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Cue exposure and response prevention with heavy smokers: a laboratory-based randomised placebo-controlled trial examining the effects of D-cycloserine on cue reactivity and attentional bias
Abstract
Rationale Treatments based on exposure/response prevention (Exp/RP) produce only modest benefits in substance dependence disorders. However, a new strategy, which has shown promise in animal models of addiction involves combining Exp/RP with extinction-enhancing pharmacological treatments. A prototype of the latter is D-cycloserine (DCS), a partial agonist at the glycine site of the NMDA receptor.Methods In a laboratory-based randomised, double-blind, placebo-controlled trial with non-treatment-seeking heavy smokers (n = 32), we examined the efficacy of Exp/RP combined with DCS (125 mg). Two sessions of Exp/RP were carried out during which cue reactivity was monitored. Effects on attentional bias and/or subjective craving and smoking behaviour were also evaluated after at least 48 h and 2 weeks following session 2 of Exp/RP.Results Within- and between-session reductions in cue reactivity were observed in both treatment groups, although the DCS group did not show an enhanced reduction by the end of session 2. However, a subtle effect of DCS on the emotionality subscale of the Tobacco Craving Questionnaire was observed, with a trend towards a sustained reduction in this aspect of craving at 2-week follow-up.Conclusion Our findings suggest that two sessions of Exp/RP combined with DCS does not enhance the reduction in episodic cue reactivity in non-treatment seeking smokers. A trend towards a greater sustained reduction in the emotionality scale of the TCQ in the DCS group suggests that further detailed study of the effects of combined Exp/RP-DCS on different aspects of craving is warranted, especially in smokers with a current intention to quit.
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Ordinary extended cue exposure has limited effects on smoking-related cue reactivity (subjective craving and physiological responding), even when combined with drugs that ostensibly enhance extinction learning.
“‘ordinary’ extended cue exposure has limited effects on smoking-related cue reactivity (subjective craving and physiological responding), even when combined with drugs that ostensibly enhance extinction learning (e.g. Kamboj et al. 2012).”
From Mindfulness, Acceptance and Defusion Strategies in Smokers: A Systematic Review of Laboratory Studies (2018) · cites this paper as Kamboj et al. 2012
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Metadata
- Authors
- Kamboj, S. K., Joye, A., Das, R. K., Gibson, A. J. W., Morgan, C. J. A., & Curran, H. V.
- Affiliations
- University College London (GB)
- Corresponding author
- Kamboj, Sunjeev K.
- Venue
- Psychopharmacology
- Published
- 2011-11-22
- Volume
- 221
- Issue
- 2
- Pages
- 273-284
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2105465456
- Cited by
- 44
- References
- 45
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 2 · 2013: 10 · 2012: 6
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- D-cycloserine, cue exposure, response prevention, cue reactivity, attentional bias, smoking, nicotine craving, NMDA receptor glycine site, heavy smokers, tobacco dependence
- MeSH terms
- Adult, Attention, Cues, Cycloserine, Double-Blind Method, Extinction, Psychological, Female, Follow-Up Studies, Humans, Male, Surveys and Questionnaires, Smoking, Time Factors, Smoking Cessation, Young Adult
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