Drug-Metabolizing Ability of Molybdenum Hydroxylases
Abstract
Molybdenum hydroxylases, which include aldehyde oxidase and xanthine oxidoreductase, are involved in the metabolism of some medicines in humans. They exhibit oxidase activity towards various heterocyclic compounds and aldehydes. The liver cytosol of various mammals also exhibits a significant reductase activity toward nitro, sulfoxide, N-oxide and other moieties, catalyzed by aldehyde oxidase. There is considerable variability of aldehyde oxidase activity in liver cytosol of mammals: humans show the highest activity, rats and mice show low activity, and dogs have no detectable activity. On the other hand, xanthine oxidoreductase activity is present widely among species. Interindividual variation of aldehyde oxidase activity is present in humans. Drug-drug interactions associated with aldehyde oxidase and xanthine oxidoreductase are of potential clinical significance. Drug metabolizing ability of molybdenum hydroxylases and the variation of the activity are described in this review.
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AO appears to play an important role in drug metabolism and other metabolic pathways.
“Although the function of AO in mammals is yet to be established (434, 935), AO appears to play an important role in drug metabolism and other metabolic pathways (335, 512, 513, 756, 920).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [513]
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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
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The role of aldehyde oxidase in drug metabolism
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Aldehyde Oxidase Importance In Vivo in Xenobiotic Metabolism: Imidacloprid Nitroreduction in Mice
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Self-citation
- Authors
- Kitamura, S., Sugihara, K., & Ohta, S.
- Affiliations
- Hiroshima University (JP)
- Corresponding author
- Kitamura, Shigeyuki
- ORCID
- Kitamura, Shigeyuki
- Venue
- Drug Metabolism and Pharmacokinetics
- Published
- 2006
- Volume
- 21
- Issue
- 2
- Pages
- 83-98
- ISSN
- 1347-4367 (ISSN-L)
- OpenAlex
- W2058342217
- Cited by
- 216
- References
- 159
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 13 · 2014: 15 · 2013: 14 · 2012: 22
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug Metabolism and Pharmacokinetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- molybdenum hydroxylases, aldehyde oxidase, xanthine oxidoreductase, drug metabolism, interindividual variability, interspecies variation, drug-drug interactions, liver cytosol, aldehyde oxidation, nitro group reduction, sulfoxide reduction, N-oxide reduction
- MeSH terms
- Animals, Drug Interactions, Pharmaceutical Preparations, Humans, Oxidation-Reduction, Species Specificity, Tissue Distribution, Xanthine Dehydrogenase, Aldehyde Oxidase
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