Cited by 254Personality Disorders and PsychopathologySubstance Abuse Treatment and OutcomesBipolar Disorder and Treatment

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Emotion regulation and substance use frequency in women with substance dependence and borderline personality disorder receiving dialectical behavior therapy

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Axelrod, Seth R., Perepletchikova, Francheska, Holtzman, Kevin, Sinha, Rajita·2011·The American Journal of Drug and Alcohol Abuse

DOI 10.3109/00952990.2010.535582PMC PMC3052760

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Abstract

BACKGROUND: Dialectical behavior therapy (DBT) identifies emotion dysregulation as central to the dangerous impulsivity of borderline personality disorder (BPD) including substance use disorders, and DBT targets improved emotion regulation as a primary mechanism of change. However, improved emotion regulation with DBT and associations between such improvement and behavioral outcomes such as substance use has not been previously reported. OBJECTIVE: Thus, the goal of this study was to assess for improvement in emotion regulation and to examine the relationship between improvements in the emotion regulation and substance use problems following DBT treatment. METHOD: Emotion regulation as assessed by the Difficulties in Emotion Regulation Scale, depressed mood as assessed by the Beck Depression Inventory, and their associations with substance use frequency were investigated in 27 women with substance dependence and BPD receiving 20 weeks of DBT in an academic community outpatient substance abuse treatment program. RESULTS: Results indicated improved emotion regulation, improved mood, and decreased substance use frequency. Further, emotion regulation improvement, but not improved mood, explained the variance of decreased substance use frequency. CONCLUSION AND SCIENTIFIC SIGNIFICANCE: This is the first study to demonstrate improved emotion regulation in BPD patients treated with DBT and to show that improved emotion regulation can account for increased behavioral control in BPD patients. SIGNIFICANCE AND FUTURE RESEARCH: Emotion regulation assessment is recommended for future studies to further clarify the etiology and maintenance of disorders associated with emotional dysregulation such as BPD and substance dependence and to further explore emotion regulation as a potential mechanism of change for clinical interventions.

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Authors: Axelrod, S. R., Perepletchikova, F., Holtzman, K., & Sinha, R.
Affiliations: Yale University (US)
Corresponding author: Axelrod, Seth R.
ORCID: Sinha, Rajita
Venue: The American Journal of Drug and Alcohol Abuse
Publisher: Informa UK Limited
Published: 2010-11-22
Volume: 37
Issue: 1
Pages: 37-42
ISSN: 0095-2990 (ISSN-L)
1097-9891
DOI: 10.3109/00952990.2010.535582
PMC: PMC3052760
OpenAlex: W2165284188
Cited by: 254
References: 45
Citations by year: 2026: 7 · 2025: 14 · 2024: 14 · 2023: 18 · 2022: 13 · 2021: 24 · 2020: 37 · 2019: 17 · 2018: 17 · 2017: 22 · 2016: 12 · 2015: 14 · 2014: 13 · 2013: 15 · 2012: 10
FWCI: 11.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The American Journal of Drug and Alcohol Abuse (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (T32MH062994, K99MH087627)
National Institute on Drug Abuse (P50DA016556, P50-DA0941, P50DA009241)
Topics: Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords: dialectical behavior therapy, emotion regulation, borderline personality disorder, substance dependence, substance use frequency, women, emotional dysregulation, mechanisms of change, Difficulties in Emotion Regulation Scale, depressive mood, impulsivity
MeSH terms: Adult, Analysis of Variance, Behavior Therapy, Borderline Personality Disorder, Emotions, Female, Humans, Middle Aged, Psychiatric Status Rating Scales, Treatment Outcome, Diagnosis, Dual (Psychiatry), Substance-Related Disorders

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Emotion regulation and substance use frequency in women with substance dependence and borderline personality disorder receiving dialectical behavior therapy

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