Current status of prediction of drug disposition and toxicity in humans using chimeric mice with humanized liver

Hepatitis C virus replication in mice with chimeric human livers

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Complete Plasmodium falciparum liver-stage development in liver-chimeric mice

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POTENT INHIBITION OF HUMAN LIVER ALDEHYDE OXIDASE BY RALOXIFENE

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Chimeric Mice with Humanized Liver: Tools for the Study of Drug Metabolism, Excretion, and Toxicity

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EXPRESSION OF HUMAN PHASE II ENZYMES IN CHIMERIC MICE WITH HUMANIZED LIVER

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Significant Species Difference in Amide Hydrolysis of GDC-0834, a Novel Potent and Selective Bruton’s Tyrosine Kinase Inhibitor

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Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

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In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice

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High Connectivity of Animal Populations in Deep-Sea Hydrothermal Vent Fields in the Central Indian Ridge Relevant to Its Geological Setting

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Morphological and microarray analyses of human hepatocytes from xenogeneic host livers

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Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver

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Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction

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Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver

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Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites

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IN VIVO INDUCTION OF HUMAN CYTOCHROME P450 ENZYMES EXPRESSED IN CHIMERIC MICE WITH HUMANIZED LIVER

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Can ‘humanized’ mice improve drug development in the 21st century?

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uPA+/+-SCID Mouse with Humanized Liver as a Model for In Vivo Metabolism of Exogenous Steroids: Methandienone as a Case Study

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Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms

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Aldehyde Oxidase-Catalyzed Metabolism of N1-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver

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Application of Chimeric Mice with Humanized Liver for Predictive ADME

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Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice

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Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes

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Investigation of Drug-Drug Interactions Caused by Human Pregnane X Receptor-Mediated Induction of CYP3A4 and CYP2C Subfamilies in Chimeric Mice with a Humanized Liver

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Targeted Induction of Interferon-λ in Humanized Chimeric Mouse Liver Abrogates Hepatotropic Virus Infection

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Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury

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Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes

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In Vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites Derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG Mice

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In vivoinduction of human cytochrome P450 3A4 by rifabutin in chimeric mice with humanized liver

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Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics

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Induction of Human CYP1A2 and CYP3A4 in Primary Culture of Hepatocytes from Chimeric Mice with Humanized Liver

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CYP2C9-Catalyzed Metabolism of S-Warfarin to 7-Hydroxywarfarin in Vivo and in Vitro in Chimeric Mice with Humanized Liver

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Metabolic studies with promagnon, methylclostebol and methasterone in the uPA+/+-SCID chimeric mice

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In Vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice

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Human pharmacogenetic analysis in chimeric mice with ‘humanized livers’

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Approach for in Vivo Protein Binding of 5-n-Butyl-pyrazolo[1,5-a]pyrimidine Bioactivated in Chimeric Mice with Humanized Liver by Two-Dimensional Electrophoresis with Accelerator Mass Spectrometry

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Effect of Hepatitis C Virus Infection on the mRNA Expression of Drug Transporters and Cytochrome P450 Enzymes in Chimeric Mice with Humanized Liver

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Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver

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Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism

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In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice

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Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

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CL 284,846, a novel sedative‐hypnotic: Evaluation of its metabolites for pharmacological activity in vitro and in vivo

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Mice with Liver Composed of Human Hepatocytes as an Animal Model for Drug Testing

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In vivomodeling of human liver for pharmacological study using humanized mouse

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Human Hepatocytes Can Repopulate Mouse Liver: Histopathology of the Liver in Human Hepatocyte-Transplanted Chimeric Mice and Toxicologic Responses to Acetaminophen

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Hepatic Hyperplasia Associated with Discordant Xenogeneic Parenchymal-Nonparenchymal Interactions in Human Hepatocyte-Repopulated Mice

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Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes

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Non-invasive method to detect induction of CYP3A4 in chimeric mice with a humanized liver

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Hepatitis C virus kinetics by administration of pegylated interferon-α in human and chimeric mice carrying human hepatocytes with variants of theIL28Bgene

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Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

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Characterization of Humanized Liver from Chimeric Mice Using Coumarin as a Human CYP2A6 and Mouse CYP2A5 Probe

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Revision of the Atlanta classification of acute pancreatitis: the editorial perspective

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Hepatitis C Virus Infection Suppresses the Interferon Response in the Liver of the Human Hepatocyte Chimeric Mouse

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Morphologic Characterization of PhoenixBio® (uPA+/+/SCID) Humanized Liver Chimeric Mouse Model

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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

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Predicting drug metabolism: experiment and/or computation?

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