How does stress increase risk of drug abuse and relapse?

Sinha, Rajita

doi:10.1007/s002130100917

Cited by 1,505Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

How does stress increase risk of drug abuse and relapse?

Sinha, Rajita·2001·Psychopharmacology

DOI 10.1007/s002130100917

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Abstract

Rationale The notion that stress leads to drug abuse in vulnerable individuals and relapse in addicts is not new. Most major theories of addiction postulate that stress plays an important role in increasing drug use and relapse. Several animal studies and some human laboratory studies have shown that stress exposure enhances drug self-administration. Although clinical observations suggest that exposure to stress increases drug use, and are associated with craving and relapse in addicts, human research in this area is largely correlational and at times contradictory.Objective Given the growing preclinical evidence that supports the key role of stress in substance abuse, careful examination of this research area in humans is warranted. This paper examines empirical evidence on how stress may increase the vulnerability to drug abuse, and explores whether chronic drug abuse alters the stress response and coping in addicts, thereby increasing the likelihood of drug seeking and relapse. Unanswered questions on the association between stress and substance abuse in humans are identified.Conclusion Preclinical research has shown that stress, in addition to drug itself, plays a key role in perpetuating drug abuse and relapse. However, the mechanisms underlying this association in humans remain unclear. A greater understanding of how stress may perpetuate drug abuse will likely have a significant impact on both prevention and treatment development in the field of addiction.

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Inability to handle everyday stress leads to exacerbated physiological responses and is associated with the development and course of adverse long-term health outcomes, including major depression, substance abuse, and anxiety disorders.
“Inability to handle everyday stress leads to exacerbated physiological responses and is associated with the development and course of adverse long-term health outcomes, including a wide range of psychological disorders such as major depression, substance abuse, and anxiety disorders (Duffing et al., 2014;McEwen, 2008;Sinha, 2001).”
From Cortisol Response to Stress: The Role of Expectancy and Anticipatory Stress Regulation (2020) · cites this paper as Sinha, 2001

“Stress: appraisal and coping,”
Folkman, S. (2013) · Encyclopedia of Behavioral Medicine · doi:10.1007/978-1-4419-1005-9_215 · Cited by 27,833 · see citing works
Lifetime and 12-Month Prevalence of DSM-III-R Psychiatric Disorders in the United States: Results From the National Comorbidity Survey
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370 · see citing works
Assessing coping strategies: A theoretically based approach.
Carver, C. S., Scheier, M. F., & Weintraub, J. K. (1989) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.56.2.267 · Cited by 11,679 · see citing works
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · see citing works
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Psychological stress and the coping process
Lazarus, R. S. (1966) · Medical Entomology and Zoology · Cited by 7,164 · see citing works
Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: implications for substance abuse prevention
Hawkins, J. D., Catalano, R. F., & Miller, J. Y. (1992) · Psychological Bulletin · doi:10.1037/0033-2909.112.1.64 · Cited by 5,428 · see citing works
The Stress of Life
Selye, H. (1956) · Medical Entomology and Zoology · Cited by 5,224 · see citing works
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
Self-regulation and depletion of limited resources: Does self-control resemble a muscle?
Muraven, M., & Baumeister, R. F. (2000) · Psychological Bulletin · doi:10.1037/0033-2909.126.2.247 · Cited by 4,510 · see citing works
Stress and the Individual
McEwen, B. S. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.18.2093 · Cited by 4,365 · see citing works
Comorbidity of Mental Disorders With Alcohol and Other Drug Abuse: Results From the Epidemiologic Catchment Area (ECA) Study
Regier, D. A. (1990) · JAMA · doi:10.1001/jama.1990.03450190043026 · Cited by 3,962 · see citing works
The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence
(1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.11.1259 · Cited by 2,538 · see citing works
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535 · see citing works
Meta‐analysis of cue‐reactivity in addiction research
Carter, B. L., & Tiffany, S. T. (1999) · Addiction · doi:10.1046/j.1360-0443.1999.9433273.x · Cited by 1,638 · see citing works
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · see citing works
A cognitive model of drug urges and drug-use behavior: role of automatic and nonautomatic processes
Tiffany, S. T. (1990) · Psychological Review · doi:10.1037/0033-295x.97.2.147 · Cited by 1,554 · see citing works
Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545 · see citing works
Dissociation in prefrontal cortex of affective and attentional shifts
Dias, R., Robbins, T. W., & Roberts, A. C. (1996) · Nature · doi:10.1038/380069a0 · Cited by 1,527 · see citing works
Limbic Activation During Cue-Induced Cocaine Craving
Childress, A. R., Mozley, P. D., McElgin, W., Fitzgerald, J., Reivich, M., & O’Brien, C. P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.1.11 · Cited by 1,513 · see citing works
The psychology and neurobiology of addiction: an incentive–sensitization view
Robinson, T. E., & Berridge, K. C. (2000) · Addiction · doi:10.1046/j.1360-0443.95.8s2.19.x · Cited by 1,507 · see citing works
The epidemiology of co-occurring addictive and mental disorders: Implications for prevention and service utilization.
Kessler, R. C., Nelson, C. B., McGonagle, K. A., Edlund, M. J., Frank, R. G., & Leaf, P. J. (1996) · American Journal of Orthopsychiatry · doi:10.1037/h0080151 · Cited by 1,378 · see citing works
The role of corticotropin-releasing factor in depression and anxiety disorders
Arborelius, L., Owens, M., Plotsky, P., & Nemeroff, C. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1600001 · Cited by 1,378 · see citing works
Factors That Predict Individual Vulnerability to Amphetamine Self-Administration
Piazza, P. V., Deminière, J.-M., Moal, M. L., & Simon, H. (1989) · Science · doi:10.1126/science.2781295 · Cited by 1,355 · see citing works
Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex
Volkow, N. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.318 · Cited by 1,240 · see citing works
A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
Pierce, R. C., & Kalivas, P. W. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00021-0 · Cited by 1,239 · see citing works
Neurobehavioural mechanisms of reward and motivation
Robbins, T. W., & Everitt, B. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80077-8 · Cited by 1,187 · see citing works
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037//0033-295x.91.2.251 · Cited by 1,064 · see citing works
Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037/0033-295x.91.2.251 · Cited by 1,062 · see citing works
Selective activation of the mesocortical DA system by stress
Thierry, A. M., Tassin, J., BLANC, G., & Glowinski, J. (1976) · Nature · doi:10.1038/263242a0 · Cited by 1,033 · see citing works
The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour☆
Perret, E. (1974) · Neuropsychologia · doi:10.1016/0028-3932(74)90047-5 · Cited by 1,007 · see citing works
Activation of memory circuits during cue-elicited cocaine craving.
Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.12040 · Cited by 936 · see citing works
Understanding and preventing relapse.
Brownell, K. D., Marlatt, G. A., Lichtenstein, E., & Wilson, G. T. (1986) · American Psychologist · doi:10.1037/0003-066x.41.7.765 · Cited by 926 · see citing works
Decreased dopamine D<sub>2</sub> receptor availability is associated with reduced frontal metabolism in cocaine abusers
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924 · see citing works
Characteristics of children of alcoholics: Putative risk factors, substance use and abuse, and psychopathology.
Sher, K. J., Walitzer, K. S., Wood, P. K., & Brent, E. E. (1991) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.100.4.427 · Cited by 875 · see citing works
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854 · see citing works
Aftereffects of stress on human performance and social behavior: a review of research and theory.
Cohen, S. (1980) · Psychological bulletin · doi:10.1037/0033-2909.88.1.82 · Cited by 839 · see citing works
Alcoholism: theory, problem and challenge. II. Reinforcement theory and the dynamics of alcoholism.
Conger, J. J. (1956) · PubMed · Cited by 810 · see citing works
Predicting Response to Alcohol and Drug Abuse Treatments
McLellan, A. T. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.04390010030004 · Cited by 805 · see citing works
The smoking problem: A review of the research and theory in behavioral risk modification.
Leventhal, H., & Cleary, P. D. (1980) · Psychological Bulletin · doi:10.1037/0033-2909.88.2.370 · Cited by 773 · see citing works
Innate and conditioned reactions to threat in rats with amygdaloid lesions.
Blanchard, D. C., & Blanchard, R. J. (1972) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0033521 · Cited by 753 · see citing works
Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens
Roberts, D. C. S., Koob, G. F., Klonoff, P., & Fibiger, H. C. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90166-5 · Cited by 730 · see citing works
Development and validation of a three-dimensional measure of drinking motives.
Cooper, M. L., Russell, M., Skinner, J. B., & Windle, M. T. (1992) · Psychological Assessment · doi:10.1037/1040-3590.4.2.123 · Cited by 711 · see citing works
Drug dependence: stress and dysregulation of brain reward pathways
Kreek, M. J., & Koob, G. F. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00064-7 · Cited by 696 · see citing works
Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons
Piazza, P. V., & Le Moal, M. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.002043 · Cited by 690 · see citing works
The role of stress in drug self-administration
Piazza, P. V., & Moal, M. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01115-2 · Cited by 674 · see citing works
Relapse following smoking cessation: A situational analysis.
Shiffman, S. S. (1982) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.50.1.71 · Cited by 653 · see citing works
Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.
Coplan, J. D., Andrews, M. W., Rosenblum, L. A., Owens, M. J., Friedman, S., Gorman, J. M., & Nemeroff, C. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1619 · Cited by 649 · see citing works
An 8-year follow-up of 450 sons of alcoholic and control subjects
Schuckit, M. A. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830030020005 · Cited by 627 · see citing works
Decreases in dopamine receptors but not in dopamine transporters in alcoholics
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Hitzemann, R., Ding, Y., Pappas, N., Shea, C., & Piscani, K. (1996) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb05936.x · Cited by 612 · see citing works
New concepts in cocaine addiction: The dopamine depletion hypothesis
Dackis, C. A., & Gold, M. S. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90022-3 · Cited by 607 · see citing works
Determinants of relapse: Implications for the maintenance of behavior change.
Marlatt, G. A. (1989) · Medical Entomology and Zoology · Cited by 600 · see citing works
Stress and Health: Biological and Psychological Interactions
Lovallo, W. R. (2016) · Sage eBooks · doi:10.4135/9781071801390 · Cited by 589 · see citing works
Coping, expectancies, and alcohol abuse: A test of social learning formulations.
Cooper, M. L., Russell, M., & George, W. H. (1988) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.97.2.218 · Cited by 569 · see citing works
Stress- and pharmacologically-induced behavioral sensitization increases vulnerability to acquisition of amphetamine self-administration
Piazza, P. V., Deminiere, J. M., le Moal, M., & Simon, H. (1990) · Brain Research · doi:10.1016/0006-8993(90)90431-a · Cited by 565 · see citing works
Neural activity related to drug craving in cocaine addiction
Kilts, C. D., Schweitzer, J. B., Quinn, C. K., Gross, R. E., Faber, T. L., Muhammad, F., Ely, T. D., Hoffman, J. M., & Drexler, K. P. G. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.334 · Cited by 556 · see citing works
Dissociation in Effects of Lesions of the Nucleus Accumbens Core and Shell on Appetitive Pavlovian Approach Behavior and the Potentiation of Conditioned Reinforcement and Locomotor Activity byd-Amphetamine
Parkinson, J. A., Olmstead, M. C., Burns, L. H., Robbins, T. W., & Everitt, B. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02401.1999 · Cited by 555 · see citing works
Drug addiction: A model for the molecular basis of neural plasticity
Nestler, E. J., Hope, B. T., & Widnell, K. L. (1993) · Neuron · doi:10.1016/0896-6273(93)90213-b · Cited by 544 · see citing works
Behavioral functions of nucleus accumbens dopamine: Empirical and conceptual problems with the anhedonia hypothesis
Salamone, J. D., Cousins, M. S., & Snyder, B. J. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00017-6 · Cited by 514 · see citing works
Novelty seeking, risk taking, and related constructs as predictors of adolescent substance use: An application of Cloninger's theory
Wills, T. A., Vaccaro, D., & McNamara, G. (1994) · Journal of Substance Abuse · doi:10.1016/s0899-3289(94)90039-6 · Cited by 480 · see citing works
Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & al, E. (1997) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.106.2.243 · Cited by 479 · see citing works
Alcohol cue reactivity, negative-mood reactivity, and relapse in treated alcoholic men.
Cooney, N. L., Litt, M. D., Morse, P. A., Bauer, L. O., & Gaupp, L. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.2.243 · Cited by 479 · see citing works
Psychological stress, drug-related cues and cocaine craving
Sinha, R., Fuse, T., Aubin, L.-R., & O'Malley, S. S. (2000) · Psychopharmacology · doi:10.1007/s002130000499 · Cited by 463 · see citing works
Self-citation
Impact of adolescent drug use and social support on problems of young adults: A longitudinal study.
Newcomb, M. D., & Bentler, P. M. (1988) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.97.1.64 · Cited by 459 · see citing works
Frontal lesions and sustained attention
Wilkins, A. J., Shallice, T., & McCarthy, R. (1987) · Neuropsychologia · doi:10.1016/0028-3932(87)90024-8 · Cited by 450 · see citing works
Changes in brain glucose metabolism in cocaine dependence and withdrawal
Volkow, N. D., Fowler, J. S., Wolf, A. P., Hitzemann, R., Dewey, S. L., Bendriem, B., Alpert, R., & Hoff, A. L. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.5.621 · Cited by 447 · see citing works
Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens
Taylor, J. R., & Robbins, T. W. (1984) · Psychopharmacology · doi:10.1007/bf00555222 · Cited by 440 · see citing works
Fos Protein Expression and Cocaine-Seeking Behavior in Rats after Exposure to a Cocaine Self-Administration Environment
Neisewander, J. L., Baker, D. L., Fuchs, R. A., Tran-Nguyen, L. T. L., Palmer, A., & Marshall, J. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00798.2000 · Cited by 438 · see citing works
Effects of chronic cocaine abuse on postsynaptic dopamine receptors
(1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.6.719 · Cited by 421 · see citing works
Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens
Weiss, F., Maldonado-Vlaar, C. S., Parsons, L. H., Kerr, T. M., Smith, D. L., & Ben‐Shahar, O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4321 · Cited by 416 · see citing works
Craving is associated with smoking relapse: Findings from three prospective studies.
Killen, J. D., & Fortmann, S. P. (1997) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.5.2.137 · Cited by 413 · see citing works
Psychiatric Comorbidity with Problematic Alcohol Use in High School Students
Rohde, P., Lewinsohn, P. M., & Seeley, J. R. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199601000-00018 · Cited by 412 · see citing works
Long‐Term frontal brain metabolic changes in cocaine abusers
Volkow, N. D., HITZEMANN, R. J., Wang, G., Fowler, J. S., Wolf, A. P., Dewey, S. L., & Handlesman, L. (1992) · Synapse · doi:10.1002/syn.890110303 · Cited by 411 · see citing works
Tobacco withdrawal in self-quitters.
Hughes, J. R. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.5.689 · Cited by 409 · see citing works
Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period
Erb, S. M., Shaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/s002130050150 · Cited by 406 · see citing works
Stress-induced craving and stress response in cocaine dependent individuals
Sinha, R., Catapano, D., & O’Malley, S. S. (1999) · Psychopharmacology · doi:10.1007/s002130050898 · Cited by 403 · see citing works
Self-citation
Selective activation of dopamine transmission in the shell of the nucleus accumbens by stress
Kalivas, P. W., & Duffy, P. (1995) · Brain Research · doi:10.1016/0006-8993(95)00013-g · Cited by 395 · see citing works
RESEARCH REPORT A meta‐analysis of predictors of continued drug use during and after treatment for opiate addiction
Brewer, D. D., Catalano, R. F., Haggerty, K. P., Gainey, R. R., & Fleming, C. B. (1998) · Addiction · doi:10.1046/j.1360-0443.1998.931738.x · Cited by 392 · see citing works
The First Drink
Ludwig, A. M. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760100093015 · Cited by 371 · see citing works
Nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption.
Higley, J. D., Hasert, M. F., Suomi, S. J., & Linnoila, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.7261 · Cited by 368 · see citing works
Cue Reactivity and Cue Reactivity Interventions in Drug Dependence
Childress, A. R., Hole, A. V., Ehrman, R. N., Robbins, S. J., McLellan, A. T., & O’Brien, C. P. (1993) · PsycEXTRA Dataset · doi:10.1037/e495912006-006 · Cited by 368 · see citing works
Treating Alcohol Dependence: A Coping Skills Training Guide
Monti, P. M., Kadden, R. M., Rohsenow, D. J., Cooney, N. L., & Abrams, D. B. (1989) · Cited by 362 · see citing works
Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.
Stewart, J. (2000) · PubMed Central · Cited by 361 · see citing works
Stress reinstates heroin-seeking in drug-free animals: An effect mimicking heroin, not withdrawal
Shaham, Y., & Stewart, J. (1995) · Psychopharmacology · doi:10.1007/bf02246300 · Cited by 361 · see citing works
The effect of housing and gender on morphine self-administration in rats
ALEXANDER, B. K., Coambs, R. B., & Hadaway, P. F. (1978) · Psychopharmacology · doi:10.1007/bf00426903 · Cited by 356 · see citing works
Perceived stress, quitting smoking, and smoking relapse.
Cohen, S., & Lichtenstein, E. (1990) · Health Psychology · doi:10.1037//0278-6133.9.4.466 · Cited by 350 · see citing works
Psychotherapy and Pharmacotherapy for Ambulatory Cocaine Abusers
Carroll, K. M. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030013002 · Cited by 348 · see citing works
Stress and Alcohol Interaction: An Update of Human Research
Pohorecky, L. A. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00543.x · Cited by 341 · see citing works
Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine
Meil, W. M., & See, R. E. (1997) · Behavioural Brain Research · doi:10.1016/s0166-4328(96)02270-x · Cited by 337 · see citing works
What predicts relapse? Prospective testing of antecedent models
Miller, W. R., Westerberg, V. S., Harris, R. J., & Tonigan, J. S. (1996) · Addiction · doi:10.1046/j.1360-0443.91.12s1.7.x · Cited by 336 · see citing works
The Role of Corticotropin-Releasing Factor and Corticosterone in Stress- and Cocaine-Induced Relapse to Cocaine Seeking in Rats
Erb, S. M., Shaham, Y., & Stewart, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-14-05529.1998 · Cited by 329 · see citing works
Repeated social-defeat stress, cocaine or morphine
Covington, H. E., & Miczek, K. A. (2001) · Psychopharmacology · doi:10.1007/s002130100858 · Cited by 326 · see citing works
Coping and Health
Levine, S., & Ursin, H. (1980) · Medical Entomology and Zoology · Cited by 322 · see citing works
Childhood victimization and drug abuse: A comparison of prospective and retrospective findings.
Widom, C. S., Weiler, B. L., & Cottler, L. B. (1999) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.67.6.867 · Cited by 322 · see citing works
Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats
Lê, A. D., Quan, B. H., Juzytsch, W., Fletcher, P. J., Joharchi, N., & Shaham, Y. (1998) · Psychopharmacology · doi:10.1007/s002130050498 · Cited by 319 · see citing works
Hypercortisolism associated with social subordinance or social isolation among wild baboons
Sapolsky, R. M. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830240097014 · Cited by 318 · see citing works
Dopaminergic Innervation of the Amygdala Is Highly Responsive to Stress
Inglis, F., & Moghaddam, B. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721088.x · Cited by 310 · see citing works
Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence
Diana, M., Pistis, M., Carboni, S., Gessa, G. L., & Rossetti, Z. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7966 · Cited by 309 · see citing works
Disconnection of the anterior cingulate cortex and nucleus accumbens core impairs Pavlovian approach behavior: Further evidence for limbic cortical-ventral striatopallidal systems.
Parkinson, J. A., Willoughby, P. J., Robbins, T. W., & Everitt, B. J. (2000) · Behavioral Neuroscience · doi:10.1037//0735-7044.114.1.42 · Cited by 309 · see citing works
Risk for alcoholism and individual differences in the stress-response-dampening effect of alcohol.
Sher, K. J., & LEVENSON, R. W. (1982) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.91.5.350 · Cited by 308 · see citing works
Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement.
Whitelaw, R. B., Markou, A., Robbins, T. W., & Everitt, B. J. (1996) · PubMed · Cited by 306 · see citing works
CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor 1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats
Shaham, Y., Erb, S., Leung, S., Buczek, Y., & Stewart, J. (1998) · Psychopharmacology · doi:10.1007/s002130050608 · Cited by 302 · see citing works
Commitment to abstinence and acute stress in relapse to alcohol, opiates, and nicotine.
Hall, S. M., Havassy, B. E., & Wasserman, D. A. (1990) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.58.2.175 · Cited by 301 · see citing works
Occupational Stress and Variation in Cigarette, Coffee, and Alcohol Consumption
Conway, T. L., Vickers, R. R., Ward, H., & Rahe, R. H. (1981) · Journal of Health and Social Behavior · doi:10.2307/2136291 · Cited by 300 · see citing works
Psychiatric disorders associated with substance use among children and adolescents: Findings from the Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study
Kandel, D. B., Johnson, J. G., Bird, H. R., Canino, G., Goodman, S. H., Lahey, B. B., Regier, D. A., & Schwab-Stone, M. (1997) · Journal of Abnormal Child Psychology · doi:10.1023/a:1025779412167 · Cited by 299 · see citing works
Evidence for conditional neuronal activation following exposure to a cocaine-paired environment: role of forebrain limbic structures
Brown, E., Robertson, G. S., & Fibiger, H. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-10-04112.1992 · Cited by 288 · see citing works
Non-contingent electric footshock facilitates the acquisition of intravenous cocaine self-administration in rats
Goeders, N. E., & Guerin, G. F. (1994) · Psychopharmacology · doi:10.1007/bf02245445 · Cited by 288 · see citing works
Effect of Loud Noise on Attentional Selectivity
Hockey, G. R. J. (1970) · Quarterly Journal of Experimental Psychology · doi:10.1080/14640747008401898 · Cited by 286 · see citing works
Cardiovascular differentiation of emotions.
Sinha, R., Lovallo, W. R., & Parsons, O. A. (1992) · Psychosomatic Medicine · doi:10.1097/00006842-199207000-00005 · Cited by 282 · see citing works
Self-citation
Multiple substance use among adolescent physical and sexual abuse victims
Harrison, P. A., Fulkerson, J. A., & Beebe, T. J. (1997) · Child Abuse & Neglect · doi:10.1016/s0145-2134(97)00013-6 · Cited by 278 · see citing works
The Role of Predisposing and Moderating Factors in the Stress-Illness Relationship
Cronkite, R. C., & Moos, R. H. (1984) · Journal of Health and Social Behavior · doi:10.2307/2136377 · Cited by 271 · see citing works
Alpha-2 Adrenergic Receptor Agonists Block Stress-Induced Reinstatement of Cocaine Seeking
Erb, S. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00158-x · Cited by 270 · see citing works
One-Year Follow-Up Status of Treatment-Seeking Cocaine Abusers: Psychopathology and Dependence Severity as Predictors of Outcome
CARROLL, K. M., POWER, M.-E. D., BRYANT, K., & ROUNSAVILLE, B. J. (1993) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199302000-00001 · Cited by 269 · see citing works
Blunted Stress Cortisol Response in Abstinent Alcoholic and Polysubstance-Abusing Men
Lovallo, W. R., Dickensheets, S. L., Myers, D. A., Thomas, T. L., & Nixon, S. J. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2000.tb02036.x · Cited by 266 · see citing works
Vulnerability to alcoholism in men: a behavior-genetic perspective.
Tarter, R. E., Alterman, A. I., & Edwards, K. L. (1985) · Journal of Studies on Alcohol · doi:10.15288/jsa.1985.46.329 · Cited by 266 · see citing works
Psychic cost of adaptation to an environmental stressor.
Glass, D. C., Singer, J. E., & Friedman, L. N. (1969) · Journal of Personality and Social Psychology · doi:10.1037/h0027629 · Cited by 264 · see citing works
Cocaine-but not food-seeking behavior is reinstated by stress after extinction
Ahmed, S. H., & Koob, G. F. (1997) · Psychopharmacology · doi:10.1007/s002130050347 · Cited by 257 · see citing works
Repeated stressful experiences differently affect limbic dopamine release during and following stress
Imperato, A., Angelucci, L., Casolini, P., Zocchi, A., & Puglisi-Allegra, S. (1992) · Brain Research · doi:10.1016/0006-8993(92)90274-d · Cited by 256 · see citing works
Escalated substance use: A longitudinal grouping analysis from early to middle adolescence.
Wills, T. A., McNamara, G., Vaccaro, D., & Hirky, A. E. (1996) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.105.2.166 · Cited by 255 · see citing works
A role for sensitization in craving and relapse in cocaine addiction
Kalivas, P. W., Pierce, R. C., Cornish, J. L., & Sorg, B. A. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200107 · Cited by 253 · see citing works
Social stress increases the acquisition of cocaine self-administration in male and female rats
Haney, M., Maccari, S., Moal, M. L., Simon, H., & Piazza, P. V. (1995) · Brain Research · doi:10.1016/0006-8993(95)00788-r · Cited by 250 · see citing works
Paternal and Maternal Genetic and Environmental Contributions to Cerebrospinal Fluid MonoamineMetabolites in Rhesus Monkeys (Macaca mulatta)
Higley, J. D. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820200025003 · Cited by 250 · see citing works
Evaluation of the Effectiveness of Adolescent Drug Abuse Treatment, Assessment of Risks for Relapse, and Promising Approaches for Relapse Prevention
Catalano, R. F., Hawkins, J. D., Wells, E. A., Miller, J. Y., & Brewer, D. D. (1991) · International Journal of the Addictions · doi:10.3109/10826089109081039 · Cited by 247 · see citing works
Cue Reactivity in Addictive Behaviors: Theoretical and Treatment Implications
Rohsenow, D. J., Childress, A. R., Monti, P. M., NIAURA, R. S., & Abrams, D. B. (1991) · International Journal of the Addictions · doi:10.3109/10826089109071030 · Cited by 244 · see citing works
Alterations in the Hypothalamic-Pituitary-Adrenal Axis in Actively Drinking Alcoholics*
Wand, G. S., & Dobs, A. S. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-6-1290 · Cited by 242 · see citing works
Individual differences in imagery and the psychophysiology of emotion
Miller, G. A., Levin, D. N., Kozak, M. J., Cook, E. W., McLean, A., & Lang, P. J. (1987) · Cognition & Emotion · doi:10.1080/02699938708408058 · Cited by 239 · see citing works
Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys
Letchworth, S. R., Nader, M. A., Smith, H. R., Friedman, D. P., & Porrino, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02799.2001 · Cited by 239 · see citing works
STRESS, AROUSAL, AND THE PITUITARY-ADRENAL SYSTEM: A PSYCHOENDOCRINE HYPOTHESIS
Hennessy, J. W., & Levine, S. (1979) · Cited by 238 · see citing works
A 2.5-Year Follow-up of Depression, Life Crises, and Treatment Effects on Abstinence Among Opioid Addicts
Kosten, T. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800080019003 · Cited by 229 · see citing works
Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior
See, R. E., Kruzich, P. J., & Grimm, J. W. (2001) · Psychopharmacology · doi:10.1007/s002130000636 · Cited by 222 · see citing works
Psychological model for smoking behavior.
Tomkins, S. S. (1966) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.56.12_suppl.17 · Cited by 220 · see citing works
Executive cognitive functioning and aggressive behavior in preadolescent boys at high risk for substance abuse/dependence.
Giancola, P. R., Martin, C. S., Tarter, R. E., Pelham, W. E., & Moss, H. B. (1996) · Journal of Studies on Alcohol · doi:10.15288/jsa.1996.57.352 · Cited by 218 · see citing works
Urinary free cortisol secretion in habitually violent offenders
Virkkunen, M. E. (1985) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1985.tb02568.x · Cited by 208 · see citing works
Cocaine self-administration in rats influenced by environmental conditions: implications for the etiology of drug abuse
Schenk, S., Lacelle, G., Gorman, K., & Amit, Z. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)91003-2 · Cited by 207 · see citing works
Effects of commitment to abstinence, positive moods, stress, and coping on relapse to cocaine use.
Hall, S. M., Havassy, B. E., & Wasserman, D. A. (1991) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.59.4.526 · Cited by 206 · see citing works
Stress reinstates nicotine seeking but not sucrose solution seeking in rats
Buczek, Y., Lê, A. D., Wang, A., Stewart, J., & Shaham, Y. (1999) · Psychopharmacology · doi:10.1007/s002130050992 · Cited by 206 · see citing works
Clonidine blocks stress-induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons
Shaham, Y., Highfield, D., Delfs, J., Leung, S., & Stewart, J. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00899.x · Cited by 201 · see citing works
Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome
Hildebrand, B. E., Nomikos, G. G., Hertel, P., Schilström, B., & Svensson, T. H. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01135-9 · Cited by 200 · see citing works
Similar effects of daily cocaine and stress on mesocorticolimbic dopamine neurotransmission in the rat
Kalivas, P. W., & Duffy, P. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90271-0 · Cited by 199 · see citing works
Antisocial symptoms in preadolescent boys and in their parents: Associations with cortisol
Vanyukov, M. M., Moss, H. B., Plail, J. A., Blackson, T. C., Mezzich, A. C., & Tarter, R. E. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90003-y · Cited by 199 · see citing works
Urges to smoke during the first month of abstinence: relationship to relapse and predictors
Doherty, K., Kinnunen, T., Militello, F. S., & Garvey, A. J. (1995) · Psychopharmacology · doi:10.1007/bf02246158 · Cited by 198 · see citing works
Fear of interpersonal evaluation as a determinant of alcohol consumption in male social drinkers.
Higgins, R. L., & Marlatt, G. A. (1975) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.84.6.644 · Cited by 198 · see citing works
Psychological and environmental determinants of relapse in crack cocaine smokers
Wallace, B. C. (1989) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(89)90036-6 · Cited by 198 · see citing works
Activational effects of social stress on IV cocaine self-administration in rats
Miczek, K. A., Mutschler, N. H., & Mizcek, K. A. (1996) · Psychopharmacology · doi:10.1007/s002130050133 · Cited by 192 · see citing works
Mesolimbic dopaminergic decline after cannabinoid withdrawal
Diana, M., Melis, M., Muntoni, A. L., & Gessa, G. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10269 · Cited by 192 · see citing works
Activity and mood temperament as predictors of adolescent substance use: Test of a self-regulation mediational model.
Wills, T. A., DuHamel, K., & Vaccaro, D. (1995) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.68.5.901 · Cited by 191 · see citing works
Differential Effects of Opiate Peptides and Alkaloids on Anterior Pituitary Hormone Secretion
Delitala, G., Grossman, A. B., & Besser, M. (2008) · Neuroendocrinology · doi:10.1159/000123558 · Cited by 186 · see citing works
Mood management and nicotine gum in smoking treatment: A therapeutic contact and placebo-controlled study.
Hall, S. M., Muñoz, R. F., Reus, V. I., Sees, K. L., Duncan, C., Humfleet, G. L., & Hartz, D. T. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.64.5.1003 · Cited by 186 · see citing works
Hypothalamic-Pituitary-Adrenal Axis Functioning and Cerebrospinal Fluid Corticotropin Releasing Hormone and Corticotropin Levels in Alcoholics After Recent and Long-term Abstinence
Adinoff, B. H. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810160025004 · Cited by 185 · see citing works
Stress‐Related Activation of Cerebral Dopaminergic Systemsa
Dunn, A. J. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42106.x · Cited by 185 · see citing works
Smoking : individual difference, psychopathology, and emotion
Gilbert, D. G. (1995) · Medical Entomology and Zoology · Cited by 178 · see citing works
Prospective and retrospective reports of mood states before relapse to substance use.
Hodgins, D. C., el-Guebaly, N., & Armstrong, S. J. (1995) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.63.3.400 · Cited by 177 · see citing works
High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims.
Staley, J. K., Hearn, W. L., Ruttenber, A. J., Wetli, C. V., & Mash, D. C. (1994) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24057-5 · Cited by 175 · see citing works
Can induced moods trigger drug-related responses in opiate abuse patients?
Childress, A. R., Ehrman, R., McLellan, A. T., MacRae, J., Natale, M., & O'Brien, C. P. (1994) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(94)90060-4 · Cited by 171 · see citing works
Exposure to mild stress enhances the reinforcing efficacy of intravenous heroin self-administration in rats
Shaham, Y., & Stewart, J. (1994) · Psychopharmacology · doi:10.1007/bf02249346 · Cited by 169 · see citing works
Effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex
Sorg, B. A., & Kalivas, P. W. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90617-o · Cited by 168 · see citing works
A neuroendocrine role in cocaine reinforcement
Goeders, N. E. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00027-9 · Cited by 168 · see citing works
The mediating role of emotions in alcohol use.
Russell, J. A., & Mehrabian, A. (1975) · Journal of Studies on Alcohol · doi:10.15288/jsa.1975.36.1508 · Cited by 166 · see citing works
Self-consciousness, self-esteem, and success-failure as determinants of alcohol consumption in male social drinkers.
Hull, J. G., & Young, R. D. (1983) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.44.6.1097 · Cited by 163 · see citing works
Endocrine and Hemodynamic Effects of Stress Versus Systemic CRF in Alcoholics during Early and Medium Term Abstinence
Ehrenreich, H., Schuck, J., Stender, N., Pilz, J., Gefeller, O., Schilling, L., Poser, W., & Kaw, S. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb04450.x · Cited by 160 · see citing works
Neurochemical changes in cocaine withdrawal
Kuhar, M. J., & Pilotte, N. S. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)10024-9 · Cited by 159 · see citing works
Attenuated cortisol response to psychological stress but not to CRH or ergometry in young habitual smokers
Kirschbaum, C., Strasburger, C. J., & Langkrär, J. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90162-m · Cited by 158 · see citing works
The Effects of a Psychological Stressor on Cigarette Smoking and Subsequent Behavioral and Physiological Responses
Pomerleau, C. S., & Pomerleau, O. F. (1987) · Psychophysiology · doi:10.1111/j.1469-8986.1987.tb00295.x · Cited by 157 · see citing works
Profound depression of mesolimbic dopamine release after morphine withdrawal in dependent rats
Acquas, E., Carboni, E., & Chiara, G. D. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90214-b · Cited by 157 · see citing works
Salivary cortisol responses and the risk for substance abuse in prepubertal boys.
Moss, H., Vanyukov, M., & Martin, C. S. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00382-d · Cited by 157 · see citing works
Rearing Experiences and Stress-Induced Plasma Cortisol as Early Risk Factors for Excessive Alcohol Consumption in Nonhuman Primates
Fahlke, C., Lorenz, J. G., Long, J. C., Champoux, M., Suomi, S. J., & Higley, J. D. (2000) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200005000-00008 · Cited by 156 · see citing works
Social behavior, dominance, and social deprivation of rats determine drug choice
Wolffgramm, J., & Heyne, A. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90297-f · Cited by 155 · see citing works
Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers
Wilkins, J., Carlson, H., van Vunakis, H., Hill, M., Gritz, E., & Jarvik, M. (1982) · Psychopharmacology · doi:10.1007/bf00433730 · Cited by 155 · see citing works
Orbital and Medial Prefrontal Cortex and Psychostimulant Abuse: Studies in Animal Models
Porrino, L. J. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.326 · Cited by 155 · see citing works
Effects of social stress on operant drinking of alcoholics and social drinkers
Miller, P. M., Hersen, M., Eisler, R. M., & Hilsman, G. (1974) · Behaviour Research and Therapy · doi:10.1016/0005-7967(74)90094-1 · Cited by 154 · see citing works
Elevated Striatal Dopamine Transporters During Acute Cocaine Abstinence as Measured by [123I]β-CIT SPECT
Malison, R. T., Best, S. E., van Dyck, C. H., McCance, E. F., Wallace, E. A., Laruelle, M. A., Baldwin, R. M., Seibyl, J. P., Price, L. H., Kosten, T. R., et al. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.832 · Cited by 154 · see citing works
Disturbances of hypothalamic-pituitary-adrenal axis functioning during ethanol withdrawal in six men
Adinoff, B. H., Risher‐Flowers, D., de Jong, J., Ravitz, B., Bone, G. H. A., Nutt, D., Roehrich, L., Martin, P. R., & Linnoila, M. (1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.8.1023 · Cited by 154 · see citing works
Effects of deviant child behavior on parental distress and alcohol consumption in laboratory interactions
Pelham, W. E., Lang, A. R., Atkeson, B., Murphy, D. A., Gnagy, E. M., Greiner, A. R., Vodde-Hamilton, M., & Greenslade, K. E. (1997) · Journal of Abnormal Child Psychology · doi:10.1023/a:1025789108958 · Cited by 152 · see citing works
Role of Corticosterone in Intravenous Cocaine Self-Administration in Rats
Goeders, N. E., & Guerin, G. F. (2008) · Neuroendocrinology · doi:10.1159/000127137 · Cited by 151 · see citing works
Repeated Daily Cocaine Alters Subsequent Cocaine-induced Increase of Extracellular Dopamine in the Medial Prefrontal Cortex
Sorg, B. A., Davidson, D. L., Kalivas, P. W., & Prasad, B. M. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36617-0 · Cited by 144 · see citing works
Reinstatement and spontaneous recovery of nicotine seeking in rats
Shaham, Y., Adamson, L. K., Corrigall, W. A., & Grocki, S. (1997) · Psychopharmacology · doi:10.1007/s002130050256 · Cited by 143 · see citing works
Conditioned effects of environmental stimuli paired with smoked cocaine in humans
Foltin, R. W., & Haney, M. (2000) · Psychopharmacology · doi:10.1007/s002139900340 · Cited by 142 · see citing works
Measures of affect and nicotine dependence predict differential response to smoking cessation treatments.
Zelman, D. C., Brandon, T. H., Jorenby, D. E., & Baker, T. B. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.6.943 · Cited by 141 · see citing works
Free choice ethanol intake of laboratory rats under different social conditions
Wolffgramm, J. (1990) · Psychopharmacology · doi:10.1007/bf02244132 · Cited by 139 · see citing works
Preventing relapse to cigarette smoking by behavioral skill training.
Hall, S. M., Rugg, D. L., Tunstall, C. D., & Jones, R. T. (1984) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.52.3.372 · Cited by 139 · see citing works
Changes in aggressive behavior during withdrawal from long-term marijuana use
Kouri, E. M., Pope, H. G., & Lukas, S. E. (1999) · Psychopharmacology · doi:10.1007/s002130050951 · Cited by 139 · see citing works
Cocaine’s Effects on Neuroendocrine Systems: Clinical and Preclinical Studies
Mello, N. K., & Mendelson, J. H. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00433-9 · Cited by 137 · see citing works
Severity of psychosocial stress and outcome of alcoholism treatment.
Brown, S. A., Vik, P. W., McQuaid, J. R., Patterson, T. L., Irwin, M. R., & Grant, I. (1990) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.99.4.344 · Cited by 135 · see citing works
Emotional but not physical stress enhances intravenous cocaine self-administration in drug-naive rats
Ramsey, N. F., & van Ree, J. M. (1993) · Brain Research · doi:10.1016/0006-8993(93)91461-z · Cited by 134 · see citing works
Provocation to anger and opportunity for retaliation as determinants of alcohol consumption in social drinkers.
Marlatt, G. A., Kosturn, C. F., & Lang, A. R. (1975) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.84.6.652 · Cited by 134 · see citing works
Differential effects of excitotoxic lesions of the amygdala on cocaine-induced conditioned locomotion and conditioned place preference
Brown, E. E., & Fibiger, H. C. (1993) · Psychopharmacology · doi:10.1007/bf02244344 · Cited by 132 · see citing works
Behavioral and neurochemical sensitization following cocaine self-administration
Hooks, M. S., Duffy, P., Striplin, C. D., & Kalivas, P. W. (1994) · Psychopharmacology · doi:10.1007/bf02244782 · Cited by 132 · see citing works
Behavioral consequences of adaptation to controllable and uncontrollable noise
Glass, D. C., Reim, B., & Singer, J. E. (1971) · Journal of Experimental Social Psychology · doi:10.1016/0022-1031(71)90070-9 · Cited by 128 · see citing works
Interaction of the Amygdala with the Frontal Lobe in Reward Memory
Gaffan, D., Murray, E. A., & Fabre‐Thorpe, M. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00948.x · Cited by 128 · see citing works
Escalation of Marijuana Use: Application of A General Theory of Deviant Behavior
Kaplan, H. B., Martin, S. S., Johnson, R. J., & Robbins, C. A. (1986) · Journal of Health and Social Behavior · doi:10.2307/2136502 · Cited by 128 · see citing works
Corticosterone Facilitates the Acquisition of Cocaine Self-Administration in Rats: Opposite Effects of the Type II Glucocorticoid Receptor Agonist Dexamethasone
Mantsch, J. R., Saphier, D., & Goeders, N. E. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37765-1 · Cited by 123 · see citing works
Serum steroid hormone profiles in postmenopausal smokers and nonsmokers
Friedman, A. J., Ravnikar, V. A., & Barbieri, R. L. (1987) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59044-x · Cited by 122 · see citing works
Persistent suppression of ethanol self-administration by brief social stress in rats and increased startle response as index of withdrawal
van Erp, A. M. M., & Miczek, K. A. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00458-9 · Cited by 120 · see citing works
The Relationship Between Physical and Sexual Abuse and Tobacco, Alcohol, and Illicit Drug Use Among Youths in a Juvenile Detention Center
Dembo, R., Dertke, M. C., Borders, S., Washburn, M., & Schmeidler, J. (1988) · International Journal of the Addictions · doi:10.3109/10826088809039203 · Cited by 119 · see citing works
The effect of housing and gender on preference for morphine-sucrose solutions in rats
Hadaway, P. F., ALEXANDER, B. K., Coambs, R. B., & Beyerstein, B. L. (1979) · Psychopharmacology · doi:10.1007/bf00431995 · Cited by 116 · see citing works
Striatal Dopaminergic Abnormalities in Human Cocaine Users
Little, K. Y., Zhang, L., Desmond, T., Frey, K. A., Dalack, G. W., & Cassin, B. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.238 · Cited by 116 · see citing works
Salivary cortisol responses in prepubertal boys: the effects of parental substance abuse and association with drug use behavior during adolescence
Moss, H. B., Vanyukov, M. M., Yao, J. K., & Kirillova, G. P. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00216-9 · Cited by 112 · see citing works
Stress, coping, and self-regulatory processes.
Carver, C. S., & Scheier, M. F. (1999) · Cited by 112 · see citing works
Individual Differences in the Hypothalamic‐Pituitary‐Adrenal Stress Response and the Hypothalamic CRF Systema
Meaney, M. J., Bhatnagar, S., Larocque, S., McCormick, C. M., Shanks, N. M., SHARMA, S., Smythe, J. W., Viau, V., & Plotsky, P. M. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49924.x · Cited by 111 · see citing works
Emotional imagery in simple and social phobia: Fear versus anxiety.
McNeil, D. W., Vrana, S. R., Melamed, B. G., Cuthbert, B. N., & al, E. (1993) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.102.2.212 · Cited by 110 · see citing works

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Self-rated health and mortality: a review of twenty-seven community studies.
Idler, E. L., & Benyamini, Y. (1997) · Journal of Health and Social Behavior · doi:10.2307/2955359 · Cited by 8,598 · see citing works
Chronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904 · see citing works
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The reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works
Impulsivity as a determinant and consequence of drug use: a review of underlying processes
de Wit, H. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00129.x · Cited by 1,415 · see citing works
The Effects of Stress on Physical Activity and Exercise
Stults-Kolehmainen, M. A., & Sinha, R. (2014) · Sports Medicine · doi:10.1007/s40279-013-0090-5 · Cited by 1,192 · see citing works
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The role of early life stress as a predictor for alcohol and drug dependence
Enoch, M.-A. (2011) · Psychopharmacology · doi:10.1007/s00213-010-1916-6 · Cited by 668 · see citing works
Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure
Epstein, D., Preston, K., Stewart, J., & Shaham, Y. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0529-6 · Cited by 634 · see citing works
The effects of opioids and opioid analogs on animal and human endocrine systems
Vuong, C., Van Uum, S. H. M., O'Dell, L. E., Lutfy, K., & Friedman, T. C. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0009 · Cited by 564 · see citing works
Neurobiologic processes in drug reward and addiction
Adinoff, B. (2004) · Harvard Review of Psychiatry · doi:10.1080/10673220490910844 · Cited by 546 · see citing works
Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress
Brady, K. T., & Sinha, R. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1483 · Cited by 551 · see citing works
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Stress-Induced Cocaine Craving and Hypothalamic-Pituitary-Adrenal Responses Are Predictive of Cocaine Relapse Outcomes
Sinha, R., Garcia, M., Paliwal, P., Kreek, M. J., & Rounsaville, B. J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.324 · Cited by 528 · see citing works
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The Relationship Between Discrimination and Substance Use Disorders Among Lesbian, Gay, and Bisexual Adults in the United States
McCabe, S. E., Bostwick, W. B., Hughes, T. L., West, B. T., & Boyd, C. J. (2010) · American Journal of Public Health · doi:10.2105/ajph.2009.163147 · Cited by 522 · see citing works
Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications
SINHA, R., & LI, C. ‐. R. (2007) · Drug and Alcohol Review · doi:10.1080/09595230601036960 · Cited by 497 · see citing works
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Stressful life experiences, alcohol consumption, and alcohol use disorders: the epidemiologic evidence for four main types of stressors
Keyes, K. M., Hatzenbuehler, M. L., & Hasin, D. S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2236-1 · Cited by 486 · see citing works
Substance Abuse in Women
Greenfield, S. F., Back, S. E., Lawson, K., & Brady, K. T. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2010.01.004 · Cited by 602 · see citing works
Opiate versus psychostimulant addiction: the differences do matter
Badiani, A., Belin, D., Epstein, D. H., Calu, D. J., & Shaham, Y. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3104 · Cited by 466 · see citing works
Stress-induced reinstatement of drug seeking: 20 years of progress
Mantsch, J. R., Baker, D. A., Funk, D., Lê, A. D., & Shaham, Y. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.142 · Cited by 438 · see citing works
Working-memory capacity protects model-based learning from stress
Otto, A. R., Raio, C. M., Chiang, A., Phelps, E. A., & Daw, N. D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312011110 · Cited by 472 · see citing works
Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals
Sinha, R., Fox, H. C., Hong, K. A., Bergquist, K., Bhagwagar, Z., & Siedlarz, K. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.78 · Cited by 466 · see citing works
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REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?
Heilig, M., Egli, M., Crabbe, J. C., & Becker, H. C. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00194.x · Cited by 435 · see citing works
The role of stress in addiction relapse
Sinha, R. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0050-6 · Cited by 423 · see citing works
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Negative Affect and Smoking Lapses: A Prospective Analysis.
Shiffman, S., & Waters, A. J. (2004) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.72.2.192 · Cited by 427 · see citing works
New findings on biological factors predicting addiction relapse vulnerability
Sinha, R. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0224-0 · Cited by 401 · see citing works
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Neurobiology of addiction. An integrative review.
Goodman, A. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.030 · Cited by 410 · see citing works
Neurobiology of craving, conditioned reward and relapse
Weiss, F. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.11.001 · Cited by 411 · see citing works
Difficulties in emotion regulation and impulse control during cocaine abstinence
Fox, H. C., Axelrod, S. R., Paliwal, P., Sleeper, J., & Sinha, R. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.12.026 · Cited by 383 · see citing works
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The impact of stress on addiction
Goeders, N. E. (2003) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.08.004 · Cited by 376 · see citing works
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking
Wang, B., Shaham, Y., Zitzman, D., Azari, S., Wise, R. A., & You, Z.-B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0955-05.2005 · Cited by 369 · see citing works
Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states
Sinha, R., Talih, M., Malison, R. T., Cooney, N. L., Anderson, G. M., & Kreek, M. J. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1525-8 · Cited by 366 · see citing works
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Stress-related factors in cannabis use and misuse: Implications for prevention and treatment
Hyman, S. M., & Sinha, R. (2009) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2008.08.005 · Cited by 344 · see citing works
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Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake
MICZEK, K., YAP, J., & COVINGTONIII, H. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.07.006 · Cited by 338 · see citing works
Distress tolerance as a predictor of early treatment dropout in a residential substance abuse treatment facility
Daughters, S. B., Lejuez, C. W., Bornovalova, M. A., Kahler, C. W., Strong, D. R., & Brown, R. A. (2005) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.114.4.729 · Cited by 336 · see citing works
Desperately driven and no brakes: Developmental stress exposure and subsequent risk for substance abuse
Andersen, S. L., & Teicher, M. H. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.009 · Cited by 326 · see citing works
Induction of ΔFosB in Reward-Related Brain Structures after Chronic Stress
Perrotti, L. I., Hadeishi, Y., Ulery, P. G., Barrot, M., Monteggia, L. M., Duman, R. S., & Nestler, E. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2542-04.2004 · Cited by 330 · see citing works
The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence
Heidbreder, C. A., Gardner, E. L., Xi, Z., Thanos, P. K., Mugnaini, M., Hagan, J. J., & Ashby, C. R. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.033 · Cited by 321 · see citing works
Modeling stress and drug craving in the laboratory: implications for addiction treatment development
Sinha, R. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00134.x · Cited by 314 · see citing works
Self-citation
Animal models of drug relapse and craving
Vènniro, M., Caprioli, D., & Shaham, Y. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.08.004 · Cited by 322 · see citing works
Stress‐Induced and Alcohol Cue‐Induced Craving in Recently Abstinent Alcohol‐Dependent Individuals
Fox, H. C., Bergquist, K. L., Hong, K., & Sinha, R. (2007) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00320.x · Cited by 315 · see citing works
Self-citation
Social vulnerabilities for substance use: Stressors, socially toxic environments, and discrimination and racism
Amaro, H. D. L. A., Sánchez, M., Bautista, T. G., & Cox, R. J. A. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108518 · Cited by 334 · see citing works
Gender Differences in Response to Emotional Stress: An Assessment Across Subjective, Behavioral, and Physiological Domains and Relations to Alcohol Craving
Chaplin, T., Hong, K., Bergquist, K. L., & Sinha, R. (2008) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00679.x · Cited by 309 · see citing works
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The anxiogenic drug yohimbine reinstates methamphetamine seeking in a rat model of drug relapse
Shepard, J. D., Bossert, J. M., Liu, S. Y., & Shaham, Y. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.032 · Cited by 295 · see citing works
Stress decreases the ability to resist smoking and potentiates smoking intensity and reward
McKee, S. A., Sinha, R., Weinberger, A. H., Sofuoglu, M., Harrison, E. L., Lavery, M., & Wanzer, J. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110376694 · Cited by 276 · see citing works
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Effect of environmental stressors on opiate and psychostimulant reinforcement, reinstatement and discrimination in rats: a review
Lü, L., Shepard, J. D., Hall, F. S., & Shaham, Y. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00073-3 · Cited by 278 · see citing works
Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human
Morgan, M. M., & Christie, M. J. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01335.x · Cited by 273 · see citing works
Neurobiology of relapse to heroin and cocaine seeking: An update and clinical implications
Bossert, J. M., Ghitza, U. E., Lü, L., Epstein, D. H., & Shaham, Y. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.030 · Cited by 271 · see citing works
Shared and unique mechanisms underlying binge eating disorder and addictive disorders
Schulte, E. M., Grilo, C. M., & Gearhardt, A. N. (2016) · Clinical Psychology Review · doi:10.1016/j.cpr.2016.02.001 · Cited by 271 · see citing works
Effects of Length of Abstinence on Decision-Making and Craving in Methamphetamine Abusers
Wang, G., Shi, J., Chen, N., Xu, L., Li, J., Li, P., Sun, Y., & Lu, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068791 · Cited by 261 · see citing works
Neurobiological mechanisms of the reinstatement of drug-conditioned place preference
Aguilar, M. A., Rodríguez‐Arias, M., & Miñarro, J. (2008) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.08.002 · Cited by 270 · see citing works
Stress-induced modulation of instrumental behavior: From goal-directed to habitual control of action
Schwabe, L., & Wolf, O. T. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.12.038 · Cited by 270 · see citing works
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li, C.-S. R., & Sinha, R. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.003 · Cited by 345 · see citing works
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Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse
Breese, G. R., Sinha, R., & Heilig, M. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.007 · Cited by 262 · see citing works
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Sex differences in the neurobiology of drug addiction
Bobzean, S. A. M., Nobrega, A. K. D., & Perrotti, L. I. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.022 · Cited by 261 · see citing works
Stress and alcohol: epidemiologic evidence
Keyes, K. M. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.03 · Cited by 260 · see citing works
Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders
Blaine, S. K., & Sinha, R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.037 · Cited by 257 · see citing works
“…in larger-scale adaptations and wear and tear (allostatic overload) to the reward and neuroendocrine regulation circuits (Koob and Le Moal, 2005; Sinha, 2001); these adaptations may represent the pathophysiology underlying the transition from controlled to compulsive alcohol-seeking in humans…”
InfluentialSelf-citation
Prevention and treatment of drug addiction by environmental enrichment
Solinas, M., Thiriet, N., Chauvet, C., & Jaber, M. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.08.002 · Cited by 256 · see citing works
Emotion regulation and substance use frequency in women with substance dependence and borderline personality disorder receiving dialectical behavior therapy
Axelrod, S. R., Perepletchikova, F., Holtzman, K., & Sinha, R. (2011) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2010.535582 · Cited by 254 · see citing works
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Cognitive Dysfunction and Anxious-Impulsive Personality Traits Are Endophenotypes for Drug Dependence
Ersche, K. D., Turton, A. J., Chamberlain, S. R., Müller, U., Bullmore, E. T., & Robbins, T. W. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11091421 · Cited by 252 · see citing works
Stress Enhancement of Craving During Sobriety: A Risk for Relapse
Breese, G. R., Chu, K., Dayas, C. V., Funk, D. R., Knapp, D. J., Koob, G. F., Lê, A. D., Dell, L. E. O., Overstreet, D. H., Roberts, A. J., et al. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000153544.83656.3c · Cited by 247 · see citing works
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Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats
Fuchs, R. A., Evans, K. A., Parker, M. P., & See, R. E. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1895-6 · Cited by 242 · see citing works
Effects of stress on alcohol drinking: a review of animal studies
Becker, H. C., Lopez, M. F., & Doremus‐Fitzwater, T. L. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2443-9 · Cited by 239 · see citing works
The Mothers and Toddlers Program, an attachment-based parenting intervention for substance using women: Post-treatment results from a randomized clinical pilot
Suchman, N. E., DeCoste, C., Castiglioni, N., McMahon, T. J., Rounsaville, B., & Mayes, L. (2010) · Attachment & Human Development · doi:10.1080/14616734.2010.501983 · Cited by 218 · see citing works
The COVID-19 Pandemic
Bank, W. (2020) · World Bank, Washington, DC eBooks · doi:10.1596/33696 · Cited by 218 · see citing works
kappa-Opioid receptor signaling and brain reward function
Bruijnzeel, A. W. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.09.008 · Cited by 214 · see citing works
Is Food Addictive? A Review of the Science
Gearhardt, A. N., & LaFata, E. M. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-110420-111710 · Cited by 222 · see citing works
Role of addiction and stress neurobiology on food intake and obesity
Sinha, R. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2017.05.001 · Cited by 211 · see citing works
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Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence
Smith, R. J., & Aston-Jones, G. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0191-3 · Cited by 206 · see citing works
Translational and reverse translational research on the role of stress in drug craving and relapse
Sinha, R., Shaham, Y., & Heilig, M. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2263-y · Cited by 208 · see citing works
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Stress-induced relapse to cocaine seeking: roles for the CRF2 receptor and CRF-binding protein in the ventral tegmental area of the rat
Wang, B., You, Z., Rice, K. C., & Wise, R. A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0782-3 · Cited by 207 · see citing works
Inoculation stress hypothesis of environmental enrichment.
Crofton, E. J., Zhang, Y., & Green, T. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.017 · Cited by 206 · see citing works
Psychosocial stress and cigarette smoking persistence, cessation, and relapse over 9–10 years: a prospective study of middle-aged adults in the United States
Slopen, N. B., Kontos, E. Z., Ryff, C. D., Ayanian, J. Z., Albert, M. A., & Williams, D. R. (2013) · Cancer Causes & Control · doi:10.1007/s10552-013-0262-5 · Cited by 194 · see citing works
Influence of stress associated with chronic alcohol exposure on drinking
Becker, H. C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.028 · Cited by 191 · see citing works
Stress, habits, and drug addiction: A psychoneuroendocrinological perspective.
Schwabe, L., Dickinson, A., & Wolf, O. T. (2011) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0022212 · Cited by 191 · see citing works
The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats
Marinelli, P. W., Funk, D. R., Juzytsch, W., Harding, S. E., Rice, K. C., Shaham, Y., & Lê, A. D. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0905-x · Cited by 191 · see citing works
Neural activity associated with stress-induced cocaine craving: a functional magnetic resonance imaging study
Sinha, R., Lacadie, C., Skudlarski, P., Fulbright, R. K., Rounsaville, B. J., Kosten, T. R., & Wexler, B. E. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0147-8 · Cited by 192 · see citing works
Self-citation
The Effect of Stress on Consumer Saving and Spending
Durante, K. M., & Laran, J. (2016) · Journal of Marketing Research · doi:10.1509/jmr.15.0319 · Cited by 188 · see citing works
REVIEW: Norepinephrine and stimulant addiction
Sofuoglu, M., & Sewell, R. A. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00138.x · Cited by 187 · see citing works
Alcohol Dependence, Withdrawal, and Relapse
Becker, H. C. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00019-5 · Cited by 184 · see citing works
Regulation of dopamine system responsivity and its adaptive and pathological response to stress
Belujon, P., & Grace, A. A. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.2516 · Cited by 185 · see citing works
Enhanced Sensitivity to Stress and Drug/Alcohol Craving in Abstinent Cocaine-Dependent Individuals Compared to Social Drinkers
Fox, H. C., Hong, K., Siedlarz, K. M., & Sinha, R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301470 · Cited by 182 · see citing works
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Psychostimulant abuse and neuroinflammation: emerging evidence of their interconnection.
Clark, K. H., Wiley, C. A., & Bradberry, C. W. (2013) · Neurotoxicity Research · doi:10.1007/s12640-012-9334-7 · Cited by 165 · see citing works
The Role of Stress, Trauma, and Negative Affect in the Development of Alcohol Misuse and Alcohol Use Disorders in Women
Guinle, M. I. B. (2020) · Alcohol research · doi:10.35946/arcr.v40.2.05 · Cited by 187 · see citing works
Dysfunctional connectivity patterns in chronic heroin users: An fMRI study
Liu, J., Liang, J., Qin, W., Tian, J., Yuan, K., Bai, L., Zhang, Y., Wang, W., Wang, Y., Li, Q., et al. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.05.038 · Cited by 181 · see citing works
A Gender Perspective of Addictive Disorders
Fonseca, F., Robles-Martínez, M., Tirado-Muñoz, J., Alías-Ferri, M., Mestre-Pintó, J. I., Coratu, A. M., & Torrens, M. (2021) · Current Addiction Reports · doi:10.1007/s40429-021-00357-9 · Cited by 192 · see citing works
Environmental enrichment during early stages of life reduces the behavioral, neurochemical, and molecular effects of cocaine
Solinas, M., Thiriet, N., Rawas, R. E., Lardeux, V., & Jaber, M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.51 · Cited by 175 · see citing works
Sex difference in alcoholism: Who is at a greater risk for development of alcoholic complication?
Ceylan‐Isik, A. F., McBride, S. M., & Ren, J. T. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.06.002 · Cited by 179 · see citing works
Environmental Enrichment Reduces Cocaine Seeking and Reinstatement Induced by Cues and Stress but Not by Cocaine
Chauvet, C., Lardeux, V., Goldberg, S. R., Jaber, M., & Solinas, M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.127 · Cited by 175 · see citing works
Stress-induced reduction in reward-related prefrontal cortex function
Ossewaarde, L., Qin, S., van Marle, H. J. F., van Wingen, G. A., Fernández, G., & Hermans, E. J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.068 · Cited by 172 · see citing works
Conceptual framework for the etiology of alcoholism: a “kindling”/stress hypothesis
Breese, G. R., Overstreet, D. H., & Knapp, D. J. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2016-2 · Cited by 167 · see citing works
The mothers and toddlers program, an attachment-based parenting intervention for substance-using women: results at 6-week follow-up in a randomized clinical pilot.
Suchman, N. E., Decoste, C., Mcmahon, T. J., Rounsaville, B., & Mayes, L. (2011) · Infant Mental Health Journal · doi:10.1002/imhj.20303 · Cited by 172 · see citing works
Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking
Schmidt, H. D., Anderson, S. M., Famous, K. R., Kumaresan, V., & Pierce, R. C. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.09.068 · Cited by 170 · see citing works
Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors
Overstreet, D. H. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.11.010 · Cited by 169 · see citing works
Hippocampus, amygdala, and stress: interacting systems that affect susceptibility to addiction
Belujon, P., & Grace, A. A. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05896.x · Cited by 171 · see citing works
Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents
Elman, I., Borsook, D., & Lukas, S. E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301051 · Cited by 169 · see citing works
Effects of alcohol dependence and withdrawal on stress responsiveness and alcohol consumption
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Intense cocaine self-administration after episodic social defeat stress, but not after aggressive behavior: dissociation from corticosterone activation
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Circuit and Synaptic Plasticity Mechanisms of Drug Relapse
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Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues
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Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats
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Authors: Sinha, R.
Affiliations: Yale University (US)
Corresponding author: Sinha, Rajita
ORCID: Sinha, Rajita
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2001-12-01
Volume: 158
Issue: 4
Pages: 343-359
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s002130100917
OpenAlex: W1984346427
Semantic Scholar: 81996b4691a9c531758df882218ad0286494d73e
Cited by: 1,505
References: 259
Citations by year: 2026: 25 · 2025: 43 · 2024: 45 · 2023: 53 · 2022: 67 · 2021: 76 · 2020: 134 · 2019: 75 · 2018: 102 · 2017: 65 · 2016: 77 · 2015: 67 · 2014: 73 · 2013: 67 · 2012: 81
FWCI: 13.05
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (P50DA009241, K12DA014038, DA14038, R01DA011077)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: stress, drug abuse, relapse, addiction, craving, self-administration, stress response, coping, chronic drug abuse, drug-seeking behavior, addiction prevention, addiction treatment
MeSH terms: Adaptation, Biological, Adaptation, Psychological, Animals, Humans, Models, Biological, Neural Pathways, Recurrence, Risk, Stress, Physiological, Stress, Psychological, Behavior, Addictive, Substance-Related Disorders

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