D-cycloserine and cocaine cue reactivity: preliminary findings
Open accessAbstract
BACKGROUND: D-cycloserine (DCS), a partial glutamate N-methyl-D-aspartic acid (NMDA) receptor agonist, enhances extinction of conditioned fear responding in rodents and facilitates exposure-based learning in humans with anxiety disorders. OBJECTIVES: This preliminary study investigates DCS pretreatment on response to cocaine cues in cocaine-dependent subjects. METHODS: Ten cocaine-dependent subjects were randomly assigned to receive either 50 mg DCS or matching placebo two hours before each of two 1-hour cocaine cue exposure sessions one day apart. HR and craving ratings were obtained before and during cue exposure sessions. RESULTS: There was a trend towards increased craving to cocaine cues in cocaine-dependent individuals after administration of DCS. CONCLUSIONS: The administration of DCS prior to cue exposure sessions may facilitate response activation. SCIENTIFIC SIGNIFICANCE: While facilitation of extinction-based learning by DCS may have therapeutic potential for cocaine dependence, this drug may exhibit a different profile in cocaine-dependent individuals as compared to those with anxiety disorders.
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Administration of a pharmacological agent to either disrupt the original memory or enhance extinction may worsen symptoms if the cue exposure session engages the alternative memory process.
“the administration of a pharmacological agent to either disrupt the original memory or enhance extinction may worsen symptoms if the cue exposure session engages the alternative memory process (Price et al., 2009; Gerlicher et al., 2019).”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Price et al., 2009
The Discussion (page unavailable) reports that D-cycloserine given before extinction sessions may acutely increase cocaine craving and cue reactivity, supporting the possibility of an adverse response to a drug intended to enhance extinction. It does not say that this occurs because cue exposure engages an alternative memory process, nor does it address a drug intended to disrupt the original memory. (LLM, conf=0.84)
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- Authors
- Price, K. L., McRae-Clark, A. L., Saladin, M. E., Maria, M. M. M.-S., DeSantis, S. M., Back, S. E., & Brady, K. T.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Price, Kimber L.
- Venue
- The American Journal of Drug and Alcohol Abuse
- Publisher
- Informa UK Limited
- Published
- 2009-12-15
- Volume
- 35
- Issue
- 6
- Pages
- 434-438
- ISSN
- 0095-2990 (ISSN-L)
- 1097-9891
- PMC
- PMC2805418
- OpenAlex
- W2128946570
- Cited by
- 54
- References
- 4
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2016: 3 · 2015: 7 · 2013: 5 · 2012: 8
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of Drug and Alcohol Abuse (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (5 K24 DA00435, K24DA000435)
- National Center for Research Resources (M01RR001070, 5 M01 RR01070)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- D-cycloserine, cocaine dependence, cocaine craving, NMDA receptor agonist, cue exposure, response activation, anxiety disorders, heart rate
- MeSH terms
- Adolescent, Adult, Cocaine, Cues, Cycloserine, Extinction, Psychological, Female, Heart Rate, Humans, Male, Pilot Projects, Receptors, N-Methyl-D-Aspartate, Behavior, Addictive, Cocaine-Related Disorders
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