The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Circadian Variation of the Serum Thyrotropin Level in Normal Subjects
Abstract
A circadian rhythm of serum thyrotropin (TSH) has been demonstrated by measurements performed on half-hourly blood samples collected over a 24-hour period from 8 healthy young men and 5 healthy young women. The serum TSH level decreased from 8 a.m. to 11 a.m. There was a low level during the day-time with a mean serum TSH value of 0.85 μU/ml. The level increased in the evening between 8 p.m. and 11 p.m., and a higher TSH level was maintained during the night, with a mean value of 1.34 Ü/ml. The difference between day and night level was highly significant. There was no relation between the meals and the variation of the TSH level. The rise of serum TSH preceded the onset of sleep. The circadian rhythm of serum TSH is not only of physiological interest but has also the practical consequence that blood sample collection for TSH determinations is best performed at 11 a.m., when the TSH level has fallen to the day-time level.
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“The suprachiasmatic nucleus, which is considered to be the principal circadian pacemaker of the brain, is involved in the regulation of the circadian TSH rhythm (Mariotti and Beck-Peccoz, 2016;Weeke, 1973).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Weeke, 1973
In the citing paper
“However, TSH has a circadian rhythm with the highest and lowest levels between 02:00-04:00 h and 16:00-20:00H, respectively (Mariotti and Beck-Peccoz, 2016;Weeke, 1973).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Weeke, 1973
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The effects of dopamine, dopexamine and dobutamine on TSH secretion in healthy subjects
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Metadata
- Authors
- Weeke, J.
- Affiliations
- Aarhus Municipality (DK)
- Corresponding author
- Weeke, J.
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1973-01
- Volume
- 31
- Issue
- 3
- Pages
- 337-342
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2028796360
- Cited by
- 117
- References
- 22
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 1
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Keywords
- thyroid-stimulating hormone, circadian rhythm, serum TSH, diurnal variation, sleep onset, blood sampling timing, healthy volunteers
- MeSH terms
- Adult, Animals, Buffers, Cattle, Chloramines, Chromatography, Gel, Chromatography, Paper, Circadian Rhythm, Female, Humans, Immune Sera, Iodine Radioisotopes, Isotope Labeling, Male, Mercury, Methods, Organometallic Compounds, Rabbits, Radioimmunoassay, Serum Albumin, Bovine, Sulfites, Thyrotropin, Time Factors
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