Muscle Glycogen Synthetase in Normal Subjects: Basal Values, Effect of Glycogen Depletion by Exercise and of a Carbohydrate-Rich Diet Following Exercise

Bergström, J.; Hultman, E.; Roch-Norlund, A. E.

doi:10.3109/00365517209081080

Cited by 99Metabolism, Diabetes, and CancerGlycogen Storage Diseases and MyoclonusMuscle metabolism and nutrition

Muscle Glycogen Synthetase in Normal Subjects: Basal Values, Effect of Glycogen Depletion by Exercise and of a Carbohydrate-Rich Diet Following Exercise

Bergström, J., Hultman, E., Roch-Norlund, A. E.·1972·Scandinavian Journal of Clinical and Laboratory Investigation

DOI 10.3109/00365517209081080

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Abstract

The relationship between muscle glycogen level and glycogen synthetase activity was studied in normal man. Under basal conditions 27% of the total activity was in the I form. Lowering glycogen by exercise increased I activity to 75%. As glycogen increased back to basal level during carbohydrate feeding, I activity decreased to 25%. Increase of glycogen above normal level did not further affect I activity. Total activity remained unchanged. An inverse relationship between glycogen level and per cent I activity was established in human muscle.

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Because 1 g of glycogen is stored in muscle with 3-5 g of water, an athlete's BM typically increases 1-2% after several days of CHO-loading.
“Because 1 g of glycogen is stored in muscle with 3-5 g of water (76, 98), an athlete's BM typically increases 1-2% after several days of 'CHO-loading' (12).”
From Postexercise muscle glycogen resynthesis in humans. (2017) · cites this paper as [12]
The resting muscle glycogen content of an untrained person consuming a mixed diet is ~80-85 mmol/kg of muscle wet weight and somewhat higher at ~120 mmol/kg w.w. for individuals undertaking regular endurance type exercise training.
“The resting muscle glycogen content of an untrained person consuming a mixed diet is ~80-85 mmol/kg of muscle wet weight (w.w.) and somewhat higher at ~120 mmol/kg w.w. for individuals undertaking regular endurance type exercise training (12).”
From Postexercise muscle glycogen resynthesis in humans. (2017) · cites this paper as [12]

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Authors: Bergström, J., Hultman, E., & Roch-Norlund, A. E.
Affiliations: Ersta sjukhus (SE)
ORCID: Bergström, J.
Venue: Scandinavian Journal of Clinical and Laboratory Investigation
Publisher: Informa UK Limited
Published: 1972-01
Volume: 29
Issue: 2
Pages: 231-236
ISSN: 0036-5513 (ISSN-L)
1502-7686
DOI: 10.3109/00365517209081080
OpenAlex: W2012716400
Cited by: 99
References: 24
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 1
FWCI: 1.17
Type: journal article
Language: en
Open access: closed
Locations: Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: glycogen synthase, muscle glycogen, enzyme activity, physical activity, carbohydrate feeding, skeletal muscle
MeSH terms: Adult, Biopsy, Carbon Isotopes, Dietary Carbohydrates, Physical Exertion, Glucosyltransferases, Glycogen, Humans, Muscles, Time Factors

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Muscle Glycogen Synthetase in Normal Subjects: Basal Values, Effect of Glycogen Depletion by Exercise and of a Carbohydrate-Rich Diet Following Exercise

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