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Toxicokinetics of ammonium perfluorohexanoate
Abstract
Excretion patterns and rates of ammonium perfluorohexanoate (APFHx) after administration of a single and multiple (14 days) oral dose(s) at 50 mg/kg to male and female mice and rats were examined. The test substance was [(14)C]-labeled APFHx. After a single oral administration, total excretion was rapid, with mean recoveries of over 90% of the dose at 24 hours after administration, irrespective of gender or species. The major route of elimination was via the urine (means of percentage recovery between 73.0 and 90.2% of the dose), followed by the feces (means of percentage recovery between 7.0 and 15.5% of the dose). Elimination via expired air was negligible. For the multiple dose tests, multiple (13 daily doses) oral administration of APFHx was followed by a single oral administration of [(14)C]-APFHx. Excretion was rapid, with mean recoveries of over 90% of the administered dose (mean values >95% of the ultimately recovered material) at 24 hours after dosing, irrespective of gender or species. The major route of elimination was via the urine (means of percentage recovery between 77.8 and 83.4% of the dose), followed by the feces (means of percentage recovery between 9.6 and 12.9% of the dose).
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“In general, PFBA, PFBS and PFHxA, which can be used as alternatives to their higher homologues in some cases or occur as undesired byproducts or degradation products of PBSF- or 6:2 fluorotelomer-based alternatives, have shorter half-lives in humans and biota than their longer-chain homologues (Borg and Hakansson, 2012; Iwai, 2011; Wilhelm et al., 2010).”
From Fluorinated alternatives to long-chain perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkane sulfonic acids (PFSAs) and their potential precursors (2013) · cites this paper as Iwai, 2011
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Metadata
- Authors
- Iwai, H.
- Affiliations
- Daikin (Japan) (JP)
- Corresponding author
- Iwai, Hiroyuki
- Venue
- Drug and Chemical Toxicology
- Publisher
- Informa UK Limited
- Published
- 2011-06-22
- Volume
- 34
- Issue
- 4
- Pages
- 341-346
- ISSN
- 0148-0545 (ISSN-L)
- 1525-6014
- OpenAlex
- W2015911976
- Cited by
- 20
- References
- 1
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Physical Sciences › Chemistry › Organic Chemistry › Fluorine in Organic Chemistry
- Keywords
- toxicokinetics, perfluorinated compounds, urinary excretion, fecal excretion, multiple oral dosing, radiolabeled compounds, mice, rats, gender differences, species differences
- MeSH terms
- Administration, Oral, Animals, Caproates, Dose-Response Relationship, Drug, Female, Fluorocarbons, Male, Metabolic Clearance Rate, Mice, Inbred Strains, Sex Factors, Species Specificity, Time Factors, Tissue Distribution, Rats, Sprague-Dawley, Mice, Rats
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