Cited by 31Reproductive Health and TechnologiesOvarian function and disordersReproductive Biology and Fertility

Sequential clomiphene citrate-menotropin therapy for induction or enhancement of ovulation

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Kemmann, Ekkehard, Jones, James R.·1983·Fertility and Sterility

Abstract

Either to induce ovulation in anovulatory infertility patients or to enhance ovulation in patients with mild endometriosis or luteal phase inadequacy, we utilized a sequential regimen of low-dose clomiphene citrate (CC) followed by human menopausal gonadotropin (hMG) injections on alternate days; duration and dosage of menotropin therapy was individualized by using serum estradiol levels for monitoring until the time of administration of human chorionic gonadotropins. Previous therapeutic efforts without menotropins had been unsuccessful in all patients. One third of 70 treated patients conceived during 156 treatment cycles. The pregnancy rate was 44% in anovulatory patients (n = 34), and 26% in patients with ovulation dysfunction (n = 23). Pregnancy rates declined with patient's age. Four of the 23 patients that conceived had a spontaneous abortion (17%). The multiple gestation rate was 10.5%. A relative inhibition of cervical mucus development was noted and shown to be caused by CC. Hyperstimulation occurred in three patients. The discussed CC-hMG regimen approaches the effectiveness of standard hMG therapy; but compared with standard hMG therapy, it has significant economic advantages and seems to have a markedly lower rate of multiple gestation. However, like standard hMG therapy, CC-hMG therapy requires careful monitoring specifically, because hyperstimulation may occur.

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Crossref · 10.1016/s0015-0282(16)47116-5

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Authors
Kemmann, E., & Jones, J. R.
Affiliations
Rutgers, The State University of New Jersey (US)
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
1983-06
Volume
39
Issue
6
Pages
772-779
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2409036192
Cited by
31
References
20
Citations by year
2015: 1 · 2014: 1 · 2013: 1
FWCI
2.04
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
clomiphene citrate, human menopausal gonadotropin, anovulatory infertility, endometriosis, ovulatory dysfunction, pregnancy rate, multiple pregnancy, miscarriage, ovarian hyperstimulation, estradiol monitoring, cost-effectiveness
MeSH terms
Adult, Cervix Mucus, Clomiphene, Drug Administration Schedule, Drug Therapy, Combination, Estradiol, Female, Chorionic Gonadotropin, Humans, Menotropins, Ovulation, Ovulation Induction

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