Incidence of pituitary dysfunction following traumatic brain injury: A prospective study from a regional neurosurgical centre
Abstract
Patients with traumatic brain injury (TBI) may develop pituitary dysfunction. Although, there is now increasing awareness of and investigations into such post-traumatic hypopituitarism (PTHP), the exact prevalence and incidence remain uncertain. Here, we aim to identify the incidence of PTHP in a selected population of TBI patients deemed at risk of PTHP at a regional neurosurgical centre in the UK. A total of 105 patients have been assessed in two cohorts: (i) 58 patients in serial cohort and (ii) 47 patients in cross-sectional late cohort. We found that in serial cohort, 10.3% (6/58) of TBI patients had abnormalities of the pituitary-adrenal axis in the acute phase (Day 0-7 post injury). In comparison, in cross-sectional late cohort, 21.3% (10/47) of the patients developed dysfunction in at least one of their pituitary axes at 6 months or more post-TBI, with hypogonadotrophic hypogonadism being the most common. Twenty-two patients from these two cohorts had their growth hormone assessment at 12 months or more post-TBI and 9.1% (2/22) were found to have growth hormone deficiency. Our results suggest that PTHP is a common condition amongst sufferers of TBI, and appropriate measures should be taken to detect and manage it.
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Tan, C. L., Alavi, S. A., Baldeweg, S. E., Belli, A., Carson, A., Feeney, C., Goldstone, A. P., Greenwood, R., Menon, D. K., Simpson, H. L., et al. (2017) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-315500 · Cited by 111 · see citing works
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Post-Traumatic Hypopituitarism: A Neglected Consequence of Traumatic Brain Injury
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- Authors
- Alavi, S. A., Tan, C. L., Menon, D. K., Simpson, H. L., & Hutchinson, P. J.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Hutchinson, Peter J.
- Venue
- British Journal of Neurosurgery
- Publisher
- Informa UK Limited
- Published
- 2015-11-26
- Volume
- 30
- Issue
- 3
- Pages
- 302-306
- ISSN
- 0268-8697 (ISSN-L)
- 1360-046X
- OpenAlex
- W2179155710
- Cited by
- 35
- References
- 16
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 9 · 2018: 2 · 2017: 2 · 2016: 2
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- British Journal of Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0512-10090, NIHR-RP-R3-12-013)
- NIHR Cambridge Biomedical Research Centre
- NIHR Sheffield Biomedical Research Centre
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- traumatic brain injury, post-traumatic hypopituitarism, pituitary dysfunction, incidence, hypogonadotropic hypogonadism, growth hormone deficiency, pituitary-adrenal axis
- MeSH terms
- Brain Injuries, Traumatic, Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Humans, Hypopituitarism, Male, Middle Aged, Pituitary Diseases, Prospective Studies, Incidence, Young Adult
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