Sequential clomiphene citrate-menotropin therapy for induction or enhancement of ovulation
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Either to induce ovulation in anovulatory infertility patients or to enhance ovulation in patients with mild endometriosis or luteal phase inadequacy, we utilized a sequential regimen of low-dose clomiphene citrate (CC) followed by human menopausal gonadotropin (hMG) injections on alternate days; duration and dosage of menotropin therapy was individualized by using serum estradiol levels for monitoring until the time of administration of human chorionic gonadotropins. Previous therapeutic efforts without menotropins had been unsuccessful in all patients. One third of 70 treated patients conceived during 156 treatment cycles. The pregnancy rate was 44% in anovulatory patients (n = 34), and 26% in patients with ovulation dysfunction (n = 23). Pregnancy rates declined with patient's age. Four of the 23 patients that conceived had a spontaneous abortion (17%). The multiple gestation rate was 10.5%. A relative inhibition of cervical mucus development was noted and shown to be caused by CC. Hyperstimulation occurred in three patients. The discussed CC-hMG regimen approaches the effectiveness of standard hMG therapy; but compared with standard hMG therapy, it has significant economic advantages and seems to have a markedly lower rate of multiple gestation. However, like standard hMG therapy, CC-hMG therapy requires careful monitoring specifically, because hyperstimulation may occur.
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The gonadotropin requirement can be significantly reduced by combining gonadotropin treatment with clomiphene citrate.
“The gonadotropin requirement can be significantly reduced by combining this treatment with clomiphene citrate (9).”
From Effects of letrozole on superovulation with gonadotropins in women undergoing intrauterine insemination (2003) · cites this paper as [9]
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- Authors
- Kemmann, E., & Jones, J. R.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- ORCID
- Jones, James R.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1983-06
- Volume
- 39
- Issue
- 6
- Pages
- 772-779
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2409036192
- Cited by
- 31
- References
- 20
- Citations by year
- 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- clomiphene citrate, human menopausal gonadotropin, anovulatory infertility, endometriosis, ovulatory dysfunction, pregnancy rate, multiple pregnancy, miscarriage, ovarian hyperstimulation, estradiol monitoring, cost-effectiveness
- MeSH terms
- Adult, Cervix Mucus, Clomiphene, Drug Administration Schedule, Drug Therapy, Combination, Estradiol, Female, Chorionic Gonadotropin, Humans, Menotropins, Ovulation, Ovulation Induction
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