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Cited by 117Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsDiabetes Management and Research

Effects of hyperglycemia on interdigestive gastrointestinal motility in humans

Björnsson, E. S., Urbanavicius, V., Eliasson, B., Attvall, S., Smith, U., Abrahamsson, H.·1994·Scandinavian Journal of Gastroenterology
DOI 10.3109/00365529409094894
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Abstract

BACKGROUND: Gastrointestinal motility disorders are common in patients with diabetes mellitus. Recent studies indicate that hyperglycemia can affect gastric emptying and gastric motility in healthy subjects and diabetics. METHODS: The effect of acute hyperglycemia on gastrointestinal motility was studied with a manometric technique in healthy subjects. Seven individuals, four men and three women, 23-34 years old, were studied on 2 different days. On 1 of the days a 5-h registration was performed after an overnight fast. On another day and after an initial basal period, acute steady-state hyperglycemia was induced by intravenous glucose infusion for 90 min. Motility variables were evaluated in four segments: in the gastric antrum, the proximal duodenum, the distal duodenum, and the proximal jejunum. RESULTS: Fasting migrating motor complex rhythm including migration of phase III prevailed during hyperglycemia. Compared with euglycemia, the motility index in phase II was lower during hyperglycemia in all segments studied. In the antrum the difference was 62% (p < 0.01); in the proximal duodenum, 37% (p < 0.01); in the distal duodenum, 44% (p < 0.05); and in the jejunum, 58% (p < 0.01). During hyperglycemia the prevalence of propagated contractions in phase II was significantly lower than during euglycemia both in the antrum and the proximal duodenum. In the last part of phase III in proximal duodenum most individual contractions were propagated in orad direction compared with early phase III, and this difference persisted during hyperglycemia. The number of long clusters was significantly increased during hyperglycemia as compared with euglycemia: 2.0 +/- 0.6 per hour versus 0.4 +/- 0.14 (p < 0.01). In late phase II plasma levels of motilin and pancreatic polypeptide were significantly decreased during hyperglycemia. CONCLUSION: Hyperglycemia not only reduces the motility in the stomach but also inhibits motility in both the duodenum and the jejunum. The results show that acute hyperglycemia has an important impact on small-intestinal motility.

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Crossref · 10.3109/00365529409094894

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  • In critically ill patients, transit time is substantially slowed by various pathophysiological and therapeutic factors.

    “In critically ill patients, transit time is substantially slowed by various pathophysiological (glucose and electrolyte disturbances8,9 and endogenous opioid production) and therapeutic (sedatives, opiates, and systemic catecholamines21) factors.”

    From The microbiome and critical illness (2016) · cites this paper as [8]

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Authors
Björnsson, E. S., Urbanavicius, V., Eliasson, B., Attvall, S., Smith, U., & Abrahamsson, H.
Affiliations
Sahlgrenska University Hospital (SE)
ORCID
Venue
Scandinavian Journal of Gastroenterology
Publisher
Informa UK Limited
Published
1994-01
Volume
29
Issue
12
Pages
1096-1104
ISSN
  • 0036-5521 (ISSN-L)
  • 1502-7708
DOI
10.3109/00365529409094894
OpenAlex
W2040209960
Cited by
117
References
38
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 4 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 2 · 2013: 4 · 2012: 2
FWCI
3.26
Type
journal article
Language
en
Open access
closed
Locations
  • Scandinavian Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
hyperglycemia, gastrointestinal motility, interdigestive period, migrating motor complex, gastric antrum, duodenum, jejunum, motilin, pancreatic polypeptide, intravenous glucose infusion, diabetes mellitus
MeSH terms
Adult, Analysis of Variance, Female, Gastric Emptying, Gastrointestinal Motility, Humans, Hyperglycemia, Intestine, Small, Male, Motilin, Pyloric Antrum, Somatostatin, Glucose Clamp Technique

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