M. T., & Scott, A. M. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.192203 · Cited by 61
Lv, Y., Lv, X., Liu, W., Judenhofer, M. S., Zwingenberger, A. L., Wisner, E. R., Berg, E., McKenney, S. E., Leung, E. K., Spencer, B. A., et al. (2019) · Physics in Medicine and Biology · doi:10.1088/1361-6560/aafc6c · Cited by 50
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Spencer, B. A., Berg, E., Schmall, J. P., Omidvari, N., Leung, E. K., Abdelhafez, Y. G., Tang, S., Deng, Z., Dong, Y., Lv, Y., et al. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.120.250597 · Cited by 403
Self-citationAdvances in PET imaging of cancer
Schwenck, J., Sonanini, D., Cotton, J. M., Rammensee, H.-G., la Fougère, C., Zender, L., & Pichler, B. J. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-023-00576-4 · Cited by 312
Radiolabelling of nanomaterials for medical imaging and therapy
Pellico, J., Gawne, P. J., & T. M. de Rosales, R. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00384k · Cited by 304
Roadmap toward the 10 ps time-of-flight PET challenge
Lecoq, P., Morel, C., Prior, J. O., Visvikis, D., Gundacker, S., Auffray, E., Križan, P., Turtos, R. M., Thers, D., Charbon, E., et al. (2020) · Physics in Medicine & Biology · doi:10.1088/1361-6560/ab9500 · Cited by 258
Zhang, Y.-Q., Hu, P.-C., Wu, R.-Z., Gu, Y.-S., Chen, S.-G., Yu, H.-J., Wang, X.-Q., Song, J., & Shi, H.-C. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-04823-w · Cited by 123
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Metadata
- Authors
- Badawi, R. D., Shi, H., Hu, P., Chen, S., Xu, T., Price, P. M., Ding, Y., Spencer, B. A., Nardo, L., Liu, W., Bao, J., Jones, T., Li, H., & Cherry, S. R.
- Venue
- Journal of Nuclear Medicine
- Publisher
- Society of Nuclear Medicine
- Published
- 2019-02-07
- Volume
- 60
- Issue
- 3
- Pages
- 299-303
- ISSN
- 0161-5505 (ISSN-L)
- 2159-662X
- OpenAlex
- W2914020168
- Cited by
- 722
- References
- 6
- FWCI
- 55.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Badawi, R. D., Shi, H., Hu, P., Chen, S., Xu, T., Price, P. M., Ding, Y., Spencer, B. A., Nardo, L., Liu, W., Bao, J., Jones, T., Li, H., & Cherry, S. R. (2019). First Human Imaging Studies with the EXPLORER Total-Body PET Scanner*. Journal of Nuclear Medicine. https://doi.org/10.2967/jnumed.119.226498
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