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Cited by 133Helicobacter pylori-related gastroenterology studiesGastrointestinal Bleeding Diagnosis and TreatmentIron Metabolism and Disorders

Reversal of Long-Standing Iron Deficiency Anaemia after Eradication of Helicobacter pylori Infection

Marignani, M., Angeletti, S., Bordi, C., Malagnino, F., Mancino, C., Fave, G. Delle, Annibale, B.·1997·Scandinavian Journal of Gastroenterology
DOI 10.3109/00365529709025109
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Abstract

Helicobacter pylori has been proposed as a major determinant in multiple gastric disorders. We describe the case of a young adult with a long-standing medical history of sideropenic anaemia and of oral iron consumption dependence with a chronic superficial H. pylori-positive gastritis. All other causes of sideropenic anaemia were carefully excluded. Histology showed a peculiar pattern of non-active H. pylori-positive gastritis. The bacterium was a non-VacA-producing strain. The first attempt at eradication caused a reduction in bacterial load and led to a partial normalization of haematologic variables without improving the ferritin level. A successful second course of eradication therapy completely reversed the anaemia and restored the iron deposit, which persisted at the 29-month follow-up. H. pylori infection can be involved in unexplained cases of iron deficiency anaemia in adults, and its cure can normalize the haematologic picture.

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Crossref · 10.3109/00365529709025109

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27 of 27 references verified0 citation errors · 0 not checkable

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  • Eradication of H pylori infection can lead to correction of the anemia.

    “Eradication of H pylori infection can lead to correction of the anemia.167”

    From Forging a field: the golden age of iron biology. (2008) · cites this paper as [167]

  • H pylori infection, even in the absence of significant bleeding, can lead to profound iron deficiency anemia that is poorly responsive to oral iron therapy.

    “Recently it was rediscovered that infection with H pylori, even in the absence of significant bleeding, can lead to profound iron deficiency anemia that is poorly responsive to oral iron therapy.”

    From Forging a field: the golden age of iron biology. (2008) · cites this paper as [167]

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Authors
Marignani, M., Angeletti, S., Bordi, C., Malagnino, F., Mancino, C., Fave, G. D., & Annibale, B.
Affiliations
University of Parma (IT)
ORCID
Venue
Scandinavian Journal of Gastroenterology
Publisher
Informa UK Limited
Published
1997-01
Volume
32
Issue
6
Pages
617-622
ISSN
  • 0036-5521 (ISSN-L)
  • 1502-7708
DOI
10.3109/00365529709025109
OpenAlex
W1997114824
Cited by
133
References
27
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 4
FWCI
7.66
Type
journal article
Language
en
Open access
closed
Locations
  • Scandinavian Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
Helicobacter pylori, iron deficiency anemia, anemia of chronic disease, eradication therapy, oral iron supplementation, ferritin
MeSH terms
Adult, Anti-Ulcer Agents, Anti-Bacterial Agents, Bismuth, Drug Therapy, Combination, Gastritis, Humans, Male, Metronidazole, Omeprazole, Organometallic Compounds, Salicylates, Tetracycline, Helicobacter pylori, Helicobacter Infections, Clarithromycin, Anemia, Iron-Deficiency

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