Cited by 216Pharmacogenetics and Drug MetabolismMetal-Catalyzed Oxygenation MechanismsDrug-Induced Hepatotoxicity and Protection

Drug-Metabolizing Ability of Molybdenum Hydroxylases

Kitamura, Shigeyuki, Sugihara, Kazumi, Ohta, Shigeru·2006·Drug Metabolism and Pharmacokinetics

Abstract

Molybdenum hydroxylases, which include aldehyde oxidase and xanthine oxidoreductase, are involved in the metabolism of some medicines in humans. They exhibit oxidase activity towards various heterocyclic compounds and aldehydes. The liver cytosol of various mammals also exhibits a significant reductase activity toward nitro, sulfoxide, N-oxide and other moieties, catalyzed by aldehyde oxidase. There is considerable variability of aldehyde oxidase activity in liver cytosol of mammals: humans show the highest activity, rats and mice show low activity, and dogs have no detectable activity. On the other hand, xanthine oxidoreductase activity is present widely among species. Interindividual variation of aldehyde oxidase activity is present in humans. Drug-drug interactions associated with aldehyde oxidase and xanthine oxidoreductase are of potential clinical significance. Drug metabolizing ability of molybdenum hydroxylases and the variation of the activity are described in this review.

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Crossref · 10.2133/dmpk.21.83

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  • AO appears to play an important role in drug metabolism and other metabolic pathways.

    “Although the function of AO in mammals is yet to be established (434, 935), AO appears to play an important role in drug metabolism and other metabolic pathways (335, 512, 513, 756, 920).”

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Authors
Kitamura, S., Sugihara, K., & Ohta, S.
Affiliations
Hiroshima University (JP)
Corresponding author
Kitamura, Shigeyuki
Venue
Drug Metabolism and Pharmacokinetics
Published
2006
Volume
21
Issue
2
Pages
83-98
ISSN
1347-4367 (ISSN-L)
OpenAlex
W2058342217
Cited by
216
References
159
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 13 · 2014: 15 · 2013: 14 · 2012: 22
FWCI
1.82
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Metabolism and Pharmacokinetics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
molybdenum hydroxylases, aldehyde oxidase, xanthine oxidoreductase, drug metabolism, interindividual variability, interspecies variation, drug-drug interactions, liver cytosol, aldehyde oxidation, nitro group reduction, sulfoxide reduction, N-oxide reduction
MeSH terms
Animals, Drug Interactions, Pharmaceutical Preparations, Humans, Oxidation-Reduction, Species Specificity, Tissue Distribution, Xanthine Dehydrogenase, Aldehyde Oxidase

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