The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Effect of Fiber Source on Short-Chain Fatty Acid Production and on the Growth and Toxin Production by Clostridium difficile
Abstract
BACKGROUND: Fermentable fiber promotes the growth of resident gut microbes, which modify the environment of the gastrointestinal tract and thus prevent colonization by Clostridium difficile. METHODS: An in vitro system with pigs as fecal inoculum donors was used to estimate fiber fermentability and changes in intestinal microbiota. RESULTS: Acetate and propionate production (mumol/mg substrate fermented/day) was greatest for gum arabic (1013.4 and 704.1, respectively); butyrate production was greatest for xylo-oligosaccharide (345.6). Growth of total anaerobes and clostridia was greatest for gum arabic (21.2 and 16.2 x 10(8) counts/ml, respectively) and xylo-oligosaccharides (21.0 and 19.6 x 10(8) respectively); growth of acidogenic bacteria was greatest with fructo-oligosaccharide (6.7 x 10(8) counts/ml). No culturable counts of C. difficile were obtained, nor was toxin A detected. CONCLUSIONS: Fermentable fibers support the growth of indigenous intestinal bacteria, particularly acidogenic bacteria, and yield large amounts of short-chain fatty acids with decreased gut pH. These factors contribute to the prevention of growth and toxin elaboration by C. difficile.
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Cites
A selective medium for the isolation and enumeration of oral and fecal lactobacilli
Rogosa, M., Mitchell, J. A., & Wiseman, R. F. (1951) · Journal of Bacteriology · doi:10.1128/jb.62.1.132-133.1951 · Cited by 653
Cited by
Campbell, J. M., Fahey, G. C., & Wolf, B. W. (1997) · The Journal of Nutrition · doi:10.1093/jn/127.1.130 · Cited by 719
Self-citationBiological effects of gum arabic: A review of some recent research
Ali, B. H., Ziada, A., & Blunden, G. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.07.001 · Cited by 486
Weingarden, A. R., Chen, C., Bobr, A., Yao, D., Lu, Y., Nelson, V. M., Sadowsky, M. J., & Khoruts, A. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00282.2013 · Cited by 423
Reeves, A. E., Koenigsknecht, M. J., Bergin, I. L., & Young, V. B. (2012) · Infection and Immunity · doi:10.1128/iai.00647-12 · Cited by 292
Yang, H.-T., Chen, J.-W., Rathod, J., Jiang, Y.-Z., Tsai, P.-J., Hung, Y.-P., Ko, W.-C., Paredes-Sabja, D., & Huang, I.-H. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02635 · Cited by 117
Metadata
- Authors
- May, T., Mackie, R. I., Fahey, G. C., Cremin, J. C., & Garleb, K. A.
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 1994-01
- Volume
- 29
- Issue
- 10
- Pages
- 916-922
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2132011434
- Cited by
- 160
- References
- 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- May, T., Mackie, R. I., Fahey, G. C., Cremin, J. C., & Garleb, K. A. (1994). Effect of Fiber Source on Short-Chain Fatty Acid Production and on the Growth and Toxin Production by Clostridium difficile. Scandinavian Journal of Gastroenterology. https://doi.org/10.3109/00365529409094863
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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